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Volumn 94, Issue , 2007, Pages 109-125

Targeting of AID-Mediated Sequence Diversification by cis-Acting Determinants

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; BETA ACTIN; CIS ACTING ELEMENT; CYTIDINE DERIVATIVE; DACTINOMYCIN; DNA; ENHANCED GREEN FLUORESCENT PROTEIN; HISTONE; IMMUNOGLOBULIN; RNA; RNA POLYMERASE II; UNCLASSIFIED DRUG;

EID: 34249810672     PISSN: 00652776     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-2776(06)94004-8     Document Type: Review
Times cited : (23)

References (84)
  • 1
    • 0037083364 scopus 로고    scopus 로고
    • Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion
    • Arakawa H., Hauschild J., and Buerstedde J.M. Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion. Science 295 (2002) 1301-1306
    • (2002) Science , vol.295 , pp. 1301-1306
    • Arakawa, H.1    Hauschild, J.2    Buerstedde, J.M.3
  • 2
    • 0035871625 scopus 로고    scopus 로고
    • Increased transcription levels induce higher mutation rates in a hypermutating cell line
    • Bachl J., Carlson C., Gray-Schopfer V., Dessing M., and Olsson C. Increased transcription levels induce higher mutation rates in a hypermutating cell line. J. Immunol. 166 (2001) 5051-5057
    • (2001) J. Immunol. , vol.166 , pp. 5051-5057
    • Bachl, J.1    Carlson, C.2    Gray-Schopfer, V.3    Dessing, M.4    Olsson, C.5
  • 3
    • 0015814177 scopus 로고
    • Mutations in immunoglobulin-producing mouse myeloma cells
    • Baumal R., Birshtein B.K., Coffino P., and Scharff M.D. Mutations in immunoglobulin-producing mouse myeloma cells. Science 182 (1973) 164-166
    • (1973) Science , vol.182 , pp. 164-166
    • Baumal, R.1    Birshtein, B.K.2    Coffino, P.3    Scharff, M.D.4
  • 4
    • 19344378943 scopus 로고    scopus 로고
    • Rules of engagement: Co-transcriptional recruitment of pre-mRNA processing factors
    • Bentley D.L. Rules of engagement: Co-transcriptional recruitment of pre-mRNA processing factors. Curr. Opin. Cell Biol. 17 (2005) 251-256
    • (2005) Curr. Opin. Cell Biol. , vol.17 , pp. 251-256
    • Bentley, D.L.1
  • 5
    • 33646862623 scopus 로고    scopus 로고
    • The transcription elongation complex directs activation-induced cytidine deaminase-mediated DNA deamination
    • Besmer E., Market E., and Papavasiliou F.N. The transcription elongation complex directs activation-induced cytidine deaminase-mediated DNA deamination. Mol. Cell. Biol. 26 (2006) 4378-4385
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 4378-4385
    • Besmer, E.1    Market, E.2    Papavasiliou, F.N.3
  • 6
    • 0028270307 scopus 로고
    • Elements regulating somatic hypermutation of an immunoglobulin kappa gene: Critical role for the intron enhancer/matrix attachment region
    • Betz A.G., Milstein C., Gonzalez-Fernandez A., Pannell R., Larson T., and Neuberger M.S. Elements regulating somatic hypermutation of an immunoglobulin kappa gene: Critical role for the intron enhancer/matrix attachment region. Cell 77 (1994) 239-248
    • (1994) Cell , vol.77 , pp. 239-248
    • Betz, A.G.1    Milstein, C.2    Gonzalez-Fernandez, A.3    Pannell, R.4    Larson, T.5    Neuberger, M.S.6
  • 7
    • 0027952630 scopus 로고
    • S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process
    • Bottaro A., Lansford R., Xu L., Zhang J., Rothman P., and Alt F.W. S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process. EMBO J. 13 (1994) 665-674
    • (1994) EMBO J. , vol.13 , pp. 665-674
    • Bottaro, A.1    Lansford, R.2    Xu, L.3    Zhang, J.4    Rothman, P.5    Alt, F.W.6
  • 8
    • 0037452080 scopus 로고    scopus 로고
    • Transcription-targeted DNA deamination by the AID antibody diversification enzyme
    • Chaudhuri J., Tian M., Khuong C., Chua K., Pinaud E., and Alt F.W. Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature 422 (2003) 726-730
    • (2003) Nature , vol.422 , pp. 726-730
    • Chaudhuri, J.1    Tian, M.2    Khuong, C.3    Chua, K.4    Pinaud, E.5    Alt, F.W.6
  • 9
    • 30944469861 scopus 로고    scopus 로고
    • The chicken Ig light chain 3′-enhancer is essential for gene expression and regulates gene conversion via the transcription factor E2A
    • Conlon T.M., and Meyer K.B. The chicken Ig light chain 3′-enhancer is essential for gene expression and regulates gene conversion via the transcription factor E2A. Eur. J. Immunol. 36 (2006) 139-148
    • (2006) Eur. J. Immunol. , vol.36 , pp. 139-148
    • Conlon, T.M.1    Meyer, K.B.2
  • 10
    • 0037026482 scopus 로고    scopus 로고
    • Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase
    • Di Noia J., and Neuberger M.S. Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase. Nature 419 (2002) 43-48
    • (2002) Nature , vol.419 , pp. 43-48
    • Di Noia, J.1    Neuberger, M.S.2
  • 11
    • 1642345456 scopus 로고    scopus 로고
    • Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID-mediated deoxycytidine deamination
    • Di Noia J.M., and Neuberger M.S. Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID-mediated deoxycytidine deamination. Eur. J. Immunol. 34 (2004) 504-508
    • (2004) Eur. J. Immunol. , vol.34 , pp. 504-508
    • Di Noia, J.M.1    Neuberger, M.S.2
  • 12
    • 32544439248 scopus 로고    scopus 로고
    • SMUG1 is able to excise uracil from immunoglobulin genes: Insight into mutation versus repair
    • Di Noia J.M., Rada C., and Neuberger M.S. SMUG1 is able to excise uracil from immunoglobulin genes: Insight into mutation versus repair. EMBO J. 25 (2006) 585-595
    • (2006) EMBO J. , vol.25 , pp. 585-595
    • Di Noia, J.M.1    Rada, C.2    Neuberger, M.S.3
  • 13
    • 0037561998 scopus 로고    scopus 로고
    • AID mediates hypermutation by deaminating single stranded DNA
    • Dickerson S.K., Market E., Besmer E., and Papavasiliou F.N. AID mediates hypermutation by deaminating single stranded DNA. J. Exp. Med. 197 (2003) 1291-1296
    • (2003) J. Exp. Med. , vol.197 , pp. 1291-1296
    • Dickerson, S.K.1    Market, E.2    Besmer, E.3    Papavasiliou, F.N.4
  • 16
    • 0032127810 scopus 로고    scopus 로고
    • Somatic hypermutation in the heavy chain locus correlates with transcription
    • Fukita Y., Jacobs H., and Rajewsky K. Somatic hypermutation in the heavy chain locus correlates with transcription. Immunity 9 (1998) 105-114
    • (1998) Immunity , vol.9 , pp. 105-114
    • Fukita, Y.1    Jacobs, H.2    Rajewsky, K.3
  • 17
    • 0030221916 scopus 로고    scopus 로고
    • Involvement of the E2A basic helix-loop-helix protein in immunoglobulin heavy chain class switching
    • Goldfarb A.N., Flores J.P., and Lewandowska K. Involvement of the E2A basic helix-loop-helix protein in immunoglobulin heavy chain class switching. Mol. Immunol. 33 (1996) 947-956
    • (1996) Mol. Immunol. , vol.33 , pp. 947-956
    • Goldfarb, A.N.1    Flores, J.P.2    Lewandowska, K.3
  • 18
    • 0037388211 scopus 로고    scopus 로고
    • Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a)
    • Gordon M.S., Kanegai C.M., Doerr J.R., and Wall R. Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a). Proc. Natl. Acad. Sci. USA 100 (2003) 4126-4131
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 4126-4131
    • Gordon, M.S.1    Kanegai, C.M.2    Doerr, J.R.3    Wall, R.4
  • 19
    • 33744967284 scopus 로고    scopus 로고
    • A role for activation-induced cytidine deaminase in the host response against a transforming retrovirus
    • Gourzi P., Leonova T., and Papavasiliou F.N. A role for activation-induced cytidine deaminase in the host response against a transforming retrovirus. Immunity 24 (2006) 779-786
    • (2006) Immunity , vol.24 , pp. 779-786
    • Gourzi, P.1    Leonova, T.2    Papavasiliou, F.N.3
  • 20
    • 8544241736 scopus 로고    scopus 로고
    • Retroviral restriction by APOBEC proteins
    • Harris R.S., and Liddament M.T. Retroviral restriction by APOBEC proteins. Nat. Rev. Immunol. 4 (2004) 868-877
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 868-877
    • Harris, R.S.1    Liddament, M.T.2
  • 21
    • 0037022540 scopus 로고    scopus 로고
    • AID is essential for immunoglobulin V gene conversion in a cultured B cell line
    • Harris R.S., Sale J.E., Petersen-Mahrt S.K., and Neuberger M.S. AID is essential for immunoglobulin V gene conversion in a cultured B cell line. Curr. Biol. 12 (2002) 435-438
    • (2002) Curr. Biol. , vol.12 , pp. 435-438
    • Harris, R.S.1    Sale, J.E.2    Petersen-Mahrt, S.K.3    Neuberger, M.S.4
  • 22
    • 3843120056 scopus 로고    scopus 로고
    • What functions do linker histones provide?
    • Harvey C.A., and Downs J.A. What functions do linker histones provide?. Mol. Microbiol. 53 (2004) 771-775
    • (2004) Mol. Microbiol. , vol.53 , pp. 771-775
    • Harvey, C.A.1    Downs, J.A.2
  • 23
    • 0033946934 scopus 로고    scopus 로고
    • E2A proteins: Essential regulators at multiple stages of B-cell development
    • Kee B.L., Quong M.W., and Murre C. E2A proteins: Essential regulators at multiple stages of B-cell development. Immunol. Rev. 175 (2000) 138-149
    • (2000) Immunol. Rev. , vol.175 , pp. 138-149
    • Kee, B.L.1    Quong, M.W.2    Murre, C.3
  • 24
    • 0142149019 scopus 로고    scopus 로고
    • Estimating hypermutation rates from clonal tree data
    • Kleinstein S.H., Louzoun Y., and Shlomchik M.J. Estimating hypermutation rates from clonal tree data. J. Immunol. 171 (2003) 4639-4649
    • (2003) J. Immunol. , vol.171 , pp. 4639-4649
    • Kleinstein, S.H.1    Louzoun, Y.2    Shlomchik, M.J.3
  • 25
    • 0035839959 scopus 로고    scopus 로고
    • Mechanisms of chromosomal translocations in B cell lymphomas
    • Kuppers R., and Dalla-Favera R. Mechanisms of chromosomal translocations in B cell lymphomas. Oncogene 20 (2001) 5580-5594
    • (2001) Oncogene , vol.20 , pp. 5580-5594
    • Kuppers, R.1    Dalla-Favera, R.2
  • 26
    • 0030715354 scopus 로고    scopus 로고
    • Mutations in the Fas antigen in patients with multiple myeloma
    • Landowski T.H., Qu N., Buyuksal I., Painter J.S., and Dalton W.S. Mutations in the Fas antigen in patients with multiple myeloma. Blood 90 (1997) 4266-4270
    • (1997) Blood , vol.90 , pp. 4266-4270
    • Landowski, T.H.1    Qu, N.2    Buyuksal, I.3    Painter, J.S.4    Dalton, W.S.5
  • 28
    • 0025630537 scopus 로고
    • Boundaries of somatic mutation in rearranged immunoglobulin genes: 5′ boundary is near the promoter, and 3′ boundary is approximately 1 kb from V(D)J gene
    • Lebecque S.G., and Gearhart P.J. Boundaries of somatic mutation in rearranged immunoglobulin genes: 5′ boundary is near the promoter, and 3′ boundary is approximately 1 kb from V(D)J gene. J. Exp. Med. 172 (1990) 1717-1727
    • (1990) J. Exp. Med. , vol.172 , pp. 1717-1727
    • Lebecque, S.G.1    Gearhart, P.J.2
  • 29
    • 7444234734 scopus 로고    scopus 로고
    • Differential regulation of histone acetylation and generation of mutations in switch regions is associated with Ig class switching
    • Li Z., Luo Z., and Scharff M.D. Differential regulation of histone acetylation and generation of mutations in switch regions is associated with Ig class switching. Proc. Natl. Acad. Sci. USA 101 (2004) 15428-15433
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 15428-15433
    • Li, Z.1    Luo, Z.2    Scharff, M.D.3
  • 31
    • 33644636246 scopus 로고    scopus 로고
    • AID in somatic hypermutation and class switch recombination
    • Longerich S., Basu U., Alt F., and Storb U. AID in somatic hypermutation and class switch recombination. Curr. Opin. Immunol. 18 (2006) 164-174
    • (2006) Curr. Opin. Immunol. , vol.18 , pp. 164-174
    • Longerich, S.1    Basu, U.2    Alt, F.3    Storb, U.4
  • 32
    • 0037126038 scopus 로고    scopus 로고
    • Somatic hypermutation of the AID transgene in B and non-B cells
    • Martin A., and Scharff M.D. Somatic hypermutation of the AID transgene in B and non-B cells. Proc. Natl. Acad. Sci. USA 99 (2002) 12304-12308
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 12304-12308
    • Martin, A.1    Scharff, M.D.2
  • 34
    • 0008476550 scopus 로고
    • Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin
    • McKean D., Huppi K., Bell M., Staudt L., Gerhard W., and Weigert M. Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin. Proc. Natl. Acad. Sci. USA 81 (1984) 3180-3184
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , pp. 3180-3184
    • McKean, D.1    Huppi, K.2    Bell, M.3    Staudt, L.4    Gerhard, W.5    Weigert, M.6
  • 35
    • 0041931059 scopus 로고    scopus 로고
    • The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription
    • Michael N., Shen H.M., Longerich S., Kim N., Longacre A., and Storb U. The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription. Immunity 19 (2003) 235-242
    • (2003) Immunity , vol.19 , pp. 235-242
    • Michael, N.1    Shen, H.M.2    Longerich, S.3    Kim, N.4    Longacre, A.5    Storb, U.6
  • 36
    • 10644282845 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: Implications for epigenetic reprogramming
    • Morgan H.D., Dean W., Coker H.A., Reik W., and Petersen-Mahrt S.K. Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: Implications for epigenetic reprogramming. J. Biol. Chem. 279 (2004) 52353-52360
    • (2004) J. Biol. Chem. , vol.279 , pp. 52353-52360
    • Morgan, H.D.1    Dean, W.2    Coker, H.A.3    Reik, W.4    Petersen-Mahrt, S.K.5
  • 37
    • 0034268780 scopus 로고    scopus 로고
    • Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    • Muramatsu M., Kinoshita K., Fagarasan S., Yamada S., Shinkai Y., and Honjo T. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102 (2000) 553-563
    • (2000) Cell , vol.102 , pp. 553-563
    • Muramatsu, M.1    Kinoshita, K.2    Fagarasan, S.3    Yamada, S.4    Shinkai, Y.5    Honjo, T.6
  • 38
    • 0034684682 scopus 로고    scopus 로고
    • Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reaction
    • Muschen M., Re D., Jungnickel B., Diehl V., Rajewsky K., and Kuppers R. Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reaction. J. Exp. Med. 192 (2000) 1833-1840
    • (2000) J. Exp. Med. , vol.192 , pp. 1833-1840
    • Muschen, M.1    Re, D.2    Jungnickel, B.3    Diehl, V.4    Rajewsky, K.5    Kuppers, R.6
  • 39
    • 0346362489 scopus 로고    scopus 로고
    • Transcription-coupled events associating with immunoglobulin switch region chromatin
    • Nambu Y., Sugai M., Gonda H., Lee C.G., Katakai T., Agata Y., Yokota Y., and Shimizu A. Transcription-coupled events associating with immunoglobulin switch region chromatin. Science 302 (2003) 2137-2140
    • (2003) Science , vol.302 , pp. 2137-2140
    • Nambu, Y.1    Sugai, M.2    Gonda, H.3    Lee, C.G.4    Katakai, T.5    Agata, Y.6    Yokota, Y.7    Shimizu, A.8
  • 40
    • 33746574474 scopus 로고    scopus 로고
    • Targeting of somatic hypermutation
    • Odegard V.H., and Schatz D.G. Targeting of somatic hypermutation. Nat. Rev. Immunol. 6 (2006) 573-583
    • (2006) Nat. Rev. Immunol. , vol.6 , pp. 573-583
    • Odegard, V.H.1    Schatz, D.G.2
  • 42
    • 0037149473 scopus 로고    scopus 로고
    • The AID enzyme induces class switch recombination in fibroblasts
    • Okazaki I.M., Kinoshita K., Muramatsu M., Yoshikawa K., and Honjo T. The AID enzyme induces class switch recombination in fibroblasts. Nature 416 (2002) 340-345
    • (2002) Nature , vol.416 , pp. 340-345
    • Okazaki, I.M.1    Kinoshita, K.2    Muramatsu, M.3    Yoshikawa, K.4    Honjo, T.5
  • 43
    • 0034626802 scopus 로고    scopus 로고
    • Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes
    • Papavasiliou F.N., and Schatz D.G. Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes. Nature 408 (2000) 216-221
    • (2000) Nature , vol.408 , pp. 216-221
    • Papavasiliou, F.N.1    Schatz, D.G.2
  • 44
    • 33747869927 scopus 로고    scopus 로고
    • AID mutates a non-immunoglobulin transgene independent of chromosomal position
    • Parsa J.Y., Basit W., Wang C.L., Gommerman J.L., Carlyle J.R., and Martin A. AID mutates a non-immunoglobulin transgene independent of chromosomal position. Mol. Immunol. 44 4 (2007) 567-575
    • (2007) Mol. Immunol. , vol.44 , Issue.4 , pp. 567-575
    • Parsa, J.Y.1    Basit, W.2    Wang, C.L.3    Gommerman, J.L.4    Carlyle, J.R.5    Martin, A.6
  • 47
    • 0030063726 scopus 로고    scopus 로고
    • Somatic hypermutation of immunoglobulin genes is linked to transcription initiation
    • Peters A., and Storb U. Somatic hypermutation of immunoglobulin genes is linked to transcription initiation. Immunity 4 (1996) 57-65
    • (1996) Immunity , vol.4 , pp. 57-65
    • Peters, A.1    Storb, U.2
  • 48
    • 0037019315 scopus 로고    scopus 로고
    • AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification
    • Petersen-Mahrt S.K., Harris R.S., and Neuberger M.S. AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature 418 (2002) 99-103
    • (2002) Nature , vol.418 , pp. 99-103
    • Petersen-Mahrt, S.K.1    Harris, R.S.2    Neuberger, M.S.3
  • 49
    • 0037926476 scopus 로고    scopus 로고
    • Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation
    • Pham P., Bransteitter R., Petruska J., and Goodman M.F. Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation. Nature 424 (2003) 103-107
    • (2003) Nature , vol.424 , pp. 103-107
    • Pham, P.1    Bransteitter, R.2    Petruska, J.3    Goodman, M.F.4
  • 50
    • 0033571526 scopus 로고    scopus 로고
    • E2A activity is induced during B-cell activation to promote immunoglobulin class switch recombination
    • Quong M.W., Harris D.P., Swain S.L., and Murre C. E2A activity is induced during B-cell activation to promote immunoglobulin class switch recombination. EMBO J. 18 (1999) 6307-6318
    • (1999) EMBO J. , vol.18 , pp. 6307-6318
    • Quong, M.W.1    Harris, D.P.2    Swain, S.L.3    Murre, C.4
  • 51
    • 0035881820 scopus 로고    scopus 로고
    • The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially
    • Rada C., and Milstein C. The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially. EMBO J. 20 (2001) 4570-4576
    • (2001) EMBO J. , vol.20 , pp. 4570-4576
    • Rada, C.1    Milstein, C.2
  • 52
    • 0028243803 scopus 로고
    • The 5′ boundary of somatic hypermutation in a V kappa gene is in the leader intron
    • Rada C., Gonzalez-Fernandez A., Jarvis J.M., and Milstein C. The 5′ boundary of somatic hypermutation in a V kappa gene is in the leader intron. Eur. J. Immunol. 24 (1994) 1453-1457
    • (1994) Eur. J. Immunol. , vol.24 , pp. 1453-1457
    • Rada, C.1    Gonzalez-Fernandez, A.2    Jarvis, J.M.3    Milstein, C.4
  • 53
    • 0037108463 scopus 로고    scopus 로고
    • Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice
    • Rada C., Williams G.T., Nilsen H., Barnes D.E., Lindahl T., and Neuberger M.S. Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice. Curr. Biol. 12 (2002) 1748-1755
    • (2002) Curr. Biol. , vol.12 , pp. 1748-1755
    • Rada, C.1    Williams, G.T.2    Nilsen, H.3    Barnes, D.E.4    Lindahl, T.5    Neuberger, M.S.6
  • 54
    • 6344256944 scopus 로고    scopus 로고
    • Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation
    • Rada C., Di Noia J.M., and Neuberger M.S. Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation. Mol. Cell 16 (2004) 163-171
    • (2004) Mol. Cell , vol.16 , pp. 163-171
    • Rada, C.1    Di Noia, J.M.2    Neuberger, M.S.3
  • 55
    • 0038293484 scopus 로고    scopus 로고
    • Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand
    • Ramiro A.R., Stavropoulos P., Jankovic M., and Nussenzweig M.C. Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand. Nat. Immunol. 4 (2003) 452-456
    • (2003) Nat. Immunol. , vol.4 , pp. 452-456
    • Ramiro, A.R.1    Stavropoulos, P.2    Jankovic, M.3    Nussenzweig, M.C.4
  • 57
    • 0032844742 scopus 로고    scopus 로고
    • Transcriptional regulation of the Ig kappa gene by promoter-proximal pausing of RNA polymerase II
    • Raschke E.E., Albert T., and Eick D. Transcriptional regulation of the Ig kappa gene by promoter-proximal pausing of RNA polymerase II. J. Immunol. 163 (1999) 4375-4382
    • (1999) J. Immunol. , vol.163 , pp. 4375-4382
    • Raschke, E.E.1    Albert, T.2    Eick, D.3
  • 59
    • 12344335547 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase fails to induce a mutator phenotype in the human pre-B cell line Nalm-6
    • Ruckerl F., and Bachl J. Activation-induced cytidine deaminase fails to induce a mutator phenotype in the human pre-B cell line Nalm-6. Eur. J. Immunol. 35 (2005) 290-298
    • (2005) Eur. J. Immunol. , vol.35 , pp. 290-298
    • Ruckerl, F.1    Bachl, J.2
  • 60
    • 5144225733 scopus 로고    scopus 로고
    • Dual reporter system to dissect cis- and trans-effects influencing the mutation rate in a hypermutating cell line
    • Ruckerl F., Mailhammer R., and Bachl J. Dual reporter system to dissect cis- and trans-effects influencing the mutation rate in a hypermutating cell line. Mol. Immunol. 41 (2004) 1135-1143
    • (2004) Mol. Immunol. , vol.41 , pp. 1135-1143
    • Ruckerl, F.1    Mailhammer, R.2    Bachl, J.3
  • 61
    • 33644543350 scopus 로고    scopus 로고
    • Episomal vectors to monitor and induce somatic hypermutation in human Burkitt-Lymphoma cell lines
    • Ruckerl F., Busse B., and Bachl J. Episomal vectors to monitor and induce somatic hypermutation in human Burkitt-Lymphoma cell lines. Mol. Immunol. 43 10 (2006) 1645-1652
    • (2006) Mol. Immunol. , vol.43 , Issue.10 , pp. 1645-1652
    • Ruckerl, F.1    Busse, B.2    Bachl, J.3
  • 62
    • 0022018911 scopus 로고
    • Somatic mutation and clonal expansion of B cells in an antigen-driven immune response
    • Sablitzky F., Wildner G., and Rajewsky K. Somatic mutation and clonal expansion of B cells in an antigen-driven immune response. EMBO J. 4 (1985) 345-350
    • (1985) EMBO J. , vol.4 , pp. 345-350
    • Sablitzky, F.1    Wildner, G.2    Rajewsky, K.3
  • 63
    • 0032435650 scopus 로고    scopus 로고
    • TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line
    • Sale J.E., and Neuberger M.S. TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line. Immunity 9 (1998) 859-869
    • (1998) Immunity , vol.9 , pp. 859-869
    • Sale, J.E.1    Neuberger, M.S.2
  • 64
  • 65
    • 0038515309 scopus 로고    scopus 로고
    • E-proteins directly regulate expression of activation-induced deaminase in mature B cells
    • Sayegh C.E., Quong M.W., Agata Y., and Murre C. E-proteins directly regulate expression of activation-induced deaminase in mature B cells. Nat. Immunol. 4 (2003) 586-593
    • (2003) Nat. Immunol. , vol.4 , pp. 586-593
    • Sayegh, C.E.1    Quong, M.W.2    Agata, Y.3    Murre, C.4
  • 67
    • 33747876747 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase (AID) is expressed in normal spermatogenesis but only infrequently in testicular germ cell tumours
    • Schreck S., Buettner M., Kremmer E., Bogdan M., Herbst H., and Niedobitek G. Activation-induced cytidine deaminase (AID) is expressed in normal spermatogenesis but only infrequently in testicular germ cell tumours. J. Pathol. 210 1 (2006) 26-31
    • (2006) J. Pathol. , vol.210 , Issue.1 , pp. 26-31
    • Schreck, S.1    Buettner, M.2    Kremmer, E.3    Bogdan, M.4    Herbst, H.5    Niedobitek, G.6
  • 68
    • 0034307172 scopus 로고    scopus 로고
    • Dynamic association of capping enzymes with transcribing RNA polymerase II
    • Schroeder S.C., Schwer B., Shuman S., and Bentley D. Dynamic association of capping enzymes with transcribing RNA polymerase II. Genes Dev. 14 (2000) 2435-2440
    • (2000) Genes Dev. , vol.14 , pp. 2435-2440
    • Schroeder, S.C.1    Schwer, B.2    Shuman, S.3    Bentley, D.4
  • 69
    • 2642623612 scopus 로고    scopus 로고
    • Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes
    • Shen H.M., Peters A., Baron B., Zhu X., and Storb U. Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes. Science 280 (1998) 1750-1752
    • (1998) Science , vol.280 , pp. 1750-1752
    • Shen, H.M.1    Peters, A.2    Baron, B.3    Zhu, X.4    Storb, U.5
  • 70
    • 0033898483 scopus 로고    scopus 로고
    • The TATA binding protein, c-Myc and survivin genes are not somatically hypermutated, while Ig and BCL6 genes are hypermutated in human memory B cells
    • Shen H.M., Michael N., Kim N., and Storb U. The TATA binding protein, c-Myc and survivin genes are not somatically hypermutated, while Ig and BCL6 genes are hypermutated in human memory B cells. Int. Immunol. 12 (2000) 1085-1093
    • (2000) Int. Immunol. , vol.12 , pp. 1085-1093
    • Shen, H.M.1    Michael, N.2    Kim, N.3    Storb, U.4
  • 71
    • 0034744191 scopus 로고    scopus 로고
    • The 3′ Igkappa enhancer contains RNA polymerase II promoters: Implications for endogenous and transgenic kappa gene expression
    • Shen H.M., Peters A., Kao D., and Storb U. The 3′ Igkappa enhancer contains RNA polymerase II promoters: Implications for endogenous and transgenic kappa gene expression. Int. Immunol. 13 (2001) 665-674
    • (2001) Int. Immunol. , vol.13 , pp. 665-674
    • Shen, H.M.1    Peters, A.2    Kao, D.3    Storb, U.4
  • 72
    • 28544447014 scopus 로고    scopus 로고
    • Targeting of the activation-induced cytosine deaminase is strongly influenced by the sequence and structure of the targeted DNA
    • Shen H.M., Ratnam S., and Storb U. Targeting of the activation-induced cytosine deaminase is strongly influenced by the sequence and structure of the targeted DNA. Mol. Cell. Biol. 25 (2005) 10815-10821
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 10815-10821
    • Shen, H.M.1    Ratnam, S.2    Storb, U.3
  • 73
    • 0037901850 scopus 로고    scopus 로고
    • Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations
    • Sohail A., Klapacz J., Samaranayake M., Ullah A., and Bhagwat A.S. Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations. Nucleic Acids Res. 31 (2003) 2990-2994
    • (2003) Nucleic Acids Res. , vol.31 , pp. 2990-2994
    • Sohail, A.1    Klapacz, J.2    Samaranayake, M.3    Ullah, A.4    Bhagwat, A.S.5
  • 74
    • 20444494936 scopus 로고    scopus 로고
    • Interchromosomal associations between alternatively expressed loci
    • Spilianakis C.G., Lalioti M.D., Town T., Lee G.R., and Flavell R.A. Interchromosomal associations between alternatively expressed loci. Nature 435 (2005) 637-645
    • (2005) Nature , vol.435 , pp. 637-645
    • Spilianakis, C.G.1    Lalioti, M.D.2    Town, T.3    Lee, G.R.4    Flavell, R.A.5
  • 75
    • 0031041632 scopus 로고    scopus 로고
    • The transcriptional promoter regulates hypermutation of the antibody heavy chain locus
    • Tumas-Brundage K., and Manser T. The transcriptional promoter regulates hypermutation of the antibody heavy chain locus. J. Exp. Med. 185 (1997) 239-250
    • (1997) J. Exp. Med. , vol.185 , pp. 239-250
    • Tumas-Brundage, K.1    Manser, T.2
  • 77
    • 31344445404 scopus 로고    scopus 로고
    • AID-dependent histone acetylation is detected in immunoglobulin S regions
    • Wang L., Whang N., Wuerffel R., and Kenter A.L. AID-dependent histone acetylation is detected in immunoglobulin S regions. J. Exp. Med. 203 (2006) 215-226
    • (2006) J. Exp. Med. , vol.203 , pp. 215-226
    • Wang, L.1    Whang, N.2    Wuerffel, R.3    Kenter, A.L.4
  • 78
    • 0030821156 scopus 로고    scopus 로고
    • Insertion of 2 kb of bacteriophage DNA between an immunoglobulin promoter and leader exon stops somatic hypermutation in a kappa transgene
    • Winter D.B., Sattar N., Mai J.J., and Gearhart P.J. Insertion of 2 kb of bacteriophage DNA between an immunoglobulin promoter and leader exon stops somatic hypermutation in a kappa transgene. Mol. Immunol. 34 (1997) 359-366
    • (1997) Mol. Immunol. , vol.34 , pp. 359-366
    • Winter, D.B.1    Sattar, N.2    Mai, J.J.3    Gearhart, P.J.4
  • 79
    • 0142188274 scopus 로고    scopus 로고
    • Induction of somatic hypermutation is associated with modifications in immunoglobulin variable region chromatin
    • Woo C.J., Martin A., and Scharff M.D. Induction of somatic hypermutation is associated with modifications in immunoglobulin variable region chromatin. Immunity 19 (2003) 479-489
    • (2003) Immunity , vol.19 , pp. 479-489
    • Woo, C.J.1    Martin, A.2    Scharff, M.D.3
  • 80
    • 33845901812 scopus 로고    scopus 로고
    • Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences
    • Yang S.Y., Fugmann S.D., and Schatz D.G. Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences. J. Exp. Med. 203 13 (2006) 2919-2928
    • (2006) J. Exp. Med. , vol.203 , Issue.13 , pp. 2919-2928
    • Yang, S.Y.1    Fugmann, S.D.2    Schatz, D.G.3
  • 81
    • 34249787475 scopus 로고    scopus 로고
    • Yang, S. Y., Fugmann, S. D., Gramlich, H. S., and Schatz, D. G. AID-mediated sequence diversification is transiently targeted to newly integrated DNA substrates. (Submitted for publication.)


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