Biochemical and functional characterization of human transmembrane tryptase (TMT)/tryptase γ: TMT is an exocytosed mast cell protease that induces airway hyperresponsiveness in vivo via an interleukin-13/interleukin-4 receptor α/signal transducer and activator of transcription (STAT) 6-dependent pathway

Journal of Biological Chemistry

Volumn 277, Issue 44, 2002, Pages 41906-41915

  Wong, Guang W ^b   Foster, Paul S ^b   Yasuda, Shinsuke ^b   Qi, Jian C ^b   Mahalingam, Surendran ^b   Mellor, Elizabeth A ^b   Katsoulotos, Gregory ^b   Li, Xin ^b   Boyce, Joshua A ^b   Krilis, Steven A ^c   Stevens, Richard L ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b Biology and Environment   (Australia)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOLOGICAL MEMBRANES; CELLS; GENES; GENETIC ENGINEERING; LIVING SYSTEMS STUDIES; RNA;

SIGNAL TRANSDUCERS;

ENZYMES;

ALPHA 1 ANTITRYPSIN; INTERLEUKIN 13 RECEPTOR; INTERLEUKIN 4 RECEPTOR; STAT6 PROTEIN; TRANSMEMBRANE TRYPTASE; TRYPTASE; TRYPTASE GAMMA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASOPHIL; BRONCHUS HYPERREACTIVITY; CHROMOSOME 16P; CONTROLLED STUDY; CYTOKINE RELEASE; DEGRANULATION; ENZYME ANALYSIS; ENZYME SPECIFICITY; EXOCYTOSIS; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MAST CELL; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; SECRETORY GRANULE; TRANSGENIC MOUSE;

ANIMALS; BRONCHIAL HYPERREACTIVITY; CELLS, CULTURED; EXOCYTOSIS; HUMANS; INTERLEUKIN-13; INTERLEUKIN-13 RECEPTOR ALPHA1 SUBUNIT; MALE; MAST CELLS; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-13; RECEPTORS, INTERLEUKIN-4; RECOMBINANT PROTEINS; SERINE ENDOPEPTIDASES; SIGNAL TRANSDUCTION; STAT6 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRYPTASES;

ANIMALIA; BRONCHUS; MUS MUSCULUS;

EID: 0036830570     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M205868200     Document Type: Article

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