-
1
-
-
0037083364
-
Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion
-
Arakawa H., Hauschild J., and Buerstedde J.M. Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion. Science 295 (2002) 1301-1306
-
(2002)
Science
, vol.295
, pp. 1301-1306
-
-
Arakawa, H.1
Hauschild, J.2
Buerstedde, J.M.3
-
2
-
-
0035871625
-
Increased transcription levels induce higher mutation rates in a hypermutating cell line
-
Bachl J., Carlson C., Gray-Schopfer V., Dessing M., and Olsson C. Increased transcription levels induce higher mutation rates in a hypermutating cell line. J. Immunol. 166 (2001) 5051-5057
-
(2001)
J. Immunol.
, vol.166
, pp. 5051-5057
-
-
Bachl, J.1
Carlson, C.2
Gray-Schopfer, V.3
Dessing, M.4
Olsson, C.5
-
3
-
-
0015814177
-
Mutations in immunoglobulin-producing mouse myeloma cells
-
Baumal R., Birshtein B.K., Coffino P., and Scharff M.D. Mutations in immunoglobulin-producing mouse myeloma cells. Science 182 (1973) 164-166
-
(1973)
Science
, vol.182
, pp. 164-166
-
-
Baumal, R.1
Birshtein, B.K.2
Coffino, P.3
Scharff, M.D.4
-
4
-
-
19344378943
-
Rules of engagement: Co-transcriptional recruitment of pre-mRNA processing factors
-
Bentley D.L. Rules of engagement: Co-transcriptional recruitment of pre-mRNA processing factors. Curr. Opin. Cell Biol. 17 (2005) 251-256
-
(2005)
Curr. Opin. Cell Biol.
, vol.17
, pp. 251-256
-
-
Bentley, D.L.1
-
5
-
-
33646862623
-
The transcription elongation complex directs activation-induced cytidine deaminase-mediated DNA deamination
-
Besmer E., Market E., and Papavasiliou F.N. The transcription elongation complex directs activation-induced cytidine deaminase-mediated DNA deamination. Mol. Cell. Biol. 26 (2006) 4378-4385
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 4378-4385
-
-
Besmer, E.1
Market, E.2
Papavasiliou, F.N.3
-
6
-
-
0028270307
-
Elements regulating somatic hypermutation of an immunoglobulin kappa gene: Critical role for the intron enhancer/matrix attachment region
-
Betz A.G., Milstein C., Gonzalez-Fernandez A., Pannell R., Larson T., and Neuberger M.S. Elements regulating somatic hypermutation of an immunoglobulin kappa gene: Critical role for the intron enhancer/matrix attachment region. Cell 77 (1994) 239-248
-
(1994)
Cell
, vol.77
, pp. 239-248
-
-
Betz, A.G.1
Milstein, C.2
Gonzalez-Fernandez, A.3
Pannell, R.4
Larson, T.5
Neuberger, M.S.6
-
7
-
-
0027952630
-
S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process
-
Bottaro A., Lansford R., Xu L., Zhang J., Rothman P., and Alt F.W. S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process. EMBO J. 13 (1994) 665-674
-
(1994)
EMBO J.
, vol.13
, pp. 665-674
-
-
Bottaro, A.1
Lansford, R.2
Xu, L.3
Zhang, J.4
Rothman, P.5
Alt, F.W.6
-
8
-
-
0037452080
-
Transcription-targeted DNA deamination by the AID antibody diversification enzyme
-
Chaudhuri J., Tian M., Khuong C., Chua K., Pinaud E., and Alt F.W. Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature 422 (2003) 726-730
-
(2003)
Nature
, vol.422
, pp. 726-730
-
-
Chaudhuri, J.1
Tian, M.2
Khuong, C.3
Chua, K.4
Pinaud, E.5
Alt, F.W.6
-
9
-
-
30944469861
-
The chicken Ig light chain 3′-enhancer is essential for gene expression and regulates gene conversion via the transcription factor E2A
-
Conlon T.M., and Meyer K.B. The chicken Ig light chain 3′-enhancer is essential for gene expression and regulates gene conversion via the transcription factor E2A. Eur. J. Immunol. 36 (2006) 139-148
-
(2006)
Eur. J. Immunol.
, vol.36
, pp. 139-148
-
-
Conlon, T.M.1
Meyer, K.B.2
-
10
-
-
0037026482
-
Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase
-
Di Noia J., and Neuberger M.S. Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase. Nature 419 (2002) 43-48
-
(2002)
Nature
, vol.419
, pp. 43-48
-
-
Di Noia, J.1
Neuberger, M.S.2
-
11
-
-
1642345456
-
Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID-mediated deoxycytidine deamination
-
Di Noia J.M., and Neuberger M.S. Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID-mediated deoxycytidine deamination. Eur. J. Immunol. 34 (2004) 504-508
-
(2004)
Eur. J. Immunol.
, vol.34
, pp. 504-508
-
-
Di Noia, J.M.1
Neuberger, M.S.2
-
12
-
-
32544439248
-
SMUG1 is able to excise uracil from immunoglobulin genes: Insight into mutation versus repair
-
Di Noia J.M., Rada C., and Neuberger M.S. SMUG1 is able to excise uracil from immunoglobulin genes: Insight into mutation versus repair. EMBO J. 25 (2006) 585-595
-
(2006)
EMBO J.
, vol.25
, pp. 585-595
-
-
Di Noia, J.M.1
Rada, C.2
Neuberger, M.S.3
-
14
-
-
0036732772
-
AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line
-
Faili A., Aoufouchi S., Gueranger Q., Zober C., Leon A., Bertocci B., Weill J.C., and Reynaud C.A. AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line. Nat. Immunol. 3 (2002) 815-821
-
(2002)
Nat. Immunol.
, vol.3
, pp. 815-821
-
-
Faili, A.1
Aoufouchi, S.2
Gueranger, Q.3
Zober, C.4
Leon, A.5
Bertocci, B.6
Weill, J.C.7
Reynaud, C.A.8
-
15
-
-
30744445418
-
H2AX prevents DNA breaks from progressing to chromosome breaks and translocations
-
Franco S., Gostissa M., Zha S., Lombard D.B., Murphy M.M., Zarrin A.A., Yan C., Tepsuporn S., Morales J.C., Adams M.M., Lou Z., Bassing C.H., et al. H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol. Cell 21 (2006) 201-214
-
(2006)
Mol. Cell
, vol.21
, pp. 201-214
-
-
Franco, S.1
Gostissa, M.2
Zha, S.3
Lombard, D.B.4
Murphy, M.M.5
Zarrin, A.A.6
Yan, C.7
Tepsuporn, S.8
Morales, J.C.9
Adams, M.M.10
Lou, Z.11
Bassing, C.H.12
-
16
-
-
0032127810
-
Somatic hypermutation in the heavy chain locus correlates with transcription
-
Fukita Y., Jacobs H., and Rajewsky K. Somatic hypermutation in the heavy chain locus correlates with transcription. Immunity 9 (1998) 105-114
-
(1998)
Immunity
, vol.9
, pp. 105-114
-
-
Fukita, Y.1
Jacobs, H.2
Rajewsky, K.3
-
17
-
-
0030221916
-
Involvement of the E2A basic helix-loop-helix protein in immunoglobulin heavy chain class switching
-
Goldfarb A.N., Flores J.P., and Lewandowska K. Involvement of the E2A basic helix-loop-helix protein in immunoglobulin heavy chain class switching. Mol. Immunol. 33 (1996) 947-956
-
(1996)
Mol. Immunol.
, vol.33
, pp. 947-956
-
-
Goldfarb, A.N.1
Flores, J.P.2
Lewandowska, K.3
-
18
-
-
0037388211
-
Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a)
-
Gordon M.S., Kanegai C.M., Doerr J.R., and Wall R. Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a). Proc. Natl. Acad. Sci. USA 100 (2003) 4126-4131
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 4126-4131
-
-
Gordon, M.S.1
Kanegai, C.M.2
Doerr, J.R.3
Wall, R.4
-
19
-
-
33744967284
-
A role for activation-induced cytidine deaminase in the host response against a transforming retrovirus
-
Gourzi P., Leonova T., and Papavasiliou F.N. A role for activation-induced cytidine deaminase in the host response against a transforming retrovirus. Immunity 24 (2006) 779-786
-
(2006)
Immunity
, vol.24
, pp. 779-786
-
-
Gourzi, P.1
Leonova, T.2
Papavasiliou, F.N.3
-
20
-
-
8544241736
-
Retroviral restriction by APOBEC proteins
-
Harris R.S., and Liddament M.T. Retroviral restriction by APOBEC proteins. Nat. Rev. Immunol. 4 (2004) 868-877
-
(2004)
Nat. Rev. Immunol.
, vol.4
, pp. 868-877
-
-
Harris, R.S.1
Liddament, M.T.2
-
21
-
-
0037022540
-
AID is essential for immunoglobulin V gene conversion in a cultured B cell line
-
Harris R.S., Sale J.E., Petersen-Mahrt S.K., and Neuberger M.S. AID is essential for immunoglobulin V gene conversion in a cultured B cell line. Curr. Biol. 12 (2002) 435-438
-
(2002)
Curr. Biol.
, vol.12
, pp. 435-438
-
-
Harris, R.S.1
Sale, J.E.2
Petersen-Mahrt, S.K.3
Neuberger, M.S.4
-
22
-
-
3843120056
-
What functions do linker histones provide?
-
Harvey C.A., and Downs J.A. What functions do linker histones provide?. Mol. Microbiol. 53 (2004) 771-775
-
(2004)
Mol. Microbiol.
, vol.53
, pp. 771-775
-
-
Harvey, C.A.1
Downs, J.A.2
-
23
-
-
0033946934
-
E2A proteins: Essential regulators at multiple stages of B-cell development
-
Kee B.L., Quong M.W., and Murre C. E2A proteins: Essential regulators at multiple stages of B-cell development. Immunol. Rev. 175 (2000) 138-149
-
(2000)
Immunol. Rev.
, vol.175
, pp. 138-149
-
-
Kee, B.L.1
Quong, M.W.2
Murre, C.3
-
24
-
-
0142149019
-
Estimating hypermutation rates from clonal tree data
-
Kleinstein S.H., Louzoun Y., and Shlomchik M.J. Estimating hypermutation rates from clonal tree data. J. Immunol. 171 (2003) 4639-4649
-
(2003)
J. Immunol.
, vol.171
, pp. 4639-4649
-
-
Kleinstein, S.H.1
Louzoun, Y.2
Shlomchik, M.J.3
-
25
-
-
0035839959
-
Mechanisms of chromosomal translocations in B cell lymphomas
-
Kuppers R., and Dalla-Favera R. Mechanisms of chromosomal translocations in B cell lymphomas. Oncogene 20 (2001) 5580-5594
-
(2001)
Oncogene
, vol.20
, pp. 5580-5594
-
-
Kuppers, R.1
Dalla-Favera, R.2
-
26
-
-
0030715354
-
Mutations in the Fas antigen in patients with multiple myeloma
-
Landowski T.H., Qu N., Buyuksal I., Painter J.S., and Dalton W.S. Mutations in the Fas antigen in patients with multiple myeloma. Blood 90 (1997) 4266-4270
-
(1997)
Blood
, vol.90
, pp. 4266-4270
-
-
Landowski, T.H.1
Qu, N.2
Buyuksal, I.3
Painter, J.S.4
Dalton, W.S.5
-
27
-
-
10644229388
-
Methylation protects cytidines from AID-mediated deamination
-
Larijani M., Frieder D., Sonbuchner T.M., Bransteitter R., Goodman M.F., Bouhassira E.E., Scharff M.D., and Martin A. Methylation protects cytidines from AID-mediated deamination. Mol. Immunol. 42 (2005) 599-604
-
(2005)
Mol. Immunol.
, vol.42
, pp. 599-604
-
-
Larijani, M.1
Frieder, D.2
Sonbuchner, T.M.3
Bransteitter, R.4
Goodman, M.F.5
Bouhassira, E.E.6
Scharff, M.D.7
Martin, A.8
-
28
-
-
0025630537
-
Boundaries of somatic mutation in rearranged immunoglobulin genes: 5′ boundary is near the promoter, and 3′ boundary is approximately 1 kb from V(D)J gene
-
Lebecque S.G., and Gearhart P.J. Boundaries of somatic mutation in rearranged immunoglobulin genes: 5′ boundary is near the promoter, and 3′ boundary is approximately 1 kb from V(D)J gene. J. Exp. Med. 172 (1990) 1717-1727
-
(1990)
J. Exp. Med.
, vol.172
, pp. 1717-1727
-
-
Lebecque, S.G.1
Gearhart, P.J.2
-
29
-
-
7444234734
-
Differential regulation of histone acetylation and generation of mutations in switch regions is associated with Ig class switching
-
Li Z., Luo Z., and Scharff M.D. Differential regulation of histone acetylation and generation of mutations in switch regions is associated with Ig class switching. Proc. Natl. Acad. Sci. USA 101 (2004) 15428-15433
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 15428-15433
-
-
Li, Z.1
Luo, Z.2
Scharff, M.D.3
-
30
-
-
33746228114
-
Interchromosomal interactions and olfactory receptor choice
-
Lomvardas S., Barnea G., Pisapia D.J., Mendelsohn M., Kirkland J., and Axel R. Interchromosomal interactions and olfactory receptor choice. Cell 126 (2006) 403-413
-
(2006)
Cell
, vol.126
, pp. 403-413
-
-
Lomvardas, S.1
Barnea, G.2
Pisapia, D.J.3
Mendelsohn, M.4
Kirkland, J.5
Axel, R.6
-
31
-
-
33644636246
-
AID in somatic hypermutation and class switch recombination
-
Longerich S., Basu U., Alt F., and Storb U. AID in somatic hypermutation and class switch recombination. Curr. Opin. Immunol. 18 (2006) 164-174
-
(2006)
Curr. Opin. Immunol.
, vol.18
, pp. 164-174
-
-
Longerich, S.1
Basu, U.2
Alt, F.3
Storb, U.4
-
32
-
-
0037126038
-
Somatic hypermutation of the AID transgene in B and non-B cells
-
Martin A., and Scharff M.D. Somatic hypermutation of the AID transgene in B and non-B cells. Proc. Natl. Acad. Sci. USA 99 (2002) 12304-12308
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 12304-12308
-
-
Martin, A.1
Scharff, M.D.2
-
33
-
-
33745048221
-
Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation
-
McBride K.M., Gazumyan A., Woo E.M., Barreto V.M., Robbiani D.F., Chait B.T., and Nussenzweig M.C. Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation. Proc. Natl. Acad. Sci. USA 103 (2006) 8798-8803
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 8798-8803
-
-
McBride, K.M.1
Gazumyan, A.2
Woo, E.M.3
Barreto, V.M.4
Robbiani, D.F.5
Chait, B.T.6
Nussenzweig, M.C.7
-
34
-
-
0008476550
-
Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin
-
McKean D., Huppi K., Bell M., Staudt L., Gerhard W., and Weigert M. Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin. Proc. Natl. Acad. Sci. USA 81 (1984) 3180-3184
-
(1984)
Proc. Natl. Acad. Sci. USA
, vol.81
, pp. 3180-3184
-
-
McKean, D.1
Huppi, K.2
Bell, M.3
Staudt, L.4
Gerhard, W.5
Weigert, M.6
-
35
-
-
0041931059
-
The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription
-
Michael N., Shen H.M., Longerich S., Kim N., Longacre A., and Storb U. The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription. Immunity 19 (2003) 235-242
-
(2003)
Immunity
, vol.19
, pp. 235-242
-
-
Michael, N.1
Shen, H.M.2
Longerich, S.3
Kim, N.4
Longacre, A.5
Storb, U.6
-
36
-
-
10644282845
-
Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: Implications for epigenetic reprogramming
-
Morgan H.D., Dean W., Coker H.A., Reik W., and Petersen-Mahrt S.K. Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: Implications for epigenetic reprogramming. J. Biol. Chem. 279 (2004) 52353-52360
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 52353-52360
-
-
Morgan, H.D.1
Dean, W.2
Coker, H.A.3
Reik, W.4
Petersen-Mahrt, S.K.5
-
37
-
-
0034268780
-
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
-
Muramatsu M., Kinoshita K., Fagarasan S., Yamada S., Shinkai Y., and Honjo T. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102 (2000) 553-563
-
(2000)
Cell
, vol.102
, pp. 553-563
-
-
Muramatsu, M.1
Kinoshita, K.2
Fagarasan, S.3
Yamada, S.4
Shinkai, Y.5
Honjo, T.6
-
38
-
-
0034684682
-
Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reaction
-
Muschen M., Re D., Jungnickel B., Diehl V., Rajewsky K., and Kuppers R. Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reaction. J. Exp. Med. 192 (2000) 1833-1840
-
(2000)
J. Exp. Med.
, vol.192
, pp. 1833-1840
-
-
Muschen, M.1
Re, D.2
Jungnickel, B.3
Diehl, V.4
Rajewsky, K.5
Kuppers, R.6
-
39
-
-
0346362489
-
Transcription-coupled events associating with immunoglobulin switch region chromatin
-
Nambu Y., Sugai M., Gonda H., Lee C.G., Katakai T., Agata Y., Yokota Y., and Shimizu A. Transcription-coupled events associating with immunoglobulin switch region chromatin. Science 302 (2003) 2137-2140
-
(2003)
Science
, vol.302
, pp. 2137-2140
-
-
Nambu, Y.1
Sugai, M.2
Gonda, H.3
Lee, C.G.4
Katakai, T.5
Agata, Y.6
Yokota, Y.7
Shimizu, A.8
-
40
-
-
33746574474
-
Targeting of somatic hypermutation
-
Odegard V.H., and Schatz D.G. Targeting of somatic hypermutation. Nat. Rev. Immunol. 6 (2006) 573-583
-
(2006)
Nat. Rev. Immunol.
, vol.6
, pp. 573-583
-
-
Odegard, V.H.1
Schatz, D.G.2
-
41
-
-
22544443073
-
Histone modifications associated with somatic hypermutation
-
Odegard V.H., Kim S.T., Anderson S.M., Shlomchik M.J., and Schatz D.G. Histone modifications associated with somatic hypermutation. Immunity 23 (2005) 101-110
-
(2005)
Immunity
, vol.23
, pp. 101-110
-
-
Odegard, V.H.1
Kim, S.T.2
Anderson, S.M.3
Shlomchik, M.J.4
Schatz, D.G.5
-
42
-
-
0037149473
-
The AID enzyme induces class switch recombination in fibroblasts
-
Okazaki I.M., Kinoshita K., Muramatsu M., Yoshikawa K., and Honjo T. The AID enzyme induces class switch recombination in fibroblasts. Nature 416 (2002) 340-345
-
(2002)
Nature
, vol.416
, pp. 340-345
-
-
Okazaki, I.M.1
Kinoshita, K.2
Muramatsu, M.3
Yoshikawa, K.4
Honjo, T.5
-
43
-
-
0034626802
-
Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes
-
Papavasiliou F.N., and Schatz D.G. Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes. Nature 408 (2000) 216-221
-
(2000)
Nature
, vol.408
, pp. 216-221
-
-
Papavasiliou, F.N.1
Schatz, D.G.2
-
44
-
-
33747869927
-
AID mutates a non-immunoglobulin transgene independent of chromosomal position
-
Parsa J.Y., Basit W., Wang C.L., Gommerman J.L., Carlyle J.R., and Martin A. AID mutates a non-immunoglobulin transgene independent of chromosomal position. Mol. Immunol. 44 4 (2007) 567-575
-
(2007)
Mol. Immunol.
, vol.44
, Issue.4
, pp. 567-575
-
-
Parsa, J.Y.1
Basit, W.2
Wang, C.L.3
Gommerman, J.L.4
Carlyle, J.R.5
Martin, A.6
-
45
-
-
13144259651
-
BCL-6 mutations in normal germinal center B cells: Evidence of somatic hypermutation acting outside Ig loci
-
Pasqualucci L., Migliazza A., Fracchiolla N., William C., Neri A., Baldini L., Chaganti R.S., Klein U., Kuppers R., Rajewsky K., and Dalla-Favera R. BCL-6 mutations in normal germinal center B cells: Evidence of somatic hypermutation acting outside Ig loci. Proc. Natl. Acad. Sci. USA 95 (1998) 11816-11821
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 11816-11821
-
-
Pasqualucci, L.1
Migliazza, A.2
Fracchiolla, N.3
William, C.4
Neri, A.5
Baldini, L.6
Chaganti, R.S.7
Klein, U.8
Kuppers, R.9
Rajewsky, K.10
Dalla-Favera, R.11
-
46
-
-
0035913362
-
Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas
-
Pasqualucci L., Neumeister P., Goossens T., Nanjangud G., Chaganti R.S., Kuppers R., and Dalla-Favera R. Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas. Nature 412 (2001) 341-346
-
(2001)
Nature
, vol.412
, pp. 341-346
-
-
Pasqualucci, L.1
Neumeister, P.2
Goossens, T.3
Nanjangud, G.4
Chaganti, R.S.5
Kuppers, R.6
Dalla-Favera, R.7
-
47
-
-
0030063726
-
Somatic hypermutation of immunoglobulin genes is linked to transcription initiation
-
Peters A., and Storb U. Somatic hypermutation of immunoglobulin genes is linked to transcription initiation. Immunity 4 (1996) 57-65
-
(1996)
Immunity
, vol.4
, pp. 57-65
-
-
Peters, A.1
Storb, U.2
-
48
-
-
0037019315
-
AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification
-
Petersen-Mahrt S.K., Harris R.S., and Neuberger M.S. AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature 418 (2002) 99-103
-
(2002)
Nature
, vol.418
, pp. 99-103
-
-
Petersen-Mahrt, S.K.1
Harris, R.S.2
Neuberger, M.S.3
-
49
-
-
0037926476
-
Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation
-
Pham P., Bransteitter R., Petruska J., and Goodman M.F. Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation. Nature 424 (2003) 103-107
-
(2003)
Nature
, vol.424
, pp. 103-107
-
-
Pham, P.1
Bransteitter, R.2
Petruska, J.3
Goodman, M.F.4
-
50
-
-
0033571526
-
E2A activity is induced during B-cell activation to promote immunoglobulin class switch recombination
-
Quong M.W., Harris D.P., Swain S.L., and Murre C. E2A activity is induced during B-cell activation to promote immunoglobulin class switch recombination. EMBO J. 18 (1999) 6307-6318
-
(1999)
EMBO J.
, vol.18
, pp. 6307-6318
-
-
Quong, M.W.1
Harris, D.P.2
Swain, S.L.3
Murre, C.4
-
51
-
-
0035881820
-
The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially
-
Rada C., and Milstein C. The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially. EMBO J. 20 (2001) 4570-4576
-
(2001)
EMBO J.
, vol.20
, pp. 4570-4576
-
-
Rada, C.1
Milstein, C.2
-
52
-
-
0028243803
-
The 5′ boundary of somatic hypermutation in a V kappa gene is in the leader intron
-
Rada C., Gonzalez-Fernandez A., Jarvis J.M., and Milstein C. The 5′ boundary of somatic hypermutation in a V kappa gene is in the leader intron. Eur. J. Immunol. 24 (1994) 1453-1457
-
(1994)
Eur. J. Immunol.
, vol.24
, pp. 1453-1457
-
-
Rada, C.1
Gonzalez-Fernandez, A.2
Jarvis, J.M.3
Milstein, C.4
-
53
-
-
0037108463
-
Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice
-
Rada C., Williams G.T., Nilsen H., Barnes D.E., Lindahl T., and Neuberger M.S. Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice. Curr. Biol. 12 (2002) 1748-1755
-
(2002)
Curr. Biol.
, vol.12
, pp. 1748-1755
-
-
Rada, C.1
Williams, G.T.2
Nilsen, H.3
Barnes, D.E.4
Lindahl, T.5
Neuberger, M.S.6
-
54
-
-
6344256944
-
Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation
-
Rada C., Di Noia J.M., and Neuberger M.S. Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation. Mol. Cell 16 (2004) 163-171
-
(2004)
Mol. Cell
, vol.16
, pp. 163-171
-
-
Rada, C.1
Di Noia, J.M.2
Neuberger, M.S.3
-
55
-
-
0038293484
-
Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand
-
Ramiro A.R., Stavropoulos P., Jankovic M., and Nussenzweig M.C. Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand. Nat. Immunol. 4 (2003) 452-456
-
(2003)
Nat. Immunol.
, vol.4
, pp. 452-456
-
-
Ramiro, A.R.1
Stavropoulos, P.2
Jankovic, M.3
Nussenzweig, M.C.4
-
56
-
-
33644643189
-
Role of genomic instability and p53 in AID-induced c-myc-Igh translocations
-
Ramiro A.R., Jankovic M., Callen E., Difilippantonio S., Chen H.T., McBride K.M., Eisenreich T.R., Chen J., Dickins R.A., Lowe S.W., Nussenzweig A., and Nussenzweig M.C. Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature 440 (2006) 105-109
-
(2006)
Nature
, vol.440
, pp. 105-109
-
-
Ramiro, A.R.1
Jankovic, M.2
Callen, E.3
Difilippantonio, S.4
Chen, H.T.5
McBride, K.M.6
Eisenreich, T.R.7
Chen, J.8
Dickins, R.A.9
Lowe, S.W.10
Nussenzweig, A.11
Nussenzweig, M.C.12
-
57
-
-
0032844742
-
Transcriptional regulation of the Ig kappa gene by promoter-proximal pausing of RNA polymerase II
-
Raschke E.E., Albert T., and Eick D. Transcriptional regulation of the Ig kappa gene by promoter-proximal pausing of RNA polymerase II. J. Immunol. 163 (1999) 4375-4382
-
(1999)
J. Immunol.
, vol.163
, pp. 4375-4382
-
-
Raschke, E.E.1
Albert, T.2
Eick, D.3
-
58
-
-
0034264851
-
Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)
-
Revy P., Muto T., Levy Y., Geissmann F., Plebani A., Sanal O., Catalan N., Forveille M., Dufourcq-Labelouse R., Gennery A., Tezcan I., Ersoy F., et al. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2). Cell 102 (2000) 565-575
-
(2000)
Cell
, vol.102
, pp. 565-575
-
-
Revy, P.1
Muto, T.2
Levy, Y.3
Geissmann, F.4
Plebani, A.5
Sanal, O.6
Catalan, N.7
Forveille, M.8
Dufourcq-Labelouse, R.9
Gennery, A.10
Tezcan, I.11
Ersoy, F.12
-
59
-
-
12344335547
-
Activation-induced cytidine deaminase fails to induce a mutator phenotype in the human pre-B cell line Nalm-6
-
Ruckerl F., and Bachl J. Activation-induced cytidine deaminase fails to induce a mutator phenotype in the human pre-B cell line Nalm-6. Eur. J. Immunol. 35 (2005) 290-298
-
(2005)
Eur. J. Immunol.
, vol.35
, pp. 290-298
-
-
Ruckerl, F.1
Bachl, J.2
-
60
-
-
5144225733
-
Dual reporter system to dissect cis- and trans-effects influencing the mutation rate in a hypermutating cell line
-
Ruckerl F., Mailhammer R., and Bachl J. Dual reporter system to dissect cis- and trans-effects influencing the mutation rate in a hypermutating cell line. Mol. Immunol. 41 (2004) 1135-1143
-
(2004)
Mol. Immunol.
, vol.41
, pp. 1135-1143
-
-
Ruckerl, F.1
Mailhammer, R.2
Bachl, J.3
-
61
-
-
33644543350
-
Episomal vectors to monitor and induce somatic hypermutation in human Burkitt-Lymphoma cell lines
-
Ruckerl F., Busse B., and Bachl J. Episomal vectors to monitor and induce somatic hypermutation in human Burkitt-Lymphoma cell lines. Mol. Immunol. 43 10 (2006) 1645-1652
-
(2006)
Mol. Immunol.
, vol.43
, Issue.10
, pp. 1645-1652
-
-
Ruckerl, F.1
Busse, B.2
Bachl, J.3
-
62
-
-
0022018911
-
Somatic mutation and clonal expansion of B cells in an antigen-driven immune response
-
Sablitzky F., Wildner G., and Rajewsky K. Somatic mutation and clonal expansion of B cells in an antigen-driven immune response. EMBO J. 4 (1985) 345-350
-
(1985)
EMBO J.
, vol.4
, pp. 345-350
-
-
Sablitzky, F.1
Wildner, G.2
Rajewsky, K.3
-
63
-
-
0032435650
-
TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line
-
Sale J.E., and Neuberger M.S. TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line. Immunity 9 (1998) 859-869
-
(1998)
Immunity
, vol.9
, pp. 859-869
-
-
Sale, J.E.1
Neuberger, M.S.2
-
64
-
-
29644440411
-
Uracil DNA glycosylase disruption blocks Ig gene conversion and induces transition mutations
-
Saribasak H., Saribasak N.N., Ipek F.M., Ellwart J.W., Arakawa H., and Buerstedde J.M. Uracil DNA glycosylase disruption blocks Ig gene conversion and induces transition mutations. J. Immunol. 176 (2006) 365-371
-
(2006)
J. Immunol.
, vol.176
, pp. 365-371
-
-
Saribasak, H.1
Saribasak, N.N.2
Ipek, F.M.3
Ellwart, J.W.4
Arakawa, H.5
Buerstedde, J.M.6
-
65
-
-
0038515309
-
E-proteins directly regulate expression of activation-induced deaminase in mature B cells
-
Sayegh C.E., Quong M.W., Agata Y., and Murre C. E-proteins directly regulate expression of activation-induced deaminase in mature B cells. Nat. Immunol. 4 (2003) 586-593
-
(2003)
Nat. Immunol.
, vol.4
, pp. 586-593
-
-
Sayegh, C.E.1
Quong, M.W.2
Agata, Y.3
Murre, C.4
-
66
-
-
33745309534
-
E2A expression stimulates Ig hypermutation
-
Schoetz U., Cervelli M., Wang Y.D., Fiedler P., and Buerstedde J.M. E2A expression stimulates Ig hypermutation. J. Immunol. 177 (2006) 395-400
-
(2006)
J. Immunol.
, vol.177
, pp. 395-400
-
-
Schoetz, U.1
Cervelli, M.2
Wang, Y.D.3
Fiedler, P.4
Buerstedde, J.M.5
-
67
-
-
33747876747
-
Activation-induced cytidine deaminase (AID) is expressed in normal spermatogenesis but only infrequently in testicular germ cell tumours
-
Schreck S., Buettner M., Kremmer E., Bogdan M., Herbst H., and Niedobitek G. Activation-induced cytidine deaminase (AID) is expressed in normal spermatogenesis but only infrequently in testicular germ cell tumours. J. Pathol. 210 1 (2006) 26-31
-
(2006)
J. Pathol.
, vol.210
, Issue.1
, pp. 26-31
-
-
Schreck, S.1
Buettner, M.2
Kremmer, E.3
Bogdan, M.4
Herbst, H.5
Niedobitek, G.6
-
68
-
-
0034307172
-
Dynamic association of capping enzymes with transcribing RNA polymerase II
-
Schroeder S.C., Schwer B., Shuman S., and Bentley D. Dynamic association of capping enzymes with transcribing RNA polymerase II. Genes Dev. 14 (2000) 2435-2440
-
(2000)
Genes Dev.
, vol.14
, pp. 2435-2440
-
-
Schroeder, S.C.1
Schwer, B.2
Shuman, S.3
Bentley, D.4
-
69
-
-
2642623612
-
Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes
-
Shen H.M., Peters A., Baron B., Zhu X., and Storb U. Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes. Science 280 (1998) 1750-1752
-
(1998)
Science
, vol.280
, pp. 1750-1752
-
-
Shen, H.M.1
Peters, A.2
Baron, B.3
Zhu, X.4
Storb, U.5
-
70
-
-
0033898483
-
The TATA binding protein, c-Myc and survivin genes are not somatically hypermutated, while Ig and BCL6 genes are hypermutated in human memory B cells
-
Shen H.M., Michael N., Kim N., and Storb U. The TATA binding protein, c-Myc and survivin genes are not somatically hypermutated, while Ig and BCL6 genes are hypermutated in human memory B cells. Int. Immunol. 12 (2000) 1085-1093
-
(2000)
Int. Immunol.
, vol.12
, pp. 1085-1093
-
-
Shen, H.M.1
Michael, N.2
Kim, N.3
Storb, U.4
-
71
-
-
0034744191
-
The 3′ Igkappa enhancer contains RNA polymerase II promoters: Implications for endogenous and transgenic kappa gene expression
-
Shen H.M., Peters A., Kao D., and Storb U. The 3′ Igkappa enhancer contains RNA polymerase II promoters: Implications for endogenous and transgenic kappa gene expression. Int. Immunol. 13 (2001) 665-674
-
(2001)
Int. Immunol.
, vol.13
, pp. 665-674
-
-
Shen, H.M.1
Peters, A.2
Kao, D.3
Storb, U.4
-
72
-
-
28544447014
-
Targeting of the activation-induced cytosine deaminase is strongly influenced by the sequence and structure of the targeted DNA
-
Shen H.M., Ratnam S., and Storb U. Targeting of the activation-induced cytosine deaminase is strongly influenced by the sequence and structure of the targeted DNA. Mol. Cell. Biol. 25 (2005) 10815-10821
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 10815-10821
-
-
Shen, H.M.1
Ratnam, S.2
Storb, U.3
-
73
-
-
0037901850
-
Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations
-
Sohail A., Klapacz J., Samaranayake M., Ullah A., and Bhagwat A.S. Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations. Nucleic Acids Res. 31 (2003) 2990-2994
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 2990-2994
-
-
Sohail, A.1
Klapacz, J.2
Samaranayake, M.3
Ullah, A.4
Bhagwat, A.S.5
-
74
-
-
20444494936
-
Interchromosomal associations between alternatively expressed loci
-
Spilianakis C.G., Lalioti M.D., Town T., Lee G.R., and Flavell R.A. Interchromosomal associations between alternatively expressed loci. Nature 435 (2005) 637-645
-
(2005)
Nature
, vol.435
, pp. 637-645
-
-
Spilianakis, C.G.1
Lalioti, M.D.2
Town, T.3
Lee, G.R.4
Flavell, R.A.5
-
75
-
-
0031041632
-
The transcriptional promoter regulates hypermutation of the antibody heavy chain locus
-
Tumas-Brundage K., and Manser T. The transcriptional promoter regulates hypermutation of the antibody heavy chain locus. J. Exp. Med. 185 (1997) 239-250
-
(1997)
J. Exp. Med.
, vol.185
, pp. 239-250
-
-
Tumas-Brundage, K.1
Manser, T.2
-
77
-
-
31344445404
-
AID-dependent histone acetylation is detected in immunoglobulin S regions
-
Wang L., Whang N., Wuerffel R., and Kenter A.L. AID-dependent histone acetylation is detected in immunoglobulin S regions. J. Exp. Med. 203 (2006) 215-226
-
(2006)
J. Exp. Med.
, vol.203
, pp. 215-226
-
-
Wang, L.1
Whang, N.2
Wuerffel, R.3
Kenter, A.L.4
-
78
-
-
0030821156
-
Insertion of 2 kb of bacteriophage DNA between an immunoglobulin promoter and leader exon stops somatic hypermutation in a kappa transgene
-
Winter D.B., Sattar N., Mai J.J., and Gearhart P.J. Insertion of 2 kb of bacteriophage DNA between an immunoglobulin promoter and leader exon stops somatic hypermutation in a kappa transgene. Mol. Immunol. 34 (1997) 359-366
-
(1997)
Mol. Immunol.
, vol.34
, pp. 359-366
-
-
Winter, D.B.1
Sattar, N.2
Mai, J.J.3
Gearhart, P.J.4
-
79
-
-
0142188274
-
Induction of somatic hypermutation is associated with modifications in immunoglobulin variable region chromatin
-
Woo C.J., Martin A., and Scharff M.D. Induction of somatic hypermutation is associated with modifications in immunoglobulin variable region chromatin. Immunity 19 (2003) 479-489
-
(2003)
Immunity
, vol.19
, pp. 479-489
-
-
Woo, C.J.1
Martin, A.2
Scharff, M.D.3
-
80
-
-
33845901812
-
Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences
-
Yang S.Y., Fugmann S.D., and Schatz D.G. Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences. J. Exp. Med. 203 13 (2006) 2919-2928
-
(2006)
J. Exp. Med.
, vol.203
, Issue.13
, pp. 2919-2928
-
-
Yang, S.Y.1
Fugmann, S.D.2
Schatz, D.G.3
-
81
-
-
34249787475
-
-
Yang, S. Y., Fugmann, S. D., Gramlich, H. S., and Schatz, D. G. AID-mediated sequence diversification is transiently targeted to newly integrated DNA substrates. (Submitted for publication.)
-
-
-
-
82
-
-
0029067875
-
Targeting of non-Ig sequences in place of the V segment by somatic hypermutation
-
Yelamos J., Klix N., Goyenechea B., Lozano F., Chui Y.L., Gonzalez Fernandez A., Pannell R., Neuberger M.S., and Milstein C. Targeting of non-Ig sequences in place of the V segment by somatic hypermutation. Nature 376 (1995) 225-229
-
(1995)
Nature
, vol.376
, pp. 225-229
-
-
Yelamos, J.1
Klix, N.2
Goyenechea, B.3
Lozano, F.4
Chui, Y.L.5
Gonzalez Fernandez, A.6
Pannell, R.7
Neuberger, M.S.8
Milstein, C.9
-
83
-
-
0037076967
-
AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts
-
Yoshikawa K., Okazaki I.M., Eto T., Kinoshita K., Muramatsu M., Nagaoka H., and Honjo T. AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts. Science 296 (2002) 2033-2036
-
(2002)
Science
, vol.296
, pp. 2033-2036
-
-
Yoshikawa, K.1
Okazaki, I.M.2
Eto, T.3
Kinoshita, K.4
Muramatsu, M.5
Nagaoka, H.6
Honjo, T.7
-
84
-
-
20044396719
-
The dynamic organization of gene-regulatory machinery in nuclear microenvironments
-
Zaidi S.K., Young D.W., Choi J.Y., Pratap J., Javed A., Montecino M., Stein J.L., Van Wijnen A.J., Lian J.B., and Stein G.S. The dynamic organization of gene-regulatory machinery in nuclear microenvironments. EMBO Rep. 6 (2005) 128-133
-
(2005)
EMBO Rep.
, vol.6
, pp. 128-133
-
-
Zaidi, S.K.1
Young, D.W.2
Choi, J.Y.3
Pratap, J.4
Javed, A.5
Montecino, M.6
Stein, J.L.7
Van Wijnen, A.J.8
Lian, J.B.9
Stein, G.S.10
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