Changes induced by physical activity and weight loss in the morphology of intermyofibrillar mitochondria in obese men and women

Journal of Clinical Endocrinology and Metabolism

Volumn 91, Issue 8, 2006, Pages 3224-3227

  Toledo, Frederico G S ^a,b   Watkins, Simon ^a   Kelley, David E ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AEROBIC EXERCISE; ARTICLE; CLINICAL ARTICLE; CLINICAL RESEARCH; CONTROLLED STUDY; DIABETES MELLITUS; DIET RESTRICTION; FEMALE; GLUCOSE CLAMP TECHNIQUE; HUMAN; HUMAN TISSUE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIFESTYLE; MALE; MITOCHONDRION; MORPHOLOGY; MORPHOMETRICS; MUSCLE FIBRIL; MUSCLE MASS; OBESITY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TRANSMISSION ELECTRON MICROSCOPY; VASTUS LATERALIS MUSCLE; WEIGHT REDUCTION;

EID: 33747702159     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2006-0002     Document Type: Article

References (20)

1. Toledo FGS, Kelley DE 2005 Mitochondrial dysfunction in the pathogenesis of insulin resistance associated with obesity, diabetes, and aging. Curr Opin Endocrinol Metab 12:157-162
2. Kelley D, Goodpaster B, Wing R, Simoneau JA 1999 Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity and weight loss. Am J Physiol 277:E1130-E1141
3. Kelley DE, He J, Menshikova EV, Ritov VB 2002 Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 51:2944-2950
4. Holloszy JO, Coyle EF 1984 Adaptations of skeletal muscle to endurance exercise and their metabolic consequences. J Appl Physiol 56:831-838
5. Hoppeler H, Fluck M 2003 Plasticity of skeletal muscle mitochondria: structure and function. Med Sci Sports Exerc 35:95-104
6. Gollnick PD 1986 Metabolic regulation in skeletal muscle: influence of endurance training as exerted by mitochondrial protein concentration. Acta Physiol Scand Suppl 556:53-66
7. Pette D, Spamer C 1986 Metabolic properties of muscle fibers. Fed Proc 45:2910-2914
8. Hoppeler H, Luthi P, Claassen H, Weibel ER, Howald H 1973 The ultrastructure of the normal human skeletal muscle. A morphometric analysis on untrained men, women and well-trained orienteers. Pflugers Arch 344:217-232
9. Puntschart A, Claassen H, Jostarndt K, Hoppeler H, Billeter R 1995 mRNAs of enzymes involved in energy metabolism and mtDNA are increased in endurance-trained athletes. Am J Physiol 269:C619-C625
10. Suter E, Hoppeler H, Claassen H, Billeter R, Aebi U, Horber F, Jaeger P, Marti B 1995 Ultrastructural modification of human skeletal muscle tissue with 6-month moderate-intensity exercise training. Int J Sports Med 16:160-166
11. Goodpaster BH, Katsiaras A, Kelley DE 2003 Enhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in obesity. Diabetes 52:2191-2197
12. He J, Goodpaster BH, Kelley DE 2004 Effects of weight loss and physical activity on muscle lipid content and droplet size. Obes Res 12:761-769
13. Menshikova EV, Ritov VB, Toledo FG, Ferrell RE, Goodpaster BH, Kelley DE 2005 Effects of weight loss and physical activity on skeletal muscle mitochondrial function in obesity. Am J Physiol Endocrinol Metab 288:E818-E825
14. Weibel ER 1979 Stereological methods. Practical methods for biological morphometry. New York: Academic Press
15. Gundersen HJ, Bendtsen TF, Korbo L, Marcussen N, Moller A, Nielsen K, Nyengaard JR, Pakkenberg B, Sorensen FB, Vesterby A, West MJ 1988 Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS 96:379-394
16. Hoppeler H, Howald H, Conley K, Lindstedt SL, Claassen H, Vock P, Weibel ER 1985 Endurance training in humans: aerobic capacity and structure of skeletal muscle. J Appl Physiol 59:320-327
17. Kiessling KH, Piehl K, Lundquist CG 1970 Effect of physical training on ultrastructural features in human skeletal muscle. In Karolinska Institute Symposia: muscle metabolism during exercise. New York: Plenum Press; 97-101
18. Jerusalem F, Engel AG, Peterson HA 1975 Human muscle fiber fine structure: morphometric data on controls. Neurology 25:127-134
19. Kirkwood SP, Packer L, Brooks GA 1987 Effects of endurance training on a mitochondrial reticulum in limb skeletal muscle. Arch Biochem Biophys 255:80-88
20. Ogata T, Yamasaki Y 1997 Ultra-high-resolution scanning electron microscopy of mitochondria and sarcoplasmic reticulum arrangement in human red, white, and intermediate muscle fibers. Anat Rec 248:214-223