Mast cell β-tryptase selectively cleaves eotaxin and RANTES and abrogates their eosinophil chemotactic activities

Journal of Immunology

Volumn 176, Issue 6, 2006, Pages 3788-3795

  Pang, Linhua ^a   Nie, Mei ^a   Corbett, Lisa ^a   Sutcliffe, Amy ^a   Knox, Alan J ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA TRYPTASE; CHEMOATTRACTANT; CHEMOKINE; CHYMASE; EOTAXIN; HEPARIN; LEUPEPTIN; MESSENGER RNA; PROTEINASE; PROTEINASE INHIBITOR; RANTES; RECOMBINANT ENZYME; RECOMBINANT EOTAXIN; RECOMBINANT HUMAN BETA TRYPTASE; RECOMBINANT PROTEIN; RECOMBINANT RANTES; TRYPTASE; UNCLASSIFIED DRUG;

AIRWAY SMOOTH MUSCLE; ARTICLE; ASTHMA; BREATHING MUSCLE; CHEMOTAXIS; CONCENTRATION RESPONSE; ENZYME ACTIVITY; ENZYME INACTIVATION; EOSINOPHIL; GENE EXPRESSION; HEAT TREATMENT; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; LEUKOCYTE MIGRATION; MAST CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION;

EID: 33644847416     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.176.6.3788     Document Type: Article

References (42)

1. Brightling, C. E., P. Bradding, F. A. Symon, S. T. Holgate, A. J. Wardlaw, and I. D. Pavord. 2002. Mast cell infiltration of airway smooth muscle in asthma. N. Engl. J. Med. 346: 1699-1703.
2. Carroll, N. G., S. Mutavdzic, and A. J. James. 2002. Distribution and degranulation of airway mast cells in normal and asthmatic subjects. Eur. Respir. J. 19: 879-885.
3. Pallaoro, M., M. S. Fejzo, L. Shayesteh, J. L. Blount, and G. H. Caughey. 1999. Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3. J. Biol. Chem. 274: 3355-3362.
4. Little, S. S., and D. A. Johnson. 1995. Human mast cell tryptase isoforms: separation and examination of substrate-specificity differences. Biochem. J. 307: 341-346.
5. Fukuoka, Y., and L. B. Schwartz. 2004. Human β-tryptase: detection and characterization of the active monomer and prevention of tetramer reconstitution by protease inhibitors. Biochemistry 43: 10757-10764.
6. 2- agonists and corticosteroids. FASEB J. 15:261-269.
7. Pype, J. L., L. J. Dupont, P. Menten, E. Van Coillie, G. Opdenakker, J. Van Damme, K. F. Chung, M. G. Demedts, and G. M. Verleden. 1999. Expression of monocyte chemotactic protein (MCP)-1, MCP-2, and MCP-3 by human airway smooth-muscle cells; modulation by corticosteroids and T-helper 2 cytokines. Am. J. Respir. Cell Mol. Biol. 21: 528-536.
8. Pang, L., and A. J. Knox. 1998. Bradykinin stimulates IL-8 production in cultured human airway smooth muscle cefls: role of cyclooxygenase products. J. Immunol. 161: 2509-2515.
9. Kassel, O., F. Schmidlin, C. Duvernelle, B. Gasser, G. Massard, and N. Frossard. 1999. Human bronchial smooth muscle cells in culture produce stem cell factor. Eur. Respir. J. 13: 951-954.
10. Ammit, A. J., A. L. Lazaar, C. Irani, G. M. O'Neill, N. D. Gordon, Y. Amrani, R. B. Penn, and R. A. Panettieri, Jr. 2002. Tumor necrosis factor-α-induced secretion of RANTES and interleukin-6 from human airway smooth muscle cells: modulation by glucocorticoids and β-agonists. Am. J. Respir. Cell Mol. Biol. 26: 465-474.
11. Saunders, M. A., J. A. Mitchell, P. M. Seldon, M. H. Yacoub, P. J. Barnes, M. A. Giembycz, and M. G. Belvisi. 1997. Release of granulocyte- macrophage colony stimulating factor by human cultured airway smooth muscle cells: suppression by dexamethasone. Br. J. Pharmacol. 120: 545-546.
12. Berger, P., P. O. Girodet, H. Begueret, O. Ousova, D. W. Perng, R. Marthan, A. F. Walls, and J. M. Tunon De Lara. 2003. Tryptase-stimulated human airway smooth muscle cells induce cytokine synthesis and mast cell chemotaxis. FASEB J. 17: 2139-2141.
13. Brown, J. K., C. A. Jones, L. A. Rooney, G. H. Caughey, and I. P. Hall. 2002. Tryptase's potent mitogenic effects in human airway smooth muscle cells are via nonproteolytic actions. Am. J. Physiol. 282: L197-L206.
14. Lazaar, A. L., M. I. Plotnick, U. Kucich, I. Crichton, S. Lotfi, S. F. Das, S. Kane, J. Rosenbloom, R. A. Panettieri, Jr., N. M. Schechter, et al. 2002. Mast cell chymase modifies cell-matrix interactions and inhibits mitogen-induced proliferation of human airway smooth muscle cells. J. Immunol. 169: 1014-1020.
15. Kameyoshi, Y., A. Dorschner, A. I. Mallet, E. Christophers, and J. M. Schroder. 1992. Cytokine RANTES released by thrombin-stimulated platelets is a potent attractant for human eosinophils. J. Exp. Med. 176: 587-592.
16. Schall, T. J., K. Bacon, K. J. Toy, and D. V. Goedded. 1990. Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES. Nature 347: 669-671.
17. Oravecz, T., M. Pall, G. Roderiquez, M. D. Gorrell, M. Ditto, N. Y. Nguyen, R. Boykins, E. Unsworth, and M. A. Norcross. 1997. Regulation of the receptor specificity and function of the chemokine RANTES (regulated on activation, normal T cell expressed and secreted) by dipeptidyl peptidase IV (CD26)-mediated cleavage. J. Exp. Med. 186: 1865-1872.
18. Struyf, S., P. Proost, P. Schols, E. De Clercq, G. Opdenakker, J. P. Lenaerts, M. Detheux, M. Parmentier, I. De Meester, S. Scharpé, et al. 1999. CD26/dipeptidyl-peptidase IV down-regulates the eosinophil chemotactic potency, but not the anti-HIV activity of human eotaxin by affecting its interaction with CC chemokine receptor 3. J. Immunol. 162: 4903-4909.
19. Culley, F. J., A. Brown, D. M. Conroy, I. Sabroe, D. I. Pritchard, and T. J. Williams. 2000. Eotaxin is specifically cleaved by hookworm metalloproteases preventing its action in vitro and in vivo. J. Immunol. 165: 6447-6453.
20. Ghaffar, O., Q. Hamid, P. M. Renzi, Z. Allakhverdi, S. Molet, J. C. Hogg, S. A. Shore, A. D. Luster, and B. Lamkhioued. 1999. Constitutive and cytokine-stimulated expression of eotaxin by human airway smooth muscle cells. Am. J. Respir. Crit. Care Med. 159: 1933-1942.
21. Berkman, N., V. L. Krishnan, T. Gilbey, R. Newton, B. O'Connor, P. J. Barnes, and K. F. Chung. 1996. Expression of RANTES mRNA and protein in airways of patients with mild asthma. Am. J. Respir. Crit. Care Med. 154: 1804-1811.
22. Broide, D. H., G. J. Gleich, A. J. Cuomo, D. A. Coburn, E. C. Federman, L. B. Schwartz, and S. I. Wasserman. 1991. Evidence of ongoing mast cell and eosinophil degranulation in symptomatic asthma airway. J. Allergy Clin. Immunol. 88: 637-648.
23. Pang, L., and A. J. Knox. 1997. Effect of interleukin-1β, tumour necrosis factor-α and interferon-r on the induction of cyclo-oxygenase-2 in cultured human airway smooth muscle cells. Br. J. Pharmacol. 121: 579-587.
24. 2- agonists. J. Biol. Chem. 280: 2550-2561.
25. Ferreira, H. H. A., M. L. S. Lodo, A. R. Martins, L. Kandratavicius, A. F. Salaroli, N. Conran, E. Antunes, and G. De Nucci. 2002. Expression of nitric oxide synthases and in vitro migration of eosinophils from allergic rhinitis subjects. Eur. J. Pharmacol. 442: 155-162.
26. Borchers, M. T., T. Ansay, R. DeSalle, B. L. Daugherty, H. Shen, M. Metzger, N. A. Lee, and J. J. Lee. 2002. In vitro assessment of chemokine receptor-ligand interactions mediating mouse eosinophil migration. J. Leukocyte Biol. 71: 1033-1041.
27. He, S. H., P. Chen, and H. Q. Chen. 2003. Modulation of enzymatic activity of human mast cell tryptase and chymase by protease inhibitors. Acta Pharmacol. Sin. 24: 923-929.
28. Tam, E. K., and G. H. Caughey. 1990. Degradation of airway neuropeptides by human lung tryptase. Am. J. Respir. Cell Mol. Biol. 3: 27-32.
29. Lohi, J., I. Harvima, and J. Keski-Oja. 1992. Pericellular substrates of human mast cell tryptase: 72,000 dalton gelatinase and fibronectin. J. Cell. Biochem. 50: 337-349.
30. Gruber, B. L., M. J. Marchese, K. Suziki, L. B. Schwartz, Y. Okada, H. Nagase, and N. S. Ramamurthy. 1989. Synovial procollagenase activation by human mast cell tryptase: dependence upon matrix metalloproteinase 3 activation. J. Clin. Invest. 84: 1657-1662.
31. Ruoss, S. J., T. Hartmann, and G. H. Caughey. 1991. Mast cell tryptase is a mitogen for cultured fibroblasts. J. Clin. Invest. 88: 493-499.
32. Cairns, J. A., and A. F. Walls. 1996. Mast cell tryptase is a mitogen for epithelial cells: stimulation of IL-8 production and intercellular adhesion molecule-1 expression. J. Immunol. 156: 275-283.
33. Compton, S. J., J. A. Cairns, S. T. Holgate, and A. F. Walls. 1998. The role of mast cell tryptase in regulating endothelial cell proliferation, cytokine release, and adhesion molecule expression: tryptase induces expression of mRNA for IL-1β and IL-8 and stimulates the selective release of IL-8 from human umbilical vein endothelial cells. J. Immunol. 161: 1939-1946.
34. Knox, A. J., L. Corbett, J. Stocks, E. Holland, Y. M. Zhu, and L. Pang. 2001. Human airway smooth muscle cells secrete vascular endothelial growth factor: up-regulation by bradykinin via a protein kinase C and prostanoid-dependent mechanism. FASEB J. 15: 2480-2488.
35. Zuyderduyn, S., P. S. Hiemstra, and K. F. Rabe. 2004. TGF-β differentially regulates Th2 cytokine-induced eotaxin and eotaxin-3 release by human airway smooth muscle cells. J. Allergy Clin. Immunol. 114: 791-798.
36. Ponath, P. D., S. Qin, D. J. Ringler, I. Clark-Lewis, J. Wang, N. Kassam, H. Smith, X. Shi, J. A. Gonzalo, W. Newman, et al. 1996. Cloning of the human eosinophil chemoattractant, eotaxin: expression, receptor binding and functional properties suggest a mechanism for the selective recruitment of eosinophils. J. Clin. Invest. 97: 604-612.
37. Uguccioni, M., C. R. Mackay, B. Ochensberger, P. Loetscher, S. Rhis, G. J. LaRosa, P. Rao, P. D. Ponath, M. Baggiolini, and C. A. Dahinden. 1997. High expression of the chemokine receptor CCR3 in human blood basophils: role in activation by eotaxin, MCP-4 and other chemokines. J. Clin. Invest. 100: 1137-1143.
38. Sallusto, F., C. R. Mackay, and A. Lanzavecchia. 1997. Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. Science 277: 2005-2007.
39. Romagnani, P., A. De Paulis, C. Beltrame, F. Annunziato, V. Dente, E. Maggi, S. Romagnani, and G. Marone. 1999. Tryptase-chymase double-positive human mast cells express the eotaxin receptor CCR3 and are attracted by CCR3-binding chemokines. Am. J. Pathol. 155: 1195-1204.
40. Brightling, C. E., A. J. Ammit, D. Kaur, J. L. Black, A. J. Wardlaw, J. M. Hughes, and P. Bradding. 2005. The CXCL10/CXCR3 axis mediates human lung mast cell migration to asthmatic airway smooth muscle. Am. J. Respir. Crit. Care Med. 171: 1103-1108.
41. Leckie, M. J., A. T. Brinke, J. Khan, Z. Diamant, B. J. O'Connor, C. M. Walls, A. K. Mathur, H. C. Cowley, K. F. Chung, R. Djukanovic, et al. 2000. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyperresponsiveness, and the late asthmatic response. Lancet 356: 2144-2148.
42. Kips, J. C., B. J. O'Connor, S. J. Langley, A. Woodcock, H. A. Kerstjens, D. S. Postma, M. Danzig, F. Cuss, and R. A. Pauwels. 2003. Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot study. Am. J. Respir. Crit. Care Med. 167: 1655-1659.