Adaptations of intestinal macrophages to an antigen-rich environment

Seminars in Immunology

Volumn 19, Issue 2, 2007, Pages 84-93

  Schenk, Mirjam ^a   Mueller, Christoph ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Functional adaptations; Inflammation; Macrophages; Mucosal immunity

Indexed keywords

CELL COMPOSITION; ENTERITIS; EVOLUTIONARY ADAPTATION; HUMAN; IMMUNE SYSTEM; INTESTINE FLORA; INTESTINE FUNCTION; INTESTINE MUCOSA; LAMINA PROPRIA; MACROPHAGE; MONOCYTE; NONHUMAN; PATHOGENESIS; PHENOTYPE; REVIEW;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; ANTIGENS, CD14; BACTERIA; BACTERIAL PHYSIOLOGY; HUMANS; INFLAMMATORY BOWEL DISEASES; INTESTINAL MUCOSA; INTESTINES; MACROPHAGES; PARTICULATE MATTER; RECEPTORS, FC; TOLL-LIKE RECEPTOR 4;

EID: 34249337149     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.smim.2006.09.002     Document Type: Review

References (100)

1. Macpherson A.J., and Harris N.L. Interactions between commensal intestinal bacteria and the immune system. Nat Rev Immunol 4 (2004) 478-485
2. Madara J.L., Nash S., Moore R., and Atisook K. Structure and function of the intestinal epithelial barrier in health and disease. Monogr Pathol (1990) 306-324
3. Frey A., et al. Role of the glycocalyx in regulating access of microparticles to apical plasma membranes of intestinal epithelial cells: implications for microbial attachment and oral vaccine targeting. J Exp Med 184 (1996) 1045-1059
4. Corfield A.P., et al. Mucins and mucosal protection in the gastrointestinal tract: new prospects for mucins in the pathology of gastrointestinal disease. Gut 47 (2000) 589-594
5. Boman H.G. Innate immunity and the normal microflora. Immunol Rev 173 (2000) 5-16
6. Kaetzel C.S., Robinson J.K., Chintalacharuvu K.R., Vaerman J.P., and Lamm M.E. The polymeric immunoglobulin receptor (secretory component) mediates transport of immune complexes across epithelial cells: a local defense function for IgA. Proc Natl Acad Sci USA 88 (1991) 8796-8800
7. Crottet P., and Corthesy B. Secretory component delays the conversion of secretory IgA into antigen-binding competent F(ab′)2: a possible implication for mucosal defense. J Immunol 161 (1998) 5445-5453
8. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389 (1997) 737-742
9. Pennington D.J., et al. The inter-relatedness and interdependence of mouse T cell receptor gammadelta+ and alphabeta+ cells. Nat Immunol 4 (2003) 991-998
10. Saurer L., et al. Virus-induced activation of self-specific TCRab CD8aa intraepithelial lymphocytes does not abolish their self-tolerance in the intestine. J Immunol 172 (2004) 4176-4183
11. Poussier P., and Julius M. Intestinal intraepithelial lymphocytes: the plot thickens. J Exp Med 180 (1994) 1185-1189
12. Cook D.N., et al. CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue. Immunity 12 (2000) 495-503
13. Huang F.P., et al. A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes. J Exp Med 191 (2000) 435-444
14. Bull D.M., et al. Isolation and functional characterization of human intestinal mucosal lymphoid cells. J Clin Invest 59 (1977) 966-974
15. Golder J.P., and Doe W.F. Isolation and preliminary characterization of human intestinal macrophages. Gastroenterology 84 (1983) 795-802
16. Bockman D.E., Boydston W.R., and Beezhold D.H. The role of epithelial cells in gut-associated immune reactivity. Ann N Y Acad Sci 409 (1983) 129-144
17. Pavli P., Woodhams C.E., Doe W.F., and Hume D.A. Isolation and characterization of antigen-presenting dendritic cells from the mouse intestinal lamina propria. Immunology 70 (1990) 40-47
18. Kelsall B.L., and Rescigno M. Mucosal dendritic cells in immunity and inflammation. Nat Immunol 5 (2004) 1091-1095
19. Rugtveit J., Bakka A., and Brandtzaeg P. Differential distribution of B7.1 (CD80) and B7.2 (CD86) costimulatory molecules on mucosal macrophage subsets in human inflammatory bowel disease (IBD). Clin Exp Immunol 110 (1997) 104-113
20. Kanai T., et al. Role of the innate immune system in the development of chronic colitis. J Gastroenterol 37 Suppl. 14 (2002) 38-42
21. Gordon S. The macrophage. Bioessays 17 (1995) 977-986
22. Sokol R.J., Hudson G., James N.T., Frost I.J., and Wales J. Human macrophage development: a morphometric study. J Anat 151 (1987) 27-35
23. Volkman A., and Gowans J.L. The origin of macrophages from bone marrow in the rat. Br J Exp Pathol 46 (1965) 62-70
24. Gordon S., and Taylor P.R. Monocyte and macrophage heterogeneity. Nat Rev Immunol 5 (2005) 953-964
25. Gendelman H.E., et al. Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes. J Exp Med 167 (1988) 1428-1441
26. Crofton R.W., Diesselhoff-den Dulk M.M., and van Furth R. The origin, kinetics, and characteristics of the Kupffer cells in the normal steady state. J Exp Med 148 (1978) 1-17
27. Hickey W.F. The pathology of multiple sclerosis: a historical perspective. J Neuroimmunol 98 (1999) 37-44
28. Merad M., et al. Langerhans cells renew in the skin throughout life under steady-state conditions. Nat Immunol 3 (2002) 1135-1141
29. Sawyer R.T., Strausbauch P.H., and Volkman A. Resident macrophage proliferation in mice depleted of blood monocytes by strontium-89. Lab Invest 46 (1982) 165-170
30. Tarling J.D., Lin H.S., and Hsu S. Self-renewal of pulmonary alveolar macrophages: evidence from radiation chimera studies. J Leukoc Biol 42 (1987) 443-446
31. Fogg D.K., et al. A clonogenic bone marrow progenitor specific for macrophages and dendritic cells. Science 311 (2006) 83-87
32. Geissmann F., Jung S., and Littman D.R. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity 19 (2003) 71-82
33. Grage-Griebenow E., Flad H.D., and Ernst M. Heterogeneity of human peripheral blood monocyte subsets. J Leukoc Biol 69 (2001) 11-20
34. Palframan R.T., et al. Inflammatory chemokine transport and presentation in HEV: a remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues. J Exp Med 194 (2001) 1361-1373
35. Sunderkotter C., et al. Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response. J Immunol 172 (2004) 4410-4417
36. Smith P.D., Ochsenbauer-Jambor C., and Smythies L.E. Intestinal macrophages: unique effector cells of the innate immune system. Immunol Rev 206 (2005) 149-159
37. Smythies L.E., et al. Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity. J Clin Invest 115 (2005) 66-75
38. Smith P.D., et al. Intestinal macrophages lack CD14 and CD89 and consequently are down-regulated for LPS- and IgA-mediated activities. J Immunol 167 (2001) 2651-2656
39. Schenk M., Bouchon A., Birrer S., Colonna M., and Mueller C. Macrophages expressing triggering receptor expressed on myeloid cells-1 are underrepresented in the human intestine. J Immunol 174 (2005) 517-524
40. Bouchon A., Dietrich J., and Colonna M. Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol 164 (2000) 4991-4995
41. Bouchon A., Facchetti F., Weigand M.A., and Colonna M. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature 410 (2001) 1103-1107
42. Maloy K.J., Powrie F., and Regulatory. T cells in the control of immune pathology. Nat Immunol 2 (2001) 816-822
43. + T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. J Exp Med 197 (2003) 111-119
44. Xian C.J., Mardell C.E., and Read L.C. Specificity of the localization of transforming growth factor-alpha immunoreactivity in colon mucosa. J Histochem Cytochem 47 (1999) 949-958
45. + T cell down-regulation in human intestinal mucosa: evidence for intestinal tolerance to luminal bacterial antigens. J Immunol 158 (1997) 3626-3634
46. Ashcroft G.S., et al. Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing. Nat Med 6 (2000) 1147-1153
47. Moore K.W., O'Garra A., de Waal Malefyt R., Vieira P., and Mosmann T.R. Interleukin-10. Annu Rev Immunol 11 (1993) 165-190
48. Stordeur P., and Goldman M. Interleukin-10 as a regulatory cytokine induced by cellular stress: molecular aspects. Int Rev Immunol 16 (1998) 501-522
49. Cassatella M.A., Meda L., Gasperini S., Calzetti F., and Bonora S. Interleukin 10 (IL-10) upregulates IL-1 receptor antagonist production from lipopolysaccharide-stimulated human polymorphonuclear leukocytes by delaying mRNA degradation. J Exp Med 179 (1994) 1695-1699
50. Rogler G., et al. Differential activation of cytokine secretion in primary human colonic fibroblast/myofibroblast cultures. Scand J Gastroenterol 36 (2001) 389-398
51. Pavli P., and Gibson P.R. Pathogenic factors in inflammatory bowel disease. 2: Crohn's disease. Digest Dis 10 (1992) 72-84
52. Takahashi-Iwanaga H., Iwanaga T., and Isayama H. Porosity of the epithelial basement membrane as an indicator of macrophage-enterocyte interaction in the intestinal mucosa. Arch Histol Cytol 62 (1999) 471-481
53. Hohn H.P., et al. The role of matrix contact and of cell-cell interactions in choriocarcinoma cell differentiation. Eur J Cell Biol 69 (1996) 76-85
54. Fadok V.A., et al. Macrophages that have ingested apoptotic cells in vitro inhibit pro-inflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J Clin Invest 101 (1998) 890-898
55. Zhang W.J., and Zheng S.S. In vitro study of immunosuppressive effect of apoptotic cells. J Zhejiang Univ Sci B 6 (2005) 919-925
56. Kurosaka K., Watanabe N., and Kobayashi Y. Potentiation by human serum of anti-inflammatory cytokine production by human macrophages in response to apoptotic cells. J Leukoc Biol 71 (2002) 950-956
57. Cunliffe R.N., and Mahida Y.R. Expression and regulation of antimicrobial peptides in the gastrointestinal tract. J Leukoc Biol 75 (2004) 49-58
58. Ayabe T., et al. Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nat Immunol 1 (2000) 113-118
59. Ouellette A.J., Satchell D.P., Hsieh M.M., Hagen S.J., and Selsted M.E. Characterization of luminal paneth cell alpha-defensins in mouse small intestine. Attenuated antimicrobial activities of peptides with truncated amino termini. J Biol Chem 275 (2000) 33969-33973
60. Wong W.M., Stamp G.W., Elia G., Poulsom R., and Wright N.A. Proliferative populations in intestinal metaplasia: evidence of deregulation in Paneth and goblet cells, but not endocrine cells. J Pathol 190 (2000) 107-113
61. Cunliffe R.N., et al. Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel disease. Gut 48 (2001) 176-185
62. Hugot J.P., et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411 (2001) 599-603
63. Ogura Y., et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411 (2001) 603-606
64. Oppmann B., et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13 (2000) 715-725
65. Becker C., et al. Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells. J Clin Invest 112 (2003) 693-706
66. Niess J.H., et al. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 307 (2005) 254-258
67. Vallon-Eberhard A., Landsman L., Yogev N., Verrier B., and Jung S. Transepithelial pathogen uptake into the small intestinal lamina propria. J Immunol 176 (2006) 2465-2469
68. Nadeau K.C., Azuma H., and Tilney N.L. Sequential cytokine dynamics in chronic rejection of rat renal allografts: roles for cytokines RANTES and MCP-1. Proc Natl Acad Sci USA 92 (1995) 8729-8733
69. Nagashima R., Maeda K., Imai Y., and Takahashi T. Lamina propria macrophages in the human gastrointestinal mucosa: their distribution, immunohistological phenotype, and function. J Histochem Cytochem 44 (1996) 721-731
70. Madsen K.L., et al. Antibiotic therapy attenuates colitis in interleukin 10 gene-deficient mice. Gastroenterology 118 (2000) 1094-1105
71. Kühn R., Lohler J., Rennick D., Rajewski K., and Muller W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75 (1993) 263-274
72. Hahm K.B., et al. Loss of transforming growth factor beta signalling in the intestine contributes to tissue injury in inflammatory bowel disease. Gut 49 (2001) 190-198
73. Shull M.M., et al. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 359 (1992) 693-699
74. Hampe J., et al. Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations. Lancet 357 (2001) 1925-1928
75. Rogler G., et al. Alterations of the phenotype of colonic macrophages in inflammatory bowel disease. Eur J Gastroenterol Hepatol 9 (1997) 893-899
76. Smith P.D., et al. Isolation and purification of CD14-negative mucosal macrophages from normal human small intestine. J Immunol Methods 202 (1997) 1-11
77. Hausmann M., et al. Toll-like receptors 2 and 4 are up-regulated during intestinal inflammation. Gastroenterology 122 (2002) 1987-2000
78. Fiocchi C. Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology 115 (1998) 182-205
79. Sartor R.B. Cytokines in intestinal inflammation: pathophysiological and clinical considerations. Gastroenterology 106 (1994) 533-539
80. Rugtveit J., Brandtzaeg P., Halstensen T.S., Fausa O., and Scott H. Increased macrophage subset in inflammatory bowel disease: apparent recruitment from peripheral blood monocytes. Gut 35 (1994) 669-674
81. + population of monocytes in inflammatory bowel disease mucosa-implications for pathogenesis. Clin Exp Immunol 100 (1995) 291-297
82. Burgio V.L., Fais S., Boirivant M., Perrone A., and Pallone F. Peripheral monocyte and naive T-cell recruitment and activation in Crohn's disease. Gastroenterology 109 (1995) 1029-1038
83. Taylor P.R., and Gordon S. Monocyte heterogeneity and innate immunity. Immunity 19 (2003) 2-4
84. Austyn J.M., and Gordon S. F4/80, a monoclonal antibody directed specifically against the mouse macrophage. Eur J Immunol 11 (1981) 805-815
85. Ajuebor M.N., et al. Endogenous monocyte chemoattractant protein-1 recruits monocytes in the zymosan peritonitis model. J Leukoc Biol 63 (1998) 108-116
86. Boring L., et al. Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice. J Clin Invest 100 (1997) 2552-2561
87. Ancuta P., et al. Fractalkine preferentially mediates arrest and migration of CD16+ monocytes. J Exp Med 197 (2003) 1701-1707
88. Takeda K., et al. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 10 (1999) 39-49
89. Kamada N., et al. Abnormally differentiated subsets of intestinal macrophage play a key role in Th1-dominant chronic colitis through excess production of IL-12 and IL-23 in response to bacteria. J Immunol 175 (2005) 6900-6908
90. Girardin S.E., et al. NOD2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem 278 (2003) 8869-8872
91. Inohara N., and Nunez G. NODs: intracellular proteins involved in inflammation and apoptosis. Nat Rev Immunol 3 (2003) 371-382
92. Bonen D.K., and Cho J.H. The genetics of inflammatory bowel disease. Gastroenterology 124 (2003) 521-536
93. Chamaillard M., Girardin S.E., Viala J., and Philpott D.J. NODs, Nalps and Naip: intracellular regulators of bacterial-induced inflammation. Cell Microbiol 5 (2003) 581-592
94. Girardin S.E., Hugot J.P., and Sansonetti P.J. Lessons from NOD2 studies: towards a link between Crohn's disease and bacterial sensing. Trends Immunol 24 (2003) 652-658
95. Watanabe T., Kitani A., Murray P.J., and Strober W. NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat Immunol 5 (2004) 800-808
96. Kobayashi K.S., et al. NOD2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307 (2005) 731-734
97. Maeda S., et al. NOD2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing. Science 307 (2005) 734-738
98. van Deventer S.J. Transmembrane TNF-alpha, induction of apoptosis, and the efficacy of TNF-targeting therapies in Crohn's disease. Gastroenterology 121 (2001) 1242-1246
99. Corazza N., Eichenberger S., Eugster H.P., and Mueller C. Non-lymphocyte-derived tumor necrosis factor is required for induction of colitis in recombination activating gene (RAG)2(-/-) mice upon transfer of CD4(+)CD45RB(hi) T cells. J Exp Med 190 (1999) 1479-1492
100. Henderson R.B., Hobbs J.A., Mathies M., and Hogg N. Rapid recruitment of inflammatory monocytes is independent of neutrophil migration. Blood 102 (2003) 328-335