p130Cas: a versatile scaffold in signaling networks

Trends in Cell Biology

Volumn 16, Issue 5, 2006, Pages 257-263

  Defilippi, Paola ^a   Di Stefano, Paola ^a   Cabodi, Sara ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; CRK ASSOCIATED SUBSTRATE PROTEIN; ESTROGEN RECEPTOR; SCAFFOLD PROTEIN; TAMOXIFEN; UNCLASSIFIED DRUG;

APOPTOSIS; BREAST CANCER; CANCER; CELL INVASION; CELL MIGRATION; CELL SURVIVAL; CELL TRANSFORMATION; HUMAN; MICROORGANISM; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; CRK-ASSOCIATED SUBSTRATE PROTEIN; HUMANS; NEOPLASMS; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 33646557326     PISSN: 09628924     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tcb.2006.03.003     Document Type: Review

References (90)

1. Matsuda M., et al. Binding of transforming protein, P47gag-crk, to a broad range of phosphotyrosine-containing proteins. Science 248 (1990) 1537-1539
2. Reynolds A.B., et al. Stable association of activated pp60src with two tyrosine- phosphorylated cellular proteins. Mol. Cell. Biol. 9 (1989) 3951-3958
3. O'Neill G.M., et al. Integrin signalling: a new Cas(t) of characters enters the stage. Trends Cell Biol. 10 (2000) 111-119
4. Bouton A.H., et al. Functions of the adapter protein Cas: signal convergence and the determination of cellular responses. Oncogene 20 (2001) 6448-6458
5. Alexandropoulos K., et al. Sin: good or bad? A T lymphocyte perspective. Immunol. Rev. 192 (2003) 181-195
6. Pugacheva E.N., and Golemis E.A. The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome. Nat. Cell Biol. 7 (2005) 937-946
7. Bargon S.D., et al. The Cas family docking protein, HEF1, promotes the formation of neurite-like membrane extensions. Biochim. Biophys. Acta 1746 (2005) 143-154
8. Donlin L.T., et al. Deficiency in expression of the signaling protein Sin/Efs leads to T-lymphocyte activation and mucosal inflammation. Mol. Cell. Biol. 25 (2005) 11035-11046
9. Honda H., et al. Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas. Nat. Genet. 19 (1998) 361-365
10. Cabodi S., and Defilippi P. The Essence of Integrin Signal Transduction (2005), Springer
11. Korah R., et al. Expression of FGF-2 alters focal adhesion dynamics in migration-restricted MDA-MB-231 breast cancer cells. Breast Cancer Res. Treat. 88 (2004) 17-28
12. Avraham H.K., et al. Vascular endothelial growth factor regulates focal adhesion assembly in human brain microvascular endothelial cells through activation of the focal adhesion kinase and related adhesion focal tyrosine kinase. J. Biol. Chem. 278 (2003) 36661-36668
13. Nakamura I., et al. Distinct roles of p130Cas and c-Cbl in adhesion-induced or macrophage colony-stimulating factor-mediated signaling pathways in prefusion osteoclasts. Endocrinology 144 (2003) 4739-4741
14. Kodama H., et al. Selective involvement of p130Cas/Crk/Pyk2/c-Src in endothelin-1-induced JNK activation. Hypertension 41 (2003) 1372-1379
15. Kyaw M., et al. Src and Cas are essentially but differentially involved in angiotensin II-stimulated migration of vascular smooth muscle cells via extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase activation. Mol. Pharmacol. 65 (2004) 832-841
16. Yang C.C., et al. Chemokine receptor CCR6 transduces signals that activate p130Cas and alter cAMP-stimulated ion transport in human intestinal epithelial cells. Am. J. Physiol. Cell Physiol. 288 (2005) C321-C328
17. Yamakita Y., et al. Dissociation of FAK/p130(CAS)/c-Src complex during mitosis: role of mitosis-specific serine phosphorylation of FAK. J. Cell Biol. 144 (1999) 315-324
18. Ma A., et al. Serine phosphorylation of focal adhesion kinase in interphase and mitosis: a possible role in modulating binding to p130(Cas). Mol. Biol. Cell 12 (2001) 1-12
19. Yokoyama N., and Miller W.T. Protein phosphatase 2A interacts with the Src kinase substrate p130(CAS). Oncogene 20 (2001) 6057-6065
20. Tamada M., et al. Activation of a signaling cascade by cytoskeleton stretch. Dev. Cell 7 (2004) 709-718
21. Ridley A.J., et al. Cell migration: integrating signals from front to back. Science 302 (2003) 1704-1709
22. Mitra S.K., et al. Focal adhesion kinase: in command and control of cell motility. Nat. Rev. Mol. Cell Biol. 6 (2005) 56-68
23. Gustavsson A., et al. Temporal dissection of β1-integrin signaling indicates a role for p130Cas-Crk in filopodia formation. J. Biol. Chem. 279 (2004) 22893-22901
24. Webb D.J., et al. FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat. Cell Biol. 6 (2004) 154-161
25. Burridge K., and Wennerberg K. Rho and Rac take center stage. Cell 116 (2004) 167-179
26. Zaidel-Bar R., et al. Polarized downregulation of the paxillin-p130CAS-Rac1 pathway induced by shear flow. J. Cell Sci. 118 (2005) 3997-4007
27. Sanders M.A., and Basson M.D. p130cas but not paxillin is essential for Caco-2 intestinal epithelial cell spreading and migration on collagen IV. J. Biol. Chem. 280 (2005) 23516-23522
28. Honda H., et al. p130(Cas), an assembling molecule of actin filaments, promotes cell movement, cell migration, and cell spreading in fibroblasts. Biochem. Biophys. Res. Commun. 262 (1999) 25-30
29. Huang J., et al. Differential regulation of cell migration, actin stress fiber organization, and cell transformation by functional domains of Crk-associated substrate. J. Biol. Chem. 277 (2002) 27265-27272
30. Shin N.Y., et al. Subsets of the major tyrosine phosphorylation sites in Crk-associated substrate (CAS) are sufficient to promote cell migration. J. Biol. Chem. 279 (2004) 38331-38337
31. Goldberg G.S., et al. Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells. J. Biol. Chem. 278 (2003) 46533-46540
32. Zhang Y., et al. Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. Mol. Cell. Proteomics 4 (2005) 1240-1250
33. Abassi Y.A., et al. p130Cas Couples the tyrosine kinase Bmx/Etk with regulation of the actin cytoskeleton and cell migration. J. Biol. Chem. 278 (2003) 35636-35643
34. Gotoh T., et al. p130Cas regulates the activity of AND-34, a novel Ral, Rap1, and R-Ras guanine nucleotide exchange factor. J. Biol. Chem. 275 (2000) 30118-30123
35. Riggins R.B., et al. Synergistic promotion of c-Src activation and cell migration by Cas and AND-34/BCAR3. J. Biol. Chem. 278 (2003) 28264-28273
36. Sakakibara A., et al. Novel function of Chat in controlling cell adhesion via Cas-Crk-C3G-pathway-mediated Rap1 activation. J. Cell Sci. 115 (2002) 4915-4924
37. Kira M., et al. STAT3 deficiency in keratinocytes leads to compromised cell migration through hyperphosphorylation of p130(cas). J. Biol. Chem. 277 (2002) 12931-12936
38. Kain K.H., and Klemke R.L. Inhibition of cell migration by Abl family tyrosine kinases through uncoupling of Crk-CAS complexes. J. Biol. Chem. 276 (2001) 16185-16192
39. Takino T., et al. Tyrosine phosphorylation of the CrkII adaptor protein modulates cell migration. J. Cell Sci. 116 (2003) 3145-3155
40. Chodniewicz D., and Klemke R.L. Regulation of integrin-mediated cellular responses through assembly of a CAS/Crk scaffold. Biochim. Biophys. Acta 1692 (2004) 63-76
41. Yi J., et al. Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers. J. Biol. Chem. 277 (2002) 9580-9589
42. Lai Y.J., et al. c-Src-mediated phosphorylation of TRIP6 regulates its function in lysophosphatidic acid-induced cell migration. Mol. Cell. Biol. 25 (2005) 5859-5868
43. Pratt S.J., et al. The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration. J. Cell Biol. 168 (2005) 813-824
44. Giancotti F.G., and Tarone G. Positional control of cell fate through joint integrin/receptor protein kinase signaling. Annu. Rev. Cell Dev. Biol. 19 (2003) 173-206
45. Moro L., et al. Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines. J. Biol. Chem. 277 (2002) 9405-9414
46. Kook S., et al. Caspase-mediated cleavage of p130cas in etoposide-induced apoptotic Rat-1 cells. Mol. Biol. Cell 11 (2000) 929-939
47. Kim W., et al. The 31-kDa caspase-generated cleavage product of p130cas functions as a transcriptional repressor of E2A in apoptotic cells. J. Biol. Chem. 279 (2004) 8333-8342
48. Hoon Kim D., et al. Phosphorylation-dependent cleavage of p130cas in apoptotic rat-1 cells. Biochem. Biophys. Res. Commun. 300 (2003) 141-148
49. Wei L., et al. Anchorage-independent phosphorylation of p130(Cas) protects lung adenocarcinoma cells from anoikis. J. Cell. Biochem. 87 (2002) 439-449
50. Wei L., et al. Cleavage of p130Cas in anoikis. J. Cell. Biochem. 91 (2004) 325-335
51. Auvinen M., et al. Ornithine decarboxylase- and ras-induced cell transformations: reversal by protein tyrosine kinase inhibitors and role of pp130CAS. Mol. Cell. Biol. 15 (1995) 6513-6525
52. Brabek J., et al. CAS promotes invasiveness of Src-transformed cells. Oncogene 23 (2004) 7406-7415
53. Cabodi S., et al. p130Cas interacts with estrogen receptor alpha and modulates non-genomic estrogen signaling in breast cancer cells. J. Cell Sci. 117 (2004) 1603-1611
54. Burnham M.R., et al. Regulation of c-SRC activity and function by the adapter protein CAS. Mol. Cell. Biol. 20 (2000) 5865-5878
55. Hsia D.A., et al. Differential regulation of cell motility and invasion by FAK. J. Cell Biol. 160 (2003) 753-767
56. Nakamoto T., et al. CIZ, a zinc finger protein that interacts with p130(cas) and activates the expression of matrix metalloproteinases. Mol. Cell. Biol. 20 (2000) 1649-1658
57. Di Stefano P., et al. P130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreading. Mol. Biol. Cell 15 (2004) 787-800
58. Zhang X.A., et al. Requirement of the p130CAS-Crk coupling for metastasis suppressor KAI1/CD82-mediated inhibition of cell migration. J. Biol. Chem. 278 (2003) 27319-27328
59. Zhou B., et al. The palmitoylation of metastasis suppressor KAI1/CD82 is important for its motility- and invasiveness-inhibitory activity. Cancer Res. 64 (2004) 7455-7463
60. Dolfi F., et al. The adaptor protein Crk connects multiple cellular stimuli to the JNK signaling pathway. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 15394-15399
61. Oktay M., et al. Integrin-mediated activation of focal adhesion kinase is required for signaling to Jun NH2-terminal kinase and progression through the G1 phase of the cell cycle. J. Cell Biol. 145 (1999) 1461-1469
62. Kirsch K., et al. A p130Cas tyrosine phosphorylated substrate domain decoy disrupts v-Crk signaling. BMC Cell Biol. 3 (2002) 18
63. Ambrogio C., et al. p130cas mediates the transforming properties of the anaplastic lymphoma kinase. Blood 106 (2005) 3907-3916
64. Hamamura K., et al. Ganglioside GD3 promotes cell growth and invasion through p130Cas and paxillin in malignant melanoma cells. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 11041-11046
65. Wisniewska M., et al. The 1.1 A resolution crystal structure of the p130cas SH3 domain and ramifications for ligand selectivity. J. Mol. Biol. 347 (2005) 1005-1014
66. Briknarova K., et al. The serine-rich domain from Crk-associated substrate (p130cas) is a four-helix bundle. J. Biol. Chem. 280 (2005) 21908-21914
67. Cabodi, S. et al. p130Cas as a new regulator of mammary epithelial cell proliferation, survival and HER2-Neu oncogene dependent tumorigenesis. Cancer Res. (in press)
68. Dankort D.L., and Muller W.J. Signal transduction in mammary tumorigenesis: a transgenic perspective. Oncogene 19 (2000) 1038-1044
69. Chan Y.R., and Gallo R.L. PR-39, a syndecan-inducing antimicrobial peptide, binds and affects p130(Cas). J. Biol. Chem. 273 (1998) 28978-28985
70. Wang X., et al. Specific inhibition of FGF-induced MAPK activation by the receptor-like protein tyrosine phosphatase LAR. Oncogene 19 (2000) 2346-2353
71. Brinkman A., et al. BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells. J. Natl. Cancer Inst. 92 (2000) 112-120
72. van Agthoven T., et al. Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells. EMBO J. 17 (1998) 2799-2808
73. van der Flier S., et al. Bcar1/p130Cas protein and primary breast cancer: prognosis and response to tamoxifen treatment. J. Natl. Cancer Inst. 92 (2000) 120-127
74. Dorssers L.C., et al. Tamoxifen resistance in breast cancer: elucidating mechanisms. Drugs 61 (2001) 1721-1733
75. Felekkis K.N., et al. AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner. Mol. Cancer Res. 3 (2005) 32-41
76. Acconcia, F. and Kumar, R. (2005) Signaling regulation of genomic and nongenomic functions of estrogen receptors. Cancer Lett
77. Viboud G.I., and Bliska J.B. Yersinia outer proteins: role in modulation of host cell signaling responses and pathogenesis. Annu. Rev. Microbiol. 59 (2005) 69-89
78. Fallman M., and Gustavsson A. Cellular mechanisms of bacterial internalization counteracted by Yersinia. Int. Rev. Cytol. 246 (2005) 135-188
79. Wong K.W., and Isberg R.R. Emerging views on integrin signaling via Rac1 during invasin-promoted bacterial uptake. Curr. Opin. Microbiol. 8 (2005) 4-9
80. Weidow C.L., et al. CAS/Crk signalling mediates uptake of Yersinia into human epithelial cells. Cell. Microbiol. 2 (2000) 549-560
81. Black D.S., and Bliska J.B. Identification of p130Cas as a substrate of Yersinia YopH (Yop51), a bacterial protein tyrosine phosphatase that translocates into mammalian cells and targets focal adhesions. EMBO J. 16 (1997) 2730-2744
82. Persson C., et al. The PTPase YopH inhibits uptake of Yersinia, tyrosine phosphorylation of p130Cas and FAK, and the associated accumulation of these proteins in peripheral focal adhesions. EMBO J. 16 (1997) 2307-2318
83. Hamid N., et al. YopH dephosphorylates Cas and Fyn-binding protein in macrophages. Microb. Pathog. 27 (1999) 231-242
84. Cornelis G.R. Yersinia type III secretion: send in the effectors. J. Cell Biol. 158 (2002) 401-408
85. Ivanov M.I., et al. Two substrate-targeting sites in the Yersinia protein tyrosine phosphatase co-operate to promote bacterial virulence. Mol. Microbiol. 55 (2005) 1346-1356
86. Montagna L.G., et al. Identification of residues in the N-terminal domain of the Yersinia tyrosine phosphatase that are critical for substrate recognition. J. Biol. Chem. 276 (2001) 5005-5011
87. Deleuil F., et al. Interaction between the Yersinia protein tyrosine phosphatase YopH and eukaryotic Cas/Fyb is an important virulence mechanism. Cell. Microbiol. 5 (2003) 53-64
88. Mogemark L., et al. Disruption of target cell adhesion structures by the Yersinia effector YopH requires interaction with the substrate domain of p130Cas. Eur. J. Cell Biol. 84 (2005) 477-489
89. 1 integrin and induces intracellular signaling. J. Biol. Chem. 280 (2005) 13848-13857
90. Deng Q., et al. Uncoupling Crk-signal transduction by pseudomonas ExoT. J. Biol. Chem. 280 (2005) 35953-35960