Mast cell dipeptidyl peptidase I mediates survival from sepsis

Journal of Clinical Investigation

Volumn 113, Issue 4, 2004, Pages 628-634

  Mallen St Clair, Jon ^a   Pham, Christine T N ^b   Villalta, S Armando ^a   Caughey, George H ^a   Wolters, Paul J ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE PROTEINASE; CYTOKINE; DIPEPTIDYL PEPTIDASE I; INTERLEUKIN 6; PEPTIDASE; TRYPTASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL INFECTION; BACTERIAL PERITONITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE MODEL; ENZYME ACTIVITY; IMMUNE RESPONSE; MAST CELL; MOUSE; NONHUMAN; PERITONEAL FLUID; PRIORITY JOURNAL; PROTECTION; PROTEIN EXPRESSION; SEPSIS; SERUM; SURVIVAL; ANIMAL; ASCITES FLUID; BACTERIUM; C57BL MOUSE; ENZYMOLOGY; GENETICS; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; MORTALITY; MOUSE MUTANT; PERITONITIS;

ANIMALS; ASCITIC FLUID; BACTERIA; DIPEPTIDYL PEPTIDASE I; INTERLEUKIN-6; MAST CELLS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PERITONITIS; SEPSIS;

EID: 1642337351     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200419062     Document Type: Article

References (36)

1. Cohen, J. 2002. The immunopathogenesis of sepsis. Nature. 420:885-891.
2. Janeway, C.A., Jr., and Medzhitov, R. 2002. Innate immune recognition. Annu. Rev. Immunol. 20:197-216.
3. Echtenacher, B., Mannel, D.N., and Hultner, L. 1996. Critical protective role of mast cells in a model of acute septic peritonitis. Nature. 381:75-77.
4. Malaviya, R., Ikeda, T., Ross, E., and Abraham, S.N. 1996. Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha. Nature. 381:77-80.
5. Supajatura, V., et al. 2002. Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity. J. Clin. Invest. 109:1351-1359. doi:10.1172/JCI200214704.
6. Malaviya, R., Gao, Z., Thankavel, K., van der Merwe, P.A., and Abraham, S.N. 1999. The mast cell tumor necrosis factor alpha response to FimH-expressing Escherichia coli is mediated by the glycosylphosphatidylinositol-anchored molecule CD48. Proc. Natl. Acad. Sci. U. S. A. 96:8110-8115.
7. Gommerman, J.L., et al. 2000. A role for CD21/CD35 and CD19 in responses to acute septic peritonitis: a potential mechanism for mast cell activation. J. Immunol. 165:6915-6921.
8. Belaaouaj, A., Kim, K.S., and Shapiro, S.D. 2000. Degradation of outer membrane protein A in Escherichia coli killing by neutrophil elastase. Science. 289:1185-1188.
9. Weinrauch, Y., Drujan, D., Shapiro, S.D., Weiss, J., and Zychlinsky, A. 2002. Neutrophil elastase targets virulence factors of enterobacteria. Nature. 417:91-94.
10. McGuire, M.J., Lipsky, P.E., and Thiele, D.L. 1992. Purification and characterization of dipeptidyl peptidase I from human spleen. Arch. Biochem. Biophys. 295:280-288.
11. Adkison, A.M., Raptis, S.Z., Kelley, D.G., and Pham, C.T. 2002. Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis. J. Clin. Invest. 109:363-371.doi:10.1172/JCI200213462.
12. Wolters, P.J., Pham, C.T., Muilenburg, D.J., Ley, T.J., and Caughey, G.H. 2001. Dipeptidyl peptidase I is essential for activation of mast cell chymases, but not tryptases, in mice. J. Biol. Chem. 276:18551-18556.
13. Pham, C.T., and Ley, T.J. 1999. Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo. Proc. Natl. Acad. Sci. U. S. A. 96:8627-8632.
14. Belaaouaj, A., et al. 1998. Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis. Nat. Med. 4:615-618.
15. Reeves, E.P., et al. 2002. Killing activity of neutrophils is mediated through activation of proteases by K+ flux. Nature. 416:291-297.
16. Tkalcevic, J., et al. 2000. Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G. Immunity. 12:201-210.
17. Huang, C., et al. 2001. Evaluation of the substrate specificity of human mast cell tryptase beta I and demonstration of its importance in bacterial infections of the lung. J. Biol. Chem. 276:26276-26284.
18. Duttlinger, R., et al. 1995. The Wsh and Ph mutations affect the c-kit expression profile: c-kit misexpression in embryogenesis impairs melanogenesis in Wsh and Ph mutant mice. Proc. Natl. Acad. Sci. U. S. A. 92:3754-3758.
19. Jayr, C., et al. 1994. Alveolar Liquid and protein clearance in anesthetized ventilated rats. J. Appl. Physiol. 76:2636-2642.
20. Razin, E., et al. 1984. Interleukin 3: a differentiation and growth factor for the mouse mast cell that contains chondroitin sulfate E proteoglycan. J. Immunol. 132:1479-1486.
21. Tono, T., et al. 1992. c-kit Gene was not transcribed in cultured mast cells of mast cell-deficient Wsh/Wsh mice that have a normal number of erythrocytes and a normal c-kit coding region. Blood. 80:1448-1453.
22. Nakano, T., et al. 1985. Fate of bone marrow-derived cultured mast cells after intracutaneous, intraperitoneal, and intravenous transfer into genetically mast cell-deficient W/Wv mice. Evidence that cultured mast cells can give rise to both connective tissue type and mucosal mast cells. J. Exp. Med. 162:1025-1043.
23. Coussens, L.M., et al. 1999. Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis. Genes Dev. 13:1382-1397.
24. Wolters, P.J., Raymond, W.W., Blount, J.L., and Caughey, G.H. 1998. Regulated expression, processing, and secretion of dog mast cell dipeptidyl peptidase I. J. Biol. Chem. 273:15514-15520.
25. Dalrymple, S.A., et al. 1996. Interleukin-6 is required for a protective immune response to systemic Escherichia coli infection. Infect. Immun. 64:3231-3235.
26. Hollenberg, S.M., et al. 2001. Characterization of a hyperdynamic murine model of resuscitated sepsis using echocardiography. Am. J. Respir. Crit. Care Med. 164:891-895.
27. Barton, B.E., and Jackson, J.V. 1993. Protective role of interleukin 6 in the lipopolysaccharide-galactosamine septic shock model. Infect. Immun. 61:1496-1499.
28. Barton, B.E., Shortall, J., and Jackson, J.V. 1996. Interleukins 6 and 11 protect mice from mortality in a staphylococcal enterotoxin-induced toxic shock model. Infect. Immun. 64:714-718.
29. van der Poll, T., et al. 1997. Interleukin-6 gene-deficient mice show impaired defense against pneumococcal pneumonia. J. Infect. Dis. 176:439-444.
30. Xing, Z., et al. 1998. IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses. J. Clin. Invest. 101:311-320.
31. Maurer, M., et al. 1998. The c-kit ligand, stem cell factor, can enhance innate immunity through effects on mast cells. J. Exp. Med. 188:2343-2348.
32. Galli, S.J., Maurer, M., and Lantz, C.S. 1999. Mast cells as sentinels of innate immunity. Curr. Opin. Immunol. 11:53-59.
33. Ohshima, S., et al. 1998. Interleukin 6 plays a key role in the development of antigen-induced arthritis. Proc. Natl. Acad. Sci. U. S. A. 95:8222-8226.
34. Fattori, E., et al. 1994. Defective inflammatory response in interleukin 6-deficient mice. J. Exp. Med. 180:1243-1250.
35. Riedemann, N.C., et al. 2003. Protective effects of IL-6 blockade in sepsis are linked to reduced c5a receptor expression. J. Immunol. 170:503-507.
36. McCurdy, J.D., Lin, T.J., and Marshall, J.S. 2001. Toll-like receptor 4-mediated activation of murine mast cells. J. Leukoc. Biol. 70:977-984.