Cytokine production by skin-derived mast cells: Endogenous proteases are responsible for degradation of cytokines

Journal of Immunology

Volumn 175, Issue 4, 2005, Pages 2635-2642

  Zhao, Wei ^a   Oskeritzian, Carole A ^a,b   Pozez, Andrea L ^a   Schwartz, Lawrence B ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN G; CHYMASE; CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 13; INTERLEUKIN 5; INTERLEUKIN 6; PROTEINASE; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; MAST CELL; PRIORITY JOURNAL; PROTEIN CROSS LINKING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS;

EID: 23444460431     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.175.4.2635     Document Type: Article

References (61)

1. Schwartz, L. B. 2002. Mast cells and basophils. In Inflammatory Mechanisms in Allergic Diseases. B. a. S. L. B. Zweiman, ed. Marcel Dekker, New York, p. 3.
2. Galli, S. J. 2000. Mast cells and basophils. Curr. Opin. Hematol. 7: 32-39.
3. TC cells. J. Immunol. 147: 247-253.
4. Irani, A. A., N. M. Schechter, S. S. Craig, G. DeBlois, and L. B. Schwartz. 1986. Two types of human mast cells that have distinct neutral protease compositions. Proc. Natl. Acad. Sci. USA 83: 4464-4468.
5. TC type of human mast cell. J. Immunol. 145: 2652-2661.
6. Brightling, C. E., P. Bradding, F. A. Symon, S. T. Holgate, A. J. Wardlaw, and I. D. Pavord. 2002. Mast-cell infiltration of airway smooth muscle in asthma. N. Engl. J. Med. 346: 1699-1705.
7. Kambe, N., M. Kambe, J. P. Kochan, and L. B. Schwartz. 2001. Human skin-derived mast cells can proliferate while retaining their characteristic functional and protease phenotypes. Blood 97: 2045-2052.
8. Ochi, H., N. H. De Jesus, F. H. Hsieh, K. F. Austen, and J. A. Boyce. 2000. IL-4 and-5 prime human mast cells for different profiles of IgE-dependent cytokine production. Proc. Natl. Acad. Sci. USA 97: 10509-10513.
9. Bradding, P., Y. Okayama, P. H. Howarth, M. K. Church, and S. T. Holgate. 1995. Heterogeneity of human mast cells based on cytokine content. J. Immunol. 155: 297-307.
10. Anderson, D. F., S. L. Zhang, P. Bradding, J. I. McGill, S. T. Holgate, and W. R. Roche. 2001. The relative contribution of mast cell subsets to conjunctival T(H)2-like cytokines. Invest. Ophthalmol. Vis. Sci. 42: 995-1001.
11. Krüger-Krasagakes, S., A. M. Möller, G. Kolde, U. Lippert, M. Weber, and B. M. Henz. 1996. Production of inteuleukin-6 by human mast cells and basophilic cells. J. Invest. Dermatol. 106: 75-79.
12. Möller, A., U. Lippert, D. Lessmann, G. Kolde, K. Hamann, P. Welker, D. Schadendorf, T. Rosenbach, T. Luger, and B. M. Czarnetzki. 1993. Human mast cells produce IL-8. J. Immunol. 151: 3261-3266.
13. Gibbs, B. F., J. Wierecky, P. Welker, B. M. Henz, H. H. Wolff, and J. Grabbe. 2001. Human skin mast cells rapidly release preformed and newly generated TNF-α and IL-8 following stimulation with anti-IgE and other secretagogues. Exp. Dermatol. 10: 312-320.
14. Jaffe, J. S., D. G. Raible, T. J. Post, Y. H. Wang, M. C. Glaum, J. H. Butterfield, and E. S. Schulman. 1996. Human lung mast cell activation leads to IL-13 mRNA expression and protein release. Am. J. Respir. Cell Mol. Biol. 15: 473-481.
15. + T lymphocyte chemoattractant factor, IL-16. J. Immunol. 159: 2904-2910.
16. Ishizuka, T., Y. Okayama, H. Kobayashi, and M. Mori. 1999. Interleukin-10 is localized to and released by human lung mast cells. Clin. Exp. Allergy 29: 1424-1432.
17. Ishizuka, T., Y. Okayama, H. Kobayashi, and M. Mori. 1999. Interleukin-3 production by mast cells from human lung. Inflammation 23: 25-35.
18. Lorentz, A., S. Schwengberg, G. Sellge, R. P. Manns, and S. C. Bischoff. 2000. Human intestinal mast cells are capable of producing different cytokine profiles: role of IgE receptor cross-linking and IL-4. J. Immunol. 164: 43-48.
19. Bressler, R. B., J. Lesko, M. L. Jones, M. Wasserman, R. R. Dickason, M. M. Huston, S. W. Cook, and D. P. Huston. 1997. Production of IL-5 and granulocyte-macrophage colony-stimulating factor by naive human mast cells activated by high-affinity IgE receptor ligation. J. Allergy Clin. Immunol. 99: 508-514.
20. Buckley, M. G., C. M. M. Williams, J. Thompson, P. Pryor, K. Ray, J. H. Butterfield, and J. W. Coleman. 1995. IL-4 enhances IL-3 and IL-8 gene expression in a human leukemic mast cell line. Immunology 84: 410-415.
21. Burd, P. R., W. C. Thompson, E. E. Max, and F. C. Mills. 1995. Activated mast cells produce interleukin 13. J. Exp. Med. 181: 1373-1380.
22. Krishnaswamy, G., K. Hall, G. Youngberg, F. Hossler, D. Johnson, W. A. Block, S. K. Huang, J. Kelley, and D. S. Chi. 2002. Regulation of eosinophil-active cytokine production from human cord blood-derived mast cells. J. Interferon Cytokine Res. 22: 379-388.
23. McCurdy, J. D., T. J. Olynych, L. H. Maher, and J. S. Marshall. 2003. Cutting edge: distinct Toll-like receptor 2 activators selectively induce different classes of mediator production from human mast cells. J. Immunol. 170: 1625-1629.
24. Möller, A., B. M. Henz, A. Grützkau, U. Lippert, Y. Aragane, T. Schwarz, and S. Krüger-Krasagakes. 1998. Comparative cytokine gene expression: regulation and release by human mast cells. Immunology 93: 289-295.
25. Nilsson, G., V. Svensson, and K. Nilsson. 1995. Constitutive and inducible cytokine mRNA expression in the human mast cell line HMC-1. Scand. J. Immunol. 42: 76-81.
26. Sillaber, C., D. Bevec, J. H. Butterfield, C. Heppner, R. Valenta, O. Scheiner, D. Kraft, K. Lechner, P. Bettelheim, and P. Valent. 1993. Tumor necrosis factor α and interleukin-1β mRNA expression in HMC-1 cells: differential regulation of gene product expression by recombinant interleukin-4. Exp. Hematol. 21: 1271-1275.
27. Smith, S. J., A. M. Piliponsky, F. Rosenhead, U. Elchalal, A. Nagler, and F. Levi-Schaffer. 2002. Dexamethasone inhibits maturation, cytokine production and FcεRI expression of human cord blood-derived mast cells. Clin. Exp. Allergy 32: 906-913.
28. Toru, H., R. Pawankar, C. Ra, J. Yata, and T. Nakahata. 1998. Human mast cells produce IL-13 by high-affinity IgE receptor cross-linking: enhanced IL-13 production by IL-4-primed human mast cells. J. Allergy Clin. Immunol. 102: 491-502.
29. Warbrick, E. V., A. L. Thomas, and C. M. M. Williams. 1997. The effects of cyclosporin A, dexamethasone and other immunomodulatory drugs on induced expression of IL-3, IL-4 and IL-8 mRNA in a human mast cell line. Toxicology 116: 211-218.
30. Gibbs, B. F., J. P. Arm, K. Gibson, T. H. Lee, and F. L. Pearce. 1997. Human lung mast cells release small amounts of interleukin-4 and tumour necrosis factor-α in response to stimulation by anti-IgE cell factor. Eur. J. Pharmacol. 327: 73-78.
31. Riske, F., J. Hakimi, M. Mallamaci, M. Griffin, B. Pilson, N. Tobkes, P. Lin, W. Danho, J. Kochan, and R. Chizzonite. 1991. High affinity human IgE receptor (FcεRI): analysis of functional domains of the α-subunit with monoclonal antibodies. J. Biol. Chem. 266: 11245-11251.
32. Schwartz, L. B., T. R. Bradford, C. Rouse, A.-M. Irani, G. Rasp, J. K. Van der Zwan, and P.-W. G. Van Der Linden. 1994. Development of a new, more sensitive immunoassay for human tryptase: use in systemic anaphylaxis. J. Clin. Immunol. 14: 190-204.
33. Raymond, W. W., S. W. Ruggles, C. S. Craik, and G. H. Caughey. 2003. Albumin is a substrate of human chymase: prediction by combinatorial peptide screening and development of a selective inhibitor based on the albumin cleavage site. J. Biol. Chem. 278: 34517-34524.
34. TC types of human mast cells by immunohistochemistry using new monoclonal anti-tryptase and anti-chymase antibodies. J. Histochem. Cytochem. 37: 1509-1515.
35. Schwartz, L. B., R. A. Lewis, D. Seldin, and K. F. Austen. 1981. Acid hydrolases and tryptase from secretory granules of dispersed human lung mast cells. J. Immunol. 126: 1290-1294.
36. Schwartz, L. B., K. F. Austen, and S. I. Wasserman. 1979. Immunologic release of β-hexosaminidase and β-glucuronidase from purified rat serosal mast cells. J. Immunol. 123: 1445-1450.
37. Nakajima, K., J. C. Powers, B. M. Ashe, and M. Zimmerman. 1979. Mapping the extended substrate binding site of cathepsin G and human leukocyte elastase: studies with peptide substrates related to the α1-protease inhibitor reactive site. J. Biol. Chem. 254: 4027-4032.
38. Ren, S., A. E. Lawson, M. Carr, C. M. Baumgarten, and L. B. Schwartz. 1997. Human tryptase fibrinogenolysis is optimal at acidic pH and generates anticoagulant fragments in the presence of the anti-tryptase monoclonal antibody B12. J. Immunol. 159: 3540-3548.
39. Mallen-St Clair, J., C. T. Pham, S. A. Villalta, G. H. Caughey, and P. J. Wolters. 2004. Mast cell dipeptidyl peptidase I mediates survival from sepsis. J. Clin. Invest. 113: 628-634.
40. Schwartz, L. B., A. M. A. Irani, K. Roller, M. C. Castells, and N. M. Schlechter. 1987. Quantitation of histamine, tryptase and chymase in dispersed human T and TC mast cells. J. Immunol. 138: 2611-2615.
41. Wintroub, B. U., N. B. Schechter, G. S. Lazarus, C. E. Kaempfer, and L. B. Schwartz. 1984. Angiotensin I conversion by human and rat chymotryptic proteinases. J. Invest. Dermatol. 83: 336-339.
42. Kido, H., A. Nakano, N. Okishima, H. Wakabayashi, F. Kishi, Y. Nakaya, M. Yoshizumi, and T. Tamaki. 1998. Human chymase, an enzyme forming novel bioactive 31-amino acid length endothelins. Biol. Chem. 379: 885-891.
43. Vaday, G. G., D. Baram, P. Salamon, I. Drucker, R. Hershkoviz, and Y. A. Mekori. 2000. Cytokine production and matrix metalloproteinase (MMP)-9 release by human mast cells following cell-to-cell contact with activated T cells. Isr. Med. Assoc. J. 2: 26.
44. Kofford, M. W., L. B. Schwartz, N. M. Schechter, D. R. Yager, R. F. Diegelmann, and M. F. Graham. 1997. Cleavage of type 1 procollagen by human mast cell chymase initiates collagen fibril formation and generates a unique carboxyl-terminal propeptide. J. Biol. Chem. 272: 7127-7131.
45. Taipale, J., J. Lohi, J. Saarinen, P. T. Kovanen, and J. Keski-Oja. 1995. Human mast cell chymase and leukocyte elastase release latent transforming growth factor-β1 from the extracellular matrix of cultured human epithelial and endothelial cells. J. Biol. Chem. 270: 4689-4696.
46. Lindstedt, K. A., Y. Wang, N. Shiota, J. Saarinen, M. Hyytiainen, J. O. Kokkonen, J. Keski-Oja, and P. T. Kovanen. 2001. Activation of paracrine TGF-β1 signaling upon stimulation and degranulation of rat serosal mast cells: a novel function for chymase. FASEB J. 15: 1377-1388.
47. Mizutani, H., N. Schechter, G. Lazarus, R. A. Black, and T. S. Kupper. 1991. Rapid and specific conversion of precursor interleukin 1β (IL-1β) to an active IL-1 species by human mast cell chymase. J. Exp. Med. 174: 821-825.
48. Longley, B. J., L. Tyrrell, Y. S. Ma, D. A. Williams, R. Halaban, K. Langley, H. S. Lu, and N. M. Schechter. 1997. Chymase cleavage of stem cell factor yields a bioactive, soluble product. Proc. Natl. Acad. Sci. USA 94: 9017-9021.
49. Nortier, J., P. Vandenabeele, E. Noel, Y. Bosseloir, M. Goldman, and M. Deschodt-Lanckman. 1991. Enzymatic degradation of tumor necrosis factor by activated human neutrophils: role of elastase. Life Sci. 49: 1879-1886.
50. Scuderi, P., P. A. Nez, M. L. Duerr, B. J. Wong, and C. M. Valdez. 1991. Cathepsin-G and leukocyte elastase inactivate human tumor necrosis factor and lymphotoxin. Cell. Immunol. 135: 299-313.
51. van Kessel, K. P., J. A. van Strijp, and J. Verhoef. 1991. Inactivation of recombinant human tumor necrosis factor-α by proteolytic enzymes released from stimulated human neutrophils. J. Immunol. 147: 3862-3868.
52. Bank, U., B. Kupper, and S. Ansorge. 2000. Inactivation of interleukin-6 by neutrophil proteases at sites of inflammation: protective effects of soluble IL-6 receptor chains. Adv. Exp. Med. Biol. 477: 431-437.
53. Laouar, A., C. Villiers, J. Sanceau, C. Maison, M. Colomb, J. Wietzerbin, and B. Bauvois. 1993. Inactivation of interleukin-6 in vitro by monoblastic U937 cell plasma membranes involves both protease and peptidyl-transferase activities. Eur. J. Biochem. 215: 825-831.
54. Ruef, C., D. M. Jefferson, S. E. Schlegel-Haueter, and S. Suter. 1993. Regulation of cytokine secretion by cystic fibrosis airway epithelial cells. Eur. Respir. J. 6: 1429-1436.
55. Babina, M., S. Guhl, A. Starke, L. Kirchhof, T. Zuberbier, and B. M. Henz. 2004. Comparative cytokine profile of human skin mast cells from two compartments: strong resemblance with monocytes at baseline but induction of IL-5 by IL-4 priming. J. Leukocyte Biol. 75: 244-252.
56. Coward, W. R., Y. Okayama, H. Sagara, S. J. Wilson, S. T. Holgate, and M. K. Church. 2002. NF-κB and TNF-α: a positive autocrine loop in human lung mast cells? J. Immunol. 169: 5287-5293.
57. Kandere-Grzybowska, K., R. Letourneau, D. Kempuraj, J. Donelan, S. Poplawski, W. Boucher, A. Athanassiou, and T. C. Theoharides. 2003. IL-1 induces vesicular secretion of IL-6 without degranulation from human mast cells. J. Immunol. 171: 4830-4836.
58. Varadaradjalou, S., F. Feger, N. Thieblemont, N. B. Hamouda, J. M. Pleau, M. Dy, and M. Arock. 2003. Toll-like receptor 2 (TLR2) and TLR4 differentially activate human mast cells. Eur. J. Immunol. 33: 899-906.
59. Okayama, Y., Y. Ono, T. Nakazawa, M. K. Church, and M. Mori. 1998. Human skin mast cells produce TNF-α by substance P. Int. Arch. Allergy Immunol. 117: 48-51.
60. Walsh, L. J., G. Trinchieri, H. A. Waldorf, D. Whitaker, and G. F. Murphy. 1991. Human dermal mast cells contain and release tumor necrosis factor α, which induces endothelial leukocyte adhesion molecule 1. Proc. Natl. Acad. Sci. USA 88: 4220-4224.
61. 2 from cord blood mononuclear cells. J. Immunol. 157: 343-350.