Insertion of 2 kb of bacteriophage dna between an immunoglobulin promoter and leader exon stops somatic hypermutation in a κ transgene

Molecular Immunology

Volumn 34, Issue 5, 1997, Pages 359-366

  Winter, David B ^a,b   Sattar, Nasreen ^a   Mai, Jia Jia ^a   Gearhart, Patricia J ^a,b  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

transgene; Procaryotic insert; Promoter; Somatic hypermutation

Indexed keywords

BACTERIOPHAGE DNA; RNA;

ADOLESCENT; ANIMAL CELL; ARTICLE; B LYMPHOCYTE; EXON; GENE INSERTION; GENE MUTATION; IMMUNOGLOBULIN GENE; MOUSE; MUTATION RATE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SOMATIC MUTATION; TRANSGENE; TRANSGENIC MOUSE;

ANIMALS; BACTERIOPHAGE LAMBDA; BASE COMPOSITION; DNA, VIRAL; EXONS; GENES, IMMUNOGLOBULIN; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MICE; MICE, TRANSGENIC; MUTAGENESIS, INSERTIONAL; MUTATION; PROMOTER REGIONS (GENETICS); SEQUENCE DELETION; TRANSCRIPTION, GENETIC; TRANSGENES;

ANIMALIA; BACTERIOPHAGE LAMBDA; MUS MUSCULUS; PROKARYOTA;

EID: 0030821156     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(97)00073-4     Document Type: Article

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