Design of potent selective zinc-mediated serine protease inhibitors

Nature

Volumn 391, Issue 6667, 1998, Pages 608-612

  Katz, Bradley A ^a   Clark, James M ^a   Finer Moore, Janet S ^b   Jenkins, Thomas E ^c   Johnson, Charles R ^a   Ross, Michael J ^a   Luong, Christine ^a   Moore, William R ^a   Stroud, Robert M ^a,b  

^a Arris Pharmaceutical Corporation   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Advanced Medicine Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIS(5 AMIDINO 2 BENZIMIDAZOLYL)METHANE; BLOOD CLOTTING FACTOR 10A; CHYMASE; CHYMOTRYPSIN; EDETIC ACID; SERINE PROTEINASE INHIBITOR; THROMBIN; TRYPSIN; TRYPTASE; ZINC;

ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME INHIBITION; PRIORITY JOURNAL; PROTEINASE INHIBITION;

ANIMALS; BENZIMIDAZOLES; CATTLE; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RATS; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; ZINC;

EID: 0032484901     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35422     Document Type: Article

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