Stochastic mechanism of cellular aging - Abrupt telomere shortening as a model for stochastic nature of cellular aging

Journal of Theoretical Biology

Volumn 197, Issue 4, 1999, Pages 425-438

  Rubelj, Ivica ^a   Vondraček, Zoran ^b  

^a RUDER BO KOVI INSTITUTE   (Croatia)

^b UNIVERSITY OF ZAGREB   (Croatia)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DNA POLYMERASE; TELOMERASE;

ARTICLE; CELL AGING; CELL DIVISION; COMPUTER SIMULATION; DNA RECOMBINATION; MITOSIS INHIBITION; PRIORITY JOURNAL; STATISTICAL MODEL; TELOMERE;

EID: 0033590952     PISSN: 00225193     EISSN: None     Source Type: Journal    
DOI: 10.1006/jtbi.1998.0886     Document Type: Article

References (55)

1. Arino, O.,Kimmel, M. & Webb, G.F. (1995). Mathematical modeling of the loss of telomere sequences. J. Theor. Biol. 177, 45-57.
2. Blackburn, E. H. (1991). Structure and function of telomeres. Nature 350, 569-573.
3. Blasco, M. A., Lee, H., Prakash Hande, M., Samper, E., Lansdorp, P. M., DePinho, R. A. & Greider, C. W. (1997). Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91, 25-34.
4. Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S. & Wright, W. E. (1998). Extension of life-span by introduction of telomerase into normal human cells. Science 279, 349-352.
5. Broccoli, D., Young, J. W. & De Lange, T. (1995). Telomerase activity in normal and malignant hematopoietic cells. Proc. Nat. Acad. Sci. U.S.A. 92, 9082-9086.
6. Bryan, T. M. & Reddel, R. R. (1997). Telomere dynamics and telomerase activity in in vitro immortalised human cells. Eur. J. Cancer 33, 767-773.
7. Budarf, M. L. & Blackburn, E. H. (1986). Chromatin structure of the telomeric region and 3′-nontranscribed spacer of Tetrahymena ribosomal RNA genes. J. Biol. Chem. 261, 363-369.
8. Budarf, M. L. & Blackburn, E. H. (1987). S1 nuclease sensitivity of a double-stranded telomeric DNA sequence. Nucl. Acids Res. 15, 6273-6293.
9. Chong, L., van Steensel, B., Broccoli, D., Erdjument-Bromage, H., Hanish, J., Tempst, P. & de Lange, T. (1995). A human telomeric protein. Science 270, 1663-1667.
10. Counter, C. M., Avilion, A. A., LeFeuvre, C. E., Stewart, N. G., Greider, C. W., Harley, C. B. & Bacchetti, S. (1992). Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11, 1921-1929.
11. Cristofalo, J. V. & Pignolo, J. R. (1993). Replicative senescence of human fibroblast-like cells in culture. Physiol. Rev. 73, 617-638.
12. Cristofalo, V. J. & Sharf, B. B. (1973). Cellular senescence and DNA synthesis. Exp. Cell Res. 76, 419-427.
13. De Lange, T. (1994). Activation of telomerase in a human tumor. Proc. Nat. Acad. Sci. U.S.A. 91, 2882-2885.
14. Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., Pereira-Smith, O., Peacocke, M. & Campisi, J. (1995). A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Nat. Acad. Sci. U.S.A. 92, 9363-9367.
15. Dorer, D. R. & Henikoff, S. (1994). Expansions of transgene repeats cause heterochromatin formation and gene silencing in Drosophila. Cell 77, 993-1002.
16. Dulic, V., Kaufmann, W. K., Wilson, S. J., Tlsty, T. D., Lees, E., Harper, J. W., Elledge, S. J. & Reed, S. I. (1994). p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell 76, 1013-1023.
17. Garvik, B., Carson, M. & Hartwell, L. (1995). Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint. Mol. Cell. Biol. 15, 6128-6138.
18. Gorman, S. D. & Cristofalo, V. J. (1985). Reinitiation of cellular DNA synthesis in BrdU-selected non-dividing senescent WI-38 cells by simian virus 40 infection. J. Cell. Physiol. 125, 122-126.
19. Gottschling, D. E. (1992). Telomere-proximal DNA in Saccharomyces cerevisiae is refractory to methyltransferase activity in vivo. Proc. Nat. Acad. Sci. U.S.A. 89, 4062-4065.
20. Gottschling, D. E., Aparicio, O. M., Billington, B. L. & Zakian, V. A. (1990). Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription. Cell 63, 751-762.
21. Harley, C. B., Futcher A. B. & Greider, C. W. (1990). Telomeres shorten during ageing of human fibroblasts. Nature 345, 458-460.
22. Hayflick, L. (1965). The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 37, 614-636.
23. Hayflick, L. (1997). Mortality and immortality at the cellular level. A review. Biochemistry (Moscow) 62, 1180-1190.
24. Hayflick, L. & Moorhed, P. S. (1961). The serial cultivation of human diploid cell strains. Exp. Cell Res. 25, 585-621.
25. Holliday, R. (1996). Endless quest. BioEssays 18, 3-5.
26. Jones, R. B. & Smith, J. R. (1980). A stochastic model of cellular senescence. II. Concordance with experimental data. J. Theor. Biol. 96, 443-460
27. Jones, R. B., Lumpkin, C. K. & Smith, J. R. (1980). A stochastic model for cellular senescence. Part I. Theoretical considerations. J. Theor. Biol. 86, 581-592.
28. Jones, R. B., Whitney, R. G. & Smith, J. R. (1985). Intramitotic variation in proliferative potential: Stochastic events in cellular aging. Mech. Ageing & Dev. 29, 143-149.
29. Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L. & Shay, J. W. (1994). Specific association of human telomerase activity with immortal cells and cancer. Science 266, 2011-2014.
30. Lansdorp, P. M. (1997). Lessons from mice without telomerase. J. Cell Biol. 139, 309-312.
31. Levy, M. Z., Allsopp, R. C., Futcher, A. B., Greider, C. W. & Harley, C. B. (1992). Telomere end-replication problem and cell aging. J. Mol. Biol. 225, 951-960.
32. Lindsey, J., McGill, N. I., Lindsey, L. A., Green, D. K. & Cooke, H. J. (1991). In vivo loss of telomeric repeats with age in humans. Mutat. Res. 256, 45-48.
33. - senescence. Cell 73, 347-360.
34. Matsumara, T., Zerrudo, Z. & Hayflick, L. (1979). Senescent human diploid cells in culture: Survival, DNA synthesis and morphology. J. Gerontol. 34, 328-334.
35. n repeats. Nucl. Acids Res. 20, 1387-1391.
36. Murnane, J. P., Sabatier, L., Marder, B. A. & Morgan, W. F. (1994). Telomere dynamics in an immortal human cell line. EMBO J. 13, 4953-4962.
37. Nugent, C. I., Hughes, T. R., Lue, N. F. & Lundblad, V. (1996). Cdc 13p: A single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance. Science 274, 249-252.
38. Olovnikov, A. M. (1973). A theory of marginotomy. J. Theor. Biol. 41, 181-190.
39. Pan, C., Xue, B., Ellis, T. M., Peace, D. J. & Diaz, M. O. (1997). Changes in telomerase activity and telomere length during human T lymphocyte senescence. Exp. Cell Res. 231, 346-353.
40. Petracek, M. E., Konkel, L. M. C., Kable, M. L. & Berman, J. (1994). A Chlamydomonas protein that binds singlestranded G-strand telomere DNA. EMBO J. 13, 3648-3658.
41. Pluta, A. F. & Zakian, V. A. (1989). Recombination occurs during telomere formation in yeast. Nature 337, 429-433.
42. Rohme, D. (1981). Evidence for a relationship between longevity of mammalian species and life-spans of normal fibroblasts in vitro and erythrocytes in vivo. Proc. Nat. Acad. Sci. U.S.A. 78, 5009-5013.
43. Rubelj, I., Brdar, B. & Pereira-Smith, O. M. (1997). Replicative senescence in vitro and in vivo. Croatian Med. J. 38, 190-198.
44. Smith, J. R. & Braunschweiger, K. I. (1979). Growth of human embryonic fibroblasts at clonal density: Concordance with results from mass cultures. J. Cell. Physiol. 98, 597-602.
45. Smith, J. R. & Hayflick, L. (1974). Variation in the life-span of clones derived from human diploid cell strains. J. Cell. Biol. 62, 48-53.
46. Smith, J. R. & Whitney, R. G. (1980). Intraclonal variation in proliferative potential of human diploid fibroblasts: Stochastic mechanism for cellular aging. Science 207, 82-84.
47. Tommerup, H., Dousmanis, A. & De Lange, T. (1994). Unusual chromatin in human telomeres. Mol. Cell. Biol. 14, 5777-5785.
48. Villeponteau, B. (1997). The heterochromatin loss model of aging. Exp. Gerontol. 32, 383-394.
49. Walmsley, R. W., Chan, C. S. M., Tye, B. & Petes, T. D. (1984). Unusual DNA sequences associated with the ends of yeast chromosomes. Nature 310, 157-160.
50. Wang, S. & Zakian, V. A. (1990). Telomere-telomere recombination provides an express pathway for telomere acquisition. Nature 345, 456-458.
51. Wright, W. E. & Shay, J. W. (1992). Telomere positional effects and the regulation of cellular senescence. TIG 8, 193-198.
52. Wright, W. E. & Shay, J. W. (1995). Time, telomeres and tumours: Is cellular senescence more than an anticancer mechanism? Trends Cell Biol. 5, 293-297.
53. Wright, J. H. & Zakian, V. A. (1995). Protein-DNA interactions in soluble telosomes from Saccharomyces cerevisiae. Nucl. Acids Res. 23, 1454-1460.
54. Wright, W. E., Tesmer, V. M., Huffman, K. E., Levene, S. D. & Shay, J. W. (1997). Normal human chromosomes have long G-rich telomeric overhangs at one end. Genes Dev. 11, 2801-2809.
55. Zglinicki von, T., Saretzki, G., Docke, W. & Lotze, C. (1995). Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: A model for senescence? Exp. Cell Res. 220, 186-193.