Constitutive MEK/MAPK Activation Leads to p27Kip1 Deregulation and Antiestrogen Resistance in Human Breast Cancer Cells

Journal of Biological Chemistry

Volumn 276, Issue 44, 2001, Pages 40888-40895

  Donovan, Jeffrey C H ^b   Milic, Andrea ^b   Slingerland, Joyce M ^a  

^a SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; PROTEINS; TUMORS;

BREAST CANCER;

BIOCHEMISTRY;

ANTIESTROGEN; ANTISENSE OLIGODEOXYNUCLEOTIDE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P27; TAMOXIFEN; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1B; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; BREAST CARCINOMA; CANCER CELL; CELL CYCLE G1 PHASE; CONTROLLED STUDY; DEREGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MITOSIS INHIBITION; ONCOGENE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; BREAST TUMOR; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; DRUG RESISTANCE; ENZYMOLOGY; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SERODIAGNOSIS;

BREAST NEOPLASMS; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DRUG RESISTANCE, NEOPLASM; ENZYME ACTIVATION; ESTROGEN RECEPTOR MODULATORS; G1 PHASE; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PRECIPITIN TESTS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 0035798683     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M106448200     Document Type: Article

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