메뉴 건너뛰기




Volumn 395, Issue 3, 2006, Pages 611-618

Different mechanisms of mitochondrial proton leak in ischaemia/reperfusion injury and preconditioning: Implications for pathology and cardioprotection

Author keywords

Adenine nucleotide translocase (ANT); H+ leak; Ischaemic preconditioning (IPC); Permeability transition (PT); Sanglifehrin A (SfA); Uncoupling proteins (UCPs)

Indexed keywords

BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; BIOLOGICAL ORGANS; CELLS; PHOSPHATES; PROTONS;

EID: 33646246774     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20051927     Document Type: Article
Times cited : (101)

References (64)
  • 2
    • 10344264960 scopus 로고    scopus 로고
    • + leak and ROS generation: An odd couple
    • + leak and ROS generation: an odd couple. Free Radical Biol. Med. 38, 12-23
    • (2004) Free Radical Biol. Med. , vol.38 , pp. 12-23
    • Brookes, P.S.1
  • 3
    • 0035955753 scopus 로고    scopus 로고
    • Ischemic and pharmacological preconditioning in Girardi cells and C2C12 myotubes induce mitochondrial uncoupling
    • Minners, J., Lacerda, L., McCarthy, J., Meiring, J. J., Yellon, D. M. and Sack, M. N. (2001) Ischemic and pharmacological preconditioning in Girardi cells and C2C12 myotubes induce mitochondrial uncoupling. Circ. Res. 89, 787-792
    • (2001) Circ. Res. , vol.89 , pp. 787-792
    • Minners, J.1    Lacerda, L.2    McCarthy, J.3    Meiring, J.J.4    Yellon, D.M.5    Sack, M.N.6
  • 4
    • 0034044807 scopus 로고    scopus 로고
    • Dinitrophenol, cyclosporin A, and trimetazidine modulate preconditioning in the isolated rat heart: Support for a mitochondrial role in cardioprotection
    • Minners, J., van den Bos, E. J., Yellon, D., Schwalb, H., Opie, L. and Sack, M. (2000) Dinitrophenol, cyclosporin A, and trimetazidine modulate preconditioning in the isolated rat heart: support for a mitochondrial role in cardioprotection. Cardiovasc. Res. 47, 68-73
    • (2000) Cardiovasc. Res. , vol.47 , pp. 68-73
    • Minners, J.1    Van Den Bos, E.J.2    Yellon, D.3    Schwalb, H.4    Opie, L.5    Sack, M.6
  • 5
    • 0038799946 scopus 로고    scopus 로고
    • Effects of CCCP-induced mitochondrial uncoupling and cyclosporin A on cell volume, cell injury and preconditioning protection of isolated rabbit cardiomyocytes
    • Ganote, C. E. and Armstrong, S. C. (2003) Effects of CCCP-induced mitochondrial uncoupling and cyclosporin A on cell volume, cell injury and preconditioning protection of isolated rabbit cardiomyocytes. J. Mol. Cell. Cardiol. 35, 749-759
    • (2003) J. Mol. Cell. Cardiol. , vol.35 , pp. 749-759
    • Ganote, C.E.1    Armstrong, S.C.2
  • 6
    • 33644643584 scopus 로고    scopus 로고
    • UCP-2, a functional target in delayed preconditioning induced cardioprotection?
    • McLeod, C., Hoyt, R. and Sack, M. (2004) UCP-2, a functional target in delayed preconditioning induced cardioprotection? Cardiovasc. J. S. Afr. 15, S4
    • (2004) Cardiovasc. J. S. Afr. , vol.15
    • McLeod, C.1    Hoyt, R.2    Sack, M.3
  • 7
    • 0042526012 scopus 로고    scopus 로고
    • Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes
    • Teshima, Y., Akao, M., Jones, S. and Marban, E. (2003) Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes. Circ. Res. 93, 192-200
    • (2003) Circ. Res. , vol.93 , pp. 192-200
    • Teshima, Y.1    Akao, M.2    Jones, S.3    Marban, E.4
  • 9
    • 0038123011 scopus 로고    scopus 로고
    • Stable transfection of UCP1 confers resistance to hypoxia/reoxygenation in a heart-derived cell line
    • Bienengraeber, M., Ozcan, C. and Terzic, A. (2003) Stable transfection of UCP1 confers resistance to hypoxia/reoxygenation in a heart-derived cell line. J. Mol. Cell. Cardiol. 35, 861-865
    • (2003) J. Mol. Cell. Cardiol. , vol.35 , pp. 861-865
    • Bienengraeber, M.1    Ozcan, C.2    Terzic, A.3
  • 12
    • 0042433242 scopus 로고    scopus 로고
    • 2 production by membrane potential and NAD(P)H redox state
    • 2 production by membrane potential and NAD(P)H redox state. J. Neurochem. 86, 1101-1107
    • (2003) J. Neurochem. , vol.86 , pp. 1101-1107
    • Starkov, A.A.1    Fiskum, G.2
  • 17
    • 0033565557 scopus 로고    scopus 로고
    • The mitochondrial permeability transition pore and its role in cell death
    • Crompton, M. (1999) The mitochondrial permeability transition pore and its role in cell death. Biochem. J. 341, 233-249
    • (1999) Biochem. J. , vol.341 , pp. 233-249
    • Crompton, M.1
  • 18
    • 0032558403 scopus 로고    scopus 로고
    • Proton selective substate of the mitochondrial permeability transition pore: Regulation by the redox state of the electron transport chain
    • Broekemeier, K. M., Klocek, C. K. and Pfeiffer, D. R. (1998) Proton selective substate of the mitochondrial permeability transition pore: regulation by the redox state of the electron transport chain. Biochemistry 37, 13059-13065
    • (1998) Biochemistry , vol.37 , pp. 13059-13065
    • Broekemeier, K.M.1    Klocek, C.K.2    Pfeiffer, D.R.3
  • 19
    • 0037745119 scopus 로고    scopus 로고
    • Fluctuations in mitochondrial membrane potential caused by repetitive gating of the permeability transition pore
    • Huser, J. and Blatter, L. A. (1999) Fluctuations in mitochondrial membrane potential caused by repetitive gating of the permeability transition pore. Biochem. J. 343, 311-317
    • (1999) Biochem. J. , vol.343 , pp. 311-317
    • Huser, J.1    Blatter, L.A.2
  • 20
    • 0042859821 scopus 로고    scopus 로고
    • Role of the mitochondrial permeability transition in myocardial disease
    • Weiss, J. N., Korge, P., Honda, H. M. and Ping, P. (2003) Role of the mitochondrial permeability transition in myocardial disease. Circ. Res. 93, 292-301
    • (2003) Circ. Res. , vol.93 , pp. 292-301
    • Weiss, J.N.1    Korge, P.2    Honda, H.M.3    Ping, P.4
  • 21
    • 0142187307 scopus 로고    scopus 로고
    • Signaling and cellular mechanisms in cardiac protection by ischemic and pharmacological preconditioning
    • Zaugg, M. and Schaub, M. C. (2003) Signaling and cellular mechanisms in cardiac protection by ischemic and pharmacological preconditioning. J. Muscle Res. Cell Motil. 24, 219-249
    • (2003) J. Muscle Res. Cell Motil. , vol.24 , pp. 219-249
    • Zaugg, M.1    Schaub, M.C.2
  • 23
    • 1842788132 scopus 로고    scopus 로고
    • Increased state 4 mitochondrial respiration and swelling in early post-ischemic reperfusion of rat heart
    • Bosetti, F., Baracca, A., Lenaz, G. and Solaini, G. (2004) Increased state 4 mitochondrial respiration and swelling in early post-ischemic reperfusion of rat heart. FEBS Lett. 563, 161-164
    • (2004) FEBS Lett. , vol.563 , pp. 161-164
    • Bosetti, F.1    Baracca, A.2    Lenaz, G.3    Solaini, G.4
  • 24
    • 33646250400 scopus 로고    scopus 로고
    • Ischemic preconditioning preserves proton leakage from mitochondrial membranes but not oxidative phosphorylation during heart reperfusion
    • in the Press
    • Muscari, C., Bonafe, F., Gamberini, C., Giordano, E., Lenaz, G. and Caldarera, C. M. (2005) Ischemic preconditioning preserves proton leakage from mitochondrial membranes but not oxidative phosphorylation during heart reperfusion. Cell Biochem. Funct. in the Press
    • (2005) Cell Biochem. Funct.
    • Muscari, C.1    Bonafe, F.2    Gamberini, C.3    Giordano, E.4    Lenaz, G.5    Caldarera, C.M.6
  • 25
    • 0036591865 scopus 로고    scopus 로고
    • Mitochondrial function in response to cardiac ischemia-reperfusion after oral treatment with quercetin
    • Brookes, P. S., Digerness, S. B., Parks, D. A. and Darley-Usmar, V. M. (2002) Mitochondrial function in response to cardiac ischemia-reperfusion after oral treatment with quercetin. Free Radical Biol. Med. 32, 1220-1228
    • (2002) Free Radical Biol. Med. , vol.32 , pp. 1220-1228
    • Brookes, P.S.1    Digerness, S.B.2    Parks, D.A.3    Darley-Usmar, V.M.4
  • 27
    • 0002114258 scopus 로고
    • Measurement of mitochondrial proton-motive force
    • Brown, G.C. and Cooper, C.E., eds., IRL Press, Oxford, U.K.
    • Brand, M. (1995) Measurement of mitochondrial proton-motive force. In Bioenergetics: a Practical Approach (Brown, G.C. and Cooper, C.E., eds.), pp. 39-62, IRL Press, Oxford, U.K.
    • (1995) Bioenergetics: A Practical Approach , pp. 39-62
    • Brand, M.1
  • 28
    • 0040951645 scopus 로고    scopus 로고
    • Concentration-dependent effects of nitric oxide on mitochondrial permeability transition and cytochrome c release
    • Brookes, P., Salinas, E., Darley-Usmar, K., Eiserich, J., Freeman, B., Darley-Usmar, V. and Anderson, P. (2000) Concentration-dependent effects of nitric oxide on mitochondrial permeability transition and cytochrome c release. J. Biol. Chem. 275, 20474-20479
    • (2000) J. Biol. Chem. , vol.275 , pp. 20474-20479
    • Brookes, P.1    Salinas, E.2    Darley-Usmar, K.3    Eiserich, J.4    Freeman, B.5    Darley-Usmar, V.6    Anderson, P.7
  • 29
    • 0029589249 scopus 로고
    • Control and kinetic analysis of ischemia-damaged heart mitochondria: Which parts of the oxidative phosphorylation system are affected by ischemia?
    • Borutaite, V., Mildaziene, V., Brown, G. C. and Brand, M. D. (1995) Control and kinetic analysis of ischemia-damaged heart mitochondria: which parts of the oxidative phosphorylation system are affected by ischemia? Biochim. Biophys. Acta 1272, 154-158
    • (1995) Biochim. Biophys. Acta , vol.1272 , pp. 154-158
    • Borutaite, V.1    Mildaziene, V.2    Brown, G.C.3    Brand, M.D.4
  • 30
    • 0018969926 scopus 로고
    • Some statistical methods useful in circulation research
    • Wallenstein, S., Zucker, C. and Fleiss, J. (1980) Some statistical methods useful in circulation research. Circ. Res. 47, 1-9
    • (1980) Circ. Res. , vol.47 , pp. 1-9
    • Wallenstein, S.1    Zucker, C.2    Fleiss, J.3
  • 31
    • 0027761474 scopus 로고
    • Protection by Cyclosporin A of ischemia/reperfusion-induced damage in isolated rat hearts
    • Griffiths, E. J. and Halestrap, A. P. (1993) Protection by Cyclosporin A of ischemia/reperfusion-induced damage in isolated rat hearts. J. Mol. Cell. Cardiol. 25, 1461-1469
    • (1993) J. Mol. Cell. Cardiol. , vol.25 , pp. 1461-1469
    • Griffiths, E.J.1    Halestrap, A.P.2
  • 32
    • 0037144409 scopus 로고    scopus 로고
    • Sanglifehrin A acts as a potent inhibitor of the mitochondrial permeability transition and reperfusion injury of the heart by binding to cyclophilin-D at a different site from cyclosporin A
    • Clarke, S. J., McStay, G. P. and Halestrap, A. P. (2002) Sanglifehrin A acts as a potent inhibitor of the mitochondrial permeability transition and reperfusion injury of the heart by binding to cyclophilin-D at a different site from cyclosporin A. J. Biol. Chem. 277, 34793-34799
    • (2002) J. Biol. Chem. , vol.277 , pp. 34793-34799
    • Clarke, S.J.1    McStay, G.P.2    Halestrap, A.P.3
  • 34
    • 24944535317 scopus 로고    scopus 로고
    • Isolated heart function during ischemia and repertusion in sucrose-fed rats: Effect of insulin infusion
    • Cardenas, G., Torres, J. C., Zamora, J. and Banos, G. (2005) Isolated heart function during ischemia and repertusion in sucrose-fed rats: effect of insulin infusion. Cardiovasc. Pathol. 14, 256-226
    • (2005) Cardiovasc. Pathol. , vol.14 , pp. 256-1226
    • Cardenas, G.1    Torres, J.C.2    Zamora, J.3    Banos, G.4
  • 35
    • 0029102916 scopus 로고
    • Contractile dysfunction caused by normothermic ischaemia and KCL arrest in the isolated pig heart: A 31P NMR study
    • Kupriyanov, V. V., St Jean, M., Xiang, B., Butler, K. W. and Deslauriers, R. (1995) Contractile dysfunction caused by normothermic ischaemia and KCL arrest in the isolated pig heart: a 31P NMR study. J. Mol. Cell. Cardiol. 27, 1715-1730
    • (1995) J. Mol. Cell. Cardiol. , vol.27 , pp. 1715-1730
    • Kupriyanov, V.V.1    St Jean, M.2    Xiang, B.3    Butler, K.W.4    Deslauriers, R.5
  • 37
    • 1642503867 scopus 로고    scopus 로고
    • Hyperthyroidism causes mechanical insufficiency of myocardium with possibly increased SR Ca2+-ATPase activity
    • Takeuchi, K., Minakawa, M., Otaki, M., Odagiri, S., Itoh, K., Murakami, A., Yaku, H. and Kitamura, N. (2003) Hyperthyroidism causes mechanical insufficiency of myocardium with possibly increased SR Ca2+-ATPase activity. Jpn. J. Physiol. 53, 411-416
    • (2003) Jpn. J. Physiol. , vol.53 , pp. 411-416
    • Takeuchi, K.1    Minakawa, M.2    Otaki, M.3    Odagiri, S.4    Itoh, K.5    Murakami, A.6    Yaku, H.7    Kitamura, N.8
  • 38
    • 0034880956 scopus 로고    scopus 로고
    • Endogenous nitric oxide enhances coupling between 02 consumption and ATP synthesis in guinea pig hearts
    • Shen, W., Tian, R., Saupe, K. W., Spindler, M. and Ingwall, J. S. (2001) Endogenous nitric oxide enhances coupling between 02 consumption and ATP synthesis in guinea pig hearts. Am. J. Physiol. Heart Circ. Physiol. 281, H838-H846
    • (2001) Am. J. Physiol. Heart Circ. Physiol. , vol.281
    • Shen, W.1    Tian, R.2    Saupe, K.W.3    Spindler, M.4    Ingwall, J.S.5
  • 41
    • 1142273368 scopus 로고    scopus 로고
    • Mitochondrial permeability transition pore opening during myocardial repertusion- a target for cardioprotection
    • Halestrap, A. P., Clarke, S. J. and Javadov, S. A. (2004) Mitochondrial permeability transition pore opening during myocardial repertusion- a target for cardioprotection. Cardiovasc. Res. 61, 372-385
    • (2004) Cardiovasc. Res. , vol.61 , pp. 372-385
    • Halestrap, A.P.1    Clarke, S.J.2    Javadov, S.A.3
  • 42
    • 0037961041 scopus 로고    scopus 로고
    • Mitochondria and repertusion injury. The role of permeability transition
    • Di Lisa, F., Canton, M., Menabo, R., Dodoni, G. and Bernardi, P. (2003) Mitochondria and repertusion injury. The role of permeability transition. Basic Res. Cardiol. 98, 235-241
    • (2003) Basic Res. Cardiol. , vol.98 , pp. 235-241
    • Di Lisa, F.1    Canton, M.2    Menabo, R.3    Dodoni, G.4    Bernardi, P.5
  • 43
    • 23944497622 scopus 로고    scopus 로고
    • 2+-induced depolarization of isolated brain and liver mitochondria
    • 2+-induced depolarization of isolated brain and liver mitochondria. Biochim. Biophys. Acta 1709, 127-137
    • (2005) Biochim. Biophys. Acta , vol.1709 , pp. 127-137
    • Vergun, O.1    Reynolds, I.J.2
  • 44
  • 45
  • 46
    • 0022273195 scopus 로고
    • Principles of carrier catalysis elucidated by comparing two similar membrane translocators from mitochondria, the ADP/ATP carrier and the uncoupling protein
    • Klingenberg, M. (1985) Principles of carrier catalysis elucidated by comparing two similar membrane translocators from mitochondria, the ADP/ATP carrier and the uncoupling protein. Ann. N.Y. Acad. Sci. 456, 279-288
    • (1985) Ann. N.Y. Acad. Sci. , vol.456 , pp. 279-288
    • Klingenberg, M.1
  • 49
    • 0037033039 scopus 로고    scopus 로고
    • Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants
    • Echtay, K., Murphy, M., Smith, R., Talbot, D. and Brand, M. (2002) Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants. J. Biol. Chem. 277, 47129-47135
    • (2002) J. Biol. Chem. , vol.277 , pp. 47129-47135
    • Echtay, K.1    Murphy, M.2    Smith, R.3    Talbot, D.4    Brand, M.5
  • 51
    • 4644301489 scopus 로고    scopus 로고
    • Uncoupling protein-3 sensitizes cells to mitochondrial-dependent stimulus of apoptosis
    • Dejean, L., Camara, Y., Brigitte, S., Solanes, G. and Villarroya, F. (2004) Uncoupling protein-3 sensitizes cells to mitochondrial-dependent stimulus of apoptosis. J. Cell. Physiol. 201, 294-304
    • (2004) J. Cell. Physiol. , vol.201 , pp. 294-304
    • Dejean, L.1    Camara, Y.2    Brigitte, S.3    Solanes, G.4    Villarroya, F.5
  • 53
    • 0032560651 scopus 로고    scopus 로고
    • Mitochondrial ATP-dependent potassium channels: Novel effectors of cardioprotection?
    • Liu, Y., Sato, T., O'Rourke, B. and Marban, E. (1998) Mitochondrial ATP-dependent potassium channels: novel effectors of cardioprotection? Circulation 97, 2463-2469
    • (1998) Circulation , vol.97 , pp. 2463-2469
    • Liu, Y.1    Sato, T.2    O'Rourke, B.3    Marban, E.4
  • 54
    • 2942615283 scopus 로고    scopus 로고
    • Potassium channel openers are uncoupling protonophores: Implication in cardioprotection
    • Holmuhamedov, E. L., Jahangir, A., Oberlin, A., Komarov, A., Colombini, M. and Terzic, A. (2004) Potassium channel openers are uncoupling protonophores: implication in cardioprotection. FEBS Lett. 568, 167-170
    • (2004) FEBS Lett. , vol.568 , pp. 167-170
    • Holmuhamedov, E.L.1    Jahangir, A.2    Oberlin, A.3    Komarov, A.4    Colombini, M.5    Terzic, A.6
  • 55
    • 0037444667 scopus 로고    scopus 로고
    • Matrix volume measurements challenge the existence of diazoxide/glibencamide-sensitive KATP channels in rat mitochondria
    • Das, M., Parker, J. E. and Halestrap, A. P. (2003) Matrix volume measurements challenge the existence of diazoxide/glibencamide-sensitive KATP channels in rat mitochondria. J. Physiol. 547, 893-902
    • (2003) J. Physiol. , vol.547 , pp. 893-902
    • Das, M.1    Parker, J.E.2    Halestrap, A.P.3
  • 58
    • 24044492874 scopus 로고    scopus 로고
    • Protein kinase G transmits the cardioprotective signal from cytosol to mitochondria
    • Costa, A., Garlid, K., West, I., Lincoln, T., Downey, J., Cohen, M. and Critz, S. (2005) Protein kinase G transmits the cardioprotective signal from cytosol to mitochondria. Circ. Res. 97, 329-336
    • (2005) Circ. Res. , vol.97 , pp. 329-336
    • Costa, A.1    Garlid, K.2    West, I.3    Lincoln, T.4    Downey, J.5    Cohen, M.6    Critz, S.7
  • 60
    • 0025894922 scopus 로고
    • On the nature of the mitochondrial proton leak
    • Brown, G. and Brand, M. (1991) On the nature of the mitochondrial proton leak. Biochim. Biophys. Acta 1059, 55-62
    • (1991) Biochim. Biophys. Acta , vol.1059 , pp. 55-62
    • Brown, G.1    Brand, M.2
  • 62
    • 4043087772 scopus 로고    scopus 로고
    • Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection
    • Hausenloy, D., Wynne, A., Duchen, M. and Yellon, D. (2004) Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection. Circulation 109, 1714-1717
    • (2004) Circulation , vol.109 , pp. 1714-1717
    • Hausenloy, D.1    Wynne, A.2    Duchen, M.3    Yellon, D.4
  • 63
    • 11144339333 scopus 로고    scopus 로고
    • Does the mitochondrial permeability transition have a role in preconditioning?
    • Halestrap, A. (2004) Does the mitochondrial permeability transition have a role in preconditioning? Circulation 110, 303
    • (2004) Circulation , vol.110 , pp. 303
    • Halestrap, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.