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Volumn 29, Issue 1, 2007, Pages 24-34

High-resolution dynamics of the transcriptional response to nutrition in Drosophila: A key role for dFOXO

Author keywords

Gene expression; Insulin signaling; Metabolism; Microarray; Mitochondria; Nutrient sensing; Peroxisome proliferator coactivator 1; Target of rapamycin pathway

Indexed keywords

INSULIN; PROTEIN PROLIFERATION GAMMA COACTIVATOR 1; TARGET OF RAPAMYCIN KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXO; UNCLASSIFIED DRUG;

EID: 34248207609     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00061.2006     Document Type: Article
Times cited : (148)

References (73)
  • 1
    • 2342496712 scopus 로고    scopus 로고
    • FoxOs at the crossroads of cellular metabolism, differentiation and transformation
    • Accili D, Arden KC. FoxOs at the crossroads of cellular metabolism, differentiation and transformation. Cell 117: 421-426, 2004.
    • (2004) Cell , vol.117 , pp. 421-426
    • Accili, D.1    Arden, K.C.2
  • 2
    • 0034610367 scopus 로고    scopus 로고
    • Genomewide studies of histone deacetylase function in yeast
    • Bernstein BE, Tong JK, Schreiber SL. Genomewide studies of histone deacetylase function in yeast. Proc Natl Acad Sci USA 97: 13708-13713, 2000.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 13708-13713
    • Bernstein, B.E.1    Tong, J.K.2    Schreiber, S.L.3
  • 4
    • 17144429302 scopus 로고    scopus 로고
    • Calorie restriction, SIRT1 and metabolism: Understanding longevity
    • Bordone L, Guarente L. Calorie restriction, SIRT1 and metabolism: understanding longevity. Nat Rev Mol Cell Biol 6: 298-305, 2005.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 298-305
    • Bordone, L.1    Guarente, L.2
  • 5
    • 0035916357 scopus 로고    scopus 로고
    • An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control
    • Brogiolo W, Stocker H, Ikeya T, Rintelen F, Fernandez R, Hafen E. An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control. Curr Biol 11: 213-221, 2001.
    • (2001) Curr Biol , vol.11 , pp. 213-221
    • Brogiolo, W.1    Stocker, H.2    Ikeya, T.3    Rintelen, F.4    Fernandez, R.5    Hafen, E.6
  • 6
    • 0000473798 scopus 로고
    • Techniques for testing the constancy of regression relationships over time
    • Brown RL, Durbin J, Evans JM. Techniques for testing the constancy of regression relationships over time. J Royal Stat Soc B37: 149-163, 1975.
    • (1975) J Royal Stat Soc , vol.B37 , pp. 149-163
    • Brown, R.L.1    Durbin, J.2    Evans, J.M.3
  • 7
    • 0030060198 scopus 로고    scopus 로고
    • The Drosophila insulin receptor is required for normal growth
    • Chen C, Jack J, Garofalo, RS. The Drosophila insulin receptor is required for normal growth. Endocrinology 137: 846-856, 1996.
    • (1996) Endocrinology , vol.137 , pp. 846-856
    • Chen, C.1    Jack, J.2    Garofalo, R.S.3
  • 8
    • 0027880487 scopus 로고
    • Phenotypic plasticity and selection in Drosophila life-history evolution. I. Nutrition and the cost of reproduction
    • Chippindale AK, Leroi AM, Kim SB, Rose, MR. Phenotypic plasticity and selection in Drosophila life-history evolution. I. Nutrition and the cost of reproduction. J Evol Biol 6: 171-193, 1993.
    • (1993) J Evol Biol , vol.6 , pp. 171-193
    • Chippindale, A.K.1    Leroi, A.M.2    Kim, S.B.3    Rose, M.R.4
  • 12
    • 0028815418 scopus 로고
    • Regulation of nutrient metabolism and energy expenditure
    • Felber JP, Golay A. Regulation of nutrient metabolism and energy expenditure. Metabolism 44: 4-9, 1995.
    • (1995) Metabolism , vol.44 , pp. 4-9
    • Felber, J.P.1    Golay, A.2
  • 14
    • 20144365700 scopus 로고    scopus 로고
    • Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes
    • Frescas D, Valenti L, Accili D. Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes. J Biol Chem 280: 20589-20595, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 20589-20595
    • Frescas, D.1    Valenti, L.2    Accili, D.3
  • 15
    • 0142200472 scopus 로고    scopus 로고
    • Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivation
    • Furuyama T, Kitayama K, Yamashita H, Mori N. Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivation. Biochem J 375: 365-371, 2003.
    • (2003) Biochem J , vol.375 , pp. 365-371
    • Furuyama, T.1    Kitayama, K.2    Yamashita, H.3    Mori, N.4
  • 16
    • 0036584593 scopus 로고    scopus 로고
    • Genetic analysis of insulin signaling in Drosophila
    • Garofalo R. Genetic analysis of insulin signaling in Drosophila. Trends Endocrinol Metab 13: 156-162, 2002.
    • (2002) Trends Endocrinol Metab , vol.13 , pp. 156-162
    • Garofalo, R.1
  • 17
    • 0035169919 scopus 로고    scopus 로고
    • Age-specific mortality and reproduction respond to adult dietary restriction in Drosophila melanogaster
    • Good T, Tatar M. Age-specific mortality and reproduction respond to adult dietary restriction in Drosophila melanogaster. J Insect Physiol 47: 1467-1473, 2001.
    • (2001) J Insect Physiol , vol.47 , pp. 1467-1473
    • Good, T.1    Tatar, M.2
  • 18
    • 0031007189 scopus 로고    scopus 로고
    • Histone deacetylase activity is required for full transcriptional repression by mSin3A
    • Hassig CA, Fleischer TC, Billin AN, Schreiber SL, Ayer DE. Histone deacetylase activity is required for full transcriptional repression by mSin3A. Cell 89: 341-347, 1997.
    • (1997) Cell , vol.89 , pp. 341-347
    • Hassig, C.A.1    Fleischer, T.C.2    Billin, A.N.3    Schreiber, S.L.4    Ayer, D.E.5
  • 19
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev 18: 1926-1945, 2004.
    • (2004) Genes Dev , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 20
    • 0032526951 scopus 로고    scopus 로고
    • Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators
    • Huang N, vom Baur E, Garnier JM, Lerouge T, Vonesch JL, Lutz Y, Chambon P, Losson R. Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators. EMBO J 17: 3398-3412, 1998.
    • (1998) EMBO J , vol.17 , pp. 3398-3412
    • Huang, N.1    vom Baur, E.2    Garnier, J.M.3    Lerouge, T.4    Vonesch, J.L.5    Lutz, Y.6    Chambon, P.7    Losson, R.8
  • 21
    • 0037031147 scopus 로고    scopus 로고
    • Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila
    • Ikeya T, Galic M, Belawat P, Nairz K, Hafen E. Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila. Curr Biol 12: 1293-1300,
    • Curr Biol , vol.12 , pp. 1293-1300
    • Ikeya, T.1    Galic, M.2    Belawat, P.3    Nairz, K.4    Hafen, E.5
  • 22
    • 0242539698 scopus 로고    scopus 로고
    • The Drosophila Forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling
    • Article
    • Junger MA, Rintelen F, Stocker H, Wasserman DA, Vegh M, Radimerski T, Greenberg ME, Hafen E. The Drosophila Forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. J Biol 2: Article 20, 2003.
    • (2003) J Biol , vol.20 , pp. 2
    • Junger, M.A.1    Rintelen, F.2    Stocker, H.3    Wasserman, D.A.4    Vegh, M.5    Radimerski, T.6    Greenberg, M.E.7    Hafen, E.8
  • 24
    • 23144437890 scopus 로고    scopus 로고
    • POCO: Discovery of regulatory patterns from promoters of oppositely expressed gene sets
    • Kankainen M, Holm L. POCO: discovery of regulatory patterns from promoters of oppositely expressed gene sets. Nucleic Acids Res 33: W427-W431, 2005.
    • (2005) Nucleic Acids Res , vol.33
    • Kankainen, M.1    Holm, L.2
  • 25
    • 3042648746 scopus 로고    scopus 로고
    • Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
    • Kapahi P, Zid BM, Harper D, Koslover D, Sapin V, Benzer S. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol 14: 885-890, 2004.
    • (2004) Curr Biol , vol.14 , pp. 885-890
    • Kapahi, P.1    Zid, B.M.2    Harper, D.3    Koslover, D.4    Sapin, V.5    Benzer, S.6
  • 27
    • 1842475551 scopus 로고    scopus 로고
    • Protein kinase B-inhibits human pyruvate dehydrogenase kinase-4 gene induction by dexamethasone through inactivation of FOXO transcription factors
    • Kwon HS, Huang B, Unterman TG, Harris RA. Protein kinase B-inhibits human pyruvate dehydrogenase kinase-4 gene induction by dexamethasone through inactivation of FOXO transcription factors. Diabetes 53: 899-910, 2004.
    • (2004) Diabetes , vol.53 , pp. 899-910
    • Kwon, H.S.1    Huang, B.2    Unterman, T.G.3    Harris, R.A.4
  • 28
    • 0030969516 scopus 로고    scopus 로고
    • Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression
    • Laherty CD, Yang WM, Sun JM, Davie JR, Seto E, Eisenman RN. Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression. Cell 89: 349-356, 1997.
    • (1997) Cell , vol.89 , pp. 349-356
    • Laherty, C.D.1    Yang, W.M.2    Sun, J.M.3    Davie, J.R.4    Seto, E.5    Eisenman, R.N.6
  • 30
    • 0034710226 scopus 로고    scopus 로고
    • The Drosophila melanogaster genome: Translation factors and RNA binding proteins
    • Lasko P. The Drosophila melanogaster genome: translation factors and RNA binding proteins. J Cell Biol 150: F51-F56, 2000.
    • (2000) J Cell Biol , vol.150
    • Lasko, P.1
  • 34
    • 0141766912 scopus 로고    scopus 로고
    • Demography of dietary restriction and death in Drosophila
    • Mair W, Goymer P, Pletcher SD, Partridge L. Demography of dietary restriction and death in Drosophila. Science 19: 1731-1733, 2003.
    • (2003) Science , vol.19 , pp. 1731-1733
    • Mair, W.1    Goymer, P.2    Pletcher, S.D.3    Partridge, L.4
  • 35
    • 0036284103 scopus 로고    scopus 로고
    • Minireview: Nuclear receptor coactivators - an update
    • McKenna NJ, O'Malley BW. Minireview: nuclear receptor coactivators - an update. Endocrinology 143: 2461-2465, 2002.
    • (2002) Endocrinology , vol.143 , pp. 2461-2465
    • McKenna, N.J.1    O'Malley, B.W.2
  • 36
    • 0032527706 scopus 로고    scopus 로고
    • Human mitochondrial phosphoenolpyruvate carboxykinase: Structure, chromosomal localization and tissue-specific expression
    • Modaressi S, Brechtel K, Christ B, Jungermann K. Human mitochondrial phosphoenolpyruvate carboxykinase: Structure, chromosomal localization and tissue-specific expression. Biochem J 333: 359-366, 1998.
    • (1998) Biochem J , vol.333 , pp. 359-366
    • Modaressi, S.1    Brechtel, K.2    Christ, B.3    Jungermann, K.4
  • 38
    • 0038054341 scopus 로고    scopus 로고
    • Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, Puigserver P, Carlsson E, Ridderstrale M, Laurila E, Houstis N, Daly MJ, Patterson N, Mesirov JP, Golub TR, Tamayo P, Spiegelman B, Lander. ES, Hirschhorn JN, Altshuler D, Groop LC. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 34: 267-273, 2003.
    • Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, Puigserver P, Carlsson E, Ridderstrale M, Laurila E, Houstis N, Daly MJ, Patterson N, Mesirov JP, Golub TR, Tamayo P, Spiegelman B, Lander. ES, Hirschhorn JN, Altshuler D, Groop LC. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 34: 267-273, 2003.
  • 40
    • 10844236451 scopus 로고    scopus 로고
    • Nutrient availability regulates SIRT1 through a Forkhead-dependent pathway
    • Nemoto S, Fergusson MM, Finkel T. Nutrient availability regulates SIRT1 through a Forkhead-dependent pathway. Science 306: 2105-2108, 2004.
    • (2004) Science , vol.306 , pp. 2105-2108
    • Nemoto, S.1    Fergusson, M.M.2    Finkel, T.3
  • 41
    • 0016857510 scopus 로고
    • Neurosecretory cells in insect brain and production of hypoglycemic hormone
    • Normann T. Neurosecretory cells in insect brain and production of hypoglycemic hormone. Nature 254: 259-261, 1975.
    • (1975) Nature , vol.254 , pp. 259-261
    • Normann, T.1
  • 42
    • 0036081060 scopus 로고    scopus 로고
    • Identification of a biochemical link between energy intake and energy expenditure
    • Obici S, WJ, Chowdury R, Feng Z, Siddhanta U, Morgan K, Rossetti L. Identification of a biochemical link between energy intake and energy expenditure. J Clin Invest 109: 1599-1605, 2002.
    • (2002) J Clin Invest , vol.109 , pp. 1599-1605
    • Obici, S.W.1    Chowdury, R.2    Feng, Z.3    Siddhanta, U.4    Morgan, K.5    Rossetti, L.6
  • 43
    • 0037306190 scopus 로고    scopus 로고
    • Insulin/IGF and target of rapamycin signaling: A TOR de force in growth control
    • Oldham S, Hafen E. Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control. Trends Cell Biol 13: 79-85, 2003.
    • (2003) Trends Cell Biol , vol.13 , pp. 79-85
    • Oldham, S.1    Hafen, E.2
  • 44
    • 0037163021 scopus 로고    scopus 로고
    • The key role of anaplerosis and cataplerosis for citric acid cycle function
    • Owen OE, Kalhan SC, Hanson RW. The key role of anaplerosis and cataplerosis for citric acid cycle function. J Biol Chem 277: 30409-30412, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 30409-30412
    • Owen, O.E.1    Kalhan, S.C.2    Hanson, R.W.3
  • 46
    • 1642377274 scopus 로고    scopus 로고
    • Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes
    • Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med 350: 664-671, 2004.
    • (2004) N Engl J Med , vol.350 , pp. 664-671
    • Petersen, K.F.1    Dufour, S.2    Befroy, D.3    Garcia, R.4    Shulman, G.I.5
  • 49
    • 0042161896 scopus 로고    scopus 로고
    • Control of cell number by Drosophila FOXO: Downstream and feedback regulation of the insulin receptor pathway
    • Puig O, Marr MT, Ruhf ML, Tjian R. Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. Genes Dev 17: 2006-2020, 2003.
    • (2003) Genes Dev , vol.17 , pp. 2006-2020
    • Puig, O.1    Marr, M.T.2    Ruhf, M.L.3    Tjian, R.4
  • 50
    • 0037326196 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha): Transcriptional coactivator and metabolic regulator
    • Puigserver P, Spiegelman BM. Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha): transcriptional coactivator and metabolic regulator. Endocr Rev 24: 78-90, 2003.
    • (2003) Endocr Rev , vol.24 , pp. 78-90
    • Puigserver, P.1    Spiegelman, B.M.2
  • 51
    • 0032549811 scopus 로고    scopus 로고
    • A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
    • Puigserver P, WZ, Park CW, Graves R, Wright M, Spiegelman BM. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92: 829-839, 1998.
    • (1998) Cell , vol.92 , pp. 829-839
    • Puigserver, P.W.1    Park, C.W.2    Graves, R.3    Wright, M.4    Spiegelman, B.M.5
  • 52
    • 0032452225 scopus 로고    scopus 로고
    • Regulatory interactions between lipids and carbohydrates: The glucose-fatty acid cycle after 35 years
    • Randle PJ. Regulatory interactions between lipids and carbohydrates: the glucose-fatty acid cycle after 35 years. Diabetes Metab Rev 14: 263-283, 1998.
    • (1998) Diabetes Metab Rev , vol.14 , pp. 263-283
    • Randle, P.J.1
  • 53
  • 54
    • 8644224064 scopus 로고    scopus 로고
    • Sir2 mediates longevity in the fly through a pathway related to calorie restriction
    • Rogina B, Helfand SL. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci USA 101: 15998-16003, 2004.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 15998-16003
    • Rogina, B.1    Helfand, S.L.2
  • 55
    • 0242496315 scopus 로고    scopus 로고
    • Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction
    • Rogina B, Helfand SL, Frankel S. Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction. Science 29: 298, 2002.
    • (2002) Science , vol.29 , pp. 298
    • Rogina, B.1    Helfand, S.L.2    Frankel, S.3
  • 56
    • 0035813090 scopus 로고    scopus 로고
    • Coregulator codes of transcriptional regulation by nuclear receptors
    • Rosenfeld MG, Glass CK. Coregulator codes of transcriptional regulation by nuclear receptors. J Biol Chem 276: 36865-36868, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 36865-36868
    • Rosenfeld, M.G.1    Glass, C.K.2
  • 57
    • 0037052544 scopus 로고    scopus 로고
    • Ablation of insulin-producing neurons in flies: Growth and diabetic phenotypes
    • Rulifson EJ, Kim SK, Nusse R. Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes. Science 296: 1118-1120, 2002.
    • (2002) Science , vol.296 , pp. 1118-1120
    • Rulifson, E.J.1    Kim, S.K.2    Nusse, R.3
  • 58
    • 5444264003 scopus 로고    scopus 로고
    • Biological control through regulated transcriptional coactivators
    • Spiegelman BM, Heinrich R. Biological control through regulated transcriptional coactivators. Cell 119: 157-167, 2004.
    • (2004) Cell , vol.119 , pp. 157-167
    • Spiegelman, B.M.1    Heinrich, R.2
  • 59
  • 60
    • 0035815445 scopus 로고    scopus 로고
    • A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function
    • Tatar M, Kopelman A, Epstein D, Tu MP, Yin CM, Garofalo RS. A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 292: 107-110, 2001.
    • (2001) Science , vol.292 , pp. 107-110
    • Tatar, M.1    Kopelman, A.2    Epstein, D.3    Tu, M.P.4    Yin, C.M.5    Garofalo, R.S.6
  • 61
    • 0037470501 scopus 로고    scopus 로고
    • The endocrine regulation of aging by insulin-like signals
    • Tatar M, Bartke A, Antebi A. The endocrine regulation of aging by insulin-like signals. Science 299: 1346-1351, 2003.
    • (2003) Science , vol.299 , pp. 1346-1351
    • Tatar, M.1    Bartke, A.2    Antebi, A.3
  • 63
    • 23944525416 scopus 로고    scopus 로고
    • 4E-BP functions as a metabolic brake used under stress conditions but not during normal growth
    • Teleman AA, Chen YW, Cohen SM. 4E-BP functions as a metabolic brake used under stress conditions but not during normal growth. Genes Dev 19: 1844-1848, 2005.
    • (2005) Genes Dev , vol.19 , pp. 1844-1848
    • Teleman, A.A.1    Chen, Y.W.2    Cohen, S.M.3
  • 64
    • 23944507152 scopus 로고    scopus 로고
    • Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP
    • Tettweiler G, Miron M, Jenkins M, Sonenberg N, Lasko PF. Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP. Genes Dev 19: 1840-1843, 2005.
    • (2005) Genes Dev , vol.19 , pp. 1840-1843
    • Tettweiler, G.1    Miron, M.2    Jenkins, M.3    Sonenberg, N.4    Lasko, P.F.5
  • 65
    • 0035826271 scopus 로고    scopus 로고
    • Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
    • Tissenbaum HA, Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410: 227-230, 2001.
    • (2001) Nature , vol.410 , pp. 227-230
    • Tissenbaum, H.A.1    Guarente, L.2
  • 66
    • 0033180592 scopus 로고    scopus 로고
    • Tsai CC, Kao HY, Yoa TP, McKeown M, Evans RM. SMRTER, a Drosophila nuclear receptor coregulator, reveals that EcR-mediated repression is critical for development. Mol Cell 4: 175-186, 1999.
    • Tsai CC, Kao HY, Yoa TP, McKeown M, Evans RM. SMRTER, a Drosophila nuclear receptor coregulator, reveals that EcR-mediated repression is critical for development. Mol Cell 4: 175-186, 1999.
  • 67
    • 3242693556 scopus 로고    scopus 로고
    • Juvenile diet restriction and the aging and reproduction of adult Drosophila melanogaster
    • Tu MP, Tatar M. Juvenile diet restriction and the aging and reproduction of adult Drosophila melanogaster. Aging Cell 2: 327-333, 2003.
    • (2003) Aging Cell , vol.2 , pp. 327-333
    • Tu, M.P.1    Tatar, M.2
  • 71
    • 17144395146 scopus 로고    scopus 로고
    • The nuclear receptor corepressors NCoR and SMRT decrease peroxisome proliferator-activated receptor gamma transcriptional activity and repress 3T3-L1 adipogenesis
    • Yu C, Markan K, Temple KA, Deplewski D, Brady MJ, Cohen RN. The nuclear receptor corepressors NCoR and SMRT decrease peroxisome proliferator-activated receptor gamma transcriptional activity and repress 3T3-L1 adipogenesis. J Biol Chem 280: 13600-13605, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 13600-13605
    • Yu, C.1    Markan, K.2    Temple, K.A.3    Deplewski, D.4    Brady, M.J.5    Cohen, R.N.6
  • 72
    • 0034312315 scopus 로고    scopus 로고
    • Regulation of cellular growth by the Drosophila target of rapamycin dTOR
    • Zhang H, SJ, Ng JC, Reinhard C, Neufeld TP. Regulation of cellular growth by the Drosophila target of rapamycin dTOR. Genes Dev 14: 2712-2724, 2000.
    • (2000) Genes Dev , vol.14 , pp. 2712-2724
    • Zhang, H.1    SJ, N.J.2    Reinhard, C.3    Neufeld, T.P.4
  • 73
    • 0037112907 scopus 로고    scopus 로고
    • Nutrient control of gene expression in Drosophila: Microarray analysis of starvation and sugar-dependent response
    • Zinke I, Schutz CS, Katzenberger JD, Bauer M, Pankratz MJ. Nutrient control of gene expression in Drosophila: microarray analysis of starvation and sugar-dependent response. EMBO J 21: 6162-6173, 2002.
    • (2002) EMBO J , vol.21 , pp. 6162-6173
    • Zinke, I.1    Schutz, C.S.2    Katzenberger, J.D.3    Bauer, M.4    Pankratz, M.J.5


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