-
1
-
-
0032752063
-
Cellular survival: A play in three Akts
-
Datta, S. R., Brunet, A., and Greenberg, M. E. Cellular survival: a play in three Akts. Genes Dev., 13: 2905-2927, 1999.
-
(1999)
Genes Dev.
, vol.13
, pp. 2905-2927
-
-
Datta, S.R.1
Brunet, A.2
Greenberg, M.E.3
-
2
-
-
0026095665
-
A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region
-
Bellacosa, A., Testa, J. R., Staal, S. P., and Tsichlis, P. N. A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region. Science (Wash. DC), 254: 274-277, 1991. (Pubitemid 21917339)
-
(1991)
Science
, vol.254
, Issue.5029
, pp. 274-277
-
-
Bellacosa, A.1
Testa, J.R.2
Staal, S.P.3
Tsichlis, P.N.4
-
3
-
-
0026006501
-
Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families
-
[published erratum appears in Eur. J. Biochem., 205: 1217, 1992].
-
Coffer, P. J., and Woodgett, J. R. Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families [published erratum appears in Eur. J. Biochem., 205: 1217, 1992]. Eur J Biochem., 201: 475-481, 1991.
-
(1991)
Eur J Biochem.
, vol.201
, pp. 475-481
-
-
Coffer, P.J.1
Woodgett, J.R.2
-
4
-
-
0025882091
-
Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily
-
Jones, P. F., Jakubowicz, T., Pitossi, F. J., Maurer, F., and Hemmings, B. A. Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily. Proc. Natl. Acad. Sci. USA, 88: 4171-4175, 1991. (Pubitemid 21914501)
-
(1991)
Proceedings of the National Academy of Sciences of the United States of America
, vol.88
, Issue.10
, pp. 4171-4175
-
-
Jones, P.F.1
Jakubowicz, T.2
Pitossi, F.J.3
Maurer, F.4
Hemmings, B.A.5
-
5
-
-
0033594480
-
PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2
-
DOI 10.1016/S0960-9822(99)80186-9
-
Balendran, A., Casamayor, A., Deak, M., Paterson, A., Gaffney, P., Currie, R., Downes, C. P., and Alessi, D. R. PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2. Curr. Biol., 9: 393-404, 1999. (Pubitemid 29205782)
-
(1999)
Current Biology
, vol.9
, Issue.8
, pp. 393-404
-
-
Balendran, A.1
Casamayor, A.2
Deak, M.3
Paterson, A.4
Gaffney, P.5
Currie, R.6
Downes, C.P.7
Alessi, D.R.8
-
6
-
-
0032530482
-
Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase
-
DOI 10.1073/pnas.95.19.11211
-
Delcommenne, M., Tan, C., Gray, V., Rue, L., Woodgett, J., and Dedhar, S. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc. Natl. Acad. Sci. USA, 95: 11211-11216, 1998. (Pubitemid 28450107)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.19
, pp. 11211-11216
-
-
Delcommenne, M.1
Tan, C.2
Gray, V.3
Rue, L.4
Woodgett, J.5
Dedhar, S.6
-
7
-
-
0033599029
-
Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism
-
Lynch, D. K., Ellis, C. A., Edwards, P. A., and Hiles, I. D. Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism. Oncogene, 18: 8024-8032, 1999. (Pubitemid 30050563)
-
(1999)
Oncogene
, vol.18
, Issue.56
, pp. 8024-8032
-
-
Lynch, D.K.1
Ellis, C.A.2
Edwards, P.A.3
Hiles, I.D.4
-
8
-
-
0034708482
-
Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site
-
DOI 10.1074/jbc.275.12.8271
-
Toker, A., and Newton, A. C. Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site. J. Biol. Chem., 275:8271-8274, 2000. (Pubitemid 30180163)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.12
, pp. 8271-8274
-
-
Toker, A.1
Newton, A.C.2
-
9
-
-
0030702123
-
Akt phosphorylation of BAD couples survival signals to the cell- intrinsic death machinery
-
DOI 10.1016/S0092-8674(00)80405-5
-
Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., and Greenberg, M. E. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell, 91: 231-241, 1997. (Pubitemid 27456390)
-
(1997)
Cell
, vol.91
, Issue.2
, pp. 231-241
-
-
Datta, S.R.1
Dudek, H.2
Xu, T.3
Masters, S.4
Haian, F.5
Gotoh, Y.6
Greenberg, M.E.7
-
10
-
-
1842333237
-
Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
-
DOI 10.1126/science.278.5338.687
-
del Peso, L., Gonzalez-Garcia, M., Page, C., Herrera, R., and Nunez, G. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science (Wash. DC), 278: 687-689, 1997. (Pubitemid 27464966)
-
(1997)
Science
, vol.278
, Issue.5338
, pp. 687-689
-
-
Del, P.L.1
Gonzalez-Garcia, M.2
Page, C.3
Herrera, R.4
Nunez, G.5
-
11
-
-
0032515027
-
Regulation of cell death protease caspase-9 by phosphorylation
-
Cardone, M. H., Roy, N., Stennicke, H. R., Salvesen, G. S., Franke, T. F., Stanbridge, E., Frisch, S., and Reed, J. C. Regulation of cell death protease caspase-9 by phosphorylation [see comments]. Science (Wash. DC), 282: 1318-1321, 1998. (Pubitemid 28524494)
-
(1998)
Science
, vol.282
, Issue.5392
, pp. 1318-1321
-
-
Cardone, M.H.1
Roy, N.2
Stennicke, H.R.3
Salvesen, G.S.4
Franke, T.F.5
Stanbridge, E.6
Frisch, S.7
Reed, J.C.8
-
12
-
-
0033532056
-
Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit
-
Kang, S. S., Kwon, T., Kwon, D. Y., and Do, S. I. Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit. J. Biol. Chem., 274: 13085-13090, 1999.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 13085-13090
-
-
Kang, S.S.1
Kwon, T.2
Kwon, D.Y.3
Do, S.I.4
-
13
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor
-
Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., and Greenberg, M. E. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell, 96: 857-868, 1999. (Pubitemid 29165088)
-
(1999)
Cell
, vol.96
, Issue.6
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
Lin, M.Z.4
Juo, P.5
Hu, L.S.6
Anderson, M.J.7
Arden, K.C.8
Blenis, J.9
Greenberg, M.E.10
-
14
-
-
0033560896
-
Direct control of the forkhead transcription faotor AFX by protein kinase B
-
DOI 10.1038/19328
-
Kops, G. J., de Ruiter, N. D., De Vries-Smits, A. M., Powell, D. R., Bos, J. L., and Burgering, B. M. Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature (Lond.), 398: 630-634, 1999. (Pubitemid 29183692)
-
(1999)
Nature
, vol.398
, Issue.6728
, pp. 630-634
-
-
Kops, G.J.P.L.1
De Ruiter, N.D.2
De Vries-Smits, A.M.M.3
Powell, D.R.4
Bos, J.L.5
Burgering, B.M.Th.6
-
15
-
-
0033517189
-
NF-κB activation by tumour necrosis factor requires the Akt serine-threonine kinase
-
[see comments].
-
Ozes, O. N., Mayo, L. D., Gustin, J. A., Pfeffer, S. R., Pfeffer, L. M., and Donner, D. B. NF-κB activation by tumour necrosis factor requires the Akt serine-threonine kinase [see comments]. Nature (Lond.), 401: 82-85, 1999.
-
(1999)
Nature (Lond.)
, vol.401
, pp. 82-85
-
-
Ozes, O.N.1
Mayo, L.D.2
Gustin, J.A.3
Pfeffer, S.R.4
Pfeffer, L.M.5
Donner, D.B.6
-
16
-
-
0033517190
-
NF-κB is a target of AKT in anti-apoptotic PDGF signalling
-
[see comments].
-
Romashkova, J. A., and Makarov, S. S. NF-κB is a target of AKT in anti-apoptotic PDGF signalling [see comments]. Nature (Lond.), 401: 86-90, 1999.
-
(1999)
Nature (Lond.)
, vol.401
, pp. 86-90
-
-
Romashkova, J.A.1
Makarov, S.S.2
-
17
-
-
0031053586
-
Regulation of neuronal survival by the serine-threonine protein kinase Akt
-
DOI 10.1126/science.275.5300.661
-
Dudek, H., Datta, S. R., Franke, T. F., Birnbaum, M. J., Yao, R., Cooper, G. M., Segal, R. A., Kaplan, D. R., and Greenberg, M. E. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science (Wash. DC), 275: 661-665, 1997. (Pubitemid 27061332)
-
(1997)
Science
, vol.275
, Issue.5300
, pp. 661-665
-
-
Dudek, H.1
Datta, S.R.2
Franke, T.F.3
Birnbaum, M.J.4
Yao, R.5
Cooper, G.M.6
Segal, R.A.7
Kaplan, D.R.8
Greenberg, M.E.9
-
18
-
-
0031028730
-
Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB
-
DOI 10.1038/385544a0
-
Kauffmann-Zeh, A., Rodriguez-Viciana, P., Ulrich, E., Gilbert, C., Coffer, P., Downward, J., and Evan, G. Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB. Nature (Lond.), 385:544-548, 1997. (Pubitemid 27074674)
-
(1997)
Nature
, vol.385
, Issue.6616
, pp. 544-548
-
-
Kauffmann-Zeh, A.1
Rodriguez-Viciana, P.2
Ulrich, E.3
Gilbert, C.4
Coffer, P.5
Downward, J.6
Evan, G.7
-
19
-
-
0032808154
-
Akt/protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria
-
Kennedy, S. G., Kandel, E. S., Cross, T. K., and Hay, N. Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria. Mol. Cell. Biol., 19: 5800-5810, 1999. (Pubitemid 29339934)
-
(1999)
Molecular and Cellular Biology
, vol.19
, Issue.8
, pp. 5800-5810
-
-
Kennedy, S.G.1
Kandel, E.S.2
Cross, T.K.3
Hay, N.4
-
20
-
-
0030913673
-
Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
-
DOI 10.1093/emboj/16.10.2783
-
Khwaja, A., Rodriguez-Viciana, P., Wennstrom, S., Warne, P., and Downward, J. Matrix adhesion and ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J., 16: 2783-2793, 1997. (Pubitemid 27226215)
-
(1997)
EMBO Journal
, vol.16
, Issue.10
, pp. 2783-2793
-
-
Khwaja, A.1
Rodriguez-Viciana, P.2
Wennstrom, S.3
Warne, P.H.4
Downward, J.5
-
21
-
-
0031034574
-
Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt
-
Kulik, G., Klippel, A., and Weber, M. J. Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol. Cell. Biol., 17: 1595-1606, 1997. (Pubitemid 27097389)
-
(1997)
Molecular and Cellular Biology
, vol.17
, Issue.3
, pp. 1595-1606
-
-
Kulik, G.1
Klippel, A.2
Weber, M.J.3
-
22
-
-
0032532206
-
Suppression of transforming growth factor-β-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway
-
Chen, R. H., Su, Y. H., Chuang, R. L., and Chang, T. Y. Suppression of transforming growth factor-β-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway. Oncogene, 17: 1959-1968, 1998. (Pubitemid 28488464)
-
(1998)
Oncogene
, vol.17
, Issue.15
, pp. 1959-1968
-
-
Chen, R.-H.1
Su, Y.-H.2
Chuang, R.L.C.3
Chang, T.-Y.4
-
23
-
-
0032522924
-
Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons
-
Crowder, R. J., and Freeman, R. S. Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons. J. Neurosci., 18: 2933-2943, 1998. (Pubitemid 28163223)
-
(1998)
Journal of Neuroscience
, vol.18
, Issue.8
, pp. 2933-2943
-
-
Crowder, R.J.1
Freeman, R.S.2
-
24
-
-
0031923788
-
Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line
-
Eves, E. M., Xiong, W., Bellacosa, A., Kennedy, S. G., Tsichlis, P. N., Rosner, M. R., and Hay, N. Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line. Mol. Cell. Biol., 18:2143-2152, 1998. (Pubitemid 28152663)
-
(1998)
Molecular and Cellular Biology
, vol.18
, Issue.4
, pp. 2143-2152
-
-
Eves, E.M.1
Xiong, W.2
Bellacosa, A.3
Kennedy, S.G.4
Tsichlis, P.N.5
Rosner, M.R.6
Hay, N.7
-
25
-
-
0033560120
-
Akt-dependent potentiation of L channels by insulin-like growth factor- 1 is required for neuronal survival
-
Blair, L. A., Bence-Hanulec, K. K., Mehta, S., Franke, T., Kaplan, D., and Marshall, J. Akt-dependent potentiation of L channels by insulin-like growth factor-1 is required for neuronal survival. J. Neurosci., 19: 1940-1951, 1999. (Pubitemid 29133372)
-
(1999)
Journal of Neuroscience
, vol.19
, Issue.6
, pp. 1940-1951
-
-
Blair, L.A.C.1
Bence-Hanulec, K.K.2
Mehta, S.3
Franke, T.4
Kaplan, D.5
Marshall, J.6
-
26
-
-
0032515047
-
Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway: Requirement for Flk-1/KDR activation
-
DOI 10.1074/jbc.273.46.30336
-
Gerber, H. P., McMurtrey, A., Kowalski, J., Yan, M., Keyt, B. A., Dixit, V., and Ferrara, N. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. J. Biol. Chem., 273: 30336-30343, 1998. (Pubitemid 28545503)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.46
, pp. 30336-30343
-
-
Gerber, H.-P.1
McMurtrey, A.2
Kowalski, J.3
Yan, M.4
Keyt, B.A.5
Dixit, V.6
Ferrara, N.7
-
27
-
-
0039058167
-
Protection of CD95-mediated apoptosis by activation of phosphatidylinositide 3-kinase and protein kinase B
-
DOI 10.1002/(SICI)1521-4141(199801)28:01<57::AID-I
-
Hausler, P., Papoff, G., Eramo, A., Reif, K., Cantrell, D. A., and Ruberti, G. Protection of CD95-mediated apoptosis by activation of phosphatidylinositide 3-kinase and protein kinase B. Eur. J. Immunol., 28: 57-69, 1998. (Pubitemid 28048277)
-
(1998)
European Journal of Immunology
, vol.28
, Issue.1
, pp. 57-69
-
-
Hausler, P.1
Papoff, G.2
Eramo, A.3
Reif, K.4
Cantrell, D.A.5
Ruberti, G.6
-
28
-
-
0031770827
-
Akt-dependent and -independent survival signaling pathways utilized by insulin-like growth factor I
-
Kulik, G., and Weber, M. J. Akt-dependent and -independent survival signaling pathways utilized by insulin-like growth factor I. Mol. Cell. Biol., 18: 6711-6718, 1998. (Pubitemid 28500558)
-
(1998)
Molecular and Cellular Biology
, vol.18
, Issue.11
, pp. 6711-6718
-
-
Kulik, G.1
Weber, M.J.2
-
29
-
-
0032481127
-
The opposing roles of the Akt and c-Myc signalling pathways in survival from CD95-mediated apoptosis
-
Rohn, J. L., Hueber, A. O., McCarthy, N. J., Lyon, D., Navarro, P., Burgering, B. M., and Evan, G. I. The opposing roles of the Akt and c-Myc signalling pathways in survival from CD95-mediated apoptosis. Oncogene, 17: 2811-2818, 1998. (Pubitemid 29010051)
-
(1998)
Oncogene
, vol.17
, Issue.22
, pp. 2811-2818
-
-
Rohn, J.L.1
Hueber, A.-O.2
McCarthy, N.J.3
Lyon, D.4
Navarro, P.5
Burgering, B.M.Th.6
Evan, G.I.7
-
30
-
-
0033587742
-
Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons
-
DOI 10.1073/pnas.96.15.8745
-
Chalecka-Franaszek, E., and Chuang, D. M. Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons. Proc. Natl. Acad. Sci. USA, 96: 8745-8750, 1999. (Pubitemid 29354862)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.15
, pp. 8745-8750
-
-
Chalecka-Franaszek, E.1
Chuang, D.-M.2
-
31
-
-
0034733547
-
The bile acid taurochenodeoxycholate activates a phosphatidylinositol 3- kinase-dependent survival signaling cascade
-
DOI 10.1074/jbc.M909992199
-
Rust, C., Karnitz, L. M., Paya, C. V., Moscat, J., Simari, R. D., and Gores, G. J. The bile acid taurochenodeoxycholate activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade. J. Biol. Chem., 275: 20210-20216, 2000. (Pubitemid 30441633)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.26
, pp. 20210-20216
-
-
Rust, C.1
Karnitz, L.M.2
Paya, C.V.3
Moscat, J.4
Simari, R.D.5
Gores, G.J.6
-
32
-
-
0035872199
-
Akt/pbotein kinace B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation
-
Brognard, J., Clark, A. S., Ni, Y., and Dennis, P. A. Akt/protein kinase b is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. Cancer Res., 61: 3986-3997, 2001. (Pubitemid 32720961)
-
(2001)
Cancer Research
, vol.61
, Issue.10
, pp. 3986-3997
-
-
Brognard, J.1
Clark, A.S.2
Ni, Y.3
Dennis, P.A.4
-
33
-
-
0034629345
-
The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide- dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase
-
DOI 10.1074/jbc.275.10.7395
-
Lali, F. V., Hunt, A. E., Turner, S. J., and Foxwell, B. M. The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase. J. Biol. Chem., 275: 7395-7402, 2000. (Pubitemid 30146294)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.10
, pp. 7395-7402
-
-
Lali, F.V.1
Hunt, A.E.2
Turner, S.J.3
Foxwell, B.M.J.4
-
34
-
-
0031203265
-
Germline mutations in PTEN are present in Bannayan-Zonana syndrome
-
Marsh, D. J., Dahia, P. L., Zheng, Z., Liaw, D., Parsons, R., Gorlin, R. J., and Eng, C. Germline mutations in PTEN are present in Bannayan-Zonana syndrome. Nat. Genet., 16: 333-334, 1997.
-
(1997)
Nat. Genet.
, vol.16
, pp. 333-334
-
-
Marsh, D.J.1
Dahia, P.L.2
Zheng, Z.3
Liaw, D.4
Parsons, R.5
Gorlin, R.J.6
Eng, C.7
-
35
-
-
0030801275
-
Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas
-
Rhei, E., Kang, L., Bogomolniy, F., Federici, M. G., Borgen, P. I., and Boyd, J. Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas. Cancer Res., 57: 3657-3659, 1997. (Pubitemid 27381202)
-
(1997)
Cancer Research
, vol.57
, Issue.17
, pp. 3657-3659
-
-
Rhei, E.1
Kang, L.2
Bogomolniy, F.3
Federici, M.G.4
Borgen, P.I.5
Boyd, J.6
-
36
-
-
0033003079
-
Analysis of the 10q23 chromosomal region and the PTEN gene in human sporadic breast carcinoma
-
DOI 10.1038/sj.bjc.6690115
-
Feilotter, H. E., Coulon, V., McVeigh, J. L., Boag, A. H., Dorion-Bonnet, F., Duboue, B., Latham, W. C., Eng, C., Mulligan, L. M., and Longy, M. Analysis of the 10q23 chromosomal region and the PTEN gene in human sporadic breast carcinoma. Br. J. Cancer, 79: 718-723, 1999. (Pubitemid 29082095)
-
(1999)
British Journal of Cancer
, vol.79
, Issue.5-6
, pp. 718-723
-
-
Feilotter, H.E.1
Coulon, V.2
McVeigh, J.L.3
Boag, A.H.4
Dorion-Bonnet, F.5
Duboue, B.6
Latham, W.C.W.7
Eng, C.8
Mulligan, L.M.9
Longy, M.10
-
37
-
-
0031916211
-
Sporadic breast cancers exhibit loss of heterozygosity on chromosome segment 10q23 close to the Cowden disease locus
-
DOI 10.1002/(SICI)1098-2264(199802)21:2<166::AID-G
-
Singh, B., Ittmann, M. M., and Krolewski, J. J. Sporadic breast cancers exhibit loss of heterozygosity on chromosome segment 10q23 close to the Cowden disease locus. Genes Chromosomes Cancer, 21: 166-171, 1998. (Pubitemid 28081244)
-
(1998)
Genes Chromosomes and Cancer
, vol.21
, Issue.2
, pp. 166-171
-
-
Singh, B.1
Ittmann, M.M.2
Krolewski, J.J.3
-
38
-
-
0032534963
-
The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene
-
Li, J., Simpson, L., Takahashi, M., Miliaresis, C., Myers, M. P., Tonks, N., and Parsons, R. The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene. Cancer Res., 58: 5667-5672, 1998. (Pubitemid 29006402)
-
(1998)
Cancer Research
, vol.58
, Issue.24
, pp. 5667-5672
-
-
Li, J.1
Simpson, L.2
Takahashi, M.3
Miliaresis, C.4
Myers, M.P.5
Tonks, N.6
Parsons, R.7
-
39
-
-
0033604468
-
The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells
-
Lu, Y., Lin, Y. Z., LaPushin, R., Cuevas, B., Fang, X., Yu, S. X., Davies, M. A., Khan, H., Furui, T., Mao, M., Zinner, R., Hung, M. C., Steck, P., Siminovitch, K., and Mills, G. B. The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells. Oncogene, 18: 7034-7045, 1999. (Pubitemid 30028874)
-
(1999)
Oncogene
, vol.18
, Issue.50
, pp. 7034-7045
-
-
Lu, Y.1
Lin, Y.-Z.2
LaPushin, R.3
Cuevas, B.4
Fang, X.5
Yu, S.X.6
Davies, M.A.7
Khan, H.8
Furui, T.9
Mao, M.10
Zinner, R.11
Hung, M.-C.12
Steck, P.13
Siminovitch, K.14
Mills, G.B.15
-
40
-
-
0029127042
-
Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas
-
Bellacosa, A., de Feo, D., Godwin, A. K., Bell, D. W., Cheng, J. Q., Altomare, D. A., Wan, M., Dubeau, L., Scambia, G., Masciullo, V., et al.Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas. Int. J. Cancer, 64: 280-285, 1995.
-
(1995)
Int. J. Cancer
, vol.64
, pp. 280-285
-
-
Bellacosa, A.1
De Feo, D.2
Godwin, A.K.3
Bell, D.W.4
Cheng, J.Q.5
Altomare, D.A.6
Wan, M.7
Dubeau, L.8
Scambia, G.9
Masciullo, V.10
-
41
-
-
0033618371
-
Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines
-
Nakatani, K., Thompson, D. A., Barthel, A., Sakaue, H., Liu, W., Weigel, R. J., and Roth, R. A. Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines. J. Biol. Chem., 274: 21528-21532, 1999.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 21528-21532
-
-
Nakatani, K.1
Thompson, D.A.2
Barthel, A.3
Sakaue, H.4
Liu, W.5
Weigel, R.J.6
Roth, R.A.7
-
42
-
-
0035008874
-
Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression
-
DOI 10.1128/MCB.21.6.2203-2212.2001
-
Hutchinson, J., Jin, J., Cardiff, R. D., Woodgett, J. R., and Muller, W. J. Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression. Mol. Cell. Biol., 21: 2203-2212, 2001. (Pubitemid 32479640)
-
(2001)
Molecular and Cellular Biology
, vol.21
, Issue.6
, pp. 2203-2212
-
-
Hutchinson, J.1
Jin, J.2
Cardiff, R.D.3
Woodgett, J.R.4
Muller, W.J.5
-
43
-
-
0035134656
-
Inhibition of mammary epithelial apoptosis and sustained phosphorylation of Akt/PKB in MMTV-IGF-II transgenic mice
-
DOI 10.1038/sj.cdd.4400762
-
Moorehead, R. A., Fata, J. E., Johnson, M. B., and Khokha, R. Inhibition of mammary epithelial apoptosis and sustained phosphorylation of Akt/PKB in MMTV-IGF-II transgenic mice. Cell Death Differ., 8: 16-29, 2001. (Pubitemid 32162217)
-
(2001)
Cell Death and Differentiation
, vol.8
, Issue.1
, pp. 16-29
-
-
Moorehead, R.A.1
Fata, J.E.2
Johnson, M.B.3
Khokha, R.4
-
44
-
-
0032557646
-
Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB
-
DOI 10.1074/jbc.273.21.13150
-
van Weeren, P. C., de Bruyn, K. M., de Vries-Smits, A. M., van Lint, J., and Burgering, B. M. Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB. J. Biol. Chem., 273: 13150-13156, 1998. (Pubitemid 28246883)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.21
, pp. 13150-13156
-
-
Van Weeren, P.C.1
De Bruyn, K.M.T.2
De Vries-Smits, A.M.M.3
Van Lint, J.4
Burgering, B.M.T.5
-
45
-
-
0026496885
-
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
-
Kastan, M. B., Zhan, Q., el-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., and Fornace, A. J., Jr. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell, 71: 587-597, 1992.
-
(1992)
Cell
, vol.71
, pp. 587-597
-
-
Kastan, M.B.1
Zhan, Q.2
El-Deiry, W.S.3
Carrier, F.4
Jacks, T.5
Walsh, W.V.6
Plunkett, B.S.7
Vogelstein, B.8
Fornace Jr., A.J.9
-
46
-
-
0001458215
-
Effects of more than one inhibitor
-
New York: Academic Press
-
Webb, J. L. Effects of more than one inhibitor. Enzymes and Metabolic Inhibitors, Vol. 1, pp. 487-512. New York: Academic Press, 1963.
-
(1963)
Enzymes and Metabolic Inhibitors
, vol.1
, pp. 487-512
-
-
Webb, J.L.1
-
47
-
-
0034623179
-
Differential phosphorylation at Ser473 and Thr308 of Akt-1 in rat brain following hypoglycemic coma
-
Ouyang, Y. B., Zhang, X. H., He, Q. P., Wang, G. X., Siesjo, B. K., and Hu, B. R. Differential phosphorylation at Ser473 and Thr308 of Akt-1 in rat brain following hypoglycemic coma. Brain Res., 876: 191-195, 2000.
-
(2000)
Brain Res.
, vol.876
, pp. 191-195
-
-
Ouyang, Y.B.1
Zhang, X.H.2
He, Q.P.3
Wang, G.X.4
Siesjo, B.K.5
Hu, B.R.6
-
48
-
-
0015383455
-
Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
-
Kerr, J. F., Wyllie, A. H., and Currie, A. R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer, 26: 239-257, 1972.
-
(1972)
Br. J. Cancer
, vol.26
, pp. 239-257
-
-
Kerr, J.F.1
Wyllie, A.H.2
Currie, A.R.3
-
49
-
-
0034705239
-
Regulation of protien kinase B and 4E-BP1 by oxidative stress in cardiac myocytes
-
Pham, F. H., Sugden, P. H., and Clerk, A. Regulation of protein kinase B and 4E-BP1 by oxidative stress in cardiac myocytes. Circ. Res., 86:1252-1258, 2000. (Pubitemid 30436666)
-
(2000)
Circulation Research
, vol.86
, Issue.12
, pp. 1252-1258
-
-
Pham, F.H.1
Sugden, P.H.2
Clerk, A.3
-
50
-
-
0033529675
-
Reactive oxygen species mediate the activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cells
-
Ushio-Fukai, M., Alexander, R. W., Akers, M., Yin, Q., Fujio, Y., Walsh, K., and Griendling, K. K. Reactive oxygen species mediate the activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cells. J. Biol. Chem., 274: 22699-22704, 1999.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 22699-22704
-
-
Ushio-Fukai, M.1
Alexander, R.W.2
Akers, M.3
Yin, Q.4
Fujio, Y.5
Walsh, K.6
Griendling, K.K.7
-
51
-
-
0033544956
-
Distinct phosphatidylinositol 3-kinase lipid products accumulate upon oxidative and osmotic stress and lead to different cellular responses
-
Van der Kaay, J., Beck, M., Gray, A., and Downes, C. P. Distinct phosphatidylinositol 3-kinase lipid products accumulate upon oxidative and osmotic stress and lead to different cellular responses. J. Biol. Chem., 274: 35963-35968, 1999. (Pubitemid 129512906)
-
(1999)
Journal of Biological Chemistry
, vol.274
, Issue.50
, pp. 35963-35968
-
-
Van Der, K.J.1
Beck, M.2
Gray, A.3
Downes, C.P.4
-
52
-
-
0034640524
-
Epidermal growth factor receptor-dependent Akt activation by oxidative stress enhances cell survival
-
DOI 10.1074/jbc.275.19.14624
-
Wang, X., McCullough, K. D., Franke, T. F., and Holbrook, N. J. Epidermal growth factor receptor-dependent Akt activation by oxidative stress enhances cell survival. J. Biol. Chem., 275: 14624-14631, 2000. (Pubitemid 30339753)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.19
, pp. 14624-14631
-
-
Wang, X.1
McCullough, K.D.2
Franke, T.F.3
Holbrook, N.J.4
-
53
-
-
0033975366
-
Cleavage and inactivation of antiapoptotic Akt/PKB by caspases during apoptosis
-
DOI 10.1002/(SICI)1097-4652(200002)182:2<290::AID
-
Rokudai, S., Fujita, N., Hashimoto, Y., and Tsuruo, T. Cleavage and inactivation of antiapoptotic Akt/PKB by caspases during apoptosis. J. Cell. Physiol., 182: 290-296, 2000. (Pubitemid 30022682)
-
(2000)
Journal of Cellular Physiology
, vol.182
, Issue.2
, pp. 290-296
-
-
Rokudai, S.1
Fujita, N.2
Hashimoto, Y.3
Tsuruo, T.4
-
54
-
-
0034307305
-
Inhibition of phosphatidylinositide 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cancer cells
-
Ng, S. S. W., Tsao, M. S., Chow, S., and Hedley, D. W. Inhibition of phosphatidylinositide 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cancer cells. Cancer Res., 60: 5451-5455, 2000.
-
(2000)
Cancer Res.
, vol.60
, pp. 5451-5455
-
-
Ng, S.S.W.1
Tsao, M.S.2
Chow, S.3
Hedley, D.W.4
-
55
-
-
0033198386
-
Activation of the PI3'K-AKT pathway masks the proapoptotic effects of farnesyltransferase inhibitors
-
Du, W., Liu, A., and Prendergast, G. C. Activation of the PI3′K-AKT pathway masks the proapoptotic effects of farnesyltransferase inhibitors. Cancer Res., 59: 4208-4212, 1999. (Pubitemid 29418727)
-
(1999)
Cancer Research
, vol.59
, Issue.17
, pp. 4208-4212
-
-
Du, W.1
Liu, A.2
Prendergast, G.C.3
-
56
-
-
0034665134
-
Prevention of phosphatidylinositol 3′-kinase-Akt survival signaling pathway during topotecan-induced apoptosis
-
Nakashio, A., Fujita, N., Rokudai, S., Sato, S., and Tsuruo, T. Prevention of phosphatidylinositol 3′-kinase-Akt survival signaling pathway during topotecan-induced apoptosis. Cancer Res., 60: 5303-5309, 2000.
-
(2000)
Cancer Res.
, vol.60
, pp. 5303-5309
-
-
Nakashio, A.1
Fujita, N.2
Rokudai, S.3
Sato, S.4
Tsuruo, T.5
-
57
-
-
0034731492
-
Suppression of apoptosis by UVB irradiation: Survival signaling via PI3-kinase/Akt pathway
-
DOI 10.1006/bbrc.2000.4018
-
Ibuki, Y., and Goto, R. Suppression of apoptosis by UVB irradiation: survival signaling via PI3- kinase/Akt pathway. Biochem. Biophys. Res. Commun., 279: 872-878, 2000. (Pubitemid 32042869)
-
(2000)
Biochemical and Biophysical Research Communications
, vol.279
, Issue.3
, pp. 872-878
-
-
Ibuki, Y.1
Goto, R.2
-
58
-
-
0035816648
-
Mitogen- and stress-activated protein kinase-1 mediates activation of Akt by ultraviolet B irradiation
-
Nomura, M., Kaji, A., Ma, W. Y., Zhong, S., Liu, G., Bowden, G. T., Miyamoto Ki, K., and Dong, Z. Mitogen- and stress-activated protein kinase-1 mediates activation of Akt by ultraviolet B irradiation. J. Biol. Chem., 11: 25558-25567, 2001.
-
(2001)
J. Biol. Chem.
, vol.11
, pp. 25558-25567
-
-
Nomura, M.1
Kaji, A.2
Ma, W.Y.3
Zhong, S.4
Liu, G.5
Bowden, G.T.6
Miyamoto Ki, K.7
Dong, Z.8
-
59
-
-
0034638925
-
Molecular mechanisms underlying ErbB2/HER2 action in breast cancer
-
DOI 10.1038/sj.onc.1203973
-
Harari, D., and Yarden, Y. Molecular mechanisms underlying ErbB2/HER2 action in breast cancer. Oncogene, 19: 6102-6114, 2000. (Pubitemid 32059460)
-
(2000)
Oncogene
, vol.19
, Issue.53
, pp. 6102-6114
-
-
Harari, D.1
Yarden, Y.2
-
60
-
-
0035874898
-
Down-regulation of the erbB-2 receptor by trastuzumab (Herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that overexpress erbB-2
-
Cuello, M., Ettenberg, S. A., Clark, A. S., Keane, M. M., Posner, R. H., Nau, M. M., Dennis, P. A., and Lipkowitz, S. Down-regulation of the erbB-2 receptor by trastuzumab (herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that overexpress erbB-2. Cancer Res., 61: 4892-4900, 2001. (Pubitemid 32691907)
-
(2001)
Cancer Research
, vol.61
, Issue.12
, pp. 4892-4900
-
-
Cuello, M.1
Ettenberg, S.A.2
Clark, A.S.3
Keane, M.M.4
Posner, R.H.5
Nau, M.M.6
Dennis, P.A.7
Lipkowitz, S.8
-
61
-
-
0034727094
-
Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase
-
Simoncini, T., Hafezi-Moghadam, A., Brazil, D. P., Ley, K., Chin, W. W., and Liao, J. K. Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase. Nature (Lond.), 407: 538-541, 2000.
-
(2000)
Nature (Lond.)
, vol.407
, pp. 538-541
-
-
Simoncini, T.1
Hafezi-Moghadam, A.2
Brazil, D.P.3
Ley, K.4
Chin, W.W.5
Liao, J.K.6
-
62
-
-
18044403985
-
Estrogen induces the akt-dependent activation of endothelial nitric oxide synthase in vascular endothelial cells
-
Hisamoto, K., Ohmichi, M., Kurachi, H., Hayakawa, J., Kanda, Y., Nishio, Y., Adachi, K., Tasaka, K., Miyoshi, E., Fujiwara, N., Taniguchi, N., and Murata, Y. Estrogen induces the akt-dependent activation of endothelial nitric oxide synthase in vascular endothelial cells. J. Biol. Chem., 276: 3459-3467, 2001.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 3459-3467
-
-
Hisamoto, K.1
Ohmichi, M.2
Kurachi, H.3
Hayakawa, J.4
Kanda, Y.5
Nishio, Y.6
Adachi, K.7
Tasaka, K.8
Miyoshi, E.9
Fujiwara, N.10
Taniguchi, N.11
Murata, Y.12
-
63
-
-
0032533546
-
2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2
-
2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2. Biochem. J., 336: 241-246, 1998.
-
(1998)
Biochem. J.
, vol.336
, pp. 241-246
-
-
Shaw, M.1
Cohen, P.2
Alessi, D.R.3
-
64
-
-
0035879444
-
The role of protein kinase B (PKB) in modulating heat sensitivity in a human breast cancer cell line
-
DOI 10.1016/S0360-3016(01)01596-6, PII S0360301601015966
-
Ma, N., Jin, J., Lu, F., Woodgett, J., and Liu, F. F. The role of protein kinase B (PKB) in modulating heat sensitivity in a human breast cancer cell line. Int. J. Radiat. Oncol. Biol. Phys., 50: 1041-1050, 2001. (Pubitemid 32594843)
-
(2001)
International Journal of Radiation Oncology Biology Physics
, vol.50
, Issue.4
, pp. 1041-1050
-
-
Ma, N.1
Jin, J.2
Lu, F.3
Woodgett, J.4
Liu, F.-F.5
-
65
-
-
0035107345
-
Hypoxia activates Akt and induces phosphorylation of GSK-3 in PC12 cells
-
DOI 10.1016/S0898-6568(00)00128-5, PII S0898656800001285
-
Beitner-Johnson, D., Rust, R. T., Hsieh, T. C., and Millhorn, D. E. Hypoxia activates Akt and induces phosphorylation of GSK-3 in PC12 cells. Cell Signalling, 13: 23-27, 2001. (Pubitemid 32222969)
-
(2001)
Cellular Signalling
, vol.13
, Issue.1
, pp. 23-27
-
-
Beitner-Johnson, D.1
Rust, R.T.2
Hsieh, T.C.3
Millhorn, D.E.4
-
66
-
-
0035933726
-
Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: Protective role in apoptosis
-
Alvarez-Tejado, M., Naranjo-Suarez, S., Jimenez, C., Carrera, A. C., Landazuri, M. O., and del Peso, L. Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis. J. Biol. Chem., 9: 22368-22374, 2001.
-
(2001)
J. Biol. Chem.
, vol.9
, pp. 22368-22374
-
-
Alvarez-Tejado, M.1
Naranjo-Suarez, S.2
Jimenez, C.3
Carrera, A.C.4
Landazuri, M.O.5
Del Peso, L.6
|