Novel method to quantify neuropil threads in brains from elders with or without cognitive impairment

Journal of Histochemistry and Cytochemistry

Volumn 48, Issue 12, 2000, Pages 1627-1637

  Mitchell, T W ^a   Nissanov, J ^a   Han, L Y ^a   Mufson, E J ^a   Schneider, J A ^a   Cochran, E J ^a   Bennett, D A ^a   Lee, V M Y ^a   Trojanowski, J Q ^a   Arnold, S E ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Alzheimer's disease; Entorhinal cortex; Image analysis; Neurodegenerative disease; Neurofibrillary tangles; Neuropil threads; Stereology; Tau

Indexed keywords

TAU PROTEIN;

AGED; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DEGENERATIVE DISEASE; DEMENTIA; ENTORHINAL CORTEX; FEMALE; HUMAN; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; MALE; NEUROFIBRILLARY TANGLE; NEUROLOGIC DISEASE; NEUROPIL THREAD; PRIORITY JOURNAL; STEREOLOGY;

EID: 0033639241     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1177/002215540004801206     Document Type: Article

References (65)

1. Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease
2. The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease
3. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
4. Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease
5. Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies
6. Around the WORLD backward: An algorithm for scoring the MMSE WORLD item
7. Pathological changes in frontal cortex from biopsy to autopsy in Alzheimer's disease
8. Metric properties of nurse's ratings of parkinsonian signs with a modified Unified Parkinson's Disease Rating Scale
9. Dimensionality of parkinsonian signs in aging and Alzheimer's disease
10. A convergence theorem for the fuzzy ISODATA clustering algorithm
11. Neuropil threads occur in dendrites of tangle-bearing nerve cells
12. Neuropathological staging of Alzheimer-related changes
13. Morphological criteria for the recognition of Alzheimer's disease and the distribution pattern of cortical changes related to this disorder
14. Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: A third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques
15. Allocortical neurofibrillary changes in progressive supranuclear palsy
16. A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads
17. Extensive axonal Lewy neurites in Parkinson's disease: A novel pathological feature revealed by alpha-synuclein immunocytochemistry
18. Structural correlates of cognitive deficits in a selected group of patients with Alzheimer's disease
19. Selective vulnerability of the brain to Alzheimer's disease pathology
20. Clinico-pathologic studies in dementia: Nondemented subjects with pathologically confirmed Alzheimer's disease
21. Pathological markers associated with normal aging and dementia in the elderly
22. Associations of status and change measures of neuropsychological function with pathologic changes in elderly, originally nondemented subjects
23. Image analysis of beta-amyloid load in Alzheimer's disease and relation to dementia severity
24. Identification of normal and pathological aging in prospectively studied nondemented elderly humans
25. Progression of clinical deterioration and pathological changes in patients with Alzheimer disease evaluated at biopsy and autopsy
26. Preservation of nucleus basalis neurons containing choline acetyltransferase and the vesicular acetylcholine transporter in the elderly with mild cognitive impairment and early Alzheimer's disease
27. The neurofibrillary pathology of Alzheimer's disease
28. Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease
29. Neurofibrillary tangles in nondemented elderly subjects and mild Alzheimer disease
30. Constant neurofibrillary changes in the neocortex in progressive supranuclear palsy. Basic differences with Alzheimer's disease and aging
31. Neurofilament proteins identify vulnerable neocortical neurons: Stereologic analysis in normal aging and Alzheimer's disease
32. Unique Alzheimer's disease paired helical filament specific epitopes involve double phosphorylation at specific sites
33. Tau-based neurofibrillary lesions
34. Alpha-synuclein cortical lewy bodies correlate with dementia in Parkinson's disease
35. Massive somatodendritic sprouting of cortical neurons in Alzheimer's disease
36. The human entorhinal cortex: A cytoarchitectonic analysis
37. Amyloid deposits and plaque formation
38. Clinical, pathological, and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques Ann Neurol
39. Tau-positive glial inclusions in progressive supranuclear palsy, corticobasal degeneration and Pick's disease
40. Morphologic difference of neuropil threads in Alzheimer's disease, corticobasal degeneration and progressive supranuclear palsy: A morphometric study
41. Progressive supranuclear palsy with fronto-temporal atrophy and various tau-positive abnormal structures
42. Morphometric image analysis of neuropil threads in Alzheimer's disease
43. Neuronal and synaptic loss, reactive gliosis, microglial response, and induction
44. Subcortical neurofibrillary tangles, neuropil threads, and argentophilic glial inclusions in corticobasal degeneration
45. Neuritic pathology and dementia in Alzheimer's disease
46. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
47. Tau pathology in a family with dementia and a P301L mutation in tau
48. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer's disease
49. Entorhinal cortex β-amyloid load in individuals with mild cognitive impairment
50. Application of the National Institute on Aging (NIA)-Reagan Institute criteria for the neuropathological diagnosis of Alzheimer disease
51. Mild cognitive impairment: Clinical characterization and outcome
52. The neuropathology of a chromosome 17-linked autosomal dominant parkinsonism and dementia ('pallido-ponto-nigral degeneration')
53. Continuity of neuropil threads with tangle-bearing and tangle-free neurons in Alzheimer disease cortex. A confocal laser scanning microscopy study
54. Corticobasal degeneration: Neuropathologic and clinical heterogeneity
55. Volume and number of neurons of the human hippocampal formation in normal aging and Alzheimer's disease
56. Frontotemporal dementia and Parkinsonism linked to chromosome 17: A new group of tauopathies
57. Alpha-synuclein in Lewy bodies
58. Corticobasal degeneration: Widespread argentophilic threads and glia in addition to neurofibrillary tangles. Similarities of cytoskeletal abnormalities in corticobasal degeneration and progressive supranuclear palsy
59. NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease
60. The levels of soluble versus insoluble brain Aβ distinguish Alzheimer's disease from normal and pathologic aging
61. Detection and staging of dementia in Alzheimer's disease. Use of the neuropsychological measures developed for the Consortium to Establish a Registry for Alzheimer's Disease
62. Regionally specific loss of neurons in the aging human hippocampus
63. Advances in the study of age-related neuron loss
64. Stereological methods for estimating the total number of neurons and synapses: Issues of precision and bias
65. Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator