Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic β-subunits

Chemistry and Biology

Volumn 8, Issue 9, 2001, Pages 913-929

  Kessler, Benedikt M ^a   Tortorella, Domenico ^a   Altun, Mikael ^a   Kisselev, Alexei F ^a   Fiebiger, Edda ^a   Hekking, Brian G ^a   Ploegh, Hidde L ^a   Overkleeft, Herman S ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Active site label; Inhibitor; Peptide vinyl sulfone; Proteasome; Substrate analog

Indexed keywords

ACETYLCYSTEINE; ATP DEPENDENT 26S PROTEASE; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; DRUG DERIVATIVE; ENZYME INHIBITOR; EPOXOMICIN; LACTACYSTIN; MULTIENZYME COMPLEX; OLIGOPEPTIDE; PEPTIDE; PEPTIDE HYDROLASE; PROTEASOME; SULFONE; TRI LEUCINE VINYL SULFONE; TRI-LEUCINE-VINYL-SULFONE;

ARTICLE; CHEMISTRY; DRUG ANTAGONISM; ENZYME ACTIVE SITE; HELA CELL; HUMAN; METABOLISM; SYNTHESIS;

ACETYLCYSTEINE; CATALYTIC DOMAIN; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; ENZYME INHIBITORS; HELA CELLS; HUMANS; MULTIENZYME COMPLEXES; OLIGOPEPTIDES; PEPTIDE HYDROLASES; PEPTIDES; PROTEASOME ENDOPEPTIDASE COMPLEX; SULFONES;

MAMMALIA;

EID: 0034819479     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(01)00069-2     Document Type: Article

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