BCAR1/P130Cas expression in untreated and acquired tamoxifen-resistant human breast carcinomas

International Journal of Cancer

Volumn 89, Issue 5, 2000, Pages 465-468

  Van Der Flier, Silvia ^a   Chan, Christina M W ^b   Brinkman, Arend ^a   Smid, Marcel ^a   Johnston, Stephen R D ^b   Dorssers, Lambert C J ^a   Dowsett, Mitchell ^b  

^a JOSEPHINE NEFKENS INSTITUTE   (Netherlands)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; ESTROGEN; ESTROGEN RECEPTOR; PROTEIN P130; TAMOXIFEN;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; BREAST CARCINOMA; CHEMOLUMINESCENCE; CONTROLLED STUDY; CYTOSOL; DNA BINDING; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; WESTERN BLOTTING;

ADULT; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; DRUG RESISTANCE, NEOPLASM; ESTROGEN ANTAGONISTS; FEMALE; HUMAN; MIDDLE AGE; PHOSPHOPROTEINS; RECEPTORS, ESTROGEN; SUPPORT, NON-U.S. GOV'T; TAMOXIFEN;

EID: 0033797764     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0215(20000920)89:5<465::AID-IJC11>3.0.CO;2-O     Document Type: Article

References (29)

1. Detection of distinct pools of the adapter protein p130CAS using a panel of monoclonal antibodies
2. BCAR1, a human homologue of the adapter protein p130Cas and anti-oestrogen resistance in breast cancer cells
3. Identification of p 130Cas as a mediator of focal adhesion kinase-promoted cell migration
4. A novel estrogen receptor variant mRNA lacking exons 4 to 6 in breast carcinoma
5. Exon 5 deletion variant estrogen receptor messenger RNA expression in relation to tamoxifen resistance and progesterone receptor/ pS2 status in human breast cancer
6. Presence of exon 5-deleted oestrogen receptor in human breast cancer: Functional analysis and clinical significance
7. Induction of anti-oestrogen resistance in human breast cancer cells by random insertional mutagenesis using defective retroviruses: Identification of bcar-1, a common integration site
8. Genetic mechanisms involved in progression to hormone independence of human breast cancer
9. Oestrogen receptor mutants and variants in breast cancer
10. Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy. 133 Randomised trials involving 31,000 recurrences and 24,000 deaths among 75,000 women
11. Tamoxifen for early breast cancer: An overview of the randomised trials
12. Measurement of steroid hormone receptors in breast cancer patients on tamoxifen
13. Variant human breast tumor estrogen receptor with constitutive transcriptional activity
14. Translocation of ornithine decarboxylase to the surface membrane during cell activation and transformation
15. Comparison of estrogen receptor DNA binding in untreated and acquired anti-oestrogen-resistant human breast tumors
16. Changes in estrogen receptor, progesterone receptor, and pS2 expression in tamoxifen-resistant human breast cancer
17. Endocrine pharmacology of anti-oestrogens as antitumor agents
18. CAS/Crk coupling serves as a 'molecular switch' for induction of cell migration
19. Loss of estrogen receptor in recurrent breast cancer is associated with poor response to endocrine therapy
20. Tyrosine phosphorylation of p130Cas is involved in actin organization in osteoclasts
21. Integrin-mediated cell adhesion promotes tyrosine phosphorylation of p130Cas, a Src homology 3-containing molecule having multiple Src homology 2-binding motifs
22. Integrin signalling: A new cas(t) of characters enters the stage
23. Steroid hormone receptors in breast cancer management
24. Mechanisms of tamoxifen resistance
25. Adhesion-induced tyrosine phosphorylation of the p 130 SRC substrate
26. A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner
27. BCAR1/p130Cas protein and primary breast cancer: Prognosis and response to tamoxifen treatment
28. Induction of p130cas signaling complex formation upon integrin-mediated cell adhesion: A role for Src family kinases
29. Oestrogen receptor gene structure and function in breast cancer