A novel approach to serine protease inhibition: Kinetic characterization of inhibitors whose potencies and selectivities are dramatically enhanced by zinc(II)

Biochemistry

Volumn 39, Issue 16, 2000, Pages 4792-4800

  Janc, James W ^a   Clark, James M ^a   Warne, Robert L ^a,b   Elrod, Kyle C ^a   Katz, Bradley A ^a   Moore, William R ^a  

^a Axys Pharmaceuticals Inc   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

METAL; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; TRYPSIN; TRYPTASE; ZINC;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; KINETICS; PRIORITY JOURNAL;

CATIONS, DIVALENT; CHYMASES; DRUG SYNERGISM; EDETIC ACID; HALF-LIFE; HUMANS; KINETICS; METALS; PROTEIN BINDING; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; SERUM ALBUMIN; SUBSTRATE SPECIFICITY; THERMODYNAMICS; TRYPTASES; ZINC;

EID: 0034712661     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi992182j     Document Type: Article

References (49)

1. Mann, K. G., Jenny, R. J., and Krishnaswamy, S. (1988) Annu. Rev. Biochem. 57, 915-956.
2. Müller-Eberhard, H. J. (1988) Annu. Rev. Biochem. 57, 321-347.
3. Seidah, N. G., and Chrétien, M. (1997) Curr. Opin. Biotechnol. 8, 602-607.
4. Steiner, D. F., Smeekens, S. P., Ohagi, S., and Chan, S. J. (1992) J. Biol. Chem. 267, 23435-23438.
5. Döring, G. (1994) Am. J. Respir. Crit. Care Med. 150, S114-S117.
6. Werb, Z. (1997) Cell 91, 439-442.
7. Schmitt, M., Jänicke, F., and Graeff, H. (1992) Fibrinolysis 6, 3-26.
8. Katz, B. A., Clark, J. M., Finer-Moore, J. S., Jenkins, T. E., Johnson, C. R., Luong, C., Moore, W. R., and Stroud, R. M. (1998) Nature 391, 608-612.
9. Schwartz, L. B. (1994) Methods Enzymol. 244, 88-100.
10. Schwartz, L. B. (1990) J. Allergy Clin. Immunol. 86, 94-98.
11. Sekizawa, K., Caughey, G. H., Lazaris, S. C., Gold, W. M., and Nadel, J. A. (1989) J. Clin. Invest. 83, 175-179.
12. Clark, J. M., Abraham, W. M., Fishman, C. E., Forteza, R., Ahmed, A., Cortes, A., Warne, R. L., Moore, W. R., and Tanaka, R. D. (1995) Am. J. Respir. Crit. Care Med. 152, 2076-2083.
13. Butterfield, J. H., Weiler, D. A., Hunt, L. W., Wynn, S. R., and Roche, P. C. (1990) J. Leukocyte Biol. 47, 409-419.
14. Church, T. J., Cutshall, N. S., Gangloff, A. R., Jenkins, T. E., Linsell, M. S., Litvak, J., Rice, K. D., and Spencer, J. R. (1998) PCT Int. Appl. WO 9845275.
15. Tuppy, H., Weisbauer, U., and Wintersberger, E. (1962) Hoppe-Seyler's Z. Physiol. Chem. 329, 278-288.
16. Kuzmic, P. (1996) Anal. Biochem. 237, 260-273.
17. Kurganov, B. I., Sugrobova, N. P., and Yakovlev, V. A. (1972) FEBS Lett. 19, 308-310.
18. Morrison, J. F. (1969) Biochim. Biophys. Acta 185, 269-286.
19. Marquardt, D. W. (1963) J. Soc. Ind. Appl. Math. 11, 431-441.
20. Connors, K. A. (1987) in Binding Constants: The Measurement of Molecular Complex Stability, pp 141-187, John Wiley and Sons, New York.
21. Cleland, W. W. (1979) Methods Enzymol. 63, 103-138.
22. Yonetani, T., and Theorell, H. (1964) Arch. Biochem. Biophys. 106, 243-251.
23. Morrison, J. F., and Walsh, C. T. (1988) Adv. Enzymol. 61, 201-301.
24. Masuoka, J., Hegenauer, J., Van Dyke, B. R., and Saltman, P. (1993) J. Biol. Chem. 268, 21533-21537.
25. Berthon, G., Matuchansky, C., and May, P. (1980) J. Inorg. Biochem. 13, 63-73.
26. Tidwell, R. R., Gratz, J. D., Dann, O., Volz, G., Zeh, D., and Loewe, H. (1978) J. Med. Chem. 21, 613-623.
27. Christianson, D. W. (1991) Adv. Protein Chem. 42, 281-355.
28. Smith, R. M., and Martell, A. E. (1975) in Critical Stability Constants, Vol. 2: Amines, pp 144-255, Plenum Press, New York.
29. Irving, H., and Williams, R. J. P. (1948) Nature 162, 746-749.
30. Yonetani, T. (1982) Methods Enzymol. 87, 500-509.
31. Martinez-Irujo, J. J., Villahermosa, M. L., Mercapide, J., Cabodevilla, J. F., and Santiago, E. (1998) Biochem. J. 329, 689-698.
32. Morrison, J. F., and Stone, S. R. (1985) Comments Mol. Cell. Biophys. 2, 347-368.
33. Cha, S. (1975) Biochem. Pharmacol. 24, 2177-2185.
34. Schloss, J. V. (1988) Acc. Chem. Res. 21, 348-353.
35. Vallee, B. L. (1983) in Zinc Enzymes (Spiro, T. G., Ed.) pp 1-24, John Wiley and Sons, New York.
36. Masuoka, J., and Saltman, P. (1994) J. Biol. Chem. 269, 25557-25561.
37. Peters, T., Jr. (1985) Adv. Protein Chem. 37, 161-245.
38. Vallee, B. L., and Auld, D. S. (1990) Biochemistry 29, 5647-5659.
39. Berg, J. M., and Shi, Y. (1996) Science 271, 1081-1085.
40. O'Halloran, T. V. (1993) Science 261, 715-725.
41. Lipscomb, W. N., and Sträter, N. (1996) Chem. Rev. 96, 2375-2433.
42. Somers, W., Ultsch, M., De Vos, A. M., and Kossiakoff, A. A. (1994) Nature 372, 478-481.
43. Bernardo, M. M., Day, D. E., Olson, S. T., and Shore, J. D. (1993) J. Biol. Chem. 268, 12468-12476.
44. Higaki, J. N., Haymore, B. L., Chen, S., Fletterick, R. J., and Craik, C. S. (1990) Biochemistry 29, 8582-8586.
45. Magneson, G. R., Puvathingal, J. M., and Ray, W. J., Jr. (1987) J. Biol. Chem. 262, 11140-11148.
46. Schroeder, H. A., and Nason, A. P. (1971) Clin. Chem. 17, 461-473.
47. Giroux, E. L., Durieux, M., and Schechter, P. J. (1976) Bioinorg. Chem. 5, 211-218.
48. Parisi, A. F., and Vallee, B. L. (1970) Biochemistry 9, 2421-2426.
49. Harris, W. R., and Keen, C. (1989) J. Nutr. 119, 1677-1682.