Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity

Biochemical Journal

Volumn 378, Issue 3, 2004, Pages 727-734

  Evans, Paul C ^a   Ovaa, Huib ^b   Hamon, Maureen ^a   Kilshaw, Peter J ^a   Hamm, Svetlana ^c   Bauer, Stefan ^c   Ploegh, Hidde L ^b   Smith, Trevor S ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Inst Med Microbiol Immunol Hyg   (Germany)

Author keywords

A20; Apoptosis; De ubiquitinating enzyme; Nuclear factor B (NF B); Ovarian tumour (OTU); Ubiquitin

Indexed keywords

ACTIVATION ENERGY; CATALYSTS; CELLS; CHEMICAL BONDS; DEGRADATION; IMMUNOLOGY; STABILITY; SUBSTRATES; TUMORS; ZINC;

CELLULAR ACTIVITY; INFLAMMATION;

PROTEINS;

CYSTEINE; I KAPPA B ALPHA; I KAPPA B KINASE; I KAPPA B KINASE GAMMA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LYSINE; PROTEIN; THIOL DERIVATIVE; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR; UBIQUITIN; UNCLASSIFIED DRUG; XINC FINGER PROTEIN A20; ZINC FINGER PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ACTIVITY; CELL FATE; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STABILITY; UBIQUITINATION;

ANIMALS; CATALYTIC DOMAIN; CELL LINE; CELL SURVIVAL; ENDOPEPTIDASES; HUMANS; HYDROLYSIS; INFLAMMATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NUCLEAR PROTEINS; POLYUBIQUITIN; PROTEINS; UBIQUITINS; ZINC FINGERS;

ANIMALIA;

EID: 1642423503     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20031377     Document Type: Article

References (32)

1. Pickart, C. M. (2001) Ubiquitin enters the new millennium. Mol. Cell. 8, 499-504
2. Borodovsky, A., Kessler, B. M., Casagrande, R., Overkleeft, H. S., Wilkinson, K. D. and Ploegh, H. L (2001) A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14. EMBO J. 20, 5187-5196
3. Verma, R., Aravind, L., Oania, R., McDonald, W. H., Yates, J. R., Koonin, E. V. and Deshaies, R. J. (2002) Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26 S proteasome. Science 298, 611-615
4. Chen, X., Zhang, B. and Fischer, J. A. (2002) A specific protein substrate for a deubiquitinating enzyme: Liquid facets is the substrate of Fat facets. Genes Dev. 16, 289-294
5. Karin, M. and Ben-Neriah, Y. (2000) Phosphorylation meets ubiquitination: the control of NF-κB activity. Annu. Rev. Immunol. 18, 621-663
6. Deng, L., Wang, C., Spencer, E., Yang, L., Braun, A., You, J., Slaughter, C., Pickart, C. and Chen, Z. J. (2000) Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 103, 351-361
7. Shi, C-S. and Kehrl, J. H. (2003) Tumor necrosis factor (TNF)-induced germinal center kinase-related (GCKR) and stress-activated protein kinase (SAPK) activation depends upon the E2/E3 complex Ubc13-Uev1A/TNF receptor-associated factor 2 (TRAF2). J. Biol. Chem. 278, 15429-15434
8. Tang, E. D., Wang, C. Y., Xiong, Y. and Guan, K. L. (2003) A role for NEMO/IKKγ ubiquitination in the activation of the IκB kinase complex by tumour necrosis factor-α. J. Biol. Chem. 278, 37297-37305
9. Legler, D. F., Micheau, O., Doucey M-A., Tschopp, J. and Bron, C. (2003) Recruitment of TNF receptor 1 to lipid rafts Is essential for TNFα-mediated NF-κB activation. Immunity 18, 655-664
10. Lee, E. G., Boone, D. L., Chai, S., Libby, S. L., Chien, M., Lodolce, J. P. and Ma, A. (2000) Failure to regulate TNF-induced NF-κB and cell death responses in A20-deficient mice. Science 289, 2350-2354
11. Krikos, A., Laherty, C. D. and Dixit, V. M. (1992) Transcriptional activation of the tumor necrosis factor α-inducible zinc finger protein, A20, is mediated by κB elements. J. Biol. Chem. 267, 17971-17976
12. Zhang, S. Q., Kovalenko, A., Cantarella, G. and Wallach, D. (2000) Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKγ) upon receptor stimulation. Immunity 12, 301-311
13. Zetoune, F. S., Murthy, A. R., Shao, Z., Hlaing, T., Zeidler, M. G., Li, Y. and Vincenz, C. (2001) A20 inhibits NF-κB activation downstream of multiple MAP3 kinases and interacts with the IκB signalosome. Cytokine 15, 282-298
14. De Valck, D., Heyninck, K., Van Criekinge, W., Contreras, R., Beyaert, R. and Fiers, W. (1996) A20, an inhibitor of cell-death, self-associates by its zinc finger domain. FEBS Lett. 384, 61-64
15. Song, H. Y., Rothe, M. and Goeddel, D. V. (1996) The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-κB activation. Proc. Natl. Acad. Sci. U.S.A. 93, 6721-6725
16. Sarma, V., Lin, Z., Clark, L., Rust, B. M., Tewari, M., Noelle, R. J. and Dixit, V. M. (1995) Activation of the B-cell surface receptor CD40 induces A20, a novel zinc finger protein that inhibits apoptosis. J. Biol. Chem. 270, 12343-12346.
17. Fries, K. L., Miller, W. E. and Raab-Traub, N. (1996) Epstein-Barr virus latent membrane protein 1 blocks p53-mediated apoptosis through the induction of the A20 gene. J. Virol. 70, 8653-8659
18. De Valck, D., Jin, D. Y., Heyninck, K., Van de Craen, M., Contreras, R., Fiers, W., Jeang, K. T. and Beyaert, R. (1999) The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. Oncogene 18, 4182-4190
19. Evans, P. C., Taylor, E. R., Coadwell, J., Heyninck, K., Beyaert, R. and Kilshaw, P. J. (2001) Isolation and characterization of two novel A20-like proteins. Biochem. J. 357, 617-623
20. Evans, P. C., Smith, T. S., Lai, M. J., Williams, M. G., Burke, D. F., Heyninck, K., Kreike, M. M., Beyaert, R., Blundell, T. L. and Kilshaw, P. J. (2003) A novel type of deubiquitinating enzyme. J. Biol. Chem. 278, 23180-23186
21. Hatakeyama, S., Yada, M., Matsumoto, M., Ishida, N. and Nakayama, K. I. (2001) U box proteins as a new family of ubiquitin-protein ligases. J. Biol. Chem. 276, 33111-33120
22. Borodovsky, A., Ovaa, H., Kolli, N., Gan-Erdene, T., Wilkinson, K. D., Ploegh, H. L. and Kessler, B. M. (2002) Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family. Chem. Biol. 9, 1149-1159
23. Makarova, K. S., Aravind, L. and Koonin, E. V. (2000) A novel superfamily of predicted cysteine proteases from eukaryotes, viruses and Chlamydia pneumoniae. Trends Biochem. Sci. 25, 50-52
24. Balakirev, M. Y., Tcherniuk, S. O., Jaquinod, M. and Chroboczek, J. (2003) Otubains: a new family of cysteine proteases in the ubiquitin pathway. EMBO Rep. 4, 517-522
25. Wilkinson, K. D., Tashayev, V. L., O'Connor, L. B., Larsen, C. N., Kasperek, E. and Pickart, C. M. (1995) Metabolism of the polyubiquitin degradation signal: structure, mechanism, and role of isopeptidase T. Biochemistry 34, 14535-14546
26. Hu, M., Li, P., Li, M., Li, W., Yao, T., Wu, J. W., Gu, W., Cohen, R. E. and Shi, Y. (2002) Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde. Cell 111, 1041-1054
27. Li, M., Chen, D., Shiloh, A., Luo, J., Nikolaev, A. Y., Qin, J. and Gu, W. (2002) Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature (London) 416, 648-653
28. Trompouki, E., Hatzivassiliou, E., Tsichritzis, T., Farmer, H., Ashworth, A. and Mosialos, G. (2003) CYLD is a deubiquitinating enzyme that negatively regulates NF-κB activation by TNFR family members. Nature (London) 424, 793-796
29. Brummelkamp, T. R., Nijman, S. M. B., Dirac, A. M. G. and Bernards, R. (2003) Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB. Nature (London) 424, 797-801.
30. Kovalenko, A., Chable-Bessia, C., Cantarella, G., Israël, A., Wallach, D. and Courtois, G. (2003) The rumour suppressor CYLD negatively regulates NF-κB signalling by deubiquitination. Nature (London) 424, 801-805
31. Bignell, G. R., Warren, W., Seal, S., Takahashi, M., Rapley, E., Barfoot, R., Green, H., Brown, C., Biggs, P. J., Lakhani, S. R. et al (2000) Identification of the familial cylindromatosis tumour-suppressor gene. Nat. Genet. 25, 160-165
32. Saigoh, K., Wang, Y. L., Suh, J. G., Yamanishi, T., Sakai, Y., Kiyosawa, H., Harada, T., Ichihara, N., Wakana, S., Kikuchi, T. and Wada, K. (1999) Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice. Nat. Genet. 23, 47-51