Heme oxygenase -1 gene therapy: Recent advances and therapeutic applications

Current Gene Therapy

Volumn 7, Issue 2, 2007, Pages 89-108

  Abraham, Nader G ^a   Asija, Amit ^a   Drummond, George ^a   Peterson, Stephen ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Adenoviral; Carbon monoxide; Cell proliferation; Hemorrhage; Hypertension; Retroviral; Vascular disease

Indexed keywords

ADENOVIRUS VECTOR; ANDROGEN BINDING PROTEIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II; BILIRUBIN; BILIVERDIN; CARBON MONOXIDE; CYTOCHROME P450; FAS ANTIGEN; GAMMA GLUTAMYLTRANSFERASE; HEME OXYGENASE 1; IRON; LOSARTAN; MESOPORPHYRIN; PORPHYRIN COBALT; PROTOPORPHYRIN; PROTOPORPHYRIN ZINC; REACTIVE OXYGEN METABOLITE; RETROVIRUS VECTOR; STANNOUS CHLORIDE; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANGIOGENESIS; ANTIHYPERTENSIVE ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ATHEROSCLEROSIS; BODY GROWTH; BRAIN HEMORRHAGE; BRAIN VASOSPASM; CANCER INHIBITION; CARDIOVASCULAR DISEASE; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CELL PROTECTION; DIABETES MELLITUS; DIABETIC ANGIOPATHY; DIABETIC NEPHROPATHY; DIABETIC NEUROPATHY; DIABETIC RETINOPATHY; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVITY; ERECTILE DYSFUNCTION; GENE OVEREXPRESSION; GENE TRANSFER; GENETIC RESISTANCE; GRAFT REJECTION; HUMAN; HYPERTENSION; IN VITRO STUDY; IN VIVO STUDY; KIDNEY INJURY; LIVER CIRRHOSIS; NEUROPROTECTION; NEWBORN JAUNDICE; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PORTAL HYPERTENSION; PROMOTER REGION; PULMONARY HYPERTENSION; REVIEW; STROKE; SUBARACHNOID HEMORRHAGE; TUMOR VASCULARIZATION; UPREGULATION; VIRAL GENE DELIVERY SYSTEM;

GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HEME OXYGENASE-1; HEMORRHAGE; HUMANS; HYPERTENSION; OXIDATIVE STRESS; TISSUE DISTRIBUTION; VASCULAR DISEASES;

ORYCTOLAGUS CUNICULUS; RATTUS;

EID: 34247615614     PISSN: 15665232     EISSN: None     Source Type: Journal    
DOI: 10.2174/156652307780363134     Document Type: Review

References (233)

1. + stem cells. Exper. Hematol., 24(9): 1053.
2. Abraham, N.G. (2003): Heme oxygenase attenuated angiotensin II-mediated increase in cyclooxygenase activity and decreased isoprostane F2alpha in endothelial cells. Thromb. Res., 110: 305-309.
3. Abraham, N.G., Botros, F.T., Rezzani, R., Rodella, L., Bianchi, R. and Goodman, A.I. (2002a): Differential effect of cobalt protoporphyrin on distributions of heme oxygenase in renal structure and on blood pressure in SHR. Cell Mol. Biol. (Noisy. -le-grand), 48: 895-902.
4. Abraham, N.G., da-Silva, J.L., Lavrovsky, Y., Stoltz, R.A., Kappas, A., Dunn, M.W. and Schwartzman, M.L. (1995a): Adenovirus-mediated heme oxygenase-1 gene transfer into rabbit ocular tissues. Invest. Ophthalmol. Vis. Sci., 36:2202-2210.
5. Abraham, N.G., daSilva, J.L., Dunn, M.W., Kigasawa, K. and Shibahara, S. (1998): Retinal pigment epithelial cell-based gene therapy against hemoglobin toxicity. Inter. J. Mol. Med, 1: 657-663.
6. Abraham, N.G., Jiang, S., Yang, L., Zand, B.A., Laniado-Schwartzman, M., Marji, J., Drummond, G.S. and Kappas, A. (2000): Adenoviral vector-mediated transfer of human heme oxygenase in rats decreases renal heme-dependent arachidonic acid epoxygenase activity. J. Pharmacol. Exp. Ther., 293:494-500.
7. Abraham, N.G., Kappas, A. (2005): Heme oxygenase and the cardiovascular-renal system. Free Radic. Biol. Med., 39: 1-25.
8. Abraham, N.G., Lavrovsky, Y., Schwartzman, M.L., Stoltz, R.A., Levere, R.D., Gerritsen, M.E., Shibahara, S. and Kappas, A. (1995b): Transfection of the human heme oxygenase gene into rabbit coronary microvessel endothelial cells: protective effect against heme and hemoglobin toxicity. Proc. Natl. Acad. Sci. USA, 92: 6798-6802.
9. Abraham, N.G., Lin, J.H., Dunn, M.W. and Schwartzman, M.L. (1987): Presence of heme oxygenase and NADPH cytochrome P-450 (c) reductase in human corneal epithelium. Invest. Ophthalmol. Vis. Sci., 28: 1464-1472.
10. Abraham, N.G., Lin, J.H., Schwartzman, M.L., Levere, R.D. and Shibahara, S. (1988): The physiological significance of heme oxygenase. Int. J. Biochem., 20:543-558.
11. Abraham, N.G., Mieyal, P.A., Quart, S., Yang, L., Burke-Wolin, T., Mingone, C.J., Goodman, A.I., Nasjletti, A. and Wolin, M.S. (2002b): Modulation of cyclic GMP by retrovirus-mediated human heme oxgyenase-1 gene transfer in microvessel endothelial cells. Am. J. Physiol., 283: L1117-L1124.
12. Abraham, N.G., Rezzani, R., Rodella, L., Kruger, A., Taller, D., Li, V.G., Goodman, A.I. and Kappas, A. (2004): Overexpression of human heme oxygenase-1 attenuates endothelial cell sloughing in experimental diabetes. Am. J. Physiol. Heart Circ. Physiol., 287: H2468-H2477.
13. Abraham, N.G., Scapagnini, G. and Kappas, A. (2003): Human heme oxygenase: cell cycle-dependent expression and DNA microarray identification of multiple gene responses after transduction of endothelial cells. J. Cell Biochem., 90: 1098-1111.
14. Abraham, N., Quan, S., Shenouda, S. and Kappas, A. (2002c): Selective increase in human heme oxygenase-1 gene expression attenuates development of hypertension and increases body growth in spontaneously hypertensive rats. In In: Carbon Monoxide and Cardiovascular Functions, ed. R. ed. Wang, pp., 233-245. CRC Press, Boca Raton.
15. Agarwal, A., Balla, J., Alam, J., Croatt, A.J. and Nath, K.A. (1995): Induction of heme oxygenase in toxic renal injury: a protective role in cisplatin nephrotoxicity in the rat. Kidney Int., 48: 1298-1307.
16. Ahmad, M., Turkseven, S., Mingone, C.J., Gupte, S.A., Wolin, M. and Abraham, N.G. (2005): Heme oxygenase-1 gene expression increases vascular relaxation and decreases inducible nitric oxide synthase in diabetic rats. Cell. Mol. Biol., 51: 371-376.
17. Aizawa, T., Ishizaka, N., Taguchi, J., Nagai, R., Mori, I., Tang, S.S., Ingelfinger, J.R. and Ohno, M. (2000): Heme oxygenase-1 is upregulated in the kidney of angiotensin II-induced hypertensive rats: possible role in renoprotection. Hypertension, 35: 800-806.
18. Amersi, F., Buelow, R., Kato, H., Ke, B., Coito, A.J., Shen, X.D., Zhao, D., Zaky, J., Melinek, J., Lassman, C.R., Kolls, J.K., Alam, J., Ritter, T., Volk, H.D., Farmer, D.G., Ghobrial, R.M., Busuttil, R.W. and Kupiec-Weglinski, J.W. (1999): Upregulation of heme oxygenase-1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury. J. Clin. Invest., 104: 1631-1639.
19. Anderson, R.D., Haskell, R.E., Xia, H., Roessler, B.J. and Davidson, B.L. (2000): A simple method for the rapid generation of recombinant adenovirus vectors. Gene Ther., 7: 1034-1038.
20. Angermayr, B., Mejias, M., Gracia-Sancho, J., Garcia-Pagan, J.C., Bosch, J. and Fernandez, M. (2006): Heme oxygenase attenuates oxidative stress and inflammation, and increases VEGF expression in portal hypertensive rats. J. Hepatol., 44: 1033-1039.
21. Arts, G.J., Langemeijer, E., Tissingh, R., Ma, L., Pavliska, H., Dokic, K., Dooijes, R., Mesic, E., Clasen, R., Michiels, F., van der, S.J., Lambrecht, M., Herman, S., Brys, R., Thys, K., Hoffmann, M., Tomme, P. and van, E.H. (2003): Adenoviral vectors expressing siRNAs for discovery and validation of gene function. Genome Res., 13: 2325-2332.
22. Barrera, D., Maldonado, P.D., Medina-Campos, O.N., Hernandez-Pando, R., Ibarra-Rubio, M.E. and Pedraza-Chaverri, J. (2003): HO-1 induction attenuates renal damage and oxidative stress induced by K2Cr2O7. Free Radic. Biol. Med., 34: 1390-1398.
23. Bartosch, B., Cosset, F.L. (2004): Strategies for retargeted gene delivery using vectors derived from lentiviruses. Curr. Gene Ther., 4: 427-443.
24. Belzile, J.P., Choudhury, S.A., Cournoyer, D. and Chow, T.Y. (2006): Targeting DNA repair proteins: a promising avenue for cancer gene therapy. Curr. Gene Ther., 6: 111-123.
25. Benihoud, K., Yeh, P. and Perricaudet, M. (1999): Adenovirus vectors for gene delivery. Curr. Opin. Biotechnol., 10: 440-447.
26. Berkner, K.L. (1988): Development of adenovirus vectors for the expression of heterologous genes. Biotechniques 6: 616-629.
27. Blydt-Hansen, T.D., Katori, M., Lassman, C., Ke, B., Coito, A.J., Iyer, S., Buelow, R., Ettenger, R., Busuttil, R.W. and Kupiec-Weglinski, J.W. (2003): Gene transfer-induced local heme oxygenase-1 overexpression protects rat kidney transplants from ischemia/reperfusion injury. J. Am. Soc. Nephrol, 14: 745-754.
28. Botros, F.T., Laniado-Schwartzman, M. and Abraham, N.G. (2002): Regulation of cyclooxygenase- and cytochrome p450-derived eicosanoids by heme oxygenase in the rat kidney. Hypertension 39: 639-644.
29. Botros, F.T., Schwartzman, M.L. and Abraham, N.G. (2001): Regulation of cyclooxygenase- and cytochrome P450-derived eicosanoids by heme oxygenase isoforms in rat kidney, pp., 505-506.
30. Calo, L.A., Bertipaglia, L. and Pagnin, E. (2006): [Antioxidants, carnitine and erythropoietin]. G. Ital. Nefrol., 23 Suppl 34: S47-S50.
31. Cannon, J.B., Martin, C., Drummond, G.S. and Kappas, A. (1993): Targeted delivery of a heme oxygenase inhibitor with a lyophilized liposomal tin mesoporphyrin formulation. Pharm. Res., 10: 715-721.
32. Castellani, R., Smith, M.A., Richey, P.L., Kalaria, R., Gambetti, P. and Perry, G. (1995): Evidence for oxidative stress in Pick disease and corticobasal degeneration. Brain Res., 696: 268-271.
33. Chang, L.J., Gay, E.E. (2001): The molecular genetics of lentiviral vectors-current and future perspectives. Curr. Gene Ther., 1: 237-251.
34. Chang, L.J., Urlacher, V., Iwakuma, T., Cui, Y. and Zucali, J. (1999): Efficacy and safety analyses of a recombinant human immunodeficiency virus type 1 derived vector system. Gene Ther., 6: 715-728.
35. Chartier, C., Degryse, E., Gantzer, M., Dieterle, A., Pavirani, A. and Mehtali, M. (1996): Efficient generation of recombinant adenovirus vectors by homologous recombination in Escherichia coli. J. Virol., 70: 4805-4810.
36. Chauveau, C., Bouchet, D., Roussel, J.C., Mathieu, P., Braudeau, C., Renaudin, K., Tesson, L., Soulillou, J.P., Iyer, S., Buelow, R. and Anegon, I. (2002): Gene transfer of heme oxygenase-1 and carbon monoxide delivery inhibit chronic rejection. Am. J. Transplant., 2: 581-592.
37. Chauveau, C., Remy, S., Royer, P.J., Hill, M., Tanguy-Royer, S., Hubert, F.X., Tesson, L., Brion, R., Beriou, G., Gregoire, M., Josien, R., Cuturi, M.C. and Anegon, I. (2005): Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL-10 expression. Blood, 106: 1694-1702.
38. Cisowski, J., Loboda, A., Jozkowicz, A., Chen, S., Agarwal, A. and Dulak, J. (2005): Role of heme oxygenase-1 in hydrogen peroxide-induced VEGF synthesis: effect of HO-1 knockout. Biochem. Biophys. Res. Commun., 326: 670-676.
39. Coccoris, M., de Witte, M.A. and Schumacher, T.N. (2005): Prospects and limitations of T cell receptor gene therapy. Curr. Gene Ther., 5: 583-593.
40. Coito, A.J., Buelow, R., Shen, X.D., Amersi, F., Moore, C., Volk, H.D., Busuttil, R.W. and Kupiec-Weglinski, J.W. (2002): Heme oxygenase-1 gene transfer inhibits inducible nitric oxide synthase expression and protects genetically fat Zucker rat livers from ischemia-reperfusion injury. Transplantation, 74: 96-102.
41. Coleman, J.E., Huentelman, M.J., Kasparov, S., Metcalfe, B.L., Paton, J.F., Katovich, M.J., Semple-Rowland, S.L. and Raizada, M.K. (2003): Efficient large-scale production and concentration of HIV-1-based lentiviral vectors for use in vivo. Physiol. Genomics, 12: 221-228.
42. Colombrita, C., Lombardo, G., Scapagnini, G. and Abraham, N.G. (2003): Heme oxygenase-1 expression levels are cell cycle dependent. Biochem. Biophys. Res. Commun., 308: 1001-1008.
43. da Silva, J.L., Zand, B.A., Yang, L.M., Sabaawy, H.E., Lianos, E. and Abraham, N.G. (2001): Heme oxygenase isoform-specific expression and distribution in the rat kidney. Kidney Int., 59: 1448-1457.
44. Dai, C., Yang, J., Bastacky, S., Xia, J., Li, Y. and Liu, Y. (2004): Intravenous administration of hepatocyte growth factor gene ameliorates diabetic nephropathy in mice. J. Am. Soc. Nephrol., 15: 2637-2647.
45. Dalba, C., Klatzmann, D., Logg, C.R. and Kasahara, N. (2005): Beyond oncolytic virotherapy: replication-competent retrovirus vectors for selective and stable transduction of tumors. Curr. Gene Ther., 5: 655-667.
46. Darzynkiewicz, Z., Gong, J., Juan, G., Ardelt, B. and Traganos, F. (1996): Cytometry of cyclin proteins. Cytometry 25: 1-13.
47. Datta, P.K., Moulder, J.E., Fish, B.L., Cohen, E.P. and Lianos, E.A. (2001): Induction of heme oxygenase 1 in radiation nephropathy: role of angiotensin II. Radiat. Res., 155: 734-739.
48. Datta, P.K., Reddy, S., Sharma, M. and Lianos, E.A. (2006): Differential nephron HO-1 expression following glomerular epithelial cell injury. Nephron. Exp. Nephrol., 103: e131-e138.
49. DeBruyne, L.A., Magee, J.C., Buelow, R. and Bromberg, J.S. (2000): Gene transfer of immunomodulatory peptides correlates with heme oxygenase-1 induction and enhanced allograft survival. Transplantation, 69: 120-128.
50. Debyser, Z. (2003): Biosafety of lentiviral vectors. Curr. Gene Ther., 3: 517-525.
51. Di Noia, M.A., Van, D.S., Palmieri, F., Yang, L.M., Quan, S., Goodman, A.I. and Abraham, N.G. (2006): Heme oxygenase-1 enhances renal mitochondrial transport carriers and cytochrome C oxidase activity in experimental diabetes. J. Biol. Chem., 281: 15687-15693.
52. Dzau, V.J. (2003): Predicting the future of human gene therapy for cardiovascular diseases: what will the management of coronary artery disease be like in 2005 and 2010? Am. J. Cardiol., 92: 32N-35N.
53. Erl, W., Weber, C. and Hansson, G.K. (2000): Pyrrolidine dithiocarbamate-induced apoptosis depends on cell type, density, and the presence of Cu(2+) and Zn(2+). Am. J. Physiol. Cell Physiol., 278: C1116-C1125.
54. Erzurum, S.C., Lemarchand, P., Rosenfeld, M.A., Yoo, J.H. and Crystal, R.G. (1993): Protection of human endothelial cells from oxidant injury by adenovirus- mediated transfer of the human catalase cDNA. Nucleic Acids Res., 21: 1607-1612.
55. Falcon, B.L., Stewart, J.M., Bourassa, E., Katovich, M.J., Walter, G., Speth, R.C., Sumners, C. and Raizada, M.K. (2004): Angiotensin II type 2 receptor gene transfer elicits cardioprotective effects in an angiotensin II infusion rat model of hypertension. Physiol. Genomics, 19: 255-261.
56. Fang, J., Akaike, T. and Maeda, H. (2004): Antiapoptotic role of heme oxygenase (HO) and the potential of HO as a target in anticancer treatment. Apoptosis, 9: 27-35.
57. Fang, J., Sawa, T., Akaike, T., Akuta, T., Sahoo, S.K., Khaled, G., Hamada, A. and Maeda, H. (2003): In vivo antitumor activity of pegylated zinc protoporphyrin: targeted inhibition of heme oxygenase in solid tumor. Cancer Res., 63: 3567-3574.
58. Fang, J., Sawa, T., Akaike, T., Greish, K. and Maeda, H. (2004): Enhancement of chemotherapeutic response of tumor cells by a heme oxygenase inhibitor, pegylated zinc protoporphyrin. Int. J. Cancer, 109: 1-8.
59. Fernandez, M., Lambrecht, R.W. and Bonkovsky, H.L. (2001): Increased heme oxygenase activity in splanchnic organs from portal hypertensive rats: role in modulating mesenteric vascular reactivity. J. Hepatol., 34: 812-817.
60. Franco-Gou, R., Rosello-Catafau, J., Casillas-Ramirez, A., Massip-Salcedo, M., Rimola, A., Calvo, N., Bartrons, R. and Peralta, C. (2006): How ischaemic preconditioning protects small liver grafts. J. Pathol., 208: 62-73.
61. Fukui, T., Ishizaka, N., Rajagopalan, S., Laursen, J.B., Capers, Q., Taylor, W.R., Harrison, D.G., De Leon, H., Wilcox, J.N. and Griendling, K.K. (1997): p22phox mRNA expression and NADPH oxidase activity are increased in aortas from hypertensive rats. Circ. Res., 80: 45-51.
62. Fuller, M., Anson, D.S. (2004): Can the use of HIV-1 derived gene transfer vectors for clinical application be justified? Curr. Gene Ther., 4: 65-77.
63. Gao, G., Zhou, X., Alvira, M.R., Tran, P., Marsh, J., Lynd, K., Xiao, W. and Wilson, J.M. (2003): High throughput creation of recombinant adenovirus vectors by direct cloning, green-white selection and I-Sce I-mediated rescue of circular adenovirus plasmids in 293 cells. Gene Ther., 10: 1926-1930.
64. Gasmi, M., Glynn, J., Jin, M.J., Jolly, D.J., Yee, J.K. and Chen, S.T. (1999): Requirements for efficient production and transduction of human immunodeficiency virus type 1-based vectors. J. Virol., 73: 1828-1834.
65. Geraerts, M., Eggermont, K., Hernandez-Acosta, P., Garcia-Verdugo, J.M., Baekelandt, V. and Debyser, Z. (2006): Lentiviral vectors mediate efficient and stable gene transfer in adult neural stem cells in vivo. Hum. Gene Ther., 17: 635-650.
66. Ghanbari, H.A., Ghanbari, K., Harris, P.L., Jones, P.K., Kubat, Z., Castellani, R.J., Wolozin, B.L., Smith, M.A. and Perry, G. (2004): Oxidative damage in cultured human olfactory neurons from Alzheimer's disease patients. Aging Cell, 3: 41-44.
67. Gong, Y., Tian, H., Xi, G., Keep, R.F., Hoff, J.T. and Hua, Y. (2006): Systemic zinc protoporphyrin administration reduces intracerebral hemorrhage-induced brain injury. Acta Neurochir. Suppl., 96: 232-236.
68. Gonzales, S., Perez, M.J., Perazzo, J.C. and Tomaro, M.L. (2006): Antioxidant role of heme oxygenase-1 in prehepatic portal hypertensive rats. World J. Gastroenterol., 12: 4149-4155.
69. Goodman, A.I., Chander, P.N., Rezzani, R., Schwartzman, M.L., Regan, R.F., Rodella, L., Turkseven, S., Lianos, E.A., Dennery, P.A. and Abraham, N.G. (2006): Heme oxygenase-2 deficiency contributes to diabetes-mediated increase in superoxide anion and renal dysfunction. J. Am. Soc. Nephrol., 17: 1073-1081.
70. Goodman, A.I., Quan, S., Yang, L., Synghal, A. and Abraham, N.G. (2003): Functional expression of human heme oxygenase-1 gene in renal structure of spontaneously hypertensive rats. Exp. Biol. Med. (Maywood.) 228: 454-458.
71. Hardy, D.O., Niu, E.M. and Catterall, J.F. (2001): Kap promoter analysis in vivo: a regulatory role for a truncated L1 repeat. Mol. Cell Endocrinol., 181: 57-67.
72. Hardy, S., Kitamura, M., Harris-Stansil, T., Dai, Y. and Phipps, M.L. (1997): Construction of adenovirus vectors through Cre-lox recombination. J. Virol., 71: 1842-1849.
73. Hatanaka, K., Ohnami, S., Yoshida, K., Miura, Y., Aoyagi, K., Sasaki, H., Asaka, M., Terada, M., Yoshida, T. and Aoki, K. (2003): A simple and efficient method for constructing an adenoviral cDNA expression library. Mol. Ther., 8: 158-166.
74. Haugen, E.N., Croatt, A.J. and Nath, K.A. (2000): Angiotensin II induces renal oxidant stress in vivo and heme oxygenase-1 in vivo and in vitro. Kidney Int., 58: 144-152.
75. Hayashi, S., Takamiya, R., Yamaguchi, T., Matsumoto, K., Tojo, S.J., Tamatani, T., Kitajima, M., Makino, N., Ishimura, Y. and Suematsu, M. (1999): Induction of heme oxygenase-1 suppresses venular leukocyte adhesion elicited by oxidative stress: role of bilirubin generated by the enzyme. Circ. Res., 85: 663-671.
76. He, T.C., Zhou, S., daCosta, L.T., Yu, J., Kinzler, K.W. and Vogelstein, B. (1998): A simplified system for generating recombinant adenoviruses. Proc. Natl. Acad. Sci. USA, 95: 2509-2514.
77. He, Z., Wang, F., Kumagai-Braesch, M., Permert, J. and Holgersson, J. (2006): Long-term gene expression and metabolic control exerted by lentivirus-transduced pancreatic islets. Xenotransplantation, 13: 195-203.
78. Hill, M., Pereira, V., Chauveau, C., Zagani, R., Remy, S., Tesson, L., Mazal, D., Ubillos, L., Brion, R., Asghar, K., Mashreghi, M.F., Kotsch, K., Moffett, J., Doebis, C., Seifert, M., Boczkowski, J., Osinaga, E. and Anegon, I. (2005): Heme oxygenase-1 inhibits rat and human breast cancer cell proliferation: mutual cross inhibition with indoleamine 2,3-dioxygenase. FASEB J., 19: 1957-1968.
79. Hoekstra, K.A., Godin, D.V. and Cheng, K.M. (2004): Protective role of heme oxygenase in the blood vessel wall during atherogenesis. Biochem. Cell Biol., 82: 351-359.
80. Immenschuh, S., Ramadori, G. (2000): Gene regulation of heme oxygenase-1 as a therapeutic target. Biochem. Pharmacol., 60: 1121-1128.
81. Inamdar, N.M., Ahn, Y.I. and Alam, J. (1996): The heme-responsive element of the mouse heme oxygenase-1 gene is an extended AP-1 binding site that resembles the recognition sequences for MAF and NF-E2 transcription factors. Biochem. Biophys. Res. Commun., 221: 570-576.
82. Ishizaka, N., Aizawa, T., Mori, I., Taguchi, J., Yazaki, Y., Nagai, R. and Ohno, M. (2000): Heme oxygenase-1 is upregulated in the rat heart in response to chronic administration of angiotensin II. Am. J. Phyisiol. Heart Circ. Physiol., 279: H672-H678.
83. Ishizaka, N., De Leon, H., Laursen, J.B., Fukui, T., Wilcox, J.N., De Keulenaer, G., Griendling, K.K. and Alexander, R.W. (1997): Angiotensin II-induced hypertension increases heme oxygenase-1 expression in rat aorta. Circulation, 96: 1923-1929.
84. Ishizaka, N., Griendling, K.K. (1997): Heme oxygenase-1 is regulated by angiotensin II in rat vascular smooth muscle cells. Hypertension, 29: 790-795.
85. Iwakuma, T., Cui, Y. and Chang, L.J. (1999): Self-inactivating lentiviral vectors with U3 and U5 modifications. Virology, 261: 120-132.
86. Janssens, S.P. (2003): Applied gene therapy in preclinical models of vascular injury. Curr. Atheroscler. Rep., 5: 186-190.
87. Jiang, M., Mezentsev, A., Kemp, R., Byun, K., Falck, J.R., Miano, J.M., Nasjletti, A., Abraham, N.G. and Laniado-Schwartzman, M. (2004): Smooth muscle-specific expression of CYP4A1 induces endothelial sprouting in renal arterial microvessels. Circ. Res., 94: 167-174.
88. Jin, T., Kong, Q., Ye, T., Wu, X. and Nordberg, G.F. (2004): Renal dysfunction of cadmium-exposed workers residing in a cadmium-polluted environment. Biometals, 17: 513-518.
89. Johnson, R.A., Colombari, E., Colombari, D.S.A., Lavesa, M., Tallman, W.T. and Nasjletti, A. (1997): Role of endogenous carbon monoxide in central regulation of arterial pressure. Hypertension, 30: 962-967.
90. Johnson, R.A., Lavesa, M., DeSeyn, K., Scholer, M.J. and Nasjletti, A. (1996): Heme oxygenase substrates acutely lower blood pressure in hypertensive rats. Am. J. Physiol., 271: H1132-H1138.
91. Juan, G., Ardelt, B., Li, X., Mikulski, S.M., Shogen, K., Ardelt, W., Mittelman, A. and Darzynkiewicz, Z. (1998): G1 arrest of U937 cells by onconase is associated with suppression of cyclin D3 expression, induction of p16INK4A, p21WAF1/CIP1 and p27KIP and decreased pRb phosphorylation. Leukemia, 12: 1241-1248.
92. Juan, S.H., Lee, T.S., Tseng, K.W., Liou, J.Y., Shyue, S.K., Wu, K.K. and Chau, L.Y. (2001): Adenovirus-mediated heme oxygenase-1 gene transfer inhibits the development of atherosclerosis in apolipoprotein E-deficient mice. Circulation, 104: 1519-1525.
93. Kadoya, C., Domino, E.F., Yang, G.Y., Stern, J.D. and Betz, A.L. (1995): Preischemic but not post ischemic zinc protoporphyrin treatment reduces infarct size and edema post ischemic zinc protoporphyrin treatment reduces infarct size and edema accumulation after temporary focal cerebral ischemia in rats. Stroke, 26: 1035-1038.
94. Kagawa, T., Takemura, G., Kosai, K., Murata, I., Ohno, T., Takahashi, T., Esaki, M., Maruyama, R., Fujiwara, T., Ohashi, H. and Fujiwara, H. (2006): Hepatocyte growth factor gene therapy slows down the progression of diabetic nephropathy in db/db mice. Nephron. Physiol., 102: 92-102.
95. Kaide, J.-I., Zhang, F., Wei, Y., Jiang, H., Yu, C., Wang, W.H., Balazy, M., Abraham, N.G. and Nasjletti, A. (2001): Carbon monoxide of vascular origin attenuates the sensitivity of renal arterial vessels to vasoconstrictors. J. Clin. Invest., 107: 1163-1171.
96. Kakimura, J., Kitamura, Y., Takata, K., Umeki, M., Suzuki, S., Shibagaki, K., Taniguchi, T., Nomura, Y., Gebicke-Haerter, P.J., Smith, M.A., Perry, G. and Shimohama, S. (2002): Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins. FASEB J., 16: 601-603.
97. Kaplan, J.M. (2005): Adenovirus-based cancer gene therapy. Curr. Gene Ther., 5: 595-605.
98. Kappas, A., Drummond, G.S., Manola, T., Petmezaki, S. and Valaes, T. (1988): Sn-protoporphyrin use in the management of hyperbilirubinemia in term newborns with direct Coombs-positive ABO incompatibility. Pediatrics, 81: 485-497.
99. Kappas, A., Drummond, G. S. and Valaes, J. (2001): A single dose of Sn-mesoporphyrin prevents development of significant hyperbilirubinemia in glucose-6 phosphate dehydrogenase deficient newborns. Pedatrics, 108: 25-30.
100. Ke, B., Buelow, R., Shen, X.D., Melinek, J., Amersi, F., Gao, F., Ritter, T., Volk, H.D., Busuttil, R.W. and Kupiec-Weglinski, J.W. (2002): Heme Oxygenase 1 Gene Transfer Prevents CD95/Fas Ligand-Mediated Apoptosis and Improves Liver Allograft Survival via Carbon Monoxide Signaling Pathway. Hum. Gene Ther., 13: 1189-1199.
101. Kim, C.H., Kim, J.H., Xu, J., Hsu, C.Y. and Ahn, Y.S. (1999): Pyrrolidine dithiocarbamate induces bovine cerebral endothelial cell death by increasing the intracellular zinc level. J. Neurochem., 72: 1586-1592.
102. Kim, S., Ip, H.S., Lu, M.M., Clendenin, C. and Parmacek, M.S. (1997): A serum response factor-dependent transcriptional regulatory program identifies distinct smooth muscle cell sublineages. Mol. Cell Biol., 17: 2266-2278.
103. King, G.D., Curtin, J.F., Candolfi, M., Kroeger, K., Lowenstein, P.R. and Castro, M.G. (2005): Gene therapy and targeted toxins for glioma. Curr. Gene Ther., 5: 535-557.
104. Klages, N., Zufferey, R. and Trono, D. (2000): A stable system for the high-titer production of multiply attenuated lentiviral vectors. Mol. Ther., 2: 170-176.
105. Kolodkin-Gal, D., Zamir, G., Pikarski, E., Pikarski, A., Shimony, N., Wu, H., Haviv, Y.S. and Panet, A. (2007): A novel system to study adenovirus tropism to normal and malignant colon tissues. Virology, 357: 91-101.
106. Korhonen, J., Lahtinen, I., Halmekyto, M., Alhonen, L., Janne, J., Dumont, D. and Alitalo, K. (1995): Endothelial-specific gene expression directed by the tie gene promoter in vivo. Blood, 86: 1828-1835.
107. Kovesdi, I., Brough, D.E., Bruder, J.T. and Wickham, T.J. (1997): Adenoviral vectors for gene transfer. Curr. Opin. Biotechnol., 8: 583-589.
108. Kozma, F., Johnson, R.A., Zhang, F., Yu, C., Tong, X. and Nasjletti, A. (1999): Contribution of endogenous carbon monoxide to regulation of diameter in resistance vessels. Am. J. Physiol., 276: R1087-R1094.
109. Kushida, T., Quan, S., Yang, L., Ikehara, S., Kappas, A. and Abraham, N.G. (2002): A significant role for the heme oxygenase-1 gene in endothelial cell cycle progression. Biochem. Biophys. Res. Commun., 291: 68-75.
110. Lai, I.R., Chang, K.J., Chen, C.F. and Tsai, H.W. (2006): Transient limb ischemia induces remote preconditioning in liver among rats: the protective role of heme oxygenase-1. Transplantation, 81: 1311-1317.
111. Lanteri, R., Acquaviva, R., Di, G.C., Caltabiano, R., Li, D.G., Vanella, L., Santangelo, M., Lanzafame, S. and Di, C.A. (2006): Heme oxygenase 1 expression in postischemic reperfusion liver damage: effect of L-arginine. Microsurgery, 26: 25-32.
112. Laursen, J.B., Rajagopalan, S., Galis, Z., Tarpey, M., Freeman, B.A. and Harrison, D.G. (1997): Role of superoxide in angiotensin II-induced but not catecholamine-induced hypertension. Circulation, 95: 588-593.
113. Leffler, C.W., Nasjletti, A., Johnson, R.A. and Fedinec, A.L. (2001): Contributions of prostacyclin and nitric oxide to carbon monoxide- induced cerebrovascular dilation in piglets. Am. J. Physiol. Heart Circ. Physiol., 280: H1490-H1495.
114. Leffler, C.W., Nasjletti, A., Yu, C., Johnson, R.A., Fedinec, A.L. and Walker, N. (1999): Carbon monoxide and cerebral microvascular tone in newborn pigs. Am. J. Physiol., 276: H1641-H1646.
115. Levere, R.D., Martasek, P., Escalante, B., Schwartzman, M.L. and Abraham, N.G. (1990): Effect of heme arginate administration on blood pressure in spontaneously hypertensive rats. J. Clin. Invest., 86: 213-219.
116. Li Volti, G., Seta, F., Schwartzman, M.L., Nasjletti, A. and Abraham, N.G. (2003): Heme oxygenase attenuates angiotensin II-mediated increase in cyclooxygenase-2 activity in human femoral endothelial cells. Hypertension, 41: 715-719.
117. Li Volti, G., Wang, J., Traganos, F., Kappas, A. and Abraham, N.G. (2002): Differential effect of heme oxygenase-1 in endothelial and smooth muscle cell cycle progression. Biochem. Biophys Res Commun., 296: 1077-1082.
118. Li, P., Jiang, H., Yang, L., Quan, S., Dinocca, S., Rodriguez, F., Abraham, N.G. and Nasjletti, A. (2004a): Angiotensin II Induces Carbon Monoxide Production in the Perfused Kidney: Relation to Protein Kinase C Activation. Am. J. Physiol. Renal. Physiol., 287(5): F914-20.
119. Li, X., Clark, J.D. (2000): Heme oxygenase type 2 plays a role in formalin-induced nociception. Pain, 86: 75-80.
120. Li, X., Clark, J.D. (2003): Heme oxygenase type 2 participates in the development of chronic inflammatory and neuropathic pain. J. Pain, 4: 101-107.
121. Li, X., Lighthall, G., Liang, D.Y. and Clark, J.D. (2004b): Alterations in spinal cord gene expression after hindpaw formalin injection. J. Neurosci. Res., 78: 533-541.
122. Li, X.H., Du, J.B., Ding, Y.G., Jin, H.F., Bu, D.F., Tang, X.Y. and Tang, C.S. (2006): [Impact of hydrogen sulfide donor on experimental pulmonary hypertension induced by high pulmonary flow and endogenous carbon monoxide/heme oxygenase pathway]. Beijing Da. Xue. Xue. Bao., 38: 135-139.
123. Liang, D.Y., Li, X. and Clark, J.D. (2004): Formalin-induced spinal cord calcium/calmodulin-dependent protein kinase II alpha expression is modulated by heme oxygenase in mice. Neurosci. Lett., 360: 61-64.
124. Libermann, T.A., Zerbini, L.F. (2006): Targeting transcription factors for cancer gene therapy. Curr. Gene Ther., 6: 17-33.
125. Loboda, A., Jazwa, A., Wegiel, B., Jozkowicz, A. and Dulak, J. (2005): Heme oxygenase-1-dependent and -independent regulation of angiogenic genes expression: effect of cobalt protoporphyrin and cobalt chloride on VEGF and IL-8 synthesis in human microvascular endothelial cells. Cell Mol. Biol. (Noisy. -le-grand), 51: 347-355.
126. Lozonschi, L., Sunamura, M., Kobari, M., Egawa, S., Ding, L. and Matsuno, S. (1999): Controlling tumor angiogenesis and metastasis of C26 murine colon adenocarcinoma by a new matrix metalloproteinase inhibitor, KB-R7785, in two tumor models 4. Cancer Res., 59: 1252-1258.
127. Lu, F.Z., Kitazawa, Y., Hara, Y., Jiang, J.Y. and Li, X.K. (2005): Long-term gene expression using the lentiviral vector in rat chondrocytes. Clin. Orthop. Relat. Res., 439: 243-252.
128. Malaguarnera, L., Pilastro, M.R., Quan, S., Ghattas, M.H., Yang, L., Mezentsev, A.V., Kushida, T., Abraham, N.G. and Kappas, A. (2002): Significance of heme oxygenase in prolactin-mediated cell proliferation and angiogenesis in human endothelial cells. Int. J. Mol. Med., 10: 433-440.
129. Malaguarnera, L., Quan, S., Pilastro, M.R., Abraham, N.G. and Kappas, A. (2003): Diminished heme oxygenase potentiates cell death: pyrrolidinedithiocarbamate mediates oxidative stress. Exp. Biol. Med (Maywood.), 228:459-465.
130. Markesbery, W.R. (1997): Oxidative stress hypothesis in Alzheimer's disease. Free Radic. Biol. Med., 23: 134-147.
131. Masini, E., Vannacci, A., Marzocca, C., Pierpaoli, S., Giannini, L., Fantappie, O., Mazzanti, R. and Mannaioni, P.F. (2003): Heme oxygenase-1 and the ischemia-reperfusion injury in the rat heart. Exp. Biol. Med. (Maywood.), 228: 546-549.
132. Massip-Salcedo, M., Casillas-Ramirez, A., Franco-Gou, R., Bartrons, R., Ben, M., I, Serafin, A., Rosello-Catafau, J. and Peralta, C. (2006): Heat shock proteins and mitogen-activated protein kinases in steatotic livers undergoing ischemia-reperfusion: some answers. Am. J. Pathol., 168: 1474-1485.
133. McVey, D., Zuber, M., Brough, D.E. and Kovesdi, I. (2003): Adenovirus vector library: an approach to the discovery of gene and protein function. J. Gen. Virol., 84: 3417-3422.
134. Minamino, T., Christou, H., Hsieh, C.M., Liu, Y., Dhawan, V., Abraham, N.G., Perrella, M.A., Mitsialis, S.A. and Kourembanas, S. (2001): Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia. Proc. Natl. Acad. Sci. USA, 98: 8798-8803.
135. Mitani, K., Fujita, H., Sassa, S. and Kappas, A. (1989): Heat shock induction of heme oxygenase mRNA in human Hep3B hepatoma cells. Biochem. Biophys. Res. Commun., 165: 437-441.
136. Miyake, S., Makimura, M., Kanegae, Y., Ha̧rada, S., Sato, Y., Takamori, K., Tokuda, C. and Saito, I. (1996): Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome. Proc. Natl. Acad. Sci. USA, 93: 1320-1324.
137. Morita, T., Perrella, M.A., Lee, M. and Kourembanas, S. (1995): Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP. Proc. Natl. Acad. Sci. USA, 92: 1475-1479.
138. Mosley, K., Wembridge, D.E., Cattell, V. and Cook, H.T. (1998): Heme oxygenase is induced in nephrotoxic nephritis and hemin, a stimulator of heme oxygenase synthesis, ameliorates disease. Kidney Int., 53: 672-678.
139. Mullan, B., Dugue, C., Moutard, V., Raoux, D., Tremp, G., Denefle, P., Perricaudet, M. and Robert, J.J. (2004): Robust functional gene validation by adenoviral vectors: one-step Escherichia coli-derived recombinant adenoviral genome construction. Gene Ther., 11: 1599-1605.
140. Munz, P.L., Young, C.S. (1991): End-joining of DNA fragments in adenovirus transfection of human cells. Virology, 183: 160-169.
141. Nakano, M., Odaka, K., Takahashi, Y., Ishimura, M., Saito, I. and Kanegae, Y. (2005): Production of viral vectors using recombinase-mediated cassette exchange. Nucleic Acids Res., 33: e76.
142. Nath, K.A. (2006): Heme oxygenase-1: a provenance for cytoprotective pathways in the kidney and other tissues. Kidney Int., 70: 432-443.
143. Nath, K.A., Balla, J., Jacob, H.S., Vercellotti, G.M., Levitt, M. and Rosenberg, M.E. (1992): Induction of heme oxygenase is a rapid protective response in rhabdomyolysis in the rat. J. Clin. Invest., 90: 267-270.
144. Nath, K.A., Croatt; A.J., Likely, S., Behrens, T.W. and Warden, D. (1996): Renal oxidant injury and oxidant response induced by mercury. Kidney Int., 50: 1032-1043.
145. Nath, K.A., Vercellotti, G.M., Grande, J.P., Miyoshi, H., Paya, C.V., Manivel, J.C., Haggard, J.J., Croatt, A.J., Payne, W.D. and Alam, J. (2001): Heme protein-induced chronic renal inflammation: suppressive effect of induced heme oxygenase-1. Kidney Int., 59: 106-117.
146. Navab, M., Anantharamaiah, G.M., Reddy, S.T., Hama, S., Hough, G., Grijalva, V.R., Wagner, A.C., Frank, J.S., Datta, G., Garber, D. and Fogelman, A.M. (2004a): Oral D-4F causes formation of pre-beta high-density lipoprotein and improves high-density lipoprotein-mediated cholesterol efflux and reverse cholesterol transport from macrophages in apolipoprotein E-null mice. Circulation, 109: 3215-3220.
147. Navab, M., Ananthramaiah, G.M., Reddy, S.T., Van Lenten, B.J., Ansell, B.J., Fonarow, G.C., Vahabzadeh, K., Hama, S., Hough, G., Kamranpour, N., Berliner, J.A., Lusis, A.J. and Fogelman, A.M. (2004b): The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL. J. Lipid Res., 45: 993-1007.
148. Ndisang, J.F., Wang, R. (2003): Alterations in heme oxygenase/carbon monoxide system in pulmonary arteries in hypertension. Exp. Biol. Med. (Maywood.), 228: 557-563.
149. Ni, Y., Sun, S., Oparaocha, I., Humeau, L., Davis, B., Cohen, R., Binder, G., Chang, Y.N., Slepushkin, V. and Dropulic, B. (2005): Generation of a packaging cell line for prolonged large-scale production of high-titer HIV-1-based lentiviral vector. J. Gene Med., 7: 818-834.
150. Nicklin, S.A., Baker, A.H. (2002): Tropism-modified adenoviral and adeno-associated viral vectors for gene therapy. Curr. Gene Ther., 2: 273-293.
151. Nobel, C.I., Kimland, M., Lind, B., Orrenius, S. and Slater, A.F. (1995): Dithiocarbamates induce apoptosis in thymocytes by raising the intracellular level of redox-active copper. J. Biol. Chem., 270: 26202-26208.
152. Nunomura, A., Perry, G., Aliev, G., Hirai, K., Takeda, A., Balraj, E.K., Jones, P.K., Ghanbari, H., Wataya, T., Shimohama, S., Chiba, S., Atwood, C.S., Petersen, R.B. and Smith, M.A. (2001): Oxidative damage is the earliest event in Alzheimer disease. J. Neuropathol. Exp. Neurol., 60: 759-767.
153. Ohlfest, J.R., Freese, A.B. and Largaespada, D.A. (2005): Nonviral vectors for cancer gene therapy: prospects for integrating vectors and combination therapies. Curr. Gene Ther., 5: 629-641.
154. Olszanecki, R., Rezzani, R., Omura, S., Stec, D.E., Rodella, L., Botros, F., Goodman, A.I., Drummond, G. and Abraham, N.G. (2006): Genetic suppression of HO-1 exacerbates renal damage: Reversed by an increase in the anti-apoptotic signaling pathway. Am. J. Physiol Renal Physiol.
155. Omata, K., Abraham, N.G. and Schwartzman, M.L. (1992): Renal cytochrome P-450-arachidonic acid metabolism: localization and hormonal regulation in SHR. Am. J. Physiol., 262: F591-F599.
156. Ono, S., Komuro, T. and Macdonald, R.L. (2002): Heme oxygenase-1 gene therapy for prevention of vasospasm in rats. J. Neurosurg., 96: 1094-1102.
157. Ortiz, P.A., Garvin, J.L. (2002): Superoxide stimulates NaCl absorption by the thick ascending limb. Am. J. Physiol. Renal. Physiol., 283: F957-F962.
158. Panahian, N., Yoshiura, M. (1999): Overexpression of heme oxygenase-1 is neuroprotective in a model of permanent middle cerebral artery occlusion in transgenic mic. J. Neurochem., 72(3): 1187-1201.
159. Peter, M., Herskowitz, I. (1994): Joining the complex: cyclin-dependent kinase inhibitory proteins and the cell cycle. Cell, 79: 181-184.
160. Polyak, K., Kato, J.Y., Solomon, M.J., Sherr, C.J., Massague, J., Roberts, J.M. and Koff, A. (1994): p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev., 8: 9-22.
161. Poss, K.D., Tonegawa, S. (1997a): Heme oxygenase 1 is required for mammalian iron reutilization. Proc. Natl. Acad. Sci. USA, 94: 10919-10924.
162. Poss, K.D., Tonegawa, S. (1997b): Reduced stress defense in heme oxygenase-1 deficient cells. Proc. Natl. Acad. Sci. USA, 94: 10925-10930.
163. Pratico, D., Clark, C.M., Liun, F., Rokach, J., Lee, V.Y. and Trojanowski, J.Q. (2002): Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer disease. Arch. Neurol., 59: 972-976.
164. Price, S.A., Dent, C., Duran-Jimenez, B., Liang, Y., Zhang, L., Rebar, E.J., Case, C.C., Gregory, P.D., Martin, T.J., Spratt, S.K. and Tomlinson, D.R. (2006): Gene Transfer of an Engineered Transcription Factor Promoting Expression of VEGF-A Protects Against Experimental Diabetic Neuropathy. Diabetes, 55: 1847-1854.
165. Prud'homme, G.J., Glinka, Y., Khan, A.S. and Draghia-Akli, R. (2006): Electroporation-enhanced nonviral gene transfer for the prevention or treatment of immunological, endocrine and neoplastic diseases. Curr. Gene Ther., 6: 243-273.
166. Qiao, L., Xin, Z.C. (2002): [Advances in the research about penile erection related genes]. Zhonghua Nan. Ke. Xue., 8: 363-366.
167. Quan, S., Yang, L., Abraham, N.G. and Kappas, A, (2001): Regulation of human heme oxygenase in endothelial cells by using sense and antisense retroviral constructs. Proc. Natl. Acad. Sci. USA, 98: 12203-12208.
168. Quan, S., Yang, L., Shenouda, S., Jiang, H., Balazy, M., Schwartzman, M.L., Shibahara, I., Shinohara, K. and Abraham, N.G. (2002): Functional expression of human heme oxygenase-1 (HO-1) driven by HO-1 promoter in vitro and in vivo. J. Cell Biochem., 85: 410-421.
169. Quan, S., Yang, L., Shenouda, S., Schwartzman, M.L., Nasjletti, A., Goodman, A.I. and Abraham, N.G. (2004): Expression of human heme oxygenase-1 in the thick ascending limb attenuates angiotensin II-mediated increase in oxidative injury. Kidney Int., 65: 1628-1639.
170. Raddatz, A., Kubulus, D., Winning, J., Bauer, I., Pradarutti, S., Wolf, B., Kreuer, S. and Rensing, H. (2006): Dobutamine improves liver function after hemorrhagic shock through induction of heme oxygenase-1. Am. J. Respir. Crit. Care Med., 174: 198-207.
171. Raizada, M.K., Francis, S.C., Wang, H., Gelband, C.H., Reaves, P.Y. and Katovich, M.J. (2000): Targeting of the renin-angiotensin system by antisense gene therapy: a possible strategy for the long-term control of hypertension. J. Hypertens., 18: 353-362.
172. Redaelli, C.A., Tian, Y.H., Schaffner, T., Ledermann, M., Baer, H.U. and Dufour, J.F. (2002): Extended preservation of rat liver graft by induction of heme oxygenase- 1. Hepatology, 35: 1082-1092.
173. Rezzani, R., Rodella, L., Buffoli, B., Goodman, A.A., Abraham, N.G., Lianos, E.A. and Bianchi, R. (2005): Change in renal heme oxygenase expression in cyclosporine A-induced injury. J. Histochem. Cytochem., 53: 105-112.
174. Ribas, A. (2005): Genetically modified dendritic cells for cancer immunotherapy. Curr. Gene Ther., 5: 619-628.
175. Rodriguez, F., Kemp, R., Balazy, M. and Nasjletti, A. (2003): Effects of Exogenous Heme on Renal Function. Role of Heme Oxygenase and Cyclooxygenase. Hypertension, 42: 680-684.
176. Rodriguez, F., Lamon, B.D., Gong, W., Kemp, R. and Nasjletti, A. (2004): Nitric oxide synthesis inhibition promotes renal production of carbon monoxide. Hypertension, 43: 347-351.
177. Roman, R.J. (2002): P-450 metabolites of arachidonic acid in the control of cardiovascular function. Physiol Rev., 82: 131-185.
178. Roman, R.J. (2004): Gene therapy and heme oxygenase coming of age. Hypertension, 43: 1173-1174.
179. Sabaawy, H.E., Zhang, F., Nasjletti, A., Schwartzman, M.L. and Abraham, N.G. (2000): Transfer of the human heme oxygenase-1 gene decreases blood pressure and promotes growth in spontaneously hypertensive rats. Counc. High Blood Press, 54th Ann Fall Conf: 52.
180. Sabaawy, H.E., Zhang, F., Nguyen, X., Elhosseiny, A., Nasjletti, A., Schwartzman, M., Dennery, P., Kappas, A. and Abraham, N.G. (2001): Human heme oxygenase-1 gene transfer lowers blood pressure and promotes growth in spontaneously hypertensive rats. Hypertension, 38: 210-215.
181. Sacerdoti, D., Escalante, B., Abraham, N.G., McGiff, J.C., Levere, R.D. and Schwartzman, M.L. (1989): Treatment with tin prevents the development of hypertension in spontaneously hypertensive rats. Science, 243: 388-390.
182. Sacerdoti, D., Olszanecki, R., Li, V.G., Colombrita, C., Scapagnini, G. and Abraham, N.G. (2005): Heme oxygenase overexpression attenuates glucose-mediated oxidative stress in quiescent cell phase: linking heme to hyperglycemia complications. Curr. Neurovasc. Res., 2: 103-111.
183. Sahin, A.A., Ro, J., Ro, J.Y., Blick, M.B., El Naggar, A.K., Ordonez, N.G., Fritsche, H.A., Smith, T.L., Hortobagyi, G.N. and Ayala, A.G. (1991): Ki-67 immunostaining in node-negative stage I/II breast carcinoma. Significant correlation with prognosis. Cancer, 68: 549-557.
184. Sakoda, T., Kasahara, N., Hamamori, Y. and Kedes, L. (1999): A high-titer lentiviral production system mediates efficient transduction of differentiated cells including beating cardiac myocytes. J. Mol. Cell Cardiol., 31: 2037-2047.
185. Schaaf, G.J., Maas, R.F., de Groene, E.M. and Fink-Gremmels, J. (2002): Management of oxidative stress by heme oxygenase-1 in cisplatin-induced toxicity in renal tubular cells. Free Radic. Res., 36: 835-843.
186. Schipper, H.M. (2000): Heme oxygenase-1: role in brain aging and neurodegeneration. Exp. Gerontol., 35: 821-830.
187. Schipper, H.M. (2004): Brain iron deposition and the free radical-mitochondrial theory of ageing. Ageing Res. Rev., 3: 265-301.
188. Schipper, H.M., Bennett, D.A., Liberman, A., Bienias, J.L., Schneider, J.A., Kelly, J. and Arvanitakis, Z. (2006): Glial heme oxygenase-1 expression in Alzheimer disease and mild cognitive impairment. Neurobiol. Aging, 27: 252-261.
189. Schipper, H.M., Cisse, S. and Stopa, E.G. (1995): Expression of heme oxygenase-1 in the senescent and Alzheimer-diseased brain. Ann. Neurol., 37: 758-768.
190. Schipper, H.M., Liberman, A. and Stopa, E.G. (1998): Neural heme oxygenase-1 expression in idiopathic Parkinson's disease. Exp. Neurol., 150: 60-68.
191. Sell, S. (2006): Potential gene therapy strategies for cancer stem cells. Curr. Gene Ther., 6: 579-591.
192. Sellers, K.W., Katovich, M.J., Gelband, C.H. and Raizada, M.K. (2001): Gene therapy to control hypertension: current studies and future perspectives. Am. J. Med. Sci., 322: 1-6.
193. Sepulveda, A.R., Huang, S.L., Lebovitz, R.M. and Lieberman, M.W. (1997): A 346-base pair region of the mouse γ-glutamyl transpeptidase type II promoter contains sufficient cis-acting elements for kidney-restricted expression in transgenic mice. J. Biol. Chem., 272: 11959-11967.
194. Sharp, P.A., Moore, C. and Haverty, J.L. (1976): The infectivity of adenovirus 5 DNA-protein complex. Virology, 75: 442-456.
195. Shiraishi, F., Curtis, L.M., Truong, L., Poss, K., Visner, G.A., Madsen, K., Nick, H.S. and Agarwal, A. (2000): Heme oxygenase-1 gene ablation or expression modulates cisplatin- induced renal tubular apoptosis. Am. J. Physiol. Renal. Physiol., 278: F726-F736.
196. Shotton, H.R., Lincoln, J. (2006): Diabetes only affects nitric oxide synthase-containing myenteric neurons that do not contain heme oxygenase 2. Brain Res., 1068: 248-256.
197. Soares, M.P., Brouard, S., Smith, R.N. and Bach, F.H. (2001): Heme oxygenase-1, a protective gene that prevents the rejection of transplanted organs. Immunol. Rev., 184: 275-285.
198. Stevens, A.M., Yu-Lee, L.Y. (1992): The transcription factor interferon regulatory factor-1 is expressed during both early G1 and the G1/S transition in the prolactin-induced lymphocyte cell cycle. Mol. Endocrinol., 6: 2236-2243.
199. Stocker, R., Keaney, J.F., Jr. (2004): Role of oxidative modifications in atherosclerosis. Physiol. Rev., 84: 1381-1478.
200. Stocker, R., McDonagh, A.F., Glazer, A.N. and Ames, B.N. (1990): Antioxidant activities of bile pigments: biliverdin and bilirubin. Methods Enzymol., 186: 301-309.
201. Suematsu, M., Suzuki, H., Delano, F.A. and Schmid-Schonbein, G.W. (2002): The inflammatory aspect of the microcirculation in hypertension: oxidative stress, leukocytes/endothelial interaction, apoptosis. Microcirculation, 9: 259-276.
202. Sun, B.L., An, W., Xia, Z.L., Zheng, C.B., Li, W.X., Yang, M.F., Zhao, T. and Ye, W.J. (2006): Zinc protoporphyrin aggravates cerebral ischemic injury following experimental subarachnoid hemorrhage. Clin. Hemorheol. Microcirc., 34: 241-246.
203. Sunamura, M., Duda, D.G., Ghattas, M.H., Lozonschi, L., Tomohiro, K., Egawa, S.-I., Matsumoto, G., Shimamura, H., Kazuhiko, S., Takeda, K., Matsuno, S. and Abraham, N.G. (2003): Heme oxygenase-1 accelerates tumor angiogenesis of human pancreatic cancer. Angiogenesis, 47: 181-196.
204. Suttner, D.M., Dennery, P.A. (1999): Reversal of HO-1 related cytoprotection with increased expression is due to reactive iron. FASEB J., 13: 1800-1809.
205. Takahashi, M., Dore, S., Ferris, C.D., Tomita, T., Sawa, A., Wolosker, H., Borchelt, D.R., Iwatsubo, T., Kim, S.H., Thinakaran, G., Sisodia, S.S. and Snyder, S.H. (2000): Amyloid precursor proteins inhibit herne oxygenase activity and augment neurotoxicity in Alzheimer's disease. Neuron, 28: 461-473.
206. Takeda, A., Perry, G., Abraham, N.G., Dwyer, B.E., Kutty, R.K., Laitinen, J.T., Petersen, R.B. and Smith, M.A. (2000): Overexpression of heme oxygenase in neuronal cells, the possible interaction with Tau. J. Biol. Chem., 275: 5395-5399.
207. Tanaka, S., Akaike, T., Fang, J., Beppu, T., Ogawa, M., Tamura, F., Miyamoto, Y. and Maeda, H. (2003): Antiapoptotic effect of haem oxygenase-1 induced by nitric oxide in experimental solid tumour. Br. J. Cancer, 88: 902-909.
208. Tang, Y.L., Tang, Y., Zhang, Y.C., Qian, K., Shen, L. and Phillips, M.I. (2005): Improved graft mesenchymal stem cell survival in ischemic heart with a hypoxia-regulated heme oxygenase-1 vector. J. Am. Coll. Cardiol., 46: 1339-1350.
209. Teng, Z.P., Wang, H.M., Chau, L.Y. and Regan, R.F. (2003): Adenoviral Transfer of the Heme Oxygenase-1 Gene Protects Astrocytes from Heme-mediated Oxidative Injury. Acad. Emerg. Med, 10: 480-481.
210. Thompson, K., Menzies, S., Muckenthaler, M., Torti, F.M., Wood, T., Torti, S.V., Hentze, M.W., Beard, J. and Connor, J. (2003): Mouse brains deficient in H-ferritin have normal iron concentration but a protein profile of iron deficiency and increased evidence of oxidative stress. J. Neurosci. Res., 71: 46-63.
211. Tsao, P.S., Aoki, N., Lefere, D.J., Johnson, G. and Lefer, A.M. (1990): Time course of endothelial dysfunction and myocardial injury during myocardial ischemia and reperfusion in the cat. Circulation, 82: 1402-1412.
212. Tsui, T.Y., Lau, C.K., Ma, J., Glockzin, G., Obed, A., Schlitt, H.J. and Fan, S.T. (2006): Adeno-associated virus-mediated heme oxygenase-1 gene transfer suppresses the progression of micronodular cirrhosis in rats. World J. Gastroenterol., 12: 2016-2023.
213. Tsui, T.Y., Lau, C.K., Ma, J., Wu, X., Wang, Y.Q., Farkas, S., Xu, R., Schlitt, H.J. and Fan, S.T. (2005): rAAV-mediated stable expression of heme oxygenase- 1 in stellate cells: a new approach to attenuate liver fibrosis in rats. Hepatology, 42: 335-342.
214. Turkseven, S., Kruger, A., Mingone, C.J., Kaminski, P., Inaba, M., Rodella, L., Ikehara, S., Wolin, M.S. and Abraham, N.G. (2005): Antioxidant mechanism of heme oxygenase-1 involves an increase in superoxide dismutase and catalase in experimental diabetes. Am. J. Physiol. Heart Circ. Physiol., 289: H701-H707.
215. Uberti, D., Carsana, T., Bernardi, E., Rodella, L., Grigolato, P., Lanni, C., Racchi, M., Govoni, S. and Memo, M. (2002): Selective impairment of p53-mediated cell death in fibroblasts from sporadic Alzheimer's disease patients. J. Cell Sci., 115: 3131-3138.
216. Ushiyama, M., Morita, T., Kuramochi, T., Yagi, S. and Katayama, S. (2004): Erectile dysfunction in hypertensive rats results from impairment of the relaxation evoked by neurogenic carbon monoxide and nitric oxide. Hypertens. Res., 27: 253-261.
217. Valaes, T.S., Petmezaki, S., Henschke, G.S., Drummond, S. and Kappas, A. (1994): Control of jaundice in preterm newborns by an inhibitor of bilirubin production: studies with tin-mesoporphyrin. Pediatrics, 93: 1-11.
218. Verreault, M., Webb, M.S., Ramsay, E.C. and Bally, M.B. (2006): Gene silencing in the development of personalized cancer treatment: the targets, the agents and the delivery systems, Curr. Gene Ther., 6: 505-533.
219. Volti, G.L., Sacerdoti, D., Sangras, B., Vanella, A., Mezentsev, A., Scapagnini, G., Falck, J.R. and Abraham, N.G. (2005): Carbon monoxide signaling in promoting angiogenesis in human microvessel endothelial cells. Antioxid. Redox. Signal., 7: 704-710.
220. Wagener, F.A., Eggert, A., Boerman, O.C., Oyen, W.J., Verhofstad, A., Abraham, N.G., Adema, G., van Kooyk, Y., de Witte, T. and Figdor, C.G. (2001): Heme is a potent inducer of inflammation in mice and is counteracted by heme oxygenase. Blood, 98: 1802-1811.
221. Wagner, K.R., Hua, Y., de Court, Broderick, J.P., Nishimura, R.N., Lu, S.Y. and Dwyer, B.E. (2000): Tin-mesoporphyrin, a potent heme oxygenase inhibitor, for treatment of intracerebral. hemorrhage: in vivo and in vitro studies. Cell Mol. Biol. (Noisy. -le-grand), 46: 597-608.
222. Wang, R., Wang, Z. and Wu, L. (1997): Carbon monoxide-induced vasorelaxation and the underlying mechanisms. Br. J. Pharmacol, 121: 927-934.
223. Wu, Y.D., Wang, G.X., Wei, J.X., Wen, X.G., Liu, B.Q., Wu, C.L. and Han, R.F. (2005): [Heme oxygenase-1 gene transfer protects rat kidney transplant from ischemia/reperfusion injury]. Zhonghua Wai Ke. Za Zhi., 43: 1215-1218.
224. Xu, K., Ma, H., McCown, T.J., Verma, I.M. and Kafri, T. (2001): Generation of a stable cell line producing high-titer self-inactivating lentiviral vectors. Mol. Ther., 3: 97-104.
225. Yachie, A., Niida, Y., Wada, T., Igarashi, N., Kaneda, H., Toma, T., Ohta, K., Kasahara, Y. and Koizumi, S. (1999): Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J. Clin. Invest., 103: 129-135.
226. Yan, S.D., Chen, X., Fu, J., Chen, M., Zhu, H., Roher, A., Slattery, T., Zhao, L., Nagashima, M., Morser, J., Migheli, A., Nawroth, P., Sterǹ, D. and Schmidt, A.M. (1996): RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease. Nature, 382: 685-691.
227. Yang, L., Quan, S. and Abraham, N.G. (1999): Retrovirus-mediated HO gene transfer into endothelial cells protects against oxidant-induced injury. Am. J. Physiol., 277: L127-L133.
228. Yang, L., Quan, S., Nasjletti, A., Laniado-Schwartzman, M. and Abraham, N.G. (2004): Heme oxygenase-1 gene expression modulates angiotensin II-induced increase in blood pressure. Hypertension, 43: 1221-1226.
229. Zhang, F., Kaide, J.I., Rodriguez-Mulero, F., Abraham, N.G. and Nasjletti, A. (2001): Vasoregulatory function of the heme-heme oxygenasecarbon monoxide system. Am. J. Hypertens., 14: 62S-67S.
230. Zhang, Y., Zeng, W.C. and Chen, R. (2006): [Experimental research on antagonistic effect of heme oxygenase-1 on acute mercury chloride induced renal impairment]. Zhonghua Lao. Dong. Wei Sheng Zhi. Ye. Bing. Za Zhi., 24: 289-290.
231. Zou, A.P., Fleming, J.T., Falck, J.R., Jacobs, E.R., Gebremedhin, D., Harder, D.R. and Roman, R.J. (1996): 20-HETE is an endogenous inhibitor of the large-conductance Ca(2+)-activated K+ channel in renal arterioles. Am. J. Physiol., 270: R228-R237.
232. Zou, A.P., Imig, J.D., Ortiz-de-Montellano, P.R., Sui, Z., Falck, J.R. and Roman, R.J. (1994a): Effect of P-450 omega-hydroxylase metabolites of arachidonic acid on tubuloglomerular feedback. Am. J. Physiol., 266: F934-F941.
233. Zou, A.P., Ma, Y.H., Sui, Z.H., Ortiz-de-Montellano, P.R., Clark, J.E., Masters, B.S. and Roman, R.J. (1994b): Effects of 17-octadecynoic acid, a suicide-substrate inhibitor of cytochrome P450 fatty acid omegahydroxylase, on renal function in rats. J. Pharmacol. Exp. Ther., 268: 474-481.