-
1
-
-
84969213492
-
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
-
Wellcome Trust Case Control Consortium
-
Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447, 661-678 (2007).
-
(2007)
Nature
, vol.447
, pp. 661-678
-
-
-
2
-
-
0036083396
-
The ubiquitin-proteasome proteolytic pathway: Destruction for the sake of construction
-
Glickman, M. H. & Ciechanover, A. The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol. Rev. 82, 373-428 (2002).
-
(2002)
Physiol. Rev
, vol.82
, pp. 373-428
-
-
Glickman, M.H.1
Ciechanover, A.2
-
3
-
-
0028326667
-
Replacement of proteasome subunits X and Y by LMP7 and LMP2 induced by interferon-γ for acquirement of the functional diversity responsible for antigen processing
-
Akiyama, K. et al. Replacement of proteasome subunits X and Y by LMP7 and LMP2 induced by interferon-γ for acquirement of the functional diversity responsible for antigen processing. FEBS Lett. 343, 85-88 (1994).
-
(1994)
FEBS Lett
, vol.343
, pp. 85-88
-
-
Akiyama, K.1
-
4
-
-
34249883977
-
+ T cell development by thymus-specific proteasomes
-
+ T cell development by thymus-specific proteasomes. Science 316, 1349-1353 (2007).
-
(2007)
Science
, vol.316
, pp. 1349-1353
-
-
Murata, S.1
-
5
-
-
33745674468
-
Drug discovery in the ubiquitin-proteasome system
-
Nalepa, G., Rolfe, M. & Harper, J. W. Drug discovery in the ubiquitin-proteasome system. Nature Rev. Drug Discov. 5, 596-613 (2006).
-
(2006)
Nature Rev. Drug Discov
, vol.5
, pp. 596-613
-
-
Nalepa, G.1
Rolfe, M.2
Harper, J.W.3
-
6
-
-
27644562277
-
A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib
-
Chauhan, D. et al. A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib. Cancer Cell 8, 407-419 (2005).
-
(2005)
Cancer Cell
, vol.8
, pp. 407-419
-
-
Chauhan, D.1
-
7
-
-
33748937557
-
A new side to ubiquitin
-
Raiborg, C., Slagsvold, T. & Stenmark, H. A new side to ubiquitin. Trends Biochem. Sci. 31, 541-544 (2006).
-
(2006)
Trends Biochem. Sci
, vol.31
, pp. 541-544
-
-
Raiborg, C.1
Slagsvold, T.2
Stenmark, H.3
-
8
-
-
0035293622
-
Protein regulation by monoubiquitin
-
Hicke, L. Protein regulation by monoubiquitin. Nature Rev. Mol. Cell Biol. 2, 195-201 (2001).
-
(2001)
Nature Rev. Mol. Cell Biol
, vol.2
, pp. 195-201
-
-
Hicke, L.1
-
9
-
-
33947243954
-
A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate
-
Li, W., Tu, D., Brunger, A. T. & Ye, Y. A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate. Nature 446, 333-337 (2007).
-
(2007)
Nature
, vol.446
, pp. 333-337
-
-
Li, W.1
Tu, D.2
Brunger, A.T.3
Ye, Y.4
-
10
-
-
27144529182
-
Ubiquitylation and cell signaling
-
Haglund, K. & Dikic, I. Ubiquitylation and cell signaling. EMBO J. 24, 3353-3359 (2005).
-
(2005)
EMBO J
, vol.24
, pp. 3353-3359
-
-
Haglund, K.1
Dikic, I.2
-
11
-
-
9744227183
-
Ubiquitin: Structures, functions, mechanisms
-
Pickart, C. M. & Eddins, M. J. Ubiquitin: structures, functions, mechanisms. Biochim. Biophys. Acta 1695, 55-72 (2004).
-
(2004)
Biochim. Biophys. Acta
, vol.1695
, pp. 55-72
-
-
Pickart, C.M.1
Eddins, M.J.2
-
12
-
-
0842303313
-
Back to the future with ubiquitin
-
Pickart, C. M. Back to the future with ubiquitin. Cell 116, 181-190 (2004).
-
(2004)
Cell
, vol.116
, pp. 181-190
-
-
Pickart, C.M.1
-
13
-
-
12844275363
-
The peptidyl-prolyl isomerase Pin1 regulates phospho-Ser77 retinoic acid receptor alpha stability
-
Brondani, V., Schefer, Q., Hamy, F. & Klimkait, T. The peptidyl-prolyl isomerase Pin1 regulates phospho-Ser77 retinoic acid receptor alpha stability. Biochem. Biophys. Res. Commun. 328, 6-13 (2005).
-
(2005)
Biochem. Biophys. Res. Commun
, vol.328
, pp. 6-13
-
-
Brondani, V.1
Schefer, Q.2
Hamy, F.3
Klimkait, T.4
-
14
-
-
28344456279
-
A genomic and functional inventory of deubiquitinating enzymes
-
Nijman, S. M. et al. A genomic and functional inventory of deubiquitinating enzymes. Cell 123, 773-786 (2005).
-
(2005)
Cell
, vol.123
, pp. 773-786
-
-
Nijman, S.M.1
-
15
-
-
33845600006
-
Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities
-
Crosas, B. et al. Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities. Cell 127, 1401-1413 (2006).
-
(2006)
Cell
, vol.127
, pp. 1401-1413
-
-
Crosas, B.1
-
16
-
-
13444275087
-
Chemistry-based functional proteomics: Mechanism-based activity-profiling tools for ubiquitin and ubiquitin-like specific proteases
-
Hemelaar, J. et al. Chemistry-based functional proteomics: mechanism-based activity-profiling tools for ubiquitin and ubiquitin-like specific proteases. J. Proteome Res. 3, 268-276 (2004).
-
(2004)
J. Proteome Res
, vol.3
, pp. 268-276
-
-
Hemelaar, J.1
-
17
-
-
27944471038
-
Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-κ B activation
-
Zhou, H. et al. Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-κ B activation. J. Exp. Med. 202, 1327-1332 (2005).
-
(2005)
J. Exp. Med
, vol.202
, pp. 1327-1332
-
-
Zhou, H.1
-
18
-
-
0032578855
-
Cleavage of the C-terminus of NEDD8 by UCH-L3
-
Wada, H., Kito, K., Caskey, L. S., Yeh, E. T. & Kamitani, T. Cleavage of the C-terminus of NEDD8 by UCH-L3. Biochem. Biophys. Res. Commun. 251, 688-692 (1998).
-
(1998)
Biochem. Biophys. Res. Commun
, vol.251
, pp. 688-692
-
-
Wada, H.1
Kito, K.2
Caskey, L.S.3
Yeh, E.T.4
Kamitani, T.5
-
19
-
-
0043208977
-
DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1
-
Wu, K. et al. DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1. J. Biol. Chem. 278, 28882-28891 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 28882-28891
-
-
Wu, K.1
-
20
-
-
0041853732
-
Identification and characterization of DEN1, a deneddylase of the ULP family
-
Gan-Erdene, T. et al. Identification and characterization of DEN1, a deneddylase of the ULP family. J. Biol. Chem. 278, 28892-28900 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 28892-28900
-
-
Gan-Erdene, T.1
-
21
-
-
33646345376
-
Ubiquitin ligases: Cell-cycle control and cancer
-
Nakayama, K. I. & Nakayama, K. Ubiquitin ligases: cell-cycle control and cancer. Nature Rev. Cancer 6, 369-381 (2006).
-
(2006)
Nature Rev. Cancer
, vol.6
, pp. 369-381
-
-
Nakayama, K.I.1
Nakayama, K.2
-
22
-
-
33748991453
-
Ubiquitin and ubiquitin-like proteins in cancer pathogenesis
-
Hoeller, D., Hecker, C. M. & Dikic, I. Ubiquitin and ubiquitin-like proteins in cancer pathogenesis. Nature Rev. Cancer 6, 776-788 (2006).
-
(2006)
Nature Rev. Cancer
, vol.6
, pp. 776-788
-
-
Hoeller, D.1
Hecker, C.M.2
Dikic, I.3
-
23
-
-
0034023407
-
Short-lived green fluorescent proteins for quantifying ubiquitin/proteasome- dependent proteolysis in living cells
-
Dantuma, N. P., Lindsten, K., Glas, R., Jellne, M. & Masucci, M. G. Short-lived green fluorescent proteins for quantifying ubiquitin/proteasome- dependent proteolysis in living cells. Nature Biotechnol. 18, 538-543 (2000).
-
(2000)
Nature Biotechnol
, vol.18
, pp. 538-543
-
-
Dantuma, N.P.1
Lindsten, K.2
Glas, R.3
Jellne, M.4
Masucci, M.G.5
-
24
-
-
34248166430
-
Ubiquitin crosstalk connecting cellular processes
-
Groothuis, T. A., Dantuma, N. P., Neefjes, J. & Salomons, F. A. Ubiquitin crosstalk connecting cellular processes. Cell Div. 1, 21 (2006).
-
(2006)
Cell Div
, vol.1
, pp. 21
-
-
Groothuis, T.A.1
Dantuma, N.P.2
Neefjes, J.3
Salomons, F.A.4
-
25
-
-
33645731673
-
A dynamic ubiquitin equilibrium couples proteasomal activity to chromatin remodeling
-
Dantuma, N. P., Groothuis, T. A., Salomons, F. A. & Neefjes, J. A dynamic ubiquitin equilibrium couples proteasomal activity to chromatin remodeling. J. Cell Biol. 173, 19-26 (2006).
-
(2006)
J. Cell Biol
, vol.173
, pp. 19-26
-
-
Dantuma, N.P.1
Groothuis, T.A.2
Salomons, F.A.3
Neefjes, J.4
-
26
-
-
0037179694
-
A cryptic protease couples deubiquitination and degradation by the proteasome
-
Yao, T. & Cohen, R. E. A cryptic protease couples deubiquitination and degradation by the proteasome. Nature 419, 403-407 (2002).
-
(2002)
Nature
, vol.419
, pp. 403-407
-
-
Yao, T.1
Cohen, R.E.2
-
27
-
-
0043208904
-
A transgenic mouse model of the ubiquitin/proteasome system
-
Lindsten, K., Menendez-Benito, V., Masucci, M. G. & Dantuma, N. P. A transgenic mouse model of the ubiquitin/proteasome system. Nature Biotechnol. 21, 897-902 (2003).
-
(2003)
Nature Biotechnol
, vol.21
, pp. 897-902
-
-
Lindsten, K.1
Menendez-Benito, V.2
Masucci, M.G.3
Dantuma, N.P.4
-
28
-
-
0038378519
-
Imaging 26S proteasome activity and inhibition in living mice
-
Luker, G. D., Pica, C. M., Song, J., Luker, K. E. & Piwnica-Worms, D. Imaging 26S proteasome activity and inhibition in living mice. Nature Med. 9, 969-973 (2003).
-
(2003)
Nature Med
, vol.9
, pp. 969-973
-
-
Luker, G.D.1
Pica, C.M.2
Song, J.3
Luker, K.E.4
Piwnica-Worms, D.5
-
29
-
-
33748595526
-
Mechanism-based profiling of enzyme families
-
Evans, M. J. & Cravatt, B. F. Mechanism-based profiling of enzyme families. Chem. Rev. 106, 3279-3301 (2006).
-
(2006)
Chem. Rev
, vol.106
, pp. 3279-3301
-
-
Evans, M.J.1
Cravatt, B.F.2
-
30
-
-
11844277582
-
Bioorthogonal organic chemistry in living cells: Novel strategies for labeling biomolecules
-
van Swieten, P. F., Leeuwenburgh, M. A., Kessler, B. M. & Overkleeft, H. S. Bioorthogonal organic chemistry in living cells: novel strategies for labeling biomolecules. Org. Biomol. Chem. 3, 20-27 (2005).
-
(2005)
Org. Biomol. Chem
, vol.3
, pp. 20-27
-
-
van Swieten, P.F.1
Leeuwenburgh, M.A.2
Kessler, B.M.3
Overkleeft, H.S.4
-
31
-
-
33846807650
-
Tagging and detection strategies for activity-based proteomics
-
Sadaghiani, A. M., Verhelst, S. H. & Bogyo, M. Tagging and detection strategies for activity-based proteomics. Curr. Opin. Chem. Biol. 11, 20-28 (2007).
-
(2007)
Curr. Opin. Chem. Biol
, vol.11
, pp. 20-28
-
-
Sadaghiani, A.M.1
Verhelst, S.H.2
Bogyo, M.3
-
32
-
-
0035542852
-
Substrate specificity of the human proteasome
-
Harris, J. L., Alper, P. B., Li, J., Rechsteiner, M. & Backes, B. J. Substrate specificity of the human proteasome. Chem. Biol. 8, 1131-1141 (2001).
-
(2001)
Chem. Biol
, vol.8
, pp. 1131-1141
-
-
Harris, J.L.1
Alper, P.B.2
Li, J.3
Rechsteiner, M.4
Backes, B.J.5
-
33
-
-
0028180516
-
β-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line
-
Fenteany, G., Standaert, R. F., Reichard, G. A., Corey, E. J. & Schreiber, S. L. A β-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line. Proc. Natl Acad. Sci. USA 91, 3358-3362 (1994).
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 3358-3362
-
-
Fenteany, G.1
Standaert, R.F.2
Reichard, G.A.3
Corey, E.J.4
Schreiber, S.L.A.5
-
34
-
-
0029033981
-
Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin
-
Fenteany, G. et al. Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science 268, 726-731 (1995).
-
(1995)
Science
, vol.268
, pp. 726-731
-
-
Fenteany, G.1
-
35
-
-
0032103006
-
Substrate binding and sequence preference of the proteasome revealed by active-site-directed affinity probes
-
Bogyo, M., Shin, S., McMaster, J. S. & Ploegh, H. L. Substrate binding and sequence preference of the proteasome revealed by active-site-directed affinity probes. Chem. Biol. 5, 307-320 (1998).
-
(1998)
Chem. Biol
, vol.5
, pp. 307-320
-
-
Bogyo, M.1
Shin, S.2
McMaster, J.S.3
Ploegh, H.L.4
-
36
-
-
0031010398
-
Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors
-
Bogyo, M. et al. Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors. Proc. Natl Acad. Sci. USA 94, 6629-6634 (1997).
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 6629-6634
-
-
Bogyo, M.1
-
37
-
-
0034819479
-
Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits
-
Kessler, B. M. et al. Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits. Chem. Biol. 8, 913-929 (2001).
-
(2001)
Chem. Biol
, vol.8
, pp. 913-929
-
-
Kessler, B.M.1
-
38
-
-
0033530887
-
Proteasome inhibition by the natural products epoxomicin and dihydroeponemycin: Insights into specificity and potency
-
Kim, K. B., Myung, J., Sin, N. & Crews, C. M. Proteasome inhibition by the natural products epoxomicin and dihydroeponemycin: insights into specificity and potency. Bioorg. Med. Chem. Lett. 9, 3335-3340 (1999).
-
(1999)
Bioorg. Med. Chem. Lett
, vol.9
, pp. 3335-3340
-
-
Kim, K.B.1
Myung, J.2
Sin, N.3
Crews, C.M.4
-
39
-
-
0033517032
-
Total synthesis of the potent proteasome inhibitor epoxomicin: A useful tool for understanding proteasome biology
-
Sin, N. et al. Total synthesis of the potent proteasome inhibitor epoxomicin: a useful tool for understanding proteasome biology. Bioorg. Med. Chem. Lett. 9, 2283-2288 (1999).
-
(1999)
Bioorg. Med. Chem. Lett
, vol.9
, pp. 2283-2288
-
-
Sin, N.1
-
40
-
-
10744221240
-
Chemistry in living cells: Detection of active proteasomes by a two-step labeling strategy
-
Ovaa, H. et al. Chemistry in living cells: detection of active proteasomes by a two-step labeling strategy. Angew. Chem. Int. Ed. Engl. 42, 3626-3629 (2003).
-
(2003)
Angew. Chem. Int. Ed. Engl
, vol.42
, pp. 3626-3629
-
-
Ovaa, H.1
-
41
-
-
34249285172
-
A cell-permeable inhibitor and activity-based probe for the caspase-like activity of the proteasome
-
van Swieten, P. F. et al. A cell-permeable inhibitor and activity-based probe for the caspase-like activity of the proteasome. Bioorg. Med. Chem. Lett. 17, 3402-3405 (2007).
-
(2007)
Bioorg. Med. Chem. Lett
, vol.17
, pp. 3402-3405
-
-
van Swieten, P.F.1
-
42
-
-
18244406798
-
Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib
-
Berkers, C. R. et al. Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib. Nature Methods 2, 357-362 (2005).
-
(2005)
Nature Methods
, vol.2
, pp. 357-362
-
-
Berkers, C.R.1
-
43
-
-
34247185404
-
Disease-associated prion protein oligomers inhibit the 26S proteasome
-
Kristiansen, M. et al. Disease-associated prion protein oligomers inhibit the 26S proteasome. Mol. Cell 26, 175-188 (2007).
-
(2007)
Mol. Cell
, vol.26
, pp. 175-188
-
-
Kristiansen, M.1
-
44
-
-
34247190754
-
LMP2-specific inhibitors: Chemical genetic tools for proteasome biology
-
Ho, Y. K., Bargagna-Mohan, P., Wehenkel, M., Mohan, R. & Kim, K. B. LMP2-specific inhibitors: chemical genetic tools for proteasome biology. Chem. Biol. 14, 419-430 (2007).
-
(2007)
Chem. Biol
, vol.14
, pp. 419-430
-
-
Ho, Y.K.1
Bargagna-Mohan, P.2
Wehenkel, M.3
Mohan, R.4
Kim, K.B.5
-
45
-
-
33750989899
-
A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo
-
Verdoes, M. et al. A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo. Chem. Biol. 13, 1217-1226 (2006).
-
(2006)
Chem. Biol
, vol.13
, pp. 1217-1226
-
-
Verdoes, M.1
-
46
-
-
35548946122
-
Profiling proteasome activity in tissue with fluorescent probes
-
in the press
-
Berkers, C. R. et al. Profiling proteasome activity in tissue with fluorescent probes. Mol. Pharm. [in the press].
-
Mol. Pharm
-
-
Berkers, C.R.1
-
47
-
-
34247648240
-
Mixing of peptides and electrophilic traps gives rise to potent, broad-spectrum proteasome inhibitors
-
Verdoes, M. et al. Mixing of peptides and electrophilic traps gives rise to potent, broad-spectrum proteasome inhibitors. Org. Biomol. Chem. 5, 1416-1426 (2007).
-
(2007)
Org. Biomol. Chem
, vol.5
, pp. 1416-1426
-
-
Verdoes, M.1
-
48
-
-
24744456734
-
Effects of PS-341 on the activity and composition of proteasomes in multiple myeloma cells
-
Altun, M. et al. Effects of PS-341 on the activity and composition of proteasomes in multiple myeloma cells. Cancer Res. 65, 7896-7901 (2005).
-
(2005)
Cancer Res
, vol.65
, pp. 7896-7901
-
-
Altun, M.1
-
49
-
-
33845532759
-
Activity patterns of proteasome subunits reflect bortezomib sensitivity of hematologic malignancies and are variable in primary human leukemia cells
-
Kraus, M. et al. Activity patterns of proteasome subunits reflect bortezomib sensitivity of hematologic malignancies and are variable in primary human leukemia cells. Leukemia 21, 84-92 (2007).
-
(2007)
Leukemia
, vol.21
, pp. 84-92
-
-
Kraus, M.1
-
50
-
-
0023039206
-
Synthesis and characterization of ubiquitin ethyl ester, a new substrate for ubiquitin carboxyl-terminal hydrolase
-
Wilkinson, K. D., Cox, M. J., Mayer, A. N. & Frey, T. Synthesis and characterization of ubiquitin ethyl ester, a new substrate for ubiquitin carboxyl-terminal hydrolase. Biochemistry 25, 6644-6649 (1986).
-
(1986)
Biochemistry
, vol.25
, pp. 6644-6649
-
-
Wilkinson, K.D.1
Cox, M.J.2
Mayer, A.N.3
Frey, T.4
-
51
-
-
0032539582
-
Kinetic and mechanistic studies on the hydrolysis of ubiquitin C-terminal 7-amido-4-methylcoumarin by deubiquitinating enzymes
-
Dang, L. C., Melandri, F. D. & Stein, R. L. Kinetic and mechanistic studies on the hydrolysis of ubiquitin C-terminal 7-amido-4-methylcoumarin by deubiquitinating enzymes. Biochemistry 37, 1868-1879 (1998).
-
(1998)
Biochemistry
, vol.37
, pp. 1868-1879
-
-
Dang, L.C.1
Melandri, F.D.2
Stein, R.L.3
-
52
-
-
0000783145
-
Ubiquitin-aldehyde: A general inhibitor of ubiquitin-recycling processes
-
Hershko, A. & Rose, I. A. Ubiquitin-aldehyde: a general inhibitor of ubiquitin-recycling processes. Proc. Natl Acad. Sci. USA 84, 1829-1833 (1987).
-
(1987)
Proc. Natl Acad. Sci. USA
, vol.84
, pp. 1829-1833
-
-
Hershko, A.1
Rose, I.A.2
-
53
-
-
0023042522
-
Mechanism of ubiquitin carboxyl-terminal hydrolase. Borohydride and hydroxylamine inactivate in the presence of ubiquitin
-
Pickart, C. M. & Rose, I. A. Mechanism of ubiquitin carboxyl-terminal hydrolase. Borohydride and hydroxylamine inactivate in the presence of ubiquitin. J. Biol. Chem. 261, 10210-10217 (1986).
-
(1986)
J. Biol. Chem
, vol.261
, pp. 10210-10217
-
-
Pickart, C.M.1
Rose, I.A.2
-
54
-
-
0031038169
-
Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasome
-
Lam, Y. A., Xu, W., DeMartino, G. N. & Cohen, R. E. Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasome. Nature 385, 737-740 (1997).
-
(1997)
Nature
, vol.385
, pp. 737-740
-
-
Lam, Y.A.1
Xu, W.2
DeMartino, G.N.3
Cohen, R.E.4
-
55
-
-
0035903538
-
A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14
-
Borodovsky, A. et al. A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14. EMBO J. 20, 5187-5196 (2001).
-
(2001)
EMBO J
, vol.20
, pp. 5187-5196
-
-
Borodovsky, A.1
-
56
-
-
33744529377
-
Protein ligation: An enabling technology for the biophysical analysis of proteins
-
Muralidharan, V. & Muir, T. W. Protein ligation: an enabling technology for the biophysical analysis of proteins. Nature Methods 3, 429-438 (2006).
-
(2006)
Nature Methods
, vol.3
, pp. 429-438
-
-
Muralidharan, V.1
Muir, T.W.2
-
57
-
-
0036775490
-
Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family
-
Borodovsky, A. et al. Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family. Chem. Biol. 9, 1149-1159 (2002).
-
(2002)
Chem. Biol
, vol.9
, pp. 1149-1159
-
-
Borodovsky, A.1
-
58
-
-
13444254137
-
Proteomic insights into ubiquitin and ubiquitin-like proteins
-
Denison, C., Kirkpatrick, D. S. & Gygi, S. P. Proteomic insights into ubiquitin and ubiquitin-like proteins. Curr. Opin. Chem. Biol. 9, 69-75 (2005).
-
(2005)
Curr. Opin. Chem. Biol
, vol.9
, pp. 69-75
-
-
Denison, C.1
Kirkpatrick, D.S.2
Gygi, S.P.3
-
59
-
-
23144452492
-
Weighing in on ubiquitin: The expanding role of mass-spectrometry-based proteomics
-
Kirkpatrick, D. S., Denison, C. & Gygi, S. P. Weighing in on ubiquitin: the expanding role of mass-spectrometry-based proteomics. Nature Cell Biol. 7, 750-757 (2005).
-
(2005)
Nature Cell Biol
, vol.7
, pp. 750-757
-
-
Kirkpatrick, D.S.1
Denison, C.2
Gygi, S.P.3
-
60
-
-
10744227299
-
Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins
-
Hemelaar, J. et al. Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins. Mol. Cell Biol. 24, 84-95 (2004).
-
(2004)
Mol. Cell Biol
, vol.24
, pp. 84-95
-
-
Hemelaar, J.1
-
61
-
-
34247162291
-
Two novel ubiquitin-fold modifier 1 (Ufm1)-specific proteases, UfSP1 and UfSP2
-
Kang, S. H. et al. Two novel ubiquitin-fold modifier 1 (Ufm1)-specific proteases, UfSP1 and UfSP2. J. Biol. Chem. 282, 5256-5262 (2006).
-
(2006)
J. Biol. Chem
, vol.282
, pp. 5256-5262
-
-
Kang, S.H.1
-
62
-
-
1642423503
-
Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity
-
Evans, P. C. et al. Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity. Biochem. J. 378, 727-734 (2004).
-
(2004)
Biochem. J
, vol.378
, pp. 727-734
-
-
Evans, P.C.1
-
63
-
-
33645449857
-
Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines
-
Rolen, U. et al. Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines. Mol. Carcinog. 45, 260-269 (2006).
-
(2006)
Mol. Carcinog
, vol.45
, pp. 260-269
-
-
Rolen, U.1
-
64
-
-
1442355024
-
Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells
-
Ovaa, H. et al. Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells. Proc. Natl Acad. Sci. USA 101, 2253-2258 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 2253-2258
-
-
Ovaa, H.1
-
65
-
-
23744434659
-
A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family Herpesviridae
-
Kattenhorn, L. M., Korbel, G. A., Kessler, B. M., Spooner, E. & Ploegh, H. L. A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family Herpesviridae. Mol. Cell 19, 547-557 (2005).
-
(2005)
Mol. Cell
, vol.19
, pp. 547-557
-
-
Kattenhorn, L.M.1
Korbel, G.A.2
Kessler, B.M.3
Spooner, E.4
Ploegh, H.L.5
-
66
-
-
33744917811
-
High-molecular-weight protein (pUL48) of human cytomegalovirus is a competent deubiquitinating protease: Mutant viruses altered in its active-site cysteine or histidine are viable
-
Wang, J., Loveland, A. N., Kattenhorn, L. M., Ploegh, H. L. & Gibson, W. High-molecular-weight protein (pUL48) of human cytomegalovirus is a competent deubiquitinating protease: mutant viruses altered in its active-site cysteine or histidine are viable. J. Virol. 80, 6003-6012 (2006).
-
(2006)
J. Virol
, vol.80
, pp. 6003-6012
-
-
Wang, J.1
Loveland, A.N.2
Kattenhorn, L.M.3
Ploegh, H.L.4
Gibson, W.5
-
67
-
-
33745186215
-
Chlamydia trachomatis-derived deubiquitinating enzymes in mammalian cells during infection
-
Misaghi, S. et al. Chlamydia trachomatis-derived deubiquitinating enzymes in mammalian cells during infection. Mol. Microbiol. 61, 142-150 (2006).
-
(2006)
Mol. Microbiol
, vol.61
, pp. 142-150
-
-
Misaghi, S.1
-
68
-
-
33747032806
-
Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum
-
Artavanis-Tsakonas, K. et al. Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum. Mol. Microbiol. 61, 1187-1195 (2006).
-
(2006)
Mol. Microbiol
, vol.61
, pp. 1187-1195
-
-
Artavanis-Tsakonas, K.1
-
69
-
-
46449134021
-
-
Catic, A., Misaghi, S., Korbel, G. A. & Ploegh, H. L. ElaD, a deubiquitinating protease expressed by E. coli. PLoS. ONE 2, e381 (2007).
-
Catic, A., Misaghi, S., Korbel, G. A. & Ploegh, H. L. ElaD, a deubiquitinating protease expressed by E. coli. PLoS. ONE 2, e381 (2007).
-
-
-
-
70
-
-
33744457909
-
Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation
-
Mukherjee, S. et al. Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation. Science 312, 1211-1214 (2006).
-
(2006)
Science
, vol.312
, pp. 1211-1214
-
-
Mukherjee, S.1
-
71
-
-
0037184947
-
Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde
-
Hu, M. et al. Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde. Cell 111, 1041-1054 (2002).
-
(2002)
Cell
, vol.111
, pp. 1041-1054
-
-
Hu, M.1
-
72
-
-
33746827805
-
Structural basis of ubiquitin recognition by the deubiquitinating protease USP2
-
Renatus, M. et al. Structural basis of ubiquitin recognition by the deubiquitinating protease USP2. Structure 14, 1293-1302 (2006).
-
(2006)
Structure
, vol.14
, pp. 1293-1302
-
-
Renatus, M.1
-
73
-
-
27744516748
-
Structure and mechanisms of the proteasome- associated deubiquitinating enzyme USP14
-
Hu, M. et al. Structure and mechanisms of the proteasome- associated deubiquitinating enzyme USP14. EMBO J. 24, 3747-3756 (2005).
-
(2005)
EMBO J
, vol.24
, pp. 3747-3756
-
-
Hu, M.1
-
74
-
-
0035839603
-
-
Mullally, J. E., Moos, P. J., Edes, K. & Fitzpatrick, F. A. Cyclopentenone prostaglandins of the J series inhibit the ubiquitin isopeptidase activity of the proteasome pathway. J. Biol. Chem. 276, 30366-30373 (2001).
-
Mullally, J. E., Moos, P. J., Edes, K. & Fitzpatrick, F. A. Cyclopentenone prostaglandins of the J series inhibit the ubiquitin isopeptidase activity of the proteasome pathway. J. Biol. Chem. 276, 30366-30373 (2001).
-
-
-
-
75
-
-
12444269118
-
Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line
-
Liu, Y. et al. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem. Biol. 10, 837-846 (2003).
-
(2003)
Chem. Biol
, vol.10
, pp. 837-846
-
-
Liu, Y.1
-
76
-
-
12144286902
-
The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer
-
Graner, E. et al. The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer. Cancer Cell 5, 253-261 (2004).
-
(2004)
Cancer Cell
, vol.5
, pp. 253-261
-
-
Graner, E.1
-
77
-
-
33746820622
-
The isopeptidase USP2a protects human prostate cancer from apoptosis
-
Priolo, C. et al. The isopeptidase USP2a protects human prostate cancer from apoptosis. Cancer Res. 66, 8625-8632 (2006).
-
(2006)
Cancer Res
, vol.66
, pp. 8625-8632
-
-
Priolo, C.1
-
78
-
-
34347401998
-
The ubiquitin-specific protease USP28 is required for MYC stability
-
Popov, N. et al. The ubiquitin-specific protease USP28 is required for MYC stability. Nature Cell Biol. 9, 765-774.
-
Nature Cell Biol
, vol.9
, pp. 765-774
-
-
Popov, N.1
-
79
-
-
34347208609
-
Identification of a peptoid inhibitor of the proteasome 19S regulatory particle
-
Lim, H. S., Archer, C. T. & Kodadek, T. Identification of a peptoid inhibitor of the proteasome 19S regulatory particle. J. Am. Chem. Soc. 129, 7750-7751 (2007).
-
(2007)
J. Am. Chem. Soc
, vol.129
, pp. 7750-7751
-
-
Lim, H.S.1
Archer, C.T.2
Kodadek, T.3
-
80
-
-
10744221485
-
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
-
Vassilev, L. T. et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303, 844-848 (2004).
-
(2004)
Science
, vol.303
, pp. 844-848
-
-
Vassilev, L.T.1
-
81
-
-
11144315535
-
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors
-
Issaeva, N. et al. Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors. Nature Med. 10, 1321-1328 (2004).
-
(2004)
Nature Med
, vol.10
, pp. 1321-1328
-
-
Issaeva, N.1
-
82
-
-
30744449974
-
NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro
-
Krajewski, M., Ozdowy, P., D'Silva, L., Rothweiler, U. & Holak, T. A. NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro. Nature Med. 11, 1135-1136 (2005).
-
(2005)
Nature Med
, vol.11
, pp. 1135-1136
-
-
Krajewski, M.1
Ozdowy, P.2
D'Silva, L.3
Rothweiler, U.4
Holak, T.A.5
-
83
-
-
33947255054
-
Apoptosis induced by proteasome inhibition in cancer cells: Predominant role of the p53/PUMA pathway
-
Concannon, C. G. et al. Apoptosis induced by proteasome inhibition in cancer cells: predominant role of the p53/PUMA pathway. Oncogene 26, 1681-1692 (2007).
-
(2007)
Oncogene
, vol.26
, pp. 1681-1692
-
-
Concannon, C.G.1
-
84
-
-
33845994064
-
p53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibition
-
Nair, V. D., McNaught, K. S., Gonzalez-Maeso, J., Sealfon, S. C. & Olanow, C. W. p53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibition. J. Biol. Chem. 281, 39550-39560 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 39550-39560
-
-
Nair, V.D.1
McNaught, K.S.2
Gonzalez-Maeso, J.3
Sealfon, S.C.4
Olanow, C.W.5
-
85
-
-
18544367201
-
NF-κ B as a therapeutic target in multiple myeloma
-
Hideshima, T. et al. NF-κ B as a therapeutic target in multiple myeloma. J. Biol. Chem. 277, 16639-16647 (2002).
-
(2002)
J. Biol. Chem
, vol.277
, pp. 16639-16647
-
-
Hideshima, T.1
-
86
-
-
33744510119
-
High expression of ubiquitin carboxyterminal hydrolase-L1 and-L3 mRNA predicts early recurrence in patients with invasive breast cancer
-
Miyoshi, Y. et al. High expression of ubiquitin carboxyterminal hydrolase-L1 and-L3 mRNA predicts early recurrence in patients with invasive breast cancer. Cancer Sci. 97, 523-529 (2006).
-
(2006)
Cancer Sci
, vol.97
, pp. 523-529
-
-
Miyoshi, Y.1
-
87
-
-
13244291457
-
The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway
-
Nijman, S. M. et al. The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway. Mol. Cell 17, 331-339 (2005).
-
(2005)
Mol. Cell
, vol.17
, pp. 331-339
-
-
Nijman, S.M.1
-
88
-
-
33645708319
-
Regulation of monoubiquitinated PCNA by DUB autocleavage
-
Huang, T. T. et al. Regulation of monoubiquitinated PCNA by DUB autocleavage. Nature Cell Biol. 8, 339-347 (2006).
-
(2006)
Nature Cell Biol
, vol.8
, pp. 339-347
-
-
Huang, T.T.1
-
89
-
-
33847212425
-
The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2
-
Stevenson, L. F. et al. The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2. EMBO J. 26, 976-986 (2007).
-
(2007)
EMBO J
, vol.26
, pp. 976-986
-
-
Stevenson, L.F.1
-
90
-
-
16744364055
-
Genome-wide expression analysis of mouse liver reveals CLOCK-regulated circadian output genes
-
Oishi, K. et al. Genome-wide expression analysis of mouse liver reveals CLOCK-regulated circadian output genes. J. Biol. Chem. 278, 41519-41527 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 41519-41527
-
-
Oishi, K.1
-
91
-
-
0029008065
-
Elevated expression of Unph, a protooncogene at 3p21. 3, in human lung tumors
-
Gray, D. A. et al. Elevated expression of Unph, a protooncogene at 3p21. 3, in human lung tumors. Oncogene 10, 2179-2183 (1995).
-
(1995)
Oncogene
, vol.10
, pp. 2179-2183
-
-
Gray, D.A.1
-
92
-
-
0034730694
-
Characterization of the ubiquitin-specific protease activity of the mouse/human Unp/Unph oncoprotein
-
Gilchrist, C. A. & Baker, R. T. Characterization of the ubiquitin-specific protease activity of the mouse/human Unp/Unph oncoprotein. Biochim. Biophys. Acta 1481, 297-309 (2000).
-
(2000)
Biochim. Biophys. Acta
, vol.1481
, pp. 297-309
-
-
Gilchrist, C.A.1
Baker, R.T.2
-
93
-
-
0035957318
-
The dual role of ultraspiracle, the Drosophila retinoid X receptor, in the ecdysone response
-
Ghbeish, N. et al. The dual role of ultraspiracle, the Drosophila retinoid X receptor, in the ecdysone response. Proc. Natl Acad. Sci. USA 98, 3867-3872 (2001).
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 3867-3872
-
-
Ghbeish, N.1
-
94
-
-
0035817743
-
Association of UNP, a ubiquitin-specific protease, with the pocket proteins pRb, p107 and p130
-
Blanchette, P., Gilchrist, C. A., Baker, R. T. & Gray, D. A. Association of UNP, a ubiquitin-specific protease, with the pocket proteins pRb, p107 and p130. Oncogene 20, 5533-5537 (2001).
-
(2001)
Oncogene
, vol.20
, pp. 5533-5537
-
-
Blanchette, P.1
Gilchrist, C.A.2
Baker, R.T.3
Gray, D.A.4
-
95
-
-
0027248572
-
Unp, a mouse gene related to the tre oncogene
-
Gupta, K., Copeland, N. G., Gilbert, D. J., Jenkins, N. A. & Gray, D. A. Unp, a mouse gene related to the tre oncogene. Oncogene 8, 2307-2310 (1993).
-
(1993)
Oncogene
, vol.8
, pp. 2307-2310
-
-
Gupta, K.1
Copeland, N.G.2
Gilbert, D.J.3
Jenkins, N.A.4
Gray, D.A.5
-
96
-
-
0031463942
-
A ubiquitinspecific protease that efficiently cleaves the ubiquitinproline bond
-
Gilchrist, C. A., Gray, D. A. & Baker, R. T. A ubiquitinspecific protease that efficiently cleaves the ubiquitinproline bond. J. Biol. Chem. 272, 32280-32285 (1997).
-
(1997)
J. Biol. Chem
, vol.272
, pp. 32280-32285
-
-
Gilchrist, C.A.1
Gray, D.A.2
Baker, R.T.3
-
97
-
-
19944423795
-
Aneurysmal bone cyst variant translocations upregulate USP6 transcription by promoter swapping with the ZNF9, COL1A1, TRAP150, and OMD genes
-
Oliveira, A. M. et al. Aneurysmal bone cyst variant translocations upregulate USP6 transcription by promoter swapping with the ZNF9, COL1A1, TRAP150, and OMD genes. Oncogene 24, 3419-3426 (2005).
-
(2005)
Oncogene
, vol.24
, pp. 3419-3426
-
-
Oliveira, A.M.1
-
98
-
-
1542615085
-
USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst
-
Oliveira, A. M. et al. USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst. Cancer Res. 64, 1920-1923 (2004).
-
(2004)
Cancer Res
, vol.64
, pp. 1920-1923
-
-
Oliveira, A.M.1
-
99
-
-
7644230910
-
The TBC (Tre-2/Bub2/Cdc16) domain protein TRE17 regulates plasma membrane-endosomal trafficking through activation of Arf6
-
Martinu, L. et al. The TBC (Tre-2/Bub2/Cdc16) domain protein TRE17 regulates plasma membrane-endosomal trafficking through activation of Arf6. Mol. Cell Biol. 24, 9752-9762 (2004).
-
(2004)
Mol. Cell Biol
, vol.24
, pp. 9752-9762
-
-
Martinu, L.1
-
100
-
-
0037372202
-
The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling
-
Masuda-Robens, J. M., Kutney, S. N., Qi, H. & Chou, M. M. The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling. Mol. Cell Biol. 23, 2151-2161 (2003).
-
(2003)
Mol. Cell Biol
, vol.23
, pp. 2151-2161
-
-
Masuda-Robens, J.M.1
Kutney, S.N.2
Qi, H.3
Chou, M.M.4
-
101
-
-
33144460815
-
Association between MDM2-SNP309 and age at colorectal cancer diagnosis according to p53 mutation status
-
Menin, C. Association between MDM2-SNP309 and age at colorectal cancer diagnosis according to p53 mutation status. J. Natl Cancer Inst. 98, 285-288 (2006).
-
(2006)
J. Natl Cancer Inst
, vol.98
, pp. 285-288
-
-
Menin, C.1
-
102
-
-
33645240086
-
The HAUSP gene plays an important role in non-small cell lung carcinogenesis through p53-dependent pathways
-
Masuya, D. et al. The HAUSP gene plays an important role in non-small cell lung carcinogenesis through p53-dependent pathways. J. Pathol. 208, 724-732 (2006).
-
(2006)
J. Pathol
, vol.208
, pp. 724-732
-
-
Masuya, D.1
-
103
-
-
0037061508
-
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization
-
Li, M. et al. Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature 416, 648-653 (2002).
-
(2002)
Nature
, vol.416
, pp. 648-653
-
-
Li, M.1
-
104
-
-
1842431904
-
Tumour suppression: Disruption of HAUSP gene stabilizes p53
-
Cummins, J. M. et al. Tumour suppression: disruption of HAUSP gene stabilizes p53. Nature 428, 1 (2004).
-
(2004)
Nature
, vol.428
, pp. 1
-
-
Cummins, J.M.1
-
105
-
-
19444367393
-
Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2
-
Meulmeester, E. et al. Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2. Mol. Cell 18, 565-576 (2005).
-
(2005)
Mol. Cell
, vol.18
, pp. 565-576
-
-
Meulmeester, E.1
-
106
-
-
0033392501
-
The deubiquitinating enzyme Fam interacts with and stabilizes beta-catenin
-
Taya, S., Yamamoto, T., Kanai-Azuma, M., Wood, S. A. & Kaibuchi, K. The deubiquitinating enzyme Fam interacts with and stabilizes beta-catenin. Genes Cells 4, 757-767 (1999).
-
(1999)
Genes Cells
, vol.4
, pp. 757-767
-
-
Taya, S.1
Yamamoto, T.2
Kanai-Azuma, M.3
Wood, S.A.4
Kaibuchi, K.5
-
107
-
-
34250798032
-
Over-expression of genes and proteins of ubiquitin specific peptidases (USPs) and proteasome subunits (PSs) in breast cancer tissue observed by the methods of RFDD-PCR and proteomics
-
Deng, S. et al. Over-expression of genes and proteins of ubiquitin specific peptidases (USPs) and proteasome subunits (PSs) in breast cancer tissue observed by the methods of RFDD-PCR and proteomics. Breast Cancer Res. Treat. 104, 21-30.
-
Breast Cancer Res. Treat
, vol.104
, pp. 21-30
-
-
Deng, S.1
-
108
-
-
1642423571
-
The FAM deubiquitylating enzyme localizes to multiple points of protein trafficking in epithelia, where it associates with E-cadherin and beta-catenin
-
Murray, R. Z., Jolly, L. A. & Wood, S. A. The FAM deubiquitylating enzyme localizes to multiple points of protein trafficking in epithelia, where it associates with E-cadherin and beta-catenin. Mol. Biol. Cell 15, 1591-1599 (2004).
-
(2004)
Mol. Biol. Cell
, vol.15
, pp. 1591-1599
-
-
Murray, R.Z.1
Jolly, L.A.2
Wood, S.A.3
-
109
-
-
33751242487
-
Increased expression of thymidylate synthetase (TS), ubiquitin specific protease 10 (USP10) and survivin is associated with poor survival in glioblastoma multiforme (GBM)
-
Grunda, J. M. et al. Increased expression of thymidylate synthetase (TS), ubiquitin specific protease 10 (USP10) and survivin is associated with poor survival in glioblastoma multiforme (GBM). J. Neurooncol. 80, 261-274 (2006).
-
(2006)
J. Neurooncol
, vol.80
, pp. 261-274
-
-
Grunda, J.M.1
-
110
-
-
30044437463
-
The ubiquitin-specific protease USP10 modulates androgen receptor function
-
Faus, H., Meyer, H. A., Huber, M., Bahr, I. & Haendler, B. The ubiquitin-specific protease USP10 modulates androgen receptor function. Mol. Cell Endocrinol. 245, 138-146 (2005).
-
(2005)
Mol. Cell Endocrinol
, vol.245
, pp. 138-146
-
-
Faus, H.1
Meyer, H.A.2
Huber, M.3
Bahr, I.4
Haendler, B.5
-
111
-
-
33645748749
-
Ubiquitin-specific protease 14 expression in colorectal cancer is associated with liver and lymph node metastases
-
Shinji, S. et al. Ubiquitin-specific protease 14 expression in colorectal cancer is associated with liver and lymph node metastases. Oncol. Rep. 15, 539-543 (2006).
-
(2006)
Oncol. Rep
, vol.15
, pp. 539-543
-
-
Shinji, S.1
-
112
-
-
0033180148
-
Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases
-
Baker, R. T., Wang, X. W., Woollatt, E., White, J. A. & Sutherland, G. R. Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases. Genomics 59, 264-274 (1999).
-
(1999)
Genomics
, vol.59
, pp. 264-274
-
-
Baker, R.T.1
Wang, X.W.2
Woollatt, E.3
White, J.A.4
Sutherland, G.R.5
-
113
-
-
33947606938
-
CSN controls NF-κB by deubiquitinylation of IκBα
-
Schweitzer, K., Bozko, P. M., Dubiel, W. & Naumann, M. CSN controls NF-κB by deubiquitinylation of IκBα. EMBO J. 26, 1532-1541 (2007).
-
(2007)
EMBO J
, vol.26
, pp. 1532-1541
-
-
Schweitzer, K.1
Bozko, P.M.2
Dubiel, W.3
Naumann, M.4
-
114
-
-
22544438745
-
A leukemia-enriched cDNA microarray platform identifies new transcripts with relevance to the biology of pediatric acute lymphoblastic leukemia
-
De Pitta, C. et al. A leukemia-enriched cDNA microarray platform identifies new transcripts with relevance to the biology of pediatric acute lymphoblastic leukemia. Haematologica 90, 890-898 (2005).
-
(2005)
Haematologica
, vol.90
, pp. 890-898
-
-
De Pitta, C.1
-
115
-
-
17644421091
-
VHL proteininteracting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1α
-
373-378
-
Li, Z., Wang, D., Messing, E. M. & Wu, G. VHL proteininteracting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1α. EMBO Rep. 6, 373-378 (2005).
-
(2005)
EMBO Rep
, vol.6
-
-
Li, Z.1
Wang, D.2
Messing, E.M.3
Wu, G.4
-
116
-
-
31444449609
-
A novel and cytogenetically cryptic t(7;21)(p22;q22) in acute myeloid leukemia results in fusion of RUNX1 with the ubiquitin-specific protease gene USP42
-
Paulsson, K. et al. A novel and cytogenetically cryptic t(7;21)(p22;q22) in acute myeloid leukemia results in fusion of RUNX1 with the ubiquitin-specific protease gene USP42. Leukemia 20, 224-229 (2006).
-
(2006)
Leukemia
, vol.20
, pp. 224-229
-
-
Paulsson, K.1
-
117
-
-
18844464056
-
Identification of the familial cylindromatosis tumour-suppressor gene
-
Bignell, G. R. et al. Identification of the familial cylindromatosis tumour-suppressor gene. Nature Genet. 25, 160-165 (2000).
-
(2000)
Nature Genet
, vol.25
, pp. 160-165
-
-
Bignell, G.R.1
-
118
-
-
33747095078
-
CYLD mutations underlie Brooke-Spiegler, familial cylindromatosis, and multiple familial trichoepithelioma syndromes
-
Young, A. L. et al. CYLD mutations underlie Brooke-Spiegler, familial cylindromatosis, and multiple familial trichoepithelioma syndromes. Clin. Genet. 70, 246-249 (2006).
-
(2006)
Clin. Genet
, vol.70
, pp. 246-249
-
-
Young, A.L.1
-
119
-
-
33646531810
-
Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-κB signaling
-
Massoumi, R., Chmielarska, K., Hennecke, K., Pfeifer, A. & Fassler, R. Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-κB signaling. Cell 125, 665-677 (2006).
-
(2006)
Cell
, vol.125
, pp. 665-677
-
-
Massoumi, R.1
Chmielarska, K.2
Hennecke, K.3
Pfeifer, A.4
Fassler, R.5
-
120
-
-
0042467554
-
Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB
-
Brummelkamp, T. R., Nijman, S. M., Dirac, A. M. & Bernards, R. Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB. Nature 424, 797-801 (2003).
-
(2003)
Nature
, vol.424
, pp. 797-801
-
-
Brummelkamp, T.R.1
Nijman, S.M.2
Dirac, A.M.3
Bernards, R.4
-
121
-
-
0042467558
-
CYLD is a deubiquitinating enzyme that negatively regulates NF-κB activation by TNFR family members
-
Trompouki, E. et al. CYLD is a deubiquitinating enzyme that negatively regulates NF-κB activation by TNFR family members. Nature 424, 793-796 (2003).
-
(2003)
Nature
, vol.424
, pp. 793-796
-
-
Trompouki, E.1
-
122
-
-
4344561190
-
NF-κB is essential for induction of CYLD, the negative regulator of NF-κB: Evidence for a novel inducible autoregulatory feedback pathway
-
Jono, H. et al. NF-κB is essential for induction of CYLD, the negative regulator of NF-κB: evidence for a novel inducible autoregulatory feedback pathway. J. Biol. Chem. 279, 36171-36174 (2004).
-
(2004)
J. Biol. Chem
, vol.279
, pp. 36171-36174
-
-
Jono, H.1
-
123
-
-
0041967054
-
The tumour suppressor CYLD negatively regulates NF-κB signalling by deubiquitination
-
Kovalenko, A. et al. The tumour suppressor CYLD negatively regulates NF-κB signalling by deubiquitination. Nature 424, 801-805 (2003).
-
(2003)
Nature
, vol.424
, pp. 801-805
-
-
Kovalenko, A.1
-
124
-
-
0346333095
-
The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor κB activation by tumor necrosis factor
-
Regamey, A. et al. The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor κB activation by tumor necrosis factor. J. Exp. Med. 198, 1959-1964 (2003).
-
(2003)
J. Exp. Med
, vol.198
, pp. 1959-1964
-
-
Regamey, A.1
-
125
-
-
3943054838
-
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling
-
Wertz, I. E. et al. De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling. Nature 430, 694-699 (2004).
-
(2004)
Nature
, vol.430
, pp. 694-699
-
-
Wertz, I.E.1
-
126
-
-
34447507710
-
A20/TNFAIP3, a new estrogenregulated gene that confers tamoxifen resistance in breast cancer cells
-
12 February, Epub ahead of print
-
Vendrell, J. A. et al. A20/TNFAIP3, a new estrogenregulated gene that confers tamoxifen resistance in breast cancer cells. Oncogene 12 February 2007 (Epub ahead of print).
-
(2007)
Oncogene
-
-
Vendrell, J.A.1
-
127
-
-
15144342687
-
BAP1: A novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression
-
Jensen, D. E. et al. BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression. Oncogene 16, 1097-1112 (1998).
-
(1998)
Oncogene
, vol.16
, pp. 1097-1112
-
-
Jensen, D.E.1
-
128
-
-
34249949779
-
RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites
-
Sobhian, B. et al. RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites. Science 316, 1198-1202 (2007).
-
(2007)
Science
, vol.316
, pp. 1198-1202
-
-
Sobhian, B.1
-
129
-
-
0345276495
-
Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair
-
Dong, Y. et al. Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair. Mol. Cell 12, 1087-1099 (2003).
-
(2003)
Mol. Cell
, vol.12
, pp. 1087-1099
-
-
Dong, Y.1
-
130
-
-
33744944054
-
BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation
-
Chen, X., Arciero, C. A., Wang, C., Broccoli, D. & Godwin, A. K. BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation. Cancer Res. 66, 5039-5046 (2006).
-
(2006)
Cancer Res
, vol.66
, pp. 5039-5046
-
-
Chen, X.1
Arciero, C.A.2
Wang, C.3
Broccoli, D.4
Godwin, A.K.5
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