Mast cell tryptases and chymases in inflammation and host defense

Immunological Reviews

Volumn 217, Issue 1, 2007, Pages 141-154

  Caughey, George H ^a,b,c,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION   (United States)

^d SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Cathepsin G; Chymase; Mast cell; Tryptase

Indexed keywords

ALLERGEN; ANGIOTENSIN; CATHEPSIN G; CHYMASE; METALLOPROTEINASE; PROTEINASE ACTIVATED RECEPTOR; TRYPTASE; UROKINASE;

ATHEROSCLEROSIS; BRONCHOSPASM; CELL ACTIVATION; CELL DIFFERENTIATION; GENE MUTATION; HOST RESISTANCE; HUMAN; HYPERTENSION; IMMUNE RESPONSE; INFLAMMATORY CELL; NEUROGENIC INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PRURITUS; REVIEW; RODENT;

ANIMALS; CHYMASES; HUMANS; INFLAMMATION; MAST CELLS; SERINE ENDOPEPTIDASES; TRYPTASES;

EID: 34248140140     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/j.1600-065X.2007.00509.x     Document Type: Review

References (140)

1. Caughey GH. Tryptase genetics and anaphylaxis. J Allergy Clin Immunol 2006 117 : 1411 1414.
2. Pallaoro M, Fejzo MS, Shayesteh L, Blount JL, Caughey GH. Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3. J Biol Chem 1999 274 : 3355 3362.
3. Caughey GH, et al. Characterization of human γ-tryptases, novel members of the chromosome 16p mast cell tryptase and prostasin gene families. J Immunol 2000 164 : 6566 6575.
4. Caughey GH. Genetic insights into mast cell chymase and tryptase function. Clin Exp Allergy Rev 2004 4 : 96 101.
5. Wong GW, et al. Identification of a new member of the tryptase family of mouse and human mast cell proteases which possesses a novel COOH-terminal hydrophobic extension. J Biol Chem 1999 274 : 30784 30793.
6. Ghildyal N, et al. Lack of expression of the tryptase mouse mast cell protease 7 in mast cells of the C57BL/6J mouse. J Immunol 1994 153 : 2624 2630.
7. Vanderslice P, Craik CS, Nadel JA, Caughey GH. Molecular cloning of dog mast cell tryptase and a related protease: structural evidence of a unique mode of serine protease activation. Biochemistry 1989 28 : 4148 4155.
8. Yezzi MJ, Hsieh IE, Caughey GH. Mast cell and neutrophil expression of dog mast cell proteinase-3, a novel tryptase-related serine proteinase. J Immunol 1994 152 : 3064 3072.
9. Raymond WW, Tam EK, Blount JL, Caughey GH. Purification and characterization of dog mast cell protease-3, an oligomeric relative of tryptases. J Biol Chem 1995 270 : 13164 13170.
10. Raymond WW, Sommerhoff CP, Caughey GH. Mastin is a gelatinolytic mast cell peptidase resembling a mini-proteasome. Arch Biochem Biophys 2005 435 : 311 322.
11. Caughey GH, Viro NF, Ramachandran J, Lazarus SC, Borson DB, Nadel JA. Dog mastocytoma tryptase: affinity purification, characterization and amino-terminal sequence. Arch Biochem Biophys 1987 258 : 555 563.
12. Schwartz LB, Bradford TR. Regulation of tryptase from human lung mast cells by heparin. Stabilization of the active tetramer. J Biol Chem 1986 261 : 7372 7379.
13. Bhagwandin VJ, Hau LW, Mallen-St Clair J, Wolters PJ, Caughey GH. Structure and activity of human pancreasin, a novel tryptic serine peptidase expressed primarily by the pancreas. J Biol Chem 2003 278 : 3363 3371.
14. Wong GW, et al. Biochemical and functional characterization of human transmembrane tryptase (TMT)/tryptase gamma. TMT is an exocytosed mast cell protease that induces airway hyperresponsiveness in vivo via an interleukin-13/interleukin-4 receptor α/signal transducer and activator of transcription (STAT) 6-dependent pathway. J Biol Chem 2002 277 : 41906 41915.
15. Yuan J, et al. Expression and characterization of recombinant γ-tryptase. Protein Expr Purif 2006 49 : 47 54.
16. Verghese GM, Gutknecht F, Caughey GH. Prostasin regulates epithelial monolayer function: cell-specific Gpld1-mediated secretion and functional role for the GPI anchor. Am J Physiol Cell Physiol 2006 291 : C1258 C1270.
17. Vanderslice P, Ballinger SM, Tam EK, Goldstein SM, Craik CS, Caughey GH. Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family. Proc Natl Acad Sci USA 1990 87 : 3811 3815.
18. Soto D, Malmsten C, Blount JL, Muilenburg DJ, Caughey GH. Genetic deficiency of human mast cell α-tryptase. Clin Exp Allergy 2002 32 : 1000 1006.
19. Huang C, et al. Formation of enzymatically active, homotypic, and heterotypic tetramers of mouse mast cell tryptases. Dependence on a conserved Trp-rich domain on the surface. J Biol Chem 2000 275 : 351 358.
20. Caughey GH, et al. The human mast cell chymase gene (CMA1): mapping to the cathepsin G/granzyme gene cluster and lineage-restricted expression. Genomics 1993 15 : 614 620.
21. Caughey GH, Blount JL, Koerber KL, Kitamura M, Fang KC. Cloning and expression of the dog mast cell α-chymase gene. J Immunol 1997 159 : 4367 4375.
22. Caughey GH. New developments in the genetics and activation of mast cell proteases. Mol Immunol 2002 38 : 1353 1357.
23. Wouters MA, Liu K, Riek P, Husain A. A despecialization step underlying evolution of a family of serine proteases. Mol Cell 2003 12 : 343 354.
24. Puente XS, Lopez-Otin C. A genomic analysis of rat proteases and protease inhibitors. Genome Res 2004 14 : 609 622.
25. Gallwitz M, Reimer JM, Hellman L. Expansion of the mast cell chymase locus over the past 200 million years of mammalian evolution. Immunogenetics 2006 58 : 655 669.
26. Gallwitz M, Hellman L. Rapid lineage-specific diversification of the mast cell chymase locus during mammalian evolution. Immunogenetics 2006 58 : 641 654.
27. Kunori Y, et al. Rodent α-chymases are elastase-like proteases. Eur J Biochem 2002 269 : 5921 5930.
28. Karlson U, Pejler G, Tomasini-Johansson B, Hellman L. Extended substrate specificity of rat mast cell protease 5, a rodent α-chymase with elastase-like primary specificity. J Biol Chem 2003 278 : 39625 39631.
29. Tchougounova E, Pejler G, Abrink M. The chymase, mouse mast cell protease 4, constitutes the major chymotrypsin-like activity in peritoneum and ear tissue. A role for mouse mast cell protease 4 in thrombin regulation and fibronectin turnover. J Exp Med 2003 198 : 423 431.
30. Muilenburg DJ, Raymond WW, Wolters PJ, Caughey GH. Lys40 but not Arg143 influences selectivity of angiotensin conversion by human α-chymase. Biochim Biophys Acta 2003 1596 : 346 356.
31. Williams CM, Galli SJ. Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice. J Exp Med 2000 192 : 455 462.
32. Yu M, Tsai M, Tam SY, Jones C, Zehnder J, Galli SJ. Mast cells can promote the development of multiple features of chronic asthma in mice. J Clin Invest 2006 116 : 1633 1641.
33. Malaviya R, Ikeda T, Ross E, Abraham SN. Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-α. Nature 1996 381 : 77 80.
34. Mallen-St Clair J, Pham CT, Villalta SA, Caughey GH, Wolters PJ. Mast cell dipeptidyl peptidase I mediates survival from sepsis. J Clin Invest 2004 113 : 628 634.
35. Metz M, et al. Mast cells can enhance resistance to snake and honeybee venoms. Science 2006 313 : 526 530.
36. Xu X, et al. Mast cells protect mice from mycoplasma pneumonia. Am J Respir Crit Care Med 2006 173 : 219 225.
37. Depinay N, Hacini F, Beghdadi W, Peronet R, Mecheri S. Mast cell-dependent down-regulation of antigen-specific immune responses by mosquito bites. J Immunol 2006 176 : 4141 4146.
38. Hart PH, Grimbaldeston MA, Swift GJ, Jaksic A, Noonan FP, Finlay-Jones JJ. Dermal mast cells determine susceptibility to ultraviolet B-induced systemic suppression of contact hypersensitivity responses in mice. J Exp Med 1998 187 : 2045 2053.
39. Alard P, Kurimoto I, Niizeki H, Doherty JM, Streilein JW. Hapten-specific tolerance induced by acute, low-dose ultraviolet B radiation of skin requires mast cell degranulation. Eur J Immunol 2001 31 : 1736 1746.
40. Lu LF, et al. Mast cells are essential intermediaries in regulatory T-cell tolerance. Nature 2006 442 : 997 1002.
41. Ahmed T, Garrigo J, Danta I. Preventing bronchoconstriction in exercise-induced asthma with inhaled heparin. N Engl J Med 1993 329 : 90 95.
42. Hirasawa N, Watanabe M, Mue S, Tsurufuji S, Ohuchi K. Downward regulation of neutrophil infiltration by endogenous histamine without affecting vascular permeability responses in air-pouch-type carrageenin inflammation in rats. Inflammation 1991 15 : 117 126.
43. Jutel M, et al. Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors. Nature 2001 413 : 420 425.
44. Fang KC, Caughey GH. 2003. Mast cell proteases. In : Eissa NT, Huston DP, eds. Therapeutic Targets in Airway Inflammation. New York : Marcel Dekker, Inc., 2003 : 349 371.
45. Caughey GH, Raymond WW, Bacci E, Lombardy RJ, Tidwell RR. Bis(5-amidino-2-benzimidazolyl)methane and related amidines are potent, reversible inhibitors of mast cell tryptases. J Pharmacol Exp Ther 1993 264 : 676 682.
46. Clark JM, et al. Tryptase inhibitors block allergen-induced airway and inflammatory responses in allergic sheep. Am J Respir Crit Care Med 1995 152 : 2076 2083.
47. Katz BA, et al. Design of potent selective zinc-mediated serine protease inhibitors. Nature 1998 391 : 608 612.
48. Janc JW, Clark JM, Warne RL, Elrod KC, Katz BA, Moore WR. A novel approach to serine protease inhibition: kinetic characterization of inhibitors whose potencies and selectivities are dramatically enhanced by Zinc(II). Biochemistry 2000 39 : 4792 4800.
49. Ono S, Kuwahara S, Takeuchi M, Sakashita H, Naito Y, Kondo T. Syntheses and evaluation of amidinobenzofuran derivatives as tryptase inhibitors. Bioorg Med Chem Lett 1999 9 : 3285 3290.
50. Wright CD, et al. Inhibition of allergen-induced pulmonary responses by the selective tryptase inhibitor 1,5-bis-[4-[(3-carbamimidoyl- benzenesulfonylamino)-methyl]-phenoxy]-pentane (AMG-126737). Biochem Pharmacol 1999 58 : 1989 1996.
51. Oh S-W, et al. Tryptase inhibition blocks airway inflammation in a mouse asthma model. J Immunol 2000 168 : 1992 2000.
52. Burgess LE, et al. Potent selective nonpeptidic inhibitors of human lung tryptase. Proc Natl Acad Sci USA 1999 96 : 8348 8352.
53. Schaschke N, Dominik A, Matschiner G, Sommerhoff CP. Bivalent inhibition of β-tryptase: distance scan of neighboring subunits by dibasic inhibitors. Bioorg Med Chem Lett 2002 12 : 985 988.
54. Selwood T, Elrod KC, Schechter NM. Potent bivalent inhibition of human tryptase-beta by a synthetic inhibitor. Biol Chem 2003 384 : 1605 1611.
55. Mori S, Itoh Y, Shinohata R, Sendo T, Oishi R, Nishibori M. Nafamostat mesilate is an extremely potent inhibitor of human tryptase. J Pharmacol Sci 2003 92 : 420 423.
56. Sendo T, et al. A potent tryptase inhibitor nafamostat mesilate dramatically suppressed pulmonary dysfunction induced in rats by a radiographic contrast medium. Br J Pharmacol 2003 138 : 959 967.
57. Chen CL, et al. Serine protease inhibitors nafamostat mesilate and gabexate mesilate attenuate allergen-induced airway inflammation and eosinophilia in a murine model of asthma. J Allergy Clin Immunol 2006 118 : 105 112.
58. Krishna MT, et al. Inhibition of mast cell tryptase by inhaled APC 366 attenuates allergen-induced late-phase airway obstruction in asthma. J Allergy Clin Immunol 2001 107 : 1039 1045.
59. Erin EM, et al. Effects of a reversible β-tryptase and trypsin inhibitor (RWJ-58643) on nasal allergic responses. Clin Exp Allergy 2006 36 : 458 464.
60. Molinari JF, Moore WR, Clark J, Tanaka R, Butterfield JH, Abraham WM. Role of tryptase in immediate cutaneous responses in allergic sheep. J Appl Physiol 1995 79 : 1966 1970.
61. Molinari JF, Scuri M, Moore WR, Clark J, Tanaka R, Abraham WM. Inhaled tryptase causes bronchoconstriction in sheep via histamine release. Am J Respir Crit Care Med 1996 154 : 649 653.
62. Caughey GH. Building a better heparin. Am J Respir Cell Mol Biol 2003 28 : 129 132.
63. Maier M, Spragg J, Schwartz LB. Inactivation of human high molecular weight kininogen by human mast cell tryptase. J Immunol 1983 130 : 2352 2356.
64. Ren S, Lawson AE, Carr M, Baumgarten CM, Schwartz LB. Human tryptase fibrinogenolysis is optimal at acidic pH and generates anticoagulant fragments in the presence of the anti-tryptase monoclonal antibody B12. J Immunol 1997 159 : 3540 3548.
65. Huang CF, et al. The tryptase, mouse mast cell protease 7, exhibits anticoagulant activity in vivo and in vitro due to its ability to degrade fibrinogen in the presence of the diverse array of protease inhibitors in plasma. J Biol Chem 1997 272 : 31885 31893.
66. Thomas VA, Wheeless CJ, Stack MS, Johnson DA. Human mast cell tryptase fibrinogenolysis: kinetics, anticoagulation mechanism, and cell adhesion disruption. Biochemistry 1988 37 : 2291 2298.
67. Proud D, Siekierski ED, Bailey GS. Identification of human lung mast cell kininogenase as tryptase and relevance of tryptase kininogenase activity. Biochem Pharmacol 1988 37 : 1473 1480.
68. Imamura T, Dubin A, Moore W, Tanaka R, Travis J. Induction of vascular permeability enhancement by human tryptase: dependence on activation of prekallikrein and direct release of bradykinin from kininogens. Lab Invest 1996 74 : 861 870.
69. Kozik A, Moore RB, Potempa J, Imamura T, Rapala-Kozik M, Travis J. A novel mechanism for bradykinin production at inflammatory sites. Diverse effects of a mixture of neutrophil elastase and mast cell tryptase versus tissue and plasma kallikreins on native and oxidized kininogens. J Biol Chem 1998 273 : 33224 33229.
70. Cairns JA, Walls AF. Mast cell tryptase is a mitogen for epithelial cells: stimulation of IL-8 production and intercellular adhesion molecule-1 expression. J Immunol 1996 156 : 275 283.
71. Huang C, et al. Evaluation of the substrate specificity of human mast cell tryptase βI and demonstration of its importance in bacterial infections of the lung. J Biol Chem 2001 276 : 26276 26284.
72. Huang C, et al. Induction of a selective and persistent extravasation of neutrophils into the peritoneal cavity by tryptase mouse mast cell protease 6. J Immunol 1998 160 : 1910 1919.
73. Franconi GM, Graf PD, Lazarus SC, Nadel JA, Caughey GH. Mast cell chymase and tryptase reverse airway smooth muscle relaxation induced by vasoactive intestinal peptide in the ferret. J Pharmacol Exp Ther 1989 248 : 947 951.
74. Tam EK, Caughey GH. Degradation of airway neuropeptides by human lung tryptase. Am J Respir Cell Mol Biol 1990 3 : 27 32.
75. Tam EK, Franconi GM, Nadel JA, Caughey GH. Protease inhibitors potentiate smooth muscle relaxation induced by vasoactive intestinal peptide in isolated human bronchi. Am J Respir Cell Mol Biol 1990 2 : 449 452.
76. Sekizawa K, Caughey GH, Lazarus SC, Gold WM, Nadel JA. Mast cell tryptase causes airway smooth muscle hyperresponsiveness in dogs. J Clin Invest 1989 83 : 175 179.
77. Johnson PRA, Ammit AJ, Carlin SM, Armour CL, Caughey GH, Black JL. Mast cell tryptase potentiates histamine-induced contraction in human sensitized bronchus. Eur Respir J 1997 10 : 38 43.
78. Berger P, et al. Mast cell tryptase as a mediator of hyperresponsiveness in human isolated bronchi. Clin Exp Allergy 1999 29 : 804 812.
79. Brightling CE, Bradding P, Symon FA, Holgate ST, Wardlaw AJ, Pavord ID. Mast-cell infiltration of airway smooth muscle in asthma. N Engl J Med 2002 346 : 1699 1705.
80. Ruoss SJ, Hartmann T, Caughey GH. Mast cell tryptase is a mitogen for cultured fibroblasts. J Clin Invest 1991 88 : 493 499.
81. Hartmann T, Ruoss SJ, Raymond WW, Seuwen K, Caughey GH. Human tryptase as a potent, cell-specific mitogen: role of signalling pathways in synergistic responses. Am J Physiol Lung Cell Mol Physiol 1992 262 : L528 L534.
82. Gruber BL, et al. Human mast cells activate fibroblasts: tryptase is a fibrogenic factor stimulating collagen messenger ribonucleic acid synthesis and fibroblast chemotaxis. J Immunol 1997 158 : 2310 2317.
83. Cairns JA, Walls AF. Mast cell tryptase stimulates synthesis of type I collagen in human lung fibroblasts. J Clin Invest 1997 99 : 1313 1321.
84. Brown JK, Tyler CL, Jones CA, Ruoss SJ, Hartmann T, Caughey GH. Tryptase, the dominant secretory granular protein in humans mast cells, is a potent mitogen for cultured dog tracheal smooth muscle cells. Am J Respir Cell Mol Biol 1995 13 : 227 236.
85. Brown JK, Jones CA, Rooney LA, Caughey GH, Hall IP. Tryptase's potent mitogenic effects in human airway smooth muscle cells are via nonproteolytic actions. Am J Physiol Lung Cell Mol Physiol 2002 282 : 197 206.
86. Brown JK, Jones CA, Rooney LA, Caughey GH. Mast cell tryptase activates extracellular-regulated kinases (p44/p42) in airway smooth-muscle cells: importance of proteolytic events, time course, and role in mediating mitogenesis. Am J Respir Cell Mol Biol 2001 24 : 146 154.
87. Wenzel SE, Fowler A, Schwartz LB. Activation of pulmonary mast cells by bronchoalveolar allergen challenge. In vivo release of histamine and tryptase in atopic subjects with and without asthma. Am Rev Respir Dis 1988 137 : 1002 1008.
88. Tremaine WJ, et al. Treatment of mildly to moderately active ulcerative colitis with a tryptase inhibitor (APC 2059): an open-label pilot study. Aliment Pharmacol Ther 2002 16 : 407 413.
89. Corvera CU, et al. Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2. J Clin Invest 1997 100 : 1383 1393.
90. Steinhoff M, et al. Proteinase-activated receptor-2 in human skin: tissue distribution and activation of keratinocytes by mast cell tryptase. Exp Dermatol 1999 8 : 282 294.
91. Steinhoff M, et al. Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin. J Neurosci 2003 23 : 6176 6180.
92. Ui H, Andoh T, Lee JB, Nojima H, Kuraishi Y. Potent pruritogenic action of tryptase mediated by PAR-2 receptor and its involvement in anti-pruritic effect of nafamostat mesilate in mice. Eur J Pharmacol 2006 530 : 172 178.
93. Dugas-Breit S, Schopf P, Dugas M, Schiffl H, Rueff F, Przybilla B. Baseline serum levels of mast cell tryptase are raised in hemodialysis patients and associated with severity of pruritus. J Dtsch Dermatol Ges 2005 3 : 343 347.
94. Steinhoff M, et al. Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Nat Med 2000 6 : 151 158.
95. Blair RJ, et al. Human mast cells stimulate vascular tube formation. Tryptase is a novel, potent angiogenic factor. J Clin Invest 1997 99 : 2691 2700.
96. Coussens LM, et al. Inflammatory mast cells upregulate angiogenesis during squamous epithelial carcinogenesis. Genes Dev 1999 13 : 1382 1397.
97. Somasundaram P, et al. Mast cell tryptase may modulate endothelial cell phenotype in healing myocardial infarcts. J Pathol 2005 205 : 102 111.
98. Miller HRP, Woodbury RG, Huntley JF, Newlands G. Systemic release of mucosal mast-cell protease in primed rats challenged with Nippostrongylus brasiliensis. Immunology 1983 49 : 471 479.
99. Scudamore CL, Thornton EM, McMillan L, Newlands GF, Miller HR. Release of the mucosal mast cell granule chymase, rat mast cell protease-II, during anaphylaxis is associated with the rapid development of paracellular permeability to macromolecules in rat jejunum. J Exp Med 1995 182 : 1871 1881.
100. MacQueen G, Marshall J, Perdue M, Siegel S, Bienenstock J. Pavlovian conditioning of rat mucosal mast cells to secrete rat mast cell protease II. Science 1989 243 : 83 85.
101. Yu CK, Chen CL. Activation of mast cells is essential for development of house dust mite Dermatophagoides farinae-induced allergic airway inflammation in mice. J Immunol 2003 171 : 3808 3815.
102. Sommerhoff CP, Caughey GH, Finkbeiner WE, Lazarus SC, Basbaum CB, Nadel JA. Mast cell chymase. A potent secretagogue for airway gland serous cells. J Immunol 1989 142 : 2450 2456.
103. Sommerhoff CP, Nadel JA, Basbaum CB, Caughey GH. Neutrophil elastase and cathepsin G stimulate secretion from cultured bovine airway gland serous cells. J Clin Invest 1990 85 : 682 689.
104. Matin R, Tam EK, Nadel JA, Caughey GH. Distribution of chymase-containing mast cells in human bronchi. J Histochem Cytochem 1992 40 : 781 786.
105. Caughey GH, Viro NF, Lazarus SC, Nadel JA. Purification and characterization of dog mastocytoma chymase. Identification of an octapeptide conserved in chymotryptic leukocyte proteases. Biochim Biophys Acta 1988 952 : 142 149.
106. Caughey GH, Raymond WW, Vanderslice P. Dog mast cell chymase: molecular cloning and characterization. Biochemistry 1990 29 : 5166 5171.
107. Caughey GH, Raymond WW, Wolters PJ. Angiotensin II generation by mast cell α- and β-chymases. Biochim Biophys Acta 2000 1480 : 245 257.
108. Rubinstein I, Nadel JA, Graf PD, Caughey GH. Mast cell chymase potentiates histamine-induced wheal formation in the skin of ragweed-allergic dogs. J Clin Invest 1990 86 : 555 559.
109. Knight PA, Wright SH, Lawrence CE, Paterson YY, Miller HR. Delayed expulsion of the nematode Trichinella spiralis in mice lacking the mucosal mast cell-specific granule chymase, mouse mast cell protease-1. J Exp Med 2000 192 : 1849 1856.
110. Koga T, et al. Human chymase expression in mice induces mild hypertension with left ventricular hypertrophy. Hypertens Res 2003 26 : 759 768.
111. Tchougounova E, Lundequist A, Fajardo I, Winberg JO, Abrink M, Pejler G. A key role for mast cell chymase in the activation of pro-matrix metalloprotease-9 and pro-matrix metalloprotease-2. J Biol Chem 2005 280 : 9291 9296.
112. Fang KC, Raymond WW, Lazarus SC, Caughey GH. Dog mastocytoma cells secrete a 92-kD gelatinase activated extracellularly by mast cell chymase. J Clin Invest 1996 97 : 1589 1596.
113. Fang KC, Raymond WW, Blount JL, Caughey GH. Dog mast cell α-chymase activates progelatinase B by cleaving the Phe88-Phe89 and Phe91-Glu92 bonds of the catalytic domain. J Biol Chem 1997 272 : 25628 25635.
114. Frank BT, Rossall JC, Caughey GH, Fang KC. Mast cell tissue inhibitor of metalloproteinase-1 is cleaved and inactivated extracellularly by α-chymase. J Immunol 2001 166 : 2783 2792.
115. Lin TY, London CA. A functional comparison of canine and murine bone marrow derived cultured mast cells. Vet Immunol Immunopathol 2006 114 : 320 334.
116. Coussens LM, Tinkle CL, Hanahan D, Werb Z. MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell 2000 103 : 481 490.
117. Gruber BL, et al. Synovial procollagenase activation by human mast cell tryptase. Dependence upon matrix metalloproteinase 3 activation. J Clin Invest 1989 84 : 1657 1662.
118. Fajardo I, Pejler G. Human mast cell β-tryptase is a gelatinase. J Immunol 2003 171 : 1493 1499.
119. Abonia JP, et al. Mast cell protease 5 mediates ischemia-reperfusion injury of mouse skeletal muscle. J Immunol 2005 174 : 7285 7291.
120. Raymond WW, Waugh Ruggles S, Craik CS, Caughey GH. Albumin is a substrate of human chymase: prediction by combinatorial peptide screening and development of a selective inhibitor based on the albumin cleavage site. J Biol Chem 2003 278 : 34517 34524.
121. Li M, et al. Involvement of chymase-mediated angiotensin II generation in blood pressure regulation. J Clin Invest 2004 114 : 112 120.
122. Dell'Italia LJ, Husain A. Dissecting the role of chymase in angiotensin II formation and heart and blood vessel diseases. Curr Opin Cardiol 2002 17 : 374 379.
123. Lindstedt KA, Kovanen PT. Mast cells in vulnerable coronary plaques: potential mechanisms linking mast cell activation to plaque erosion and rupture. Curr Opin Lipidol 2004 15 : 567 573.
124. Miyazaki M, Takai S, Jin D, Muramatsu M. Pathological roles of angiotensin II produced by mast cell chymase and the effects of chymase inhibition in animal models. Pharmacol Ther 2006 112 : 668 676.
125. Reilly CF, Tewksbury DA, Schechter NB, Travis J. Rapid conversion of angiotensin I to angiotensin II by neutrophil and mast cell proteinases. J Biol Chem 1982 257 : 8619 8622.
126. Lundequist A, Tchougounova E, Abrink M, Pejler G. Cooperation between mast cell carboxypeptidase A and the chymase mouse mast cell protease 4 in the formation and degradation of angiotensin II. J Biol Chem 2004 279 : 32339 32344.
127. Suzuki H, Caughey GH, Gao X-P, Rubinstein I. Mast cell chymase-like protease(s) modulates Escherichia coli lipopolysaccharide-induced vasomotor dysfunction in skeletal muscle in vivo. J Pharmacol Exp Ther 1998 284 : 1156 1164.
128. Chen LY, et al. Transgenic study of the function of chymase in heart remodeling. J Hypertens 2002 20 : 2047 2055.
129. Ju H, Gros R, You X, Tsang S, Husain M, Rabinovitch M. Conditional and targeted overexpression of vascular chymase causes hypertension in transgenic mice. Proc Natl Acad Sci USA 2001 98 : 7469 7474.
130. Nagata N, Niwa Y, Nakaya Y. A novel 31-amino-acid-length endothelin, ET-1(1-31), can act as a biologically active peptide for vascular smooth muscle cells. Biochem Biophys Res Commun 2000 275 : 595 600.
131. Johnson JL, Jackson CL, Angelini GD, George SJ. Activation of matrix-degrading metalloproteinases by mast cell proteases in atherosclerotic plaques. Arterioscler Thromb Vasc Biol 1998 18 : 1707 1715.
132. Lindstedt KA, Kovanen PT. Proteolysis of pericellular matrix: a process linking inflammation to plaque destabilization and rupture. Arterioscler Thromb Vasc Biol 2004 24 : 2205 2206.
133. Leskinen MJ, et al. Mast cell chymase induces smooth muscle cell apoptosis by disrupting NF-κB-mediated survival signaling. Exp Cell Res 2006 312 : 1289 1298.
134. Mayranpaa MI, Heikkila HM, Lindstedt KA, Walls AF, Kovanen PT. Desquamation of human coronary artery endothelium by human mast cell proteases: implications for plaque erosion. Coron Artery Dis 2006 17 : 611 621.
135. Pang L, Nie M, Corbett L, Sutcliffe A, Knox AJ. Mast cell β-tryptase selectively cleaves eotaxin and RANTES and abrogates their eosinophil chemotactic activities. J Immunol 2006 176 : 3788 3795.
136. Zhao W, Oskeritzian CA, Pozez AL, Schwartz LB. Cytokine production by skin-derived mast cells: endogenous proteases are responsible for degradation of cytokines. J Immunol 2005 175 : 2635 2642.
137. Maurer M, et al. Mast cells promote homeostasis by limiting endothelin-1-induced toxicity. Nature 2004 432 : 512 516.
138. Brain SD, Williams TJ. Substance P regulates the vasodilator activity of calcitonin gene-related peptide. Nature 1988 335 : 73 75.
139. Mellon MB, Frank BT, Fang KC. Mast cell α-chymase reduces IgE recognition of birch pollen profilin by cleaving antibody-binding epitopes. J Immunol 2002 168 : 290 297.
140. Finkelman FD, Urban JF Jr. The other side of the coin: the protective role of the TH2 cytokines. J Allergy Clin Immunol 2001 107 : 772 780.