Tau phosphorylation and proteolysis: Insights and perspectives

Journal of Alzheimer's Disease

Volumn 9, Issue SUPPL. 3, 2006, Pages 243-250

  Johnson, Gail V W ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CALPAIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLYCOGEN SYNTHASE KINASE 3BETA; PROTEASOME; PROTEASOME INHIBITOR; TAU PROTEIN;

ALZHEIMER DISEASE; BRAIN; DEGENERATIVE DISEASE; HUMAN; IMMUNOBLOTTING; NEUROFIBRILLARY TANGLE; NEUROLOGIC DISEASE; NEUROPATHOLOGY; PAIRED HELICAL FILAMENT; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REVIEW;

EID: 33747401659     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/jad-2006-9s326     Document Type: Review

References (45)

1. N. Canu, L. Dus, C. Barbato, M.T. Ciotti, C. Brancolini, A.M. Rinaldi, M. Novak, A. Cattaneo, A. Bradbury and P. Calissano, Tau cleavage and dephosphorylation in cerebellar granule neurons undergoing apoptosis, J Neurosci 18 (1998), 7061-7074.
2. C. Cardozo and C. Michaud, Proteasome-mediated degradation of tau proteins occurs independently of the chymotrypsin-like activity by a nonprocessive pathway, Arch Biochem Biophys 408 (2002), 103-110.
3. M. Chen and A. Stracher, In situ phosphorylation of platelet actin-binding protein by cAMP-dependent protein kinase stabilizes it against proteolysis by calpain, J Biol Chem 264 (1989), 14282-14289.
4. J.H. Cho and G.V. Johnson, Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3beta (GSK3beta) plays a critical role in regulating tau's ability to bind and stabilize microtubules, J Neurochem 88 (2004), 349-358.
5. D.W. Cleveland, S.Y. Hwo and M.W. Kirschner, Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly, J Mol Biol 116 (1977), 227-247.
6. D.C. David, R. Layfield, L. Serpell, Y. Narain, M. Goedert and M.G. Spillantini, Proteasomal degradation of tau protein, J Neurochem 83 (2002), 176-185.
7. P. Delobel, O. Leroy, M. Hamdane, A.V. Sambo, A. Delacourte and L. Buee, Proteasome inhibition and Tau proteolysis: an unexpected regulation, FEBS Lett 579 (2005), 1-5.
8. F. Dou, W.J. Netzer, K. Tanemura, F. Li, F.U. Hartl, A. Takashima, G.K. Gouras, P. Greengard and H. Xu, Chaperones increase association of tau protein with microtubules, Proc Natl Acad Sci USA 100 (2003), 721-726.
9. L.M. Fleming and G.V. Johnson, Modulation of the phosphorylation state of tau in situ: the roles of calcium and cyclic AMP, Biochem J 309(Pt 1) (1995), 41-47.
10. T.C. Gamblin, F. Chen, A. Zambrano, A. Abraha, S. Lagalwar, A.L. Guillozet, M. Lu, Y. Fu, F. Garcia-Sierra, N. LaPointe, R. Miller, R.W. Berry, L.I. Binder and V.L. Cryns, Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease, Proc Natl Acad Sci USA 100 (2003), 10032-10037.
11. B.I. Giasson, M.S. Forman, M. Higuchi, L.I. Golbe, C.L. Graves, P.T. Kotzbauer, J.Q. Trojanowski and V.M. Lee, Initiation and synergistic fibrillization of tau and alpha-synuclein, Science 300 (2003), 636-640.
12. O. Goldbaum, M. Oppermann, M. Handschuh, D. Dabir, B. Zhang, M.S. Forman, J.Q. Trojanowski, V.M. Lee and C. Richter-Landsberg, Proteasome inhibition stabilizes tau inclusions in oligodendroglial cells that occur after treatment with okadaic acid, J Neurosci 23 (2003), 8872-8880.
13. I. Grundke-Iqbal, K. Iqbal, M. Quinlan, Y.C. Tung, M.S. Zaidi and H.M. Wisniewski, Microtubule-associated protein tau. A component of Alzheimer paired helical filaments, J Biol Chem 261 (1986), 6084-6089.
14. I. Grundke-Iqbal, K. Iqbal, Y.C. Tung, M. Quinlan, H.M. Wisniewski and L.I. Binder, Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology, Proc Natl Acad Sci USA 83 (1986), 4913-4917.
15. S. Hatakeyama, M. Matsumoto, T. Kamura, M. Murayama, D.H. Chui, E. Planel, R. Takahashi, K.I. Nakayama and A. Takashima, U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy, J Neurochem 91 (2004), 299-307.
16. P.H. Jensen, H. Hager, M.S. Nielsen, P. Hojrup, J. Gliemann and R. Jakes, alpha-synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356, J Biol Chem 274 (1999), 25481-25489.
17. G.A. Jicha, C. Weaver, E. Lane, C. Vianna, Y. Kress, J. Rockwood and P. Davies, cAMP-dependent protein kinase phosphorylations on tau in Alzheimer's disease, J Neurosci 19 (1999), 7486-7494.
18. 2+/calmodulin-dependent protein kinase II: metabolic and functional consequences, J Neurochem 59 (1992), 2056-2062.
19. G.V. Johnson, R.S. Jope and L.I. Binder, Proteolysis of tau by calpain, Biochem Biophys Res Commun 163 (1989), 1505-1511.
20. S. Keck, R. Nitsch, T. Grune and O. Ullrich, Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's disease, J Neurochem 85 (2003), 115-122.
21. K.S. Kosik, C.L. Joachim and D.J. Selkoe, Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease, Proc Natl Acad Sci USA 83 (1986), 4044-4048.
22. P.K. Krishnamurthy, J.L. Mays, G.N. Bijur and G.V. Johnson, Transient oxidative stress in SH-SY5Y human neuroblastoma cells results in caspase dependent and independent cell death and tau proteolysis, J Neurosci Res 61 (2000), 515-523.
23. V.M. Lee, B.J. Balin, L. Otvos, Jr. and J.Q. Trojanowski, A68: a major subunit of paired helical filaments and derivatized forms of normal Tau, Science 251 (1991), 675-678.
24. G. Lindwall and R.D. Cole, Phosphorylation affects the ability of tau protein to promote microtubule assembly, J Biol Chem 259 (1984), 5301-5305.
25. J.M. Litersky and G.V. Johnson, Phosphorylation by cAMP-dependent protein kinase inhibits the degradation of tau by calpain, J Biol Chem 267 (1992), 1563-1568.
26. J.M. Litersky and G.V. Johnson, Phosphorylation of tau in situ: inhibition of calcium-dependent proteolysis, J Neurochem 65 (1995), 903-911.
27. M.N. Malik, A.M. Sheikh, M.D. Fenko and H.M. Wisniewski, Purification and degradation of purified neurofilament proteins by the brain calcium-activated neutral proteases, Life Sci 39 (1986), 1335-1343.
28. E.S. Matsuo, R.W. Shin, M.L. Billingsley, A. Van deVoorde, M. O'Connor, J.Q. Trojanowski and V.M. Lee, Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau, Neuron 13 (1994), 989-1002.
29. M. Mercken, F. Grynspan and R.A. Nixon, Differential sensitivity to proteolysis by brain calpain of adult human tau, fetal human tau and PHF-tau, FEBS Lett 368 (1995), 10-14.
30. R.A. Nixon, B.A. Brown and C.A. Marotta, Limited proteolytic modification of a neurofilament protein involves a proteinase activated by endogenous levels of calcium, Brain Res 275 (1983), 384-388.
31. H.C. Pant, Dephosphorylation of neurofilament proteins enhances their susceptibility to degradation by calpain, Biochem J 256 (1988), 665-668.
32. L.S. Perlmutter, C. Gall, M. Baudry and G. Lynch, Distribution of calcium-activated protease calpain in the rat brain, J Comp Neurol 296 (1990), 269-276.
33. L. Petrucelli, D. Dickson, K. Kehoe, J. Taylor, H. Snyder, A. Grover, M. De Lucia, E. McGowan, J. Lewis, G. Prihar, J. Kim, W.H. Dillmann, S.E. Browne, A. Hall, R. Voellmy, Y. Tsuboi, T.M. Dawson, B. Wolozin, J. Hardy and M. Hutton, CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation, Hum Mol Genet 13 (2004), 703-714.
34. M. Pierre and J. Nunez, Multisite phosphorylation of tau proteins from rat brain, Biochem Biophys Res Commun 115 (1983), 212-219.
35. R.A. Rissman, W.W. Poon, M. Blurton-Jones, S. Oddo, R. Torp, M.P. Vitek, F.M. LaFerla, T.T. Rohn and C.W. Cotman, Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology, J Clin Invest 114 (2004), 121-130.
36. T.T. Rohn, R.A. Rissman, M.C. Davis, Y.E. Kim, C.W. Cotman and E. Head, Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain, Neurobiol Dis 11 (2002), 341-354.
37. C.W. Scott, R.C. Spreen, J.L. Herman, F.P. Chow, M.D. Davison, J. Young and C.B. Caputo, Phosphorylation of recombinant tau by cAMP-dependent protein kinase. Identification of phosphorylation sites and effect on microtubule assembly, J Biol Chem 268 (1993), 1166-1173.
38. H. Shimura, D. Schwartz, S.P. Gygi and K.S. Kosik, CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival, J Biol Chem 279 (2004), 4869-4876.
39. R. Siman, C. Gall, L.S. Perlmutter, C. Christian, M. Baudry and G. Lynch, Distribution of calpain I, an enzyme associated with degenerative activity, in rat brain, Brain Res 347 (1985), 399-403.
40. M.D. Weingarten, A.H. Lockwood, S.Y. Hwo and M.W. Kirschner, A protein factor essential for microtubule assembly, Proc Natl Acad Sci USA 72 (1975), 1858-1862.
41. J.G. Wood, S.S. Mirra, N.J. Pollock and L.I. Binder, Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau), Proc Natl Acad Sci USA 83 (1986), 4040-4043.
42. H.Q. Xie and G.V. Johnson, Calcineurin inhibition prevents calpain-mediated proteolysis of tau in differentiated PC12 cells, J Neurosci Res 53 (1998), 153-164.
43. L.S. Yang, W. Gordon-Krajcer and H. Ksiezak-Reding, Tau released from paired helical filaments with formic acid or guanidine is susceptible to calpain-mediated proteolysis, J Neurochem 69 (1997), 1548-1558.
44. L.S. Yang and H. Ksiezak-Reding, Calpain-induced proteolysis of normal human tau and tau associated with paired helical filaments, Eur J Biochem 233 (1995), 9-17.
45. Q. Zheng-Fischhofer, J. Biernat, E.M. Mandelkow, S. Illenberger, R. Godemann and E. Mandelkow, Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a pairedhelical- filament-like conformation, Eur J Biochem 252 (1998), 542-552.