Innate immunity and the normal microflora

Immunological Reviews

Volumn 173, Issue , 2000, Pages 5-16

  Boman, Hans G ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; CECROPIN; CYSTEINE; RECEPTOR;

AEROMONAS HYDROPHILA; ANTIBIOTIC RESISTANCE; BACTERIAL IMMUNITY; CAENORHABDITIS ELEGANS; EVOLUTION; FROG; GENE ACTIVATION; HELICOBACTER PYLORI; HUMAN; INFECTION; INTRON; MICROORGANISM; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BACTERIA; EVOLUTION, MOLECULAR; IMMUNITY, NATURAL; MOLECULAR SEQUENCE DATA; PEPTIDES;

EID: 0033962266     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-065X.2000.917301.x     Document Type: Review

References (76)

1. 1. Wolf E. Unforeseen Americans: the making of the New World societies in anthropological perspective. Proc Natl Acad Sci USA 1996;93:2603-2607.
2. 2. Cohen JE. The bright side of the plague. New York: Rev Books; 1999.
3. 3. Fearon DT, Locksley RM. Elements of immunity - the instructive role of innate immunity in the acquired immune response. Science 1996;272:50-54.
4. 4. Engström Y, Kadalayil L, Sun S-C, Samakovlis C, Hultmark D, Faye I. κB-like motifs regulate the induction of immune genes in Drosophila. J Mol Biol 1993;231:327-333.
5. 5. Ip YT et al. Dif, a dorsal-related gene that mediates an immune response in Drosophila. Cell 1993;75:1-20.
6. 6. Dushay MS, Åsling B, Hultmark D. Origins of immunity: relish, a compound rel-like gene in the antibacterial defense of Drosophila. Proc Natl Acad Sci USA 1996;93:10343-10347.
7. 7. Hultmark D. Macrophage differentiation marker myd88 is a member of the Toll/IL-1 receptor family. Biochem Biophys Res Commun 1994;199:144-146.
8. 8. Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoffmann JA. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 1996;86:973-983.
9. 9. Diamond G, Russell JP, Bevins CL. Inducible expression of an antibiotic peptide gene in lipopolysaccharide-challenged tracheal epithelial cells. Proc Natl Acad Sci USA 1996;93:5156-5160.
10. 10. Belvin MP, Andersen KV. A conserved signaling pathway: The Drosophila Toll-Dorsal pathway. Annu Rev Cell Dev Biol 1996;12:393-416.
11. 11. Kirschning CJ, Wesche H, Ayres TM. Human Toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide. J Exp Med 1998;188:2091-2097.
12. 12. Janeway CA. Presidential address to the American Association of Immunologists. The road less traveled by: the role of innate immunity in the adaptive immune response. J Immunol 1998;161:539-544.
13. 13. Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J-I, Cao Z, Matsumoto K. The kinase TAK1 can activate the NFκB as well as the MAP kinase cascade in the IL-1 signaling pathway. Nature 1999;398:252-256.
14. 14. Lenardo ML, Baltimore D. NF-κB: a pleotropic mediator of inducible and tissue-specific gene control. Cell 1989;58:227-229.
15. 15. Verma I, Stevenson J. IκB kinase: beginning, not the end. Proc Natl Acad Sci USA 1997;94:11758-11760.
16. 16. Auphan N, DiDonato JA, Rosette C, Helmberg A, Karin M. Immunosuppression by glucocorticoids: inhibition of NFκB through indiction of IkB synthesis. Science 1995;270:286-290.
17. 17. Scheinman RI, Cogswell PC, Lofquist AK, Baldwin AS. Role of transcriptional activation of IκBa in mediation of immunosuppression by glucocorticoids. Science 1995;270:283-286.
18. 18. Petersen U-M, Kadalayil L, Rehorn K-P, Hoshiaki DK, Reuter R, Engström Y. Serpent regulates Drosophila immunity in the larval fat body through an essential GATA motif. EMBO J 1998;18:4013-4022.
19. 19. Han ZS, Ip YT. Interaction and specificity of Rel-related proteins in regulating Drosophila immunity gene expression. J Biol Chem 1999; 274:21355-21361.
20. 20. Simmaco M, Mangoni ML, Boman A, Barra D, Boman HG. Experimental infections in Rana esculenta with Aeromonas hydrophila: a molecular mechanism for the control of the natural flora. Scand J Immunol 1998;48:357-363.
21. 21. Boman HG. Peptide antibiotics and their role in innate immunity. Annu Rev Immun 1995;13:61-92.
22. 22. Tossi A. Antimicrobial sequences database search. Available from URL: http: //www.bbcm.univ.trieste.it/~tossi/ search.html. 1999.
23. 23. Steiner H, Hultmark D, Engström Å, Bennich H, Boman HG. Sequence and specificity of two antibacterial proteins involved in insect immunity. Nature 1981;292:246-248.
24. 24. Holak TA, et al. The solution conformation of the antibacterial peptide cecropin A: a nuclear magnetic resonance and dynamical simulated annealing study. Biochemistry 1988;27:7620-7629.
25. 25. Kylsten P, Samakovlis C, Hultmark D. The cecropin locus in Drosophila - a compact gene cluster involved in the response to infection. EMBO J 1990;9:217-224.
26. 26. Brey PT, Hultmark D, eds. Molecular mechanisms of immune responses in insects. London: Chapman & Hall; 1998.
27. 27. Lee J-Y, et al. Antibacterial peptides from pig intestine: isolation of a mammalian cecropin. Proc Natl Acad Sci USA 1989;86:9159-9162.
28. 28. Zhao CQ, Liaw L, Lee IH, Lehrer RI. cDNA cloning of three cecropin-like antimicrobial peptides (Styelins) from the tunicate, Styela clova. FEBS Lett 1997;412:144-148.
29. 29. Lehrer RI, Bevins CL, Ganz, T. Defensins and other antimicrobial peptides. In: Ogra PL, Mestecky J, Lamm ME, Strober WM, McGhee JR, Bienenstock J, eds. Mucosal immunology. 2nd ed. New York: Academic Press; 1998. p. 89-99.
30. 30. Lehrer RI, Ganz T. Antimicrobial peptides in mammalian and insect host defence. Curr Opin Immunol 1999;11:23-27.
31. 31. Hill CP, Yee J, Selsted ME, Eisenberg D. Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilization. Science 1991;251:1481-1485.
32. 32. Selsted ME, Ouellette AJ. Defensins in granules and non-phagocytic cells. Trends Cell Biol 1995;5:114-119.
33. 33. Ouellette AJ. Peptide mediators of innate immunity in the small intestine. J Med Microbiol 1998;47:941-942.
34. 34. Kang JH, Lee MK, Kim KL, Hahm KS. Structure-biological activity relationships of 11-residue highly basic peptide segment of bovine lactoferrin. Int J Pept Protein Res 1996;48:357-363.
35. 35. Odell EW, Sarra R, Foxworthy M, Chappie DS, Evans RW. Antibacterial activity of peptides homologous to a loop region in human lactoferrin. FEBS Lett 1996;382:175-178.
36. 36. Hwang PM, Zhou N, Shan X, Arrowsmith CH, Vogel HJ. Three-dimensional solution structure of lactoferricin B, an antimicrobial peptide derived from bovine lactoferrin. Biochemistry 1998;37:4288-4298.
37. 37. Schibli DJ, Hwang PM, Vogel HJ. The structure of the antimicrobial active center of lactoferricin B bound to sodium dodecyl sulfate micelles. FEBS Lett 1999;446:213-217.
38. 38. Bradbury AF, Smyth DG. Peptide amidation. Trends Biol Sci 1991;16:112-115.
39. 39. Kreil G. D-amino acids in animal peptides. Annu Rev Biochem 1997;66:337-345.
40. 40. Wilson CL, et al. Regulation of intestinal α-defensin activation by the metalloproteinase matrilysin in innate host defense. Science 1999;286:113-117.
41. 41. Hoffmann JA, Kafatos FC, Janeway CA, Ezekowitz AB. Phylogenetic perspectives in innate immunity. Science 1999;284:1313-1318.
42. 42. Gazit E, Miller IR, Biggin PC, Sansom MSP, Shai Y. Structure and orientation of the mammalian antibacterial peptide cecropin P1 within phospholipid membranes. J Mol Biol 1996;258:860-870.
43. 43. Boman HG, Agerberth B, Boman A. Mechanisms of action on Escherichia coli of cecropin-P1 and PR-39, 2 antibacterial peptides from pig intestine. Infect Immun 1993;61:2978-2984.
44. 44. Gallo RL, et al. Syndecans, cell surface heparin sulfate proteoglycans, are induced by a proline-rich antimicrobial peptide from wounds. Proc Natl Acad Sci USA 1994;91:11035-11039.
45. 45. Chan YR, Gallo RL. PR-39, a syndecan-inducing antimicrobial peptide, binds and affects p130(Cas). J Biol Chem 1998;273:28978-28985.
46. 46. Shi JS, Ross CR, Leto TL, Blecha F. PR-39, a proline-rich antibacterial peptide that inhibits phagocyte NADPH oxidase activity by binding to src homology 3 domains of p47 (phox). Proc Natl Acad Sci USA 1996;93:6014-6018.
47. 47. Lillard JW, Boyaka PN, Chertov O, Oppenheim JJ, McGhee JR. Mechanisms for induction of acquired host immunity by neutrophil peptide defensins. Proc Nat Acad Sci USA 1999;96:651-656.
48. 48. Hultmark D, Engström Å, Andersson K, Steiner H, Bennich H, Boman HG. Insect immunity. Attacins, a family of antibacterial proteins from Hyalophora cecropia. EMBO J 1983;2:571-576.
49. 49. Axen A, Carlsson A, Engström A, Bennich H. Gloverin, an antibacterial protein from the immune hemolymph of Hyalophora pupae. Eur J Biochem 1997;247:614-619.
50. 50. Carlsson A, Nyström T, de Cock H, Bennich H. Attacin - an insect immune protein - binds LPS and triggers inhibition of bacterial outer membrane protein synthesis. Microbiology 1998;144:2179-2188.
51. 51. Abraham SN, Jonsson AB, Normark S. Fimbriae-mediated host-pathogen cross-talk. Curr Opin Microbiol 1998;1:75-81.
52. 52. Steiner H, Andreu D, Merrifield RB. Binding and action of cecropin and cecropin analogues: antibacterial peptides from insects. Biochim Biophys Acta 1988;939:260-266.
53. 53. Boman HG, Nilsson I, Rasmuson B. Inducible antibacterial defence system in Drosophila. Nature 1972;237:232-235.
54. 54. Hartl DL. Mariner sails into Leishmania. Science 1997;276:1659-1660
55. 55. Coates CJ, Jasinskiene N, Miyashiro L, James AA. Mariner transposition and transformation of the yellow fever mosquito, Aedes aegypti. Proc Natl Acad Sci USA 1998;95:3748-3751.
56. 56. Gudmundsson GH, et al. The human gene FALL39 and processing of the cathelin. Eur J Biochem 1996;238:325-332.
57. 57. Larrick JW, et al. Structural, functional analysis and localization of the human CAP18 gene. FEBS Lett 1996;398:74-80.
58. 58. Gilbert W, De Souza SJ, Long M. The origin of genes. Proc Natl Acad Sci USA 1997;94:7698-7703.
59. 59. Gudmundsson GH, Agerberth B, Odeberg J, Bergman T, Olsson B, Salcedo R. The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes. Eur J Biochem 1996;238:325-332.
60. 60. Frohm M, et al. Biochemical and antibacterial analysis of human wound and blister fluid. Eur J Biochem 1996;237:86-92.
61. 61. Porter EM, Poles MA, Lee JS, Naitoh J, Bevins CL, Ganz T. Isolation of human intestinal defensins from ileal neobladder urine. FEBS Lett 1998;434:272-276.
62. 62. Simmaco M, et al. Inhibition by glucocorticoids of the synthesis of antimicrobial peptides from amphibian skin. FEBS Lett 1997;416:273-275.
63. 63. The C. elegans consortium. Genome sequence of the nematode C. elegans: a platform for investigative biology. Science 1998;282:2012-2018.
64. 64. Blaxter M. Caenorhabditis elegans is a nematode. Science 1998;282:2041-2046.
65. 65. Mahajan-Miklos S, Tan MW, Rahme LG, Ausbel FM. Molecular mechanisms of bacterial virulence elucidated using a Pseudomonas aeruginosa-Caenorhabditis elegans pathogenesis model. Cell 1999;96:47-56.
66. 66. Götz P, Boman A, Boman HG. Interactions between insect immunity and an insect-pathogenic nematode with symbiotic bacteria. Proc R Soc Lond B 1981;212:333-350.
67. 67. Park IY, Park CB, Kim MS, Kim SC. Parasin I, an antimicrobial peptide derived from histone H2A in the catfish, Parasilurus asotus. FEBS Lett 1998;437:258-262.
68. 68. Pütsep K, Bränden CI, Boman HG, Normark S. Antibacterial peptide from H. pylori. Nature 1999;398:671-672.
69. 69. Tomb JF, et al. The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature 1997;388:539-547.
70. 70. Pütsep K, Normark S, Boman HG. The origin of cecropins; implications from synthetic peptides derived from ribosomal protein L1. FEBS Lett 1999;451:249-252.
71. 71. Matsunaga T, Rahman A. What brought the adaptive immune system to vertebrates? - The jaw hypothesis and the seahorse. Immunol Rev 1998;166:177-186.
72. 72. Graf J. Symbiosis of Aeromonas veronii biovar sorbia and Hirudo medicinalis, the medicinal leech: a novel model for digestive tract associations. Infect Immun 1999;67:1-7.
73. 73. Boman HG. Gene-encoded peptide antibiotics and the concept of innate immunity: an update review. Scand J Immunol 1998;48:15-25.
74. 74. Alm JS, Schwartz J, Lilja G, Scheynius A, Pershagen G. Atopy in children of families with an anthroposophic lifestyle. Lancet 1999;353:1485-1488.
75. 75. Boman HG, Normark S. To be or not to be a pathogen. In: Ernberg I, ed. Intracellular and persistent infections. Nobel Symposium 106. Amsterdam: Elsevier Science (In press).
76. 76. Klein J. Ehrlich and Darwin: homochauvinism in immunology. Immunol Cell Biol 1995;73:103-108.