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Volumn 1, Issue 9, 2002, Pages 707-717

Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; AKT1 PROTEIN, HUMAN; ANTINEOPLASTIC AGENT; CHROMONE DERIVATIVE; DOXORUBICIN; ENZYME INHIBITOR; ETOPOSIDE; MONOCLONAL ANTIBODY; MORPHOLINE DERIVATIVE; ONCOPROTEIN; PACLITAXEL; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; TAMOXIFEN; TRASTUZUMAB;

EID: 0036633164     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (589)

References (66)
  • 1
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • Datta, S. R., Brunet, A., and Greenberg, M. E. Cellular survival: a play in three Akts. Genes Dev., 13: 2905-2927, 1999.
    • (1999) Genes Dev. , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 2
    • 0026095665 scopus 로고
    • A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region
    • Bellacosa, A., Testa, J. R., Staal, S. P., and Tsichlis, P. N. A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region. Science (Wash. DC), 254: 274-277, 1991. (Pubitemid 21917339)
    • (1991) Science , vol.254 , Issue.5029 , pp. 274-277
    • Bellacosa, A.1    Testa, J.R.2    Staal, S.P.3    Tsichlis, P.N.4
  • 3
    • 0026006501 scopus 로고
    • Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families
    • [published erratum appears in Eur. J. Biochem., 205: 1217, 1992].
    • Coffer, P. J., and Woodgett, J. R. Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families [published erratum appears in Eur. J. Biochem., 205: 1217, 1992]. Eur J Biochem., 201: 475-481, 1991.
    • (1991) Eur J Biochem. , vol.201 , pp. 475-481
    • Coffer, P.J.1    Woodgett, J.R.2
  • 5
    • 0033594480 scopus 로고    scopus 로고
    • PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2
    • DOI 10.1016/S0960-9822(99)80186-9
    • Balendran, A., Casamayor, A., Deak, M., Paterson, A., Gaffney, P., Currie, R., Downes, C. P., and Alessi, D. R. PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2. Curr. Biol., 9: 393-404, 1999. (Pubitemid 29205782)
    • (1999) Current Biology , vol.9 , Issue.8 , pp. 393-404
    • Balendran, A.1    Casamayor, A.2    Deak, M.3    Paterson, A.4    Gaffney, P.5    Currie, R.6    Downes, C.P.7    Alessi, D.R.8
  • 7
    • 0033599029 scopus 로고    scopus 로고
    • Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism
    • Lynch, D. K., Ellis, C. A., Edwards, P. A., and Hiles, I. D. Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism. Oncogene, 18: 8024-8032, 1999. (Pubitemid 30050563)
    • (1999) Oncogene , vol.18 , Issue.56 , pp. 8024-8032
    • Lynch, D.K.1    Ellis, C.A.2    Edwards, P.A.3    Hiles, I.D.4
  • 8
    • 0034708482 scopus 로고    scopus 로고
    • Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site
    • DOI 10.1074/jbc.275.12.8271
    • Toker, A., and Newton, A. C. Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site. J. Biol. Chem., 275:8271-8274, 2000. (Pubitemid 30180163)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.12 , pp. 8271-8274
    • Toker, A.1    Newton, A.C.2
  • 9
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell- intrinsic death machinery
    • DOI 10.1016/S0092-8674(00)80405-5
    • Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., and Greenberg, M. E. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell, 91: 231-241, 1997. (Pubitemid 27456390)
    • (1997) Cell , vol.91 , Issue.2 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Xu, T.3    Masters, S.4    Haian, F.5    Gotoh, Y.6    Greenberg, M.E.7
  • 10
    • 1842333237 scopus 로고    scopus 로고
    • Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
    • DOI 10.1126/science.278.5338.687
    • del Peso, L., Gonzalez-Garcia, M., Page, C., Herrera, R., and Nunez, G. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science (Wash. DC), 278: 687-689, 1997. (Pubitemid 27464966)
    • (1997) Science , vol.278 , Issue.5338 , pp. 687-689
    • Del, P.L.1    Gonzalez-Garcia, M.2    Page, C.3    Herrera, R.4    Nunez, G.5
  • 12
    • 0033532056 scopus 로고    scopus 로고
    • Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit
    • Kang, S. S., Kwon, T., Kwon, D. Y., and Do, S. I. Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit. J. Biol. Chem., 274: 13085-13090, 1999.
    • (1999) J. Biol. Chem. , vol.274 , pp. 13085-13090
    • Kang, S.S.1    Kwon, T.2    Kwon, D.Y.3    Do, S.I.4
  • 14
    • 0033560896 scopus 로고    scopus 로고
    • Direct control of the forkhead transcription faotor AFX by protein kinase B
    • DOI 10.1038/19328
    • Kops, G. J., de Ruiter, N. D., De Vries-Smits, A. M., Powell, D. R., Bos, J. L., and Burgering, B. M. Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature (Lond.), 398: 630-634, 1999. (Pubitemid 29183692)
    • (1999) Nature , vol.398 , Issue.6728 , pp. 630-634
    • Kops, G.J.P.L.1    De Ruiter, N.D.2    De Vries-Smits, A.M.M.3    Powell, D.R.4    Bos, J.L.5    Burgering, B.M.Th.6
  • 15
    • 0033517189 scopus 로고    scopus 로고
    • NF-κB activation by tumour necrosis factor requires the Akt serine-threonine kinase
    • [see comments].
    • Ozes, O. N., Mayo, L. D., Gustin, J. A., Pfeffer, S. R., Pfeffer, L. M., and Donner, D. B. NF-κB activation by tumour necrosis factor requires the Akt serine-threonine kinase [see comments]. Nature (Lond.), 401: 82-85, 1999.
    • (1999) Nature (Lond.) , vol.401 , pp. 82-85
    • Ozes, O.N.1    Mayo, L.D.2    Gustin, J.A.3    Pfeffer, S.R.4    Pfeffer, L.M.5    Donner, D.B.6
  • 16
    • 0033517190 scopus 로고    scopus 로고
    • NF-κB is a target of AKT in anti-apoptotic PDGF signalling
    • [see comments].
    • Romashkova, J. A., and Makarov, S. S. NF-κB is a target of AKT in anti-apoptotic PDGF signalling [see comments]. Nature (Lond.), 401: 86-90, 1999.
    • (1999) Nature (Lond.) , vol.401 , pp. 86-90
    • Romashkova, J.A.1    Makarov, S.S.2
  • 17
    • 0031053586 scopus 로고    scopus 로고
    • Regulation of neuronal survival by the serine-threonine protein kinase Akt
    • DOI 10.1126/science.275.5300.661
    • Dudek, H., Datta, S. R., Franke, T. F., Birnbaum, M. J., Yao, R., Cooper, G. M., Segal, R. A., Kaplan, D. R., and Greenberg, M. E. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science (Wash. DC), 275: 661-665, 1997. (Pubitemid 27061332)
    • (1997) Science , vol.275 , Issue.5300 , pp. 661-665
    • Dudek, H.1    Datta, S.R.2    Franke, T.F.3    Birnbaum, M.J.4    Yao, R.5    Cooper, G.M.6    Segal, R.A.7    Kaplan, D.R.8    Greenberg, M.E.9
  • 18
    • 0031028730 scopus 로고    scopus 로고
    • Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB
    • DOI 10.1038/385544a0
    • Kauffmann-Zeh, A., Rodriguez-Viciana, P., Ulrich, E., Gilbert, C., Coffer, P., Downward, J., and Evan, G. Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB. Nature (Lond.), 385:544-548, 1997. (Pubitemid 27074674)
    • (1997) Nature , vol.385 , Issue.6616 , pp. 544-548
    • Kauffmann-Zeh, A.1    Rodriguez-Viciana, P.2    Ulrich, E.3    Gilbert, C.4    Coffer, P.5    Downward, J.6    Evan, G.7
  • 19
    • 0032808154 scopus 로고    scopus 로고
    • Akt/protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria
    • Kennedy, S. G., Kandel, E. S., Cross, T. K., and Hay, N. Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria. Mol. Cell. Biol., 19: 5800-5810, 1999. (Pubitemid 29339934)
    • (1999) Molecular and Cellular Biology , vol.19 , Issue.8 , pp. 5800-5810
    • Kennedy, S.G.1    Kandel, E.S.2    Cross, T.K.3    Hay, N.4
  • 20
    • 0030913673 scopus 로고    scopus 로고
    • Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
    • DOI 10.1093/emboj/16.10.2783
    • Khwaja, A., Rodriguez-Viciana, P., Wennstrom, S., Warne, P., and Downward, J. Matrix adhesion and ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J., 16: 2783-2793, 1997. (Pubitemid 27226215)
    • (1997) EMBO Journal , vol.16 , Issue.10 , pp. 2783-2793
    • Khwaja, A.1    Rodriguez-Viciana, P.2    Wennstrom, S.3    Warne, P.H.4    Downward, J.5
  • 21
    • 0031034574 scopus 로고    scopus 로고
    • Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt
    • Kulik, G., Klippel, A., and Weber, M. J. Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol. Cell. Biol., 17: 1595-1606, 1997. (Pubitemid 27097389)
    • (1997) Molecular and Cellular Biology , vol.17 , Issue.3 , pp. 1595-1606
    • Kulik, G.1    Klippel, A.2    Weber, M.J.3
  • 22
    • 0032532206 scopus 로고    scopus 로고
    • Suppression of transforming growth factor-β-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway
    • Chen, R. H., Su, Y. H., Chuang, R. L., and Chang, T. Y. Suppression of transforming growth factor-β-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway. Oncogene, 17: 1959-1968, 1998. (Pubitemid 28488464)
    • (1998) Oncogene , vol.17 , Issue.15 , pp. 1959-1968
    • Chen, R.-H.1    Su, Y.-H.2    Chuang, R.L.C.3    Chang, T.-Y.4
  • 23
    • 0032522924 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons
    • Crowder, R. J., and Freeman, R. S. Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons. J. Neurosci., 18: 2933-2943, 1998. (Pubitemid 28163223)
    • (1998) Journal of Neuroscience , vol.18 , Issue.8 , pp. 2933-2943
    • Crowder, R.J.1    Freeman, R.S.2
  • 24
    • 0031923788 scopus 로고    scopus 로고
    • Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line
    • Eves, E. M., Xiong, W., Bellacosa, A., Kennedy, S. G., Tsichlis, P. N., Rosner, M. R., and Hay, N. Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line. Mol. Cell. Biol., 18:2143-2152, 1998. (Pubitemid 28152663)
    • (1998) Molecular and Cellular Biology , vol.18 , Issue.4 , pp. 2143-2152
    • Eves, E.M.1    Xiong, W.2    Bellacosa, A.3    Kennedy, S.G.4    Tsichlis, P.N.5    Rosner, M.R.6    Hay, N.7
  • 25
    • 0033560120 scopus 로고    scopus 로고
    • Akt-dependent potentiation of L channels by insulin-like growth factor- 1 is required for neuronal survival
    • Blair, L. A., Bence-Hanulec, K. K., Mehta, S., Franke, T., Kaplan, D., and Marshall, J. Akt-dependent potentiation of L channels by insulin-like growth factor-1 is required for neuronal survival. J. Neurosci., 19: 1940-1951, 1999. (Pubitemid 29133372)
    • (1999) Journal of Neuroscience , vol.19 , Issue.6 , pp. 1940-1951
    • Blair, L.A.C.1    Bence-Hanulec, K.K.2    Mehta, S.3    Franke, T.4    Kaplan, D.5    Marshall, J.6
  • 26
    • 0032515047 scopus 로고    scopus 로고
    • Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway: Requirement for Flk-1/KDR activation
    • DOI 10.1074/jbc.273.46.30336
    • Gerber, H. P., McMurtrey, A., Kowalski, J., Yan, M., Keyt, B. A., Dixit, V., and Ferrara, N. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. J. Biol. Chem., 273: 30336-30343, 1998. (Pubitemid 28545503)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.46 , pp. 30336-30343
    • Gerber, H.-P.1    McMurtrey, A.2    Kowalski, J.3    Yan, M.4    Keyt, B.A.5    Dixit, V.6    Ferrara, N.7
  • 27
    • 0039058167 scopus 로고    scopus 로고
    • Protection of CD95-mediated apoptosis by activation of phosphatidylinositide 3-kinase and protein kinase B
    • DOI 10.1002/(SICI)1521-4141(199801)28:01<57::AID-I
    • Hausler, P., Papoff, G., Eramo, A., Reif, K., Cantrell, D. A., and Ruberti, G. Protection of CD95-mediated apoptosis by activation of phosphatidylinositide 3-kinase and protein kinase B. Eur. J. Immunol., 28: 57-69, 1998. (Pubitemid 28048277)
    • (1998) European Journal of Immunology , vol.28 , Issue.1 , pp. 57-69
    • Hausler, P.1    Papoff, G.2    Eramo, A.3    Reif, K.4    Cantrell, D.A.5    Ruberti, G.6
  • 28
    • 0031770827 scopus 로고    scopus 로고
    • Akt-dependent and -independent survival signaling pathways utilized by insulin-like growth factor I
    • Kulik, G., and Weber, M. J. Akt-dependent and -independent survival signaling pathways utilized by insulin-like growth factor I. Mol. Cell. Biol., 18: 6711-6718, 1998. (Pubitemid 28500558)
    • (1998) Molecular and Cellular Biology , vol.18 , Issue.11 , pp. 6711-6718
    • Kulik, G.1    Weber, M.J.2
  • 29
    • 0032481127 scopus 로고    scopus 로고
    • The opposing roles of the Akt and c-Myc signalling pathways in survival from CD95-mediated apoptosis
    • Rohn, J. L., Hueber, A. O., McCarthy, N. J., Lyon, D., Navarro, P., Burgering, B. M., and Evan, G. I. The opposing roles of the Akt and c-Myc signalling pathways in survival from CD95-mediated apoptosis. Oncogene, 17: 2811-2818, 1998. (Pubitemid 29010051)
    • (1998) Oncogene , vol.17 , Issue.22 , pp. 2811-2818
    • Rohn, J.L.1    Hueber, A.-O.2    McCarthy, N.J.3    Lyon, D.4    Navarro, P.5    Burgering, B.M.Th.6    Evan, G.I.7
  • 31
    • 0034733547 scopus 로고    scopus 로고
    • The bile acid taurochenodeoxycholate activates a phosphatidylinositol 3- kinase-dependent survival signaling cascade
    • DOI 10.1074/jbc.M909992199
    • Rust, C., Karnitz, L. M., Paya, C. V., Moscat, J., Simari, R. D., and Gores, G. J. The bile acid taurochenodeoxycholate activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade. J. Biol. Chem., 275: 20210-20216, 2000. (Pubitemid 30441633)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.26 , pp. 20210-20216
    • Rust, C.1    Karnitz, L.M.2    Paya, C.V.3    Moscat, J.4    Simari, R.D.5    Gores, G.J.6
  • 32
    • 0035872199 scopus 로고    scopus 로고
    • Akt/pbotein kinace B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation
    • Brognard, J., Clark, A. S., Ni, Y., and Dennis, P. A. Akt/protein kinase b is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. Cancer Res., 61: 3986-3997, 2001. (Pubitemid 32720961)
    • (2001) Cancer Research , vol.61 , Issue.10 , pp. 3986-3997
    • Brognard, J.1    Clark, A.S.2    Ni, Y.3    Dennis, P.A.4
  • 33
    • 0034629345 scopus 로고    scopus 로고
    • The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide- dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase
    • DOI 10.1074/jbc.275.10.7395
    • Lali, F. V., Hunt, A. E., Turner, S. J., and Foxwell, B. M. The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase. J. Biol. Chem., 275: 7395-7402, 2000. (Pubitemid 30146294)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.10 , pp. 7395-7402
    • Lali, F.V.1    Hunt, A.E.2    Turner, S.J.3    Foxwell, B.M.J.4
  • 35
    • 0030801275 scopus 로고    scopus 로고
    • Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas
    • Rhei, E., Kang, L., Bogomolniy, F., Federici, M. G., Borgen, P. I., and Boyd, J. Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas. Cancer Res., 57: 3657-3659, 1997. (Pubitemid 27381202)
    • (1997) Cancer Research , vol.57 , Issue.17 , pp. 3657-3659
    • Rhei, E.1    Kang, L.2    Bogomolniy, F.3    Federici, M.G.4    Borgen, P.I.5    Boyd, J.6
  • 37
    • 0031916211 scopus 로고    scopus 로고
    • Sporadic breast cancers exhibit loss of heterozygosity on chromosome segment 10q23 close to the Cowden disease locus
    • DOI 10.1002/(SICI)1098-2264(199802)21:2<166::AID-G
    • Singh, B., Ittmann, M. M., and Krolewski, J. J. Sporadic breast cancers exhibit loss of heterozygosity on chromosome segment 10q23 close to the Cowden disease locus. Genes Chromosomes Cancer, 21: 166-171, 1998. (Pubitemid 28081244)
    • (1998) Genes Chromosomes and Cancer , vol.21 , Issue.2 , pp. 166-171
    • Singh, B.1    Ittmann, M.M.2    Krolewski, J.J.3
  • 38
    • 0032534963 scopus 로고    scopus 로고
    • The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene
    • Li, J., Simpson, L., Takahashi, M., Miliaresis, C., Myers, M. P., Tonks, N., and Parsons, R. The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene. Cancer Res., 58: 5667-5672, 1998. (Pubitemid 29006402)
    • (1998) Cancer Research , vol.58 , Issue.24 , pp. 5667-5672
    • Li, J.1    Simpson, L.2    Takahashi, M.3    Miliaresis, C.4    Myers, M.P.5    Tonks, N.6    Parsons, R.7
  • 41
    • 0033618371 scopus 로고    scopus 로고
    • Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines
    • Nakatani, K., Thompson, D. A., Barthel, A., Sakaue, H., Liu, W., Weigel, R. J., and Roth, R. A. Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines. J. Biol. Chem., 274: 21528-21532, 1999.
    • (1999) J. Biol. Chem. , vol.274 , pp. 21528-21532
    • Nakatani, K.1    Thompson, D.A.2    Barthel, A.3    Sakaue, H.4    Liu, W.5    Weigel, R.J.6    Roth, R.A.7
  • 42
    • 0035008874 scopus 로고    scopus 로고
    • Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression
    • DOI 10.1128/MCB.21.6.2203-2212.2001
    • Hutchinson, J., Jin, J., Cardiff, R. D., Woodgett, J. R., and Muller, W. J. Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression. Mol. Cell. Biol., 21: 2203-2212, 2001. (Pubitemid 32479640)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.6 , pp. 2203-2212
    • Hutchinson, J.1    Jin, J.2    Cardiff, R.D.3    Woodgett, J.R.4    Muller, W.J.5
  • 43
    • 0035134656 scopus 로고    scopus 로고
    • Inhibition of mammary epithelial apoptosis and sustained phosphorylation of Akt/PKB in MMTV-IGF-II transgenic mice
    • DOI 10.1038/sj.cdd.4400762
    • Moorehead, R. A., Fata, J. E., Johnson, M. B., and Khokha, R. Inhibition of mammary epithelial apoptosis and sustained phosphorylation of Akt/PKB in MMTV-IGF-II transgenic mice. Cell Death Differ., 8: 16-29, 2001. (Pubitemid 32162217)
    • (2001) Cell Death and Differentiation , vol.8 , Issue.1 , pp. 16-29
    • Moorehead, R.A.1    Fata, J.E.2    Johnson, M.B.3    Khokha, R.4
  • 44
    • 0032557646 scopus 로고    scopus 로고
    • Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB
    • DOI 10.1074/jbc.273.21.13150
    • van Weeren, P. C., de Bruyn, K. M., de Vries-Smits, A. M., van Lint, J., and Burgering, B. M. Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB. J. Biol. Chem., 273: 13150-13156, 1998. (Pubitemid 28246883)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.21 , pp. 13150-13156
    • Van Weeren, P.C.1    De Bruyn, K.M.T.2    De Vries-Smits, A.M.M.3    Van Lint, J.4    Burgering, B.M.T.5
  • 46
    • 0001458215 scopus 로고
    • Effects of more than one inhibitor
    • New York: Academic Press
    • Webb, J. L. Effects of more than one inhibitor. Enzymes and Metabolic Inhibitors, Vol. 1, pp. 487-512. New York: Academic Press, 1963.
    • (1963) Enzymes and Metabolic Inhibitors , vol.1 , pp. 487-512
    • Webb, J.L.1
  • 47
    • 0034623179 scopus 로고    scopus 로고
    • Differential phosphorylation at Ser473 and Thr308 of Akt-1 in rat brain following hypoglycemic coma
    • Ouyang, Y. B., Zhang, X. H., He, Q. P., Wang, G. X., Siesjo, B. K., and Hu, B. R. Differential phosphorylation at Ser473 and Thr308 of Akt-1 in rat brain following hypoglycemic coma. Brain Res., 876: 191-195, 2000.
    • (2000) Brain Res. , vol.876 , pp. 191-195
    • Ouyang, Y.B.1    Zhang, X.H.2    He, Q.P.3    Wang, G.X.4    Siesjo, B.K.5    Hu, B.R.6
  • 48
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr, J. F., Wyllie, A. H., and Currie, A. R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer, 26: 239-257, 1972.
    • (1972) Br. J. Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.1    Wyllie, A.H.2    Currie, A.R.3
  • 49
    • 0034705239 scopus 로고    scopus 로고
    • Regulation of protien kinase B and 4E-BP1 by oxidative stress in cardiac myocytes
    • Pham, F. H., Sugden, P. H., and Clerk, A. Regulation of protein kinase B and 4E-BP1 by oxidative stress in cardiac myocytes. Circ. Res., 86:1252-1258, 2000. (Pubitemid 30436666)
    • (2000) Circulation Research , vol.86 , Issue.12 , pp. 1252-1258
    • Pham, F.H.1    Sugden, P.H.2    Clerk, A.3
  • 50
    • 0033529675 scopus 로고    scopus 로고
    • Reactive oxygen species mediate the activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cells
    • Ushio-Fukai, M., Alexander, R. W., Akers, M., Yin, Q., Fujio, Y., Walsh, K., and Griendling, K. K. Reactive oxygen species mediate the activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cells. J. Biol. Chem., 274: 22699-22704, 1999.
    • (1999) J. Biol. Chem. , vol.274 , pp. 22699-22704
    • Ushio-Fukai, M.1    Alexander, R.W.2    Akers, M.3    Yin, Q.4    Fujio, Y.5    Walsh, K.6    Griendling, K.K.7
  • 51
    • 0033544956 scopus 로고    scopus 로고
    • Distinct phosphatidylinositol 3-kinase lipid products accumulate upon oxidative and osmotic stress and lead to different cellular responses
    • Van der Kaay, J., Beck, M., Gray, A., and Downes, C. P. Distinct phosphatidylinositol 3-kinase lipid products accumulate upon oxidative and osmotic stress and lead to different cellular responses. J. Biol. Chem., 274: 35963-35968, 1999. (Pubitemid 129512906)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.50 , pp. 35963-35968
    • Van Der, K.J.1    Beck, M.2    Gray, A.3    Downes, C.P.4
  • 52
    • 0034640524 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-dependent Akt activation by oxidative stress enhances cell survival
    • DOI 10.1074/jbc.275.19.14624
    • Wang, X., McCullough, K. D., Franke, T. F., and Holbrook, N. J. Epidermal growth factor receptor-dependent Akt activation by oxidative stress enhances cell survival. J. Biol. Chem., 275: 14624-14631, 2000. (Pubitemid 30339753)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.19 , pp. 14624-14631
    • Wang, X.1    McCullough, K.D.2    Franke, T.F.3    Holbrook, N.J.4
  • 53
    • 0033975366 scopus 로고    scopus 로고
    • Cleavage and inactivation of antiapoptotic Akt/PKB by caspases during apoptosis
    • DOI 10.1002/(SICI)1097-4652(200002)182:2<290::AID
    • Rokudai, S., Fujita, N., Hashimoto, Y., and Tsuruo, T. Cleavage and inactivation of antiapoptotic Akt/PKB by caspases during apoptosis. J. Cell. Physiol., 182: 290-296, 2000. (Pubitemid 30022682)
    • (2000) Journal of Cellular Physiology , vol.182 , Issue.2 , pp. 290-296
    • Rokudai, S.1    Fujita, N.2    Hashimoto, Y.3    Tsuruo, T.4
  • 54
    • 0034307305 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositide 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cancer cells
    • Ng, S. S. W., Tsao, M. S., Chow, S., and Hedley, D. W. Inhibition of phosphatidylinositide 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cancer cells. Cancer Res., 60: 5451-5455, 2000.
    • (2000) Cancer Res. , vol.60 , pp. 5451-5455
    • Ng, S.S.W.1    Tsao, M.S.2    Chow, S.3    Hedley, D.W.4
  • 55
    • 0033198386 scopus 로고    scopus 로고
    • Activation of the PI3'K-AKT pathway masks the proapoptotic effects of farnesyltransferase inhibitors
    • Du, W., Liu, A., and Prendergast, G. C. Activation of the PI3′K-AKT pathway masks the proapoptotic effects of farnesyltransferase inhibitors. Cancer Res., 59: 4208-4212, 1999. (Pubitemid 29418727)
    • (1999) Cancer Research , vol.59 , Issue.17 , pp. 4208-4212
    • Du, W.1    Liu, A.2    Prendergast, G.C.3
  • 56
    • 0034665134 scopus 로고    scopus 로고
    • Prevention of phosphatidylinositol 3′-kinase-Akt survival signaling pathway during topotecan-induced apoptosis
    • Nakashio, A., Fujita, N., Rokudai, S., Sato, S., and Tsuruo, T. Prevention of phosphatidylinositol 3′-kinase-Akt survival signaling pathway during topotecan-induced apoptosis. Cancer Res., 60: 5303-5309, 2000.
    • (2000) Cancer Res. , vol.60 , pp. 5303-5309
    • Nakashio, A.1    Fujita, N.2    Rokudai, S.3    Sato, S.4    Tsuruo, T.5
  • 57
    • 0034731492 scopus 로고    scopus 로고
    • Suppression of apoptosis by UVB irradiation: Survival signaling via PI3-kinase/Akt pathway
    • DOI 10.1006/bbrc.2000.4018
    • Ibuki, Y., and Goto, R. Suppression of apoptosis by UVB irradiation: survival signaling via PI3- kinase/Akt pathway. Biochem. Biophys. Res. Commun., 279: 872-878, 2000. (Pubitemid 32042869)
    • (2000) Biochemical and Biophysical Research Communications , vol.279 , Issue.3 , pp. 872-878
    • Ibuki, Y.1    Goto, R.2
  • 58
    • 0035816648 scopus 로고    scopus 로고
    • Mitogen- and stress-activated protein kinase-1 mediates activation of Akt by ultraviolet B irradiation
    • Nomura, M., Kaji, A., Ma, W. Y., Zhong, S., Liu, G., Bowden, G. T., Miyamoto Ki, K., and Dong, Z. Mitogen- and stress-activated protein kinase-1 mediates activation of Akt by ultraviolet B irradiation. J. Biol. Chem., 11: 25558-25567, 2001.
    • (2001) J. Biol. Chem. , vol.11 , pp. 25558-25567
    • Nomura, M.1    Kaji, A.2    Ma, W.Y.3    Zhong, S.4    Liu, G.5    Bowden, G.T.6    Miyamoto Ki, K.7    Dong, Z.8
  • 59
    • 0034638925 scopus 로고    scopus 로고
    • Molecular mechanisms underlying ErbB2/HER2 action in breast cancer
    • DOI 10.1038/sj.onc.1203973
    • Harari, D., and Yarden, Y. Molecular mechanisms underlying ErbB2/HER2 action in breast cancer. Oncogene, 19: 6102-6114, 2000. (Pubitemid 32059460)
    • (2000) Oncogene , vol.19 , Issue.53 , pp. 6102-6114
    • Harari, D.1    Yarden, Y.2
  • 60
    • 0035874898 scopus 로고    scopus 로고
    • Down-regulation of the erbB-2 receptor by trastuzumab (Herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that overexpress erbB-2
    • Cuello, M., Ettenberg, S. A., Clark, A. S., Keane, M. M., Posner, R. H., Nau, M. M., Dennis, P. A., and Lipkowitz, S. Down-regulation of the erbB-2 receptor by trastuzumab (herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that overexpress erbB-2. Cancer Res., 61: 4892-4900, 2001. (Pubitemid 32691907)
    • (2001) Cancer Research , vol.61 , Issue.12 , pp. 4892-4900
    • Cuello, M.1    Ettenberg, S.A.2    Clark, A.S.3    Keane, M.M.4    Posner, R.H.5    Nau, M.M.6    Dennis, P.A.7    Lipkowitz, S.8
  • 61
    • 0034727094 scopus 로고    scopus 로고
    • Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase
    • Simoncini, T., Hafezi-Moghadam, A., Brazil, D. P., Ley, K., Chin, W. W., and Liao, J. K. Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase. Nature (Lond.), 407: 538-541, 2000.
    • (2000) Nature (Lond.) , vol.407 , pp. 538-541
    • Simoncini, T.1    Hafezi-Moghadam, A.2    Brazil, D.P.3    Ley, K.4    Chin, W.W.5    Liao, J.K.6
  • 63
    • 0032533546 scopus 로고    scopus 로고
    • 2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2
    • 2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2. Biochem. J., 336: 241-246, 1998.
    • (1998) Biochem. J. , vol.336 , pp. 241-246
    • Shaw, M.1    Cohen, P.2    Alessi, D.R.3
  • 64
    • 0035879444 scopus 로고    scopus 로고
    • The role of protein kinase B (PKB) in modulating heat sensitivity in a human breast cancer cell line
    • DOI 10.1016/S0360-3016(01)01596-6, PII S0360301601015966
    • Ma, N., Jin, J., Lu, F., Woodgett, J., and Liu, F. F. The role of protein kinase B (PKB) in modulating heat sensitivity in a human breast cancer cell line. Int. J. Radiat. Oncol. Biol. Phys., 50: 1041-1050, 2001. (Pubitemid 32594843)
    • (2001) International Journal of Radiation Oncology Biology Physics , vol.50 , Issue.4 , pp. 1041-1050
    • Ma, N.1    Jin, J.2    Lu, F.3    Woodgett, J.4    Liu, F.-F.5
  • 65
    • 0035107345 scopus 로고    scopus 로고
    • Hypoxia activates Akt and induces phosphorylation of GSK-3 in PC12 cells
    • DOI 10.1016/S0898-6568(00)00128-5, PII S0898656800001285
    • Beitner-Johnson, D., Rust, R. T., Hsieh, T. C., and Millhorn, D. E. Hypoxia activates Akt and induces phosphorylation of GSK-3 in PC12 cells. Cell Signalling, 13: 23-27, 2001. (Pubitemid 32222969)
    • (2001) Cellular Signalling , vol.13 , Issue.1 , pp. 23-27
    • Beitner-Johnson, D.1    Rust, R.T.2    Hsieh, T.C.3    Millhorn, D.E.4
  • 66
    • 0035933726 scopus 로고    scopus 로고
    • Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: Protective role in apoptosis
    • Alvarez-Tejado, M., Naranjo-Suarez, S., Jimenez, C., Carrera, A. C., Landazuri, M. O., and del Peso, L. Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis. J. Biol. Chem., 9: 22368-22374, 2001.
    • (2001) J. Biol. Chem. , vol.9 , pp. 22368-22374
    • Alvarez-Tejado, M.1    Naranjo-Suarez, S.2    Jimenez, C.3    Carrera, A.C.4    Landazuri, M.O.5    Del Peso, L.6


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