Mitochondria as key components of the stress response

Trends in Endocrinology and Metabolism

Volumn 18, Issue 5, 2007, Pages 190-198

  Manoli, Irini ^a,b   Alesci, Salvatore ^c   Blackman, Marc R ^d   Su, Yan A ^e   Rennert, Owen M ^f   Chrousos, George P ^b,f  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b UNIVERSITY OF ATHENS   (Greece)

^c NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^d National Institutes of Health   (United States)

^e GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^f EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOLAMINE; CYTOKINE; GLUCOCORTICOID; HEAT SHOCK PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE;

ACUTE STRESS; CHRONIC STRESS; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENVIRONMENTAL FACTOR; GENE CONTROL; GENETIC VARIABILITY; HEREDITY; HOMEOSTASIS; HUMAN; MAMMAL CELL; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; PHENOTYPE; PRIORITY JOURNAL; REVIEW; STRESS; TRANSCRIPTION REGULATION;

ADAPTATION, BIOLOGICAL; ANIMALS; HUMANS; MITOCHONDRIA; OXIDATIVE PHOSPHORYLATION;

EID: 34250812571     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tem.2007.04.004     Document Type: Review

References (91)

1. Charmandari E., et al. Endocrinology of the stress response. Annu. Rev. Physiol. 67 (2005) 259-284
2. Tsigos C., and Chrousos G.P. Stress, obesity, and metabolic syndrome. Ann. NY Acad. Sci. 1083 (2006) xi-xiii
3. Scheffler I.E. Mitochondria (1999), Wiley-Liss
4. Goldenthal M.J., and Marin-Garcia J. Mitochondrial signaling pathways: a receiver/integrator organelle. Mol. Cell Biochem. 262 (2004) 1-16
5. Rossignol R., et al. Mitochondrial threshold effects. Biochem. J. 370 (2003) 751-762
6. Chung A.B., et al. Transcriptional control of nuclear genes for the mitochondrial muscle ADP/ATP translocator and the ATP synthase beta subunit. Multiple factors interact with the OXBOX/REBOX promoter sequences. J. Biol. Chem. 267 (1992) 21154-21161
7. Demonacos C., et al. The mitochondrion as a primary site of action of glucocorticoids: the interaction of the glucocorticoid receptor with mitochondrial DNA sequences showing partial similarity to the nuclear glucocorticoid responsive elements. J. Steroid Biochem. Mol. Biol. 55 (1995) 43-55
8. Alesci S., et al. Development of a human mitochondria-focused cDNA microarray (hMitChip) and validation in skeletal muscle cells: implications for pharmaco- and mitogenomics. Pharmacogenomics J. 6 (2006) 333-342
9. Manoli I., et al. Monoamine oxidase-A is a major target gene for glucocorticoids in human skeletal muscle cells. FASEB J. 19 (2005) 1359-1361
10. Duclos M., et al. Effects of corticosterone on muscle mitochondria identifying different sensitivity to glucocorticoids in Lewis and Fischer rats. Am J Physiol Endocrinol. Metab. 286 (2004) E159-E167
11. Orzechowski A., et al. Dexamethasone-mediated regulation of death and differentiation of muscle cells. Is hydrogen peroxide involved in the process?. Reprod. Nutr. Dev. 42 (2002) 197-216
12. Weber K., et al. Glucocorticoid hormone stimulates mitochondrial biogenesis specifically in skeletal muscle. Endocrinology 143 (2002) 177-184
13. Mitsui T., et al. Mitochondrial damage in patients with long-term corticosteroid therapy: development of oculoskeletal symptoms similar to mitochondrial disease. Acta. Neuropathol. (Berl) 104 (2002) 260-266
14. McEwen B.S. Glucocorticoids, depression, and mood disorders: structural remodeling in the brain. Metabolism 54 (2005) 20-23
15. Iuchi T., et al. Glucocorticoid excess induces superoxide production in vascular endothelial cells and elicits vascular endothelial dysfunction. Circ. Res. 92 (2003) 81-87
16. Oshima Y., et al. Oxidative stress-associated mitochondrial dysfunction in corticosteroid-treated muscle cells. Muscle Nerve 30 (2004) 49-54
17. Winoto A., and Littman D.R. Nuclear hormone receptors in T lymphocytes. Cell 109 Suppl. (2002) S57-S66
18. Oberholzer C., et al. Apoptosis in sepsis: a new target for therapeutic exploration. FASEB J. 15 (2001) 879-892
19. Distelhorst C.W. Recent insights into the mechanism of glucocorticosteroid-induced apoptosis. Cell Death Differ. 9 (2002) 6-19
20. Sionov R.V., et al. Role of mitochondrial glucocorticoid receptor in glucocorticoid-induced apoptosis. J. Exp. Med. 203 (2006) 189-201
21. Wu Z., et al. Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells. Proc. Natl. Acad. Sci. USA 103 (2006) 14379-14384
22. Krauss S., et al. The mitochondrial uncoupling-protein homologues. Nat. Rev. Mol. Cell. Biol. 6 (2005) 248-261
23. Brand M.D., and Esteves T.C. Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3. Cell Metab. 2 (2005) 85-93
24. Nadtochiy S.M., et al. Different mechanisms of mitochondrial proton leak in ischaemia/reperfusion injury and preconditioning: implications for pathology and cardioprotection. Biochem. J. 395 (2006) 611-618
25. Chan C.B., et al. Uncoupling protein 2 and islet function. Diabetes 53 Suppl. 1 (2004) S136-S142
26. Derdak Z., et al. Enhanced colon tumor induction in uncoupling protein-2 deficient mice is associated with NF-kappaB activation and oxidative stress. Carcinogenesis 27 (2006) 956-961
27. Michael L.F., et al. Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1. Proc. Natl. Acad. Sci. USA 98 (2001) 3820-3825
28. Micheau O., and Tschopp J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 114 (2003) 181-190
29. Brookes P.S., et al. Concentration-dependent effects of nitric oxide on mitochondrial permeability transition and cytochrome c release. J. Biol. Chem. 275 (2000) 20474-20479
30. Seth R.B., et al. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell 122 (2005) 669-682
31. Beere H.M. Death versus survival: functional interaction between the apoptotic and stress-inducible heat shock protein pathways. J. Clin. Invest. 115 (2005) 2633-2639
32. Smith M.A., and Reid M.B. Redox modulation of contractile function in respiratory and limb skeletal muscle. Respir. Physiol. Neurobiol. 151 (2006) 229-241
33. Hultqvist M., et al. Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene. Proc. Natl. Acad. Sci. USA 101 (2004) 12646-12651
34. Chandel N.S., and Budinger G.R. The cellular basis for diverse responses to oxygen. Free Radic. Biol. Med. 42 (2007) 165-174
35. Cogswell P.C., et al. NF-kappa B and I kappa B alpha are found in the mitochondria. Evidence for regulation of mitochondrial gene expression by NF-kappa B. J. Biol. Chem. 278 (2003) 2963-2968
36. Lopez-Sanchez N., et al. Mitochondrial c-Jun NH2-terminal kinase prevents the accumulation of reactive oxygen species and reduces necrotic damage in neural tumor cells that lack trophic support. Mol. Cancer Res. 5 (2007) 47-60
37. Brealey D., et al. Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet 360 (2002) 219-223
38. Vanhorebeek I., et al. Protection of hepatocyte mitochondrial ultrastructure and function by strict blood glucose control with insulin in critically ill patients. Lancet 365 (2005) 53-59
39. Van den Berghe G., et al. Intensive insulin therapy in the medical ICU. N. Engl. J. Med. 354 (2006) 449-461
40. Cryer P.E. Hypoglycaemia: the limiting factor in the glycaemic management of the critically ill?. Diabetologia 49 (2006) 1722-1725
41. Gold P.W., et al. Divergent endocrine abnormalities in melancholic and atypical depression: clinical and pathophysiologic implications. Endocrinol. Metab. Clin. North Am. 31 (2002) 37-62 vi
42. Chrousos G.P. The role of stress and the hypothalamic-pituitary-adrenal axis in the pathogenesis of the metabolic syndrome: neuro-endocrine and target tissue-related causes. Int. J. Obes. Relat. Metab. Disord. 24 Suppl. 2 (2000) S50-S55
43. Russell L.K., et al. Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner. Circ. Res. 94 (2004) 525-533
44. Bourgeois J.M., and Tarnopolsky M.A. Pathology of skeletal muscle in mitochondrial disorders. Mitochondrion 4 (2004) 441-452
45. Duncan J.G., et al. Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-alpha/PGC-1alpha gene regulatory pathway. Circulation 115 (2007) 909-917
46. Epel E., et al. Stress may add bite to appetite in women: a laboratory study of stress-induced cortisol and eating behavior. Psychoneuroendocrinology 26 (2001) 37-49
47. McEwen B.S. Protection and damage from acute and chronic stress: allostasis and allostatic overload and relevance to the pathophysiology of psychiatric disorders. Ann. NY Acad. Sci. 1032 (2004) 1-7
48. Lowell B.B., and Shulman G.I. Mitochondrial dysfunction and type 2 diabetes. Science 307 (2005) 384-387
49. Morino K., et al. Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. J. Clin. Invest. 115 (2005) 3587-3593
50. Patti M.E., et al. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc. Natl. Acad. Sci. USA 100 (2003) 8466-8471
51. Guillausseau P.J., et al. Maternally inherited diabetes and deafness: a multicenter study. Ann. Intern. Med. 134 (2001) 721-728
52. Krempler F., et al. A functional polymorphism in the promoter of UCP2 enhances obesity risk but reduces type 2 diabetes risk in obese middle-aged humans. Diabetes 51 (2002) 3331-3335
53. Wilson F.H., et al. A cluster of metabolic defects caused by mutation in a mitochondrial tRNA. Science 306 (2004) 1190-1194
54. Sparks L.M., et al. A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle. Diabetes 54 (2005) 1926-1933
55. Um S.H., et al. Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1. Cell Metab. 3 (2006) 393-402
56. Epel E.S., et al. Accelerated telomere shortening in response to life stress. Proc. Natl. Acad. Sci. USA 101 (2004) 17312-17315
57. Hovatta I., et al. Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice. Nature 438 (2005) 662-666
58. van der Walt J.M., et al. Mitochondrial polymorphisms significantly reduce the risk of Parkinson's disease. Am. J. Hum. Genet. 72 (2003) 804-811
59. Chinnery P.F., et al. Mitochondrial DNA haplogroups and susceptibility to AD and dementia with Lewy bodies. Neurology 55 (2000) 302-304
60. De Benedictis G., et al. Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans. FASEB J. 13 (1999) 1532-1536
61. Baudouin S.V., et al. Mitochondrial DNA and survival after sepsis: a prospective study. Lancet 366 (2005) 2118-2121
62. Chrousos G.P., and Kino T. Intracellular glucocorticoid signaling: a formerly simple system turns stochastic. Sci STKE 2005 (2005) pe48
63. Wisloff U., et al. Cardiovascular risk factors emerge after artificial selection for low aerobic capacity. Science 307 (2005) 418-420
64. Heilbronn L.K., et al. Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial. J. Am. Med. Assoc. 295 (2006) 1539-1548
65. Toledo F.G., et al. Changes induced by physical activity and weight loss in the morphology of intermyofibrillar mitochondria in obese men and women. J. Clin. Endocrinol. Metab. 91 (2006) 3224-3227
66. Hursting S.D., et al. Calorie restriction, aging, and cancer prevention: mechanisms of action and applicability to humans. Annu. Rev. Med. 54 (2003) 131-152
67. Van Remmen H., et al. Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol. Genomics 16 (2003) 29-37
68. Ahmet I., et al. Cardioprotection by intermittent fasting in rats. Circulation 112 (2005) 3115-3121
69. Mattson M.P., and Kroemer G. Mitochondria in cell death: novel targets for neuroprotection and cardioprotection. Trends Mol. Med. 9 (2003) 196-205
70. Arumugam T.V., et al. Hormesis/preconditioning mechanisms, the nervous system and aging. Ageing Res. Rev. 5 (2006) 165-178
71. Adlam V.J., et al. Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury. FASEB J. 19 (2005) 1088-1095
72. Covey M.V., et al. Effect of the mitochondrial antioxidant, Mito Vitamin E, on hypoxic-ischemic striatal injury in neonatal rats: a dose-response and stereological study. Exp. Neurol. 199 (2006) 513-519
73. Schriner S.E., et al. Extension of murine life span by overexpression of catalase targeted to mitochondria. Science 308 (2005) 1909-1911
74. Kelly D.P., and Scarpulla R.C. Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Genes Dev. 18 (2004) 357-368
75. Berdanier C.D. Mitochondrial gene expression: influence of nutrients and hormones. Exp. Biol. Med. (Maywood) 231 (2006) 1593-1601
76. Puigserver P., and Spiegelman B.M. Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr. Rev. 24 (2003) 78-90
77. Meirhaeghe A., et al. Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo. Biochem. J. 373 (2003) 155-165
78. Lelliott C.J., et al. Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance. PLoS Biol. 4 (2006) e369
79. Attardi G., et al. Inter-mitochondrial complementation of mtDNA mutations and nuclear context. Nat. Genet. 30 (2002) 360
80. Matoba S., et al. p53 regulates mitochondrial respiration. Science 312 (2006) 1650-1653
81. Ryan M.T., and Hoogenraad N.J. Mitochondrial-nuclear communications. Annu. Rev. Biochem (2007) 10.1146/annurev.biochem.76.052305.091720
82. Zhao Q., et al. A mitochondrial specific stress response in mammalian cells. EMBO J. 21 (2002) 4411-4419
83. Ozcan U., et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306 (2004) 457-461
84. Ikeuchi M., et al. Overexpression of mitochondrial transcription factor a ameliorates mitochondrial deficiencies and cardiac failure after myocardial infarction. Circulation 112 (2005) 683-690
85. Hardie D.G. AMP-Activated protein kinase as a drug target. Annu. Rev. Pharmacol. Toxicol. 47 (2007) 185-210
86. Teshima Y., et al. Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes. Circ. Res. 93 (2003) 192-200
87. Arch J.R. beta(3)-Adrenoceptor agonists: potential, pitfalls and progress. Eur. J. Pharmacol. 440 (2002) 99-107
88. Hagl C., et al. Cyclosporine A as a potential neuroprotective agent: a study of prolonged hypothermic circulatory arrest in a chronic porcine model. Eur. J. Cardiothorac. Surg. 19 (2001) 756-764
89. Bes S., et al. Direct, pleiotropic protective effect of cyclosporin A against simulated ischemia-induced injury in isolated cardiomyocytes. Eur. J. Pharmacol. 511 (2005) 109-120
90. Sun Y., et al. Adeno-associated virus-mediated delivery of BCL-w gene improves outcome after transient focal cerebral ischemia. Gene Ther. 10 (2003) 115-122
91. Wang Y., et al. Mechanisms by which K(ATP) channel openers produce acute and delayed cardioprotection. Vascul. Pharmacol. 42 (2005) 253-264