Regulation of c-SRC activity and function by the adapter protein CAS

Molecular and Cellular Biology

Volumn 20, Issue 16, 2000, Pages 5865-5878

  Burnham, M R ^a   Bruce Staskal, P J ^a   Harte, M T ^a   Weidow, C L ^a   Ma, A ^a   Weed, S A ^a   Bouton, A H ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P130; PROTEIN TYROSINE KINASE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; CELL GROWTH; CELL SURVIVAL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION;

ANIMALS; CELL LINE; CRK-ASSOCIATED SUBSTRATE PROTEIN; ENZYME ACTIVATION; FIBROBLASTS; MICE; PHOSPHOPROTEINS; PROTEINS; RETINOBLASTOMA-LIKE PROTEIN P130; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; SRC-FAMILY KINASES;

ANIMALIA; MURINAE;

EID: 0033860096     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.16.5865-5878.2000     Document Type: Article

References (92)

1. Src family tyrosine kinases and growth factor signaling
2. Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel, p130(CAS)-related protein, Sin
3. The caveolae membrane system
4. Characterization of human epidermal growth factor receptor and c-Src interactions in human breast tumor cells
5. c-Src, receptor tyrosine kinases, and human cancer
6. Detection of distinct pools of the adapter protein p130(CAS) using a panel of monoclonal antibodies
7. Tyrosine phosphorylation of three cellular proteins correlates with transformation of Rat 1 cells by pp60(src)
8. Functions of lipid rafts in biological membranes
9. The role of SRC-CAS interactions in cellular transformation: Ectopic expression of the carboxy terminus of CAS inhibits SRC-CAS interaction but has no effect on cellular transformation
10. The identification of p130(CAS)-binding proteins and their role in cellular transformation
11. Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn
12. Identification of p130(Cas) as a mediator of focal adhesion kinase-promoted cell migration
13. Tyrosine phosphorylation of p130(cas) by bombesin, lysophosphatidic acid, phorbol esters, and platelet-derived growth factor
14. Insulin-like growth factor I stimulates tyrosine phosphorylation of p130(Cas), focal adhesion kinase, and paxillin
15. Extracellular-regulated kinase activation and CAS/Crk coupling regulate ceil migration and suppress apoptosis during invasion of the extracellular matrix
16. Regulation of the oncogenic activity of the cellular src protein requires the correct spacing between the kinase domain and the C-terminal phosphorylated tyrosine (Tyr-527)
17. De novo expression of pp125FAK in human macrophages regulates CSK distribution, MAP kinase activation but does not affect focal contact structure
18. Na,K-ATPase transport from endoplasmic reticulum to Golgi requires the Golgi spectrin-ankyrin G119 skeleton in Madin-Darby canine kidney cells
19. Cell adhesion regulates the interaction between the docking protein p130(Cas) and the 14-13-3 proteins
20. Identification of p130(CAS) as a substrate for the cystolic protein tyrosine phosphatase PTP-PEST
21. Regulation of fibroblast motility by the protein tyrosine phosphatase PTP-PEST
22. Integrin signaling: Specificity and control of cell survival and cell cycle progression
23. Role of focal adhesion kinase in integrin signaling
24. Cell growth control by G protein-coupled receptors: From signal transduction to signal integration
25. Cas mediates transcriptional activation of the serum response element by Src
26. Src kinase plays an essential role in integrin-mediated tyrosine phosphorylation of Crk- associated substrate p130(CAS)
27. p130(CAS), a substrate associated with v-src and v-crk, localizes to focal adhesions and binds to focal adhesion kinase
28. p130(Cas), an assembling molecule of actin filaments, promotes ceil movement, cell migration, and cell spreading in fibroblasts
29. Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130(Cas)
30. Integrin signaling and cell growth control
31. Autoregulatory mechanisms in protein-tyrosine kinases
32. Monoclonal antibodies to individual tyrosine phosphorylated protein substrates of oncogene-encoded tyrosine kinases
33. The SH2 and SH3 domains of pp60(src) direct stable association with tyrosine phosphorylated proteins p130 and p110
34. Transmembrane phosphoprotein Cbp regulates the activities of Src-family kinases
35. Direct binding of p130(Cas) to the guanine nucleotide exchange factor C3G
36. CMS: An adapter molecule involved in cytoskeletal rearrangements
37. CAS/Crk coupling serves as a 'molecular switch' for induction of ceil migration
38. Src family kinases are required for integrin but not PDGFR signal transduction
39. Signaling by integrin receptors
40. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
41. Stable association of PYK2 and p130(Cas) in osteoclasts and their co-localization in the sealing zone
42. Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the src homology 3 domain of p130(CAS)
43. Integrin-mediated signal transduction
44. Potentiation of epidermal growth factor receptor-mediated oncogenesis by c-Src: Implications for the etiology of multiple human cancers
45. Signal transduction: Clamping down on Src activity
46. The protein tyrosine kinase substrate cortactin is differentially expressed in murine B lymphoid tumors
47. Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement
48. Advanced mammalian gene transfer: High titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging ceil line
49. Direct binding of C-terminal region of p130(CAS) to SH2 and SH3 domains of src kinase
50. Integrin-mediated ceil adhesion promotes tyrosine phosphorylation of p130(CAS), a src homology 3-containing molecule having multiple src homology 2-binding motifs
51. Epidermal growth factor modulates tyrosine phosphorylation of p130(Cas)
52. Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases
53. Characterization of protein tyrosine kinases from human breast cancer: Involvement of the c-src oncogene product
54. Src family protein tyrosine kinases: Cooperating with growth factor and adhesion signaling pathways
55. Genetics of src: Structure and functional organization of a protein tyrosine kinase
56. Tyrosine phosphorylation regulates the biochemical and biological properties of pp60(c-src)
57. Interaction between focal adhesion kinase and crk-associated tyrosine kinase substrate p130(Cas)
58. Complexes of focal adhesion kinase (FAK) and crk-associated substrate p130(CAS) are elevated in cytoskeleton-associated fractions following adhesion and src transformation - Requirements for SRC kinase activity and FAK proline-rich motifs
59. Stable association of activated pp60(src) with two tyrosine-phosphorylated cellular proteins
60. Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene
61. Activation of the oncogenic potential of the avian cellular src protein by specific structural alteration of the carboxy terminus
62. Signal transduction pathways in the mitogenic response to G protein-coupled neuropeptide receptor agonists
63. A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner
64. Chat, a Cas/HEF1-associated adaptor protein that integrates multiple signaling pathways
65. Characterization, partial purification, and peptide sequencing of p130, the main phosphoprotein associated with v-crk oncoprotein
66. Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by p210BCR/ABL
67. pp125FAK: A structurally distinctive protein-tyrosine kinase associated with focal adhesions
68. Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: Involvement of the Grb2, p130(cas), and Nck adapter proteins
69. Signaling through focal adhesion kinase
70. The many faces of Src: Multiple functions of a prototypical tyrosine kinase
71. Lysophosphatidic acid stimulates tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130
72. SRC - More than the sum of its parts
73. Role of plasmalemmal caveolae in signal transduction
74. Crystal structure of the Src family tyrosine kinase Hck
75. Intercellular communication and cell-cell adhesion
76. SH2- and SH3-mediated interactions between focal adhesion kinase and Src
77. Cellular functions regulated by Src family kinases
78. Specific and redundant roles of Src and Fyn in organizing the cytoskeleton
79. Mechanism of biological synergy between cellular Src and epidermal growth factor receptor
80. Integrin-mediated signal transduction in cells lacking focal adhesion kinase p125(FAK)
81. Bcar1/ p130Cas protein and primary breast cancer: Prognosis and response to tamoxifen treatment
82. Integrin signaling: Tyrosine phosphorylation events in focal adhesion
83. Induction of p130(cas) signaling complex formation upon integrin-mediated cell adhesion: A role for src family kinases
84. Tyrosine phosphorylation of p130(Cas) and cortactin accompanies integrin-mediated cell adhesion to extracellular matrix
85. The Shp-2 tyrosine phosphatase activates the Src tyrosine kinase by a non-enzymatic mechanism
86. The 2.35 angstrom crystal structure of the inactivated form of chicken src -a dynamic molecule with multiple regulatory interactions
87. Insights into Src kinase functions: Structural comparisons
88. Enhanced EGF mitogenic response is associated with enhanced tyrosine phosphorylation of specific cellular proteins in fibroblasts overexpressing c-src
89. Expression and characterization of splice variants of PYK2, a focal adhesion kinase-related protein
90. Induction of apoptosis after expression of PYK2, a tyrosine kinase structurally related to focal adhesion kinase
91. Three-dimensional structure of the tyrosine kinase c-Src
92. Bombesin, vasopressin, and endothelin stimulation of tyrosine phosphorylatlon in Swiss 3T3 cells