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Volumn 96, Issue 2, 2006, Pages 131-146

Bidirectional cross talk between ERα and EGFR signalling pathways regulates tamoxifen-resistant growth

Author keywords

Amphiregulin; Epidermal growth factor receptor; MCF 7 cells; Mitogen activated protein kinase; Oestrogen receptor ; Serine 118; Tamoxifen resistance

Indexed keywords

2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; AMPHIREGULIN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ESTROGEN RECEPTOR ALPHA; GEFITINIB; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; NEUTRALIZING ANTIBODY; P68 RNA HELICASE; PHOSPHOTRANSFERASE INHIBITOR; RNA HELICASE; SERINE; STEROID RECEPTOR COACTIVATOR 1; TAMOXIFEN; UNCLASSIFIED DRUG;

EID: 33645234316     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10549-005-9070-2     Document Type: Article
Times cited : (130)

References (63)
  • 6
    • 0026704233 scopus 로고
    • Changes in epidermal growth factor receptor expression and response to ligand associated with acquired tamoxifen resistance or oestrogen independence in the ZR-75-1 human breast cancer cell line
    • Long B, McKibben BM, Lynch M, van den Berg HW: Changes in epidermal growth factor receptor expression and response to ligand associated with acquired tamoxifen resistance or oestrogen independence in the ZR-75-1 human breast cancer cell line. Br J Cancer 65: 865-869, 1992
    • (1992) Br J Cancer , vol.65 , pp. 865-869
    • Long, B.1    McKibben, B.M.2    Lynch, M.3    Van Den Berg, H.W.4
  • 7
    • 0032974128 scopus 로고    scopus 로고
    • The anti-proliferative effects of tyrosine kinase inhibitors towards tamoxifen-sensitive and tamoxifen-resistant human breast cancer cell lines in relation to the expression of epidermal growth factor receptors (EGF-R) and the inhibition of EGF-R tyrosine kinase
    • El-Zarruk AA, van den Berg HW: The anti-proliferative effects of tyrosine kinase inhibitors towards tamoxifen-sensitive and tamoxifen-resistant human breast cancer cell lines in relation to the expression of epidermal growth factor receptors (EGF-R) and the inhibition of EGF-R tyrosine kinase. Cancer Lett 142: 185-193, 1999
    • (1999) Cancer Lett , vol.142 , pp. 185-193
    • El-Zarruk, A.A.1    Van Den Berg, H.W.2
  • 8
    • 0037373326 scopus 로고    scopus 로고
    • Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells
    • Knowlden JM, Hutcheson IR, Jones HE, Madden T, Gee JM, Harper ME, Barrow D, Wakeling AE, Nicholson RI: Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells. Endocrinol 144: 1032-1044, 2003
    • (2003) Endocrinol , vol.144 , pp. 1032-1044
    • Knowlden, J.M.1    Hutcheson, I.R.2    Jones, H.E.3    Madden, T.4    Gee, J.M.5    Harper, M.E.6    Barrow, D.7    Wakeling, A.E.8    Nicholson, R.I.9
  • 9
    • 0026786658 scopus 로고
    • Ectopic expression of epidermal growth factor receptors induces hormone independence in ZR-75-1 human breast cancer cells
    • van Agthoven TT, van Agthoven TL, Portengen H, Foekens JA, Dorssers LC: Ectopic expression of epidermal growth factor receptors induces hormone independence in ZR-75-1 human breast cancer cells. Cancer Res 52: 5082-5088, 1992
    • (1992) Cancer Res , vol.52 , pp. 5082-5088
    • Van Agthoven, T.T.1    Van Agthoven, T.L.2    Portengen, H.3    Foekens, J.A.4    Dorssers, L.C.5
  • 11
    • 0027973875 scopus 로고
    • Emergence of MCF7 cells overexpressing a transfected epidermal growth factor receptor (EGFR) under estrogen-depleted conditions: Evidence for a role of EGFR in breast cancer growth and progression
    • Miller DL, El-Ashry D, Cheville AL, Liu Y, McLeskey SW, Kern FG: Emergence of MCF7 cells overexpressing a transfected epidermal growth factor receptor (EGFR) under estrogen-depleted conditions: evidence for a role of EGFR in breast cancer growth and progression. Cell Growth Diff 5: 1263-1274, 1994
    • (1994) Cell Growth Diff , vol.5 , pp. 1263-1274
    • Miller, D.L.1    El-Ashry, D.2    Cheville, A.L.3    Liu, Y.4    McLeskey, S.W.5    Kern, F.G.6
  • 12
    • 0028928063 scopus 로고
    • MCF-7 breast cancer cells overexpressing transfected c-erbB-2 have an in vitro growth advantage in estrogen-depleted conditions and reduced estrogen-dependence and tamoxifen-sensitivity in vivo
    • Liu Y, El-Ashry D, Chen D, Ding IY, Kern FG: MCF-7 breast cancer cells overexpressing transfected c-erbB-2 have an in vitro growth advantage in estrogen-depleted conditions and reduced estrogen-dependence and tamoxifen-sensitivity in vivo. Breast Cancer Res Treat 34: 97-117, 1995
    • (1995) Breast Cancer Res Treat , vol.34 , pp. 97-117
    • Liu, Y.1    El-Ashry, D.2    Chen, D.3    Ding, I.Y.4    Kern, F.G.5
  • 13
    • 0034667395 scopus 로고    scopus 로고
    • Inhibition of HER2/neu (erbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells
    • Kurokawa H, Lenferink AEG, Simpson JF, Piscane PI, Sliwkowski MX, Forbes JT, Arteaga CL: Inhibition of HER2/neu (erbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells. Cancer Res 60: 5887-5894, 2000
    • (2000) Cancer Res , vol.60 , pp. 5887-5894
    • Kurokawa, H.1    Lenferink, A.E.G.2    Simpson, J.F.3    Piscane, P.I.4    Sliwkowski, M.X.5    Forbes, J.T.6    Arteaga, C.L.7
  • 14
    • 0034644539 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Schlessinger J: Cell signaling by receptor tyrosine kinases. Cell 103: 211-225, 2000
    • (2000) Cell , vol.103 , pp. 211-225
    • Schlessinger, J.1
  • 15
    • 0032530222 scopus 로고    scopus 로고
    • Elevated mitogen-activated protein kinase activity in estrogen-nonresponsive human breast cancer cells
    • Coutts AS, Murphy LC: Elevated mitogen-activated protein kinase activity in estrogen-nonresponsive human breast cancer cells. Cancer Res 58: 4071-4074, 1998
    • (1998) Cancer Res , vol.58 , pp. 4071-4074
    • Coutts, A.S.1    Murphy, L.C.2
  • 16
    • 0034464912 scopus 로고    scopus 로고
    • Estradiol hypersensitivity and mitogen-activated protein kinase expression in long-term estrogen deprived human breast cancer cells in vivo
    • Shim W-S, Conaway M, Masamura S, Yue W, Wang J-P, Kumar R, Santen RJ: Estradiol hypersensitivity and mitogen-activated protein kinase expression in long-term estrogen deprived human breast cancer cells in vivo. Endocrinol 141: 396-405, 2000
    • (2000) Endocrinol , vol.141 , pp. 396-405
    • Shim, W.-S.1    Conaway, M.2    Masamura, S.3    Yue, W.4    Wang, J.-P.5    Kumar, R.6    Santen, R.J.7
  • 17
    • 0030757687 scopus 로고    scopus 로고
    • Constitutive Raf-1 kinase activity in breast cancer cells induces both estrogen-independent growth and apoptosis
    • El-Ashry D, Miller DL, Kharbanda S, Lippman ME, Kern FG: Constitutive Raf-1 kinase activity in breast cancer cells induces both estrogen-independent growth and apoptosis. Oncogene 15: 423-435, 1997
    • (1997) Oncogene , vol.15 , pp. 423-435
    • El-Ashry, D.1    Miller, D.L.2    Kharbanda, S.3    Lippman, M.E.4    Kern, F.G.5
  • 18
    • 0035798683 scopus 로고    scopus 로고
    • Constitutive MEK/MAPK activation leads to p27Kip1 deregulation and antiestrogen resistance in human breast cancer cells
    • Donovan JCH, Milic A, Slingerland JM: Constitutive MEK/MAPK activation leads to p27Kip1 deregulation and antiestrogen resistance in human breast cancer cells. J Biol Chem 276: 40,888-40,895, 1997
    • (1997) J Biol Chem , vol.276
    • Donovan, J.C.H.1    Milic, A.2    Slingerland, J.M.3
  • 19
    • 0034987631 scopus 로고    scopus 로고
    • Enhanced epidermal growth factor receptor signalling in MCF7 breast cancer cells following long-term culture in the presence of the pure antioestrogen ICI 182,780 (Faslodex)
    • McClelland RA, Barrow D, Madden T, Dutkowski CM, Pamment J, Knowlden J, Gee JM, Nicholson RI: Enhanced epidermal growth factor receptor signalling in MCF7 breast cancer cells following long-term culture in the presence of the pure antioestrogen ICI 182,780 (Faslodex). Endocrinol 142: 2776-2788, 2001
    • (2001) Endocrinol , vol.142 , pp. 2776-2788
    • McClelland, R.A.1    Barrow, D.2    Madden, T.3    Dutkowski, C.M.4    Pamment, J.5    Knowlden, J.6    Gee, J.M.7    Nicholson, R.I.8
  • 20
    • 0035919923 scopus 로고    scopus 로고
    • Phosphorylation of ERK1/2 mitogen activated protein kinase is associated with poor response to anti-hormonal therapy and decreased patient survival in clinical breast cancer
    • Gee JMW, Robertson JFR, Ellis IO, Nicholson RI: Phosphorylation of ERK1/2 mitogen activated protein kinase is associated with poor response to anti-hormonal therapy and decreased patient survival in clinical breast cancer. Int J Cancer 95: 247-254, 2001
    • (2001) Int J Cancer , vol.95 , pp. 247-254
    • Gee, J.M.W.1    Robertson, J.F.R.2    Ellis, I.O.3    Nicholson, R.I.4
  • 21
    • 0034691562 scopus 로고    scopus 로고
    • Potential prognostic value of mitogen-activated protein kinase activity for disease-free survival of primary breast cancer patients
    • Mueller H, Flury N, Eppenberger-Castori S, Kueng W, David F, Eppenberger U: Potential prognostic value of mitogen-activated protein kinase activity for disease-free survival of primary breast cancer patients. Int J Cancer (Pred Oncol) 89: 384-388, 2000
    • (2000) Int J Cancer (Pred Oncol) , vol.89 , pp. 384-388
    • Mueller, H.1    Flury, N.2    Eppenberger-Castori, S.3    Kueng, W.4    David, F.5    Eppenberger, U.6
  • 22
    • 0029877913 scopus 로고    scopus 로고
    • Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation
    • Bunone G, Briand P-A, Miksicek RJ, Picard D: Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation. EMBO J 15: 2174-2183, 1996
    • (1996) EMBO J , vol.15 , pp. 2174-2183
    • Bunone, G.1    Briand, P.-A.2    Miksicek, R.J.3    Picard, D.4
  • 24
    • 0031594574 scopus 로고    scopus 로고
    • pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167
    • Joel PB, Smith J, Sturgill TW, Fisher TL, Blenis J, Lannigan DA: pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167. Mol Cell Biol 18: 1978-1984, 1998
    • (1998) Mol Cell Biol , vol.18 , pp. 1978-1984
    • Joel, P.B.1    Smith, J.2    Sturgill, T.W.3    Fisher, T.L.4    Blenis, J.5    Lannigan, D.A.6
  • 25
    • 0037211754 scopus 로고    scopus 로고
    • Estrogen receptor phosphorylation
    • Lannigan DA: Estrogen receptor phosphorylation. Steroids 68: 1-9, 2003
    • (2003) Steroids , vol.68 , pp. 1-9
    • Lannigan, D.A.1
  • 26
    • 0032814142 scopus 로고    scopus 로고
    • Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha
    • Endoh H, Maruyama K, Masuhiro Y, Kobayashi Y, Goto M, Tai H, Yanagisawa J, Metzger D, Hashimoto S, Kato S: Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha. Mol Cell Biol 19: 5363-5372, 1999
    • (1999) Mol Cell Biol , vol.19 , pp. 5363-5372
    • Endoh, H.1    Maruyama, K.2    Masuhiro, Y.3    Kobayashi, Y.4    Goto, M.5    Tai, H.6    Yanagisawa, J.7    Metzger, D.8    Hashimoto, S.9    Kato, S.10
  • 27
    • 0041977096 scopus 로고    scopus 로고
    • Ligand-independent coactivation of ERalpha AF-1 by steroid receptor RNA activator (SRA) via MAPK activation
    • Deblois G, Giguere V: Ligand-independent coactivation of ERalpha AF-1 by steroid receptor RNA activator (SRA) via MAPK activation. J Steroid Biochem Mol Biol 85: 123-131, 2003
    • (2003) J Steroid Biochem Mol Biol , vol.85 , pp. 123-131
    • Deblois, G.1    Giguere, V.2
  • 29
    • 0027279120 scopus 로고
    • MCF7/LCC2: A 4-hydroxytamoxifen resistant human breast cancer variant that retains sensitivity to the steroidal antiestrogen ICI 182,780
    • Brunner N, Frandesen TL, Holst-Hansen C, Bei M, Thompson EW, Wakeling AE, Lippman ME, Clarke R: MCF7/LCC2: a 4-hydroxytamoxifen resistant human breast cancer variant that retains sensitivity to the steroidal antiestrogen ICI 182,780. Cancer Res 53: 3229-3232, 1993
    • (1993) Cancer Res , vol.53 , pp. 3229-3232
    • Brunner, N.1    Frandesen, T.L.2    Holst-Hansen, C.3    Bei, M.4    Thompson, E.W.5    Wakeling, A.E.6    Lippman, M.E.7    Clarke, R.8
  • 30
    • 0028329961 scopus 로고
    • Altered expression of estrogen-regulated genes in a tamoxifen-resistant and ICI 164,384 and ICI 182,780 sensitive human breast cancer cell line, MCF-7/TAM R-1
    • Lykkesfeldt AE, Mogens MW, Briand P: Altered expression of estrogen-regulated genes in a tamoxifen-resistant and ICI 164,384 and ICI 182,780 sensitive human breast cancer cell line, MCF-7/TAM R-1. Cancer Res 54: 1587-1595, 1994
    • (1994) Cancer Res , vol.54 , pp. 1587-1595
    • Lykkesfeldt, A.E.1    Mogens, M.W.2    Briand, P.3
  • 31
    • 0030028024 scopus 로고    scopus 로고
    • Oestrogen receptor: A stable phenotype in breast cancer
    • Robertson JF: Oestrogen receptor: a stable phenotype in breast cancer. Br J Cancer 73: 5-12, 1996
    • (1996) Br J Cancer , vol.73 , pp. 5-12
    • Robertson, J.F.1
  • 33
    • 0035971181 scopus 로고    scopus 로고
    • PI3 kinase/AKT-mediated activation of estrogen receptor alpha: A new model for anti-estrogen resistance
    • Campbell RA, Bhat-Nakshatri P, Patel NM, Constantinidou D, Ali S, Nakshatri H: PI3 kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance. J Biol Chem 276: 9817-9824, 2001
    • (2001) J Biol Chem , vol.276 , pp. 9817-9824
    • Campbell, R.A.1    Bhat-Nakshatri, P.2    Patel, N.M.3    Constantinidou, D.4    Ali, S.5    Nakshatri, H.6
  • 34
    • 2942652871 scopus 로고    scopus 로고
    • Mechanisms of tamoxifen resistance: Increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer
    • Shou J, Massarweh S, Osborne CK, Wakeling AE, Ali S, Weiss H, Schiff R: Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer. J Natl Cancer Inst 96: 926-935, 2004
    • (2004) J Natl Cancer Inst , vol.96 , pp. 926-935
    • Shou, J.1    Massarweh, S.2    Osborne, C.K.3    Wakeling, A.E.4    Ali, S.5    Weiss, H.6    Schiff, R.7
  • 35
    • 0036702132 scopus 로고    scopus 로고
    • Molecular changes associated with the acquisition of oestrogen hypersensitivity in MCF-7 breast cancer cells on long-term oestrogen deprivation
    • Chan CM, Martin LA, Johnston SR, Ali S, Dowsett M: Molecular changes associated with the acquisition of oestrogen hypersensitivity in MCF-7 breast cancer cells on long-term oestrogen deprivation. J Steroid Biochem Mol Biol 81: 333-341, 2002
    • (2002) J Steroid Biochem Mol Biol , vol.81 , pp. 333-341
    • Chan, C.M.1    Martin, L.A.2    Johnston, S.R.3    Ali, S.4    Dowsett, M.5
  • 36
    • 0042232592 scopus 로고    scopus 로고
    • Enhanced estrogen receptor (ER) alpha, ERBB2, and MAPK signal transduction pathways operate during the adaptation of MCF-7 cells to long term estrogen deprivation
    • Martin LA, Farmer I, Johnston SR, Ali S, Marshall C, Dowsett M: Enhanced estrogen receptor (ER) alpha, ERBB2, and MAPK signal transduction pathways operate during the adaptation of MCF-7 cells to long term estrogen deprivation. J Biol Chem 278: 30,458-30,468, 2003
    • (2003) J Biol Chem , vol.278
    • Martin, L.A.1    Farmer, I.2    Johnston, S.R.3    Ali, S.4    Marshall, C.5    Dowsett, M.6
  • 37
    • 16444369651 scopus 로고    scopus 로고
    • Molecular changes associated with the agonist activity of hydroxy-tamoxifen and the hyper-response to estradiol in hydroxy-tamoxifen- resistant breast cancer cell lines
    • Vendrell JA, Bieche I, Desmetz C, Badia E, Tozlu S, Nguyen C, Nicolas JC, Lidereau R, Cohen PA: Molecular changes associated with the agonist activity of hydroxy-tamoxifen and the hyper-response to estradiol in hydroxy-tamoxifen- resistant breast cancer cell lines. Endocr Relat Cancer 12: 75-92, 2005
    • (2005) Endocr Relat Cancer , vol.12 , pp. 75-92
    • Vendrell, J.A.1    Bieche, I.2    Desmetz, C.3    Badia, E.4    Tozlu, S.5    Nguyen, C.6    Nicolas, J.C.7    Lidereau, R.8    Cohen, P.A.9
  • 39
    • 0028267222 scopus 로고
    • Anti-proliferative and anti-estrogenic effects of ICI 164,384 and ICI 182,780 in 4-OH-tamoxifen-resistant human breast-cancer cells
    • Coopman P, Garcia M, Brunner N, Derocq D, Clarke R, Rochefort H: Anti-proliferative and anti-estrogenic effects of ICI 164,384 and ICI 182,780 in 4-OH-tamoxifen-resistant human breast-cancer cells. Int J Cancer 56: 295-300, 1994
    • (1994) Int J Cancer , vol.56 , pp. 295-300
    • Coopman, P.1    Garcia, M.2    Brunner, N.3    Derocq, D.4    Clarke, R.5    Rochefort, H.6
  • 40
    • 0028861402 scopus 로고
    • Response to a specific antioestrogen (ICI 182780) in tamoxifen-resistant breast cancer
    • Howell A, Robertson J: Response to a specific antioestrogen (ICI 182780) in tamoxifen-resistant breast cancer. Lancet 345: 989-990, 1995
    • (1995) Lancet , vol.345 , pp. 989-990
    • Howell, A.1    Robertson, J.2
  • 41
    • 0030016280 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacological and anti-tumor effects of the specific anti-estrogen ICI 182,780 in women with advanced breast cancer
    • Howell A, DeFriend DJ, Robertson JF, Blamey RW, Anderson L, Anderson E, Sutcliffe FA, Walton P: Pharmacokinetics, pharmacological and anti-tumor effects of the specific anti-estrogen ICI 182,780 in women with advanced breast cancer. Br J Cancer 74: 300-308, 1996
    • (1996) Br J Cancer , vol.74 , pp. 300-308
    • Howell, A.1    DeFriend, D.J.2    Robertson, J.F.3    Blamey, R.W.4    Anderson, L.5    Anderson, E.6    Sutcliffe, F.A.7    Walton, P.8
  • 42
    • 0036133044 scopus 로고    scopus 로고
    • AliBaba2: Context specific identification of transcription factor binding sites
    • Grabe N: AliBaba2: context specific identification of transcription factor binding sites. In Silico Biol 2: S1, 2002
    • (2002) In Silico Biol , vol.2
    • Grabe, N.1
  • 43
    • 0033990048 scopus 로고    scopus 로고
    • Primer3 on the WWW for general users and for biologist programmers
    • Krawetz S, Misener S (eds) Humana Press, Totowa, NJ
    • Rozen S, Skaletsky HJ: Primer3 on the WWW for general users and for biologist programmers. In: Krawetz S, Misener S (eds) Bioinformatics Methods and Protocols: Methods in Molecular Biology. Humana Press, Totowa, NJ 2000, pp 365-386
    • (2000) Bioinformatics Methods and Protocols: Methods in Molecular Biology , pp. 365-386
    • Rozen, S.1    Skaletsky, H.J.2
  • 44
    • 0028111526 scopus 로고
    • Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity
    • Le Goff P, Montano MM, Schodin DJ, Katzenellenbogen BS: Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity. J Biol Chem 269: 4458-4466, 1994
    • (1994) J Biol Chem , vol.269 , pp. 4458-4466
    • Le Goff, P.1    Montano, M.M.2    Schodin, D.J.3    Katzenellenbogen, B.S.4
  • 45
    • 0029163578 scopus 로고
    • Estradiol and phorbol ester cause phosphorylation of serine 118 in the human estrogen receptor
    • Joel PB, Traish AM, Lannigan DA: Estradiol and phorbol ester cause phosphorylation of serine 118 in the human estrogen receptor. Mol Endocrinol 9: 1041-1052, 1995
    • (1995) Mol Endocrinol , vol.9 , pp. 1041-1052
    • Joel, P.B.1    Traish, A.M.2    Lannigan, D.A.3
  • 47
    • 0032446607 scopus 로고    scopus 로고
    • The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by Tamoxifen
    • Shiau AK, Barstad D, Loria P, Cheng L, Kushner PJ, Agard DA, Greene GL: The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by Tamoxifen. Cell 95: 927-937, 1998
    • (1998) Cell , vol.95 , pp. 927-937
    • Shiau, A.K.1    Barstad, D.2    Loria, P.3    Cheng, L.4    Kushner, P.J.5    Agard, D.A.6    Greene, G.L.7
  • 48
    • 0033637703 scopus 로고    scopus 로고
    • Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription
    • Shang Y, Hu X, DiRenzo J, Lazar MA, Brown M: Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell 103: 843-852, 2000
    • (2000) Cell , vol.103 , pp. 843-852
    • Shang, Y.1    Hu, X.2    Direnzo, J.3    Lazar, M.A.4    Brown, M.5
  • 49
    • 0037192501 scopus 로고    scopus 로고
    • Molecular determinants for the tissue specificity of SERMs
    • Shang Y, Brown M: Molecular determinants for the tissue specificity of SERMs. Science 295: 2465-2468, 2002
    • (2002) Science , vol.295 , pp. 2465-2468
    • Shang, Y.1    Brown, M.2
  • 50
    • 1442351143 scopus 로고    scopus 로고
    • Coregulator function: A key to understanding tissue specificity of selective receptor modulators
    • Smith CL, O'Malley BW: Coregulator function: a key to understanding tissue specificity of selective receptor modulators. Endocr Rev 25: 45-71, 2004
    • (2004) Endocr Rev , vol.25 , pp. 45-71
    • Smith, C.L.1    O'Malley, B.W.2
  • 51
    • 0001392322 scopus 로고    scopus 로고
    • AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor
    • de Font Mora J, Brown M: AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor. Mol Cell Biol 20: 5041-5047, 2000
    • (2000) Mol Cell Biol , vol.20 , pp. 5041-5047
    • De Font Mora, J.1    Brown, M.2
  • 52
    • 0034635553 scopus 로고    scopus 로고
    • Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway
    • Rowan BG, Weigel NL, O'Malley BW: Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway. J Biol Chem 275: 4475-4483, 2000
    • (2000) J Biol Chem , vol.275 , pp. 4475-4483
    • Rowan, B.G.1    Weigel, N.L.2    O'Malley, B.W.3
  • 53
    • 0035933737 scopus 로고    scopus 로고
    • Growth factors signal to steroid receptors through mitogen-activated protein kinase regulation of p160 coactivator activity
    • Lopez GN, Turck CW, Schaufele F, Stallcup MR, Kushner PJ: Growth factors signal to steroid receptors through mitogen-activated protein kinase regulation of p160 coactivator activity. J Biol Chem 276: 22,177-22,182, 2001
    • (2001) J Biol Chem , vol.276
    • Lopez, G.N.1    Turck, C.W.2    Schaufele, F.3    Stallcup, M.R.4    Kushner, P.J.5
  • 54
    • 11144230050 scopus 로고    scopus 로고
    • SMRT and N-CoR corepressors are regulated by distinct kinase signaling pathways
    • Jonas BA, Privalsky ML: SMRT and N-CoR corepressors are regulated by distinct kinase signaling pathways. J Biol Chem 279: 54,676-54,686, 2004
    • (2004) J Biol Chem , vol.279
    • Jonas, B.A.1    Privalsky, M.L.2
  • 56
    • 0028901194 scopus 로고
    • Tamoxifen activation of the estrogen receptor/AP-1 pathway: Potential origin for the cell-specific estrogen-like effects of antiestrogens
    • Webb P, Lopez GN, Uht RM, Kushner PJ: Tamoxifen activation of the estrogen receptor/AP-1 pathway: potential origin for the cell-specific estrogen-like effects of antiestrogens. Mol Endocrinol 9: 443-456, 1995
    • (1995) Mol Endocrinol , vol.9 , pp. 443-456
    • Webb, P.1    Lopez, G.N.2    Uht, R.M.3    Kushner, P.J.4
  • 57
    • 0029802492 scopus 로고    scopus 로고
    • Progression of MCF7 breast cancer cells to antiestrogen-resistant phenotype is accompanied by elevated levels of AP-1 DNA-binding activity
    • Dumont JA, Bitonti AJ, Wallace CD, Baumann RJ, Cashman EA, Cross-Doersen DE: Progression of MCF7 breast cancer cells to antiestrogen-resistant phenotype is accompanied by elevated levels of AP-1 DNA-binding activity. Cell Growth Diff 7: 351-359, 1996
    • (1996) Cell Growth Diff , vol.7 , pp. 351-359
    • Dumont, J.A.1    Bitonti, A.J.2    Wallace, C.D.3    Baumann, R.J.4    Cashman, E.A.5    Cross-Doersen, D.E.6
  • 58
    • 0033049975 scopus 로고    scopus 로고
    • Increased activator protein-1 DNA binding and c-Jun NH2-terminal kinase activity in human breast tumours with acquired tamoxifen resistance
    • Johnston SRD, Lu B, Scott GK, Kushner PJ, Smith IE, Dowsett M, Benz CC: Increased activator protein-1 DNA binding and c-Jun NH2-terminal kinase activity in human breast tumours with acquired tamoxifen resistance. Clin Cancer Res 5: 251-256, 1999
    • (1999) Clin Cancer Res , vol.5 , pp. 251-256
    • Johnston, S.R.D.1    Lu, B.2    Scott, G.K.3    Kushner, P.J.4    Smith, I.E.5    Dowsett, M.6    Benz, C.C.7
  • 59
    • 0023944689 scopus 로고
    • Expression of transforming growth factor alpha and its messenger ribonucleic acid in human breast cancer: Its regulation by estrogen and its possible functional significance
    • Bates SE, Davidson NE, Valverius EM, Freter CE, Dickson RB, Tam JP, Kudlow JE, Lippman ME, Salomon DS: Expression of transforming growth factor alpha and its messenger ribonucleic acid in human breast cancer: its regulation by estrogen and its possible functional significance. Mol Endocrinol 2: 543-555, 1988
    • (1988) Mol Endocrinol , vol.2 , pp. 543-555
    • Bates, S.E.1    Davidson, N.E.2    Valverius, E.M.3    Freter, C.E.4    Dickson, R.B.5    Tam, J.P.6    Kudlow, J.E.7    Lippman, M.E.8    Salomon, D.S.9
  • 61
    • 0034864373 scopus 로고    scopus 로고
    • Estrogen receptor alpha mediated induction of the transforming growth factor alpha gene by estradiol and 4-hydroxytamoxifen in MDA-MB-231 breast cancer cells
    • MacGregor Schafer J, Liu H, Levenson AS, Horiguchi J, Chen Z, Jordan VC: Estrogen receptor alpha mediated induction of the transforming growth factor alpha gene by estradiol and 4-hydroxytamoxifen in MDA-MB-231 breast cancer cells. J Steroid Biochem Mol Biol 78: 41-50, 2001
    • (2001) J Steroid Biochem Mol Biol , vol.78 , pp. 41-50
    • MacGregor Schafer, J.1    Liu, H.2    Levenson, A.S.3    Horiguchi, J.4    Chen, Z.5    Jordan, V.C.6
  • 63
    • 0012453190 scopus 로고    scopus 로고
    • The effects of beta-estradiol on Raf activity, cell cycle progression and growth factor synthesis in the MCF-7 breast cancer cell line
    • Weinstein-Oppenheimer CR, Burrows C, Steelman LS, McCubrey JA: The effects of beta-estradiol on Raf activity, cell cycle progression and growth factor synthesis in the MCF-7 breast cancer cell line. Cancer Biol Ther 1: 256-262, 2002
    • (2002) Cancer Biol Ther , vol.1 , pp. 256-262
    • Weinstein-Oppenheimer, C.R.1    Burrows, C.2    Steelman, L.S.3    McCubrey, J.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.