Selective increase in human heme oxygenase-1 gene expression attenuates development of hypertension and increases body growth in spontaneously hypertensive rats

Carbon Monoxide and Cardiovascular Functions

Volumn , Issue , 2001, Pages 233-245

  Abraham, Nader G ^a   Quan, Shuo ^a   Shenouda, Sylvia ^a   Kappas, Attallah ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0042339554     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (41)

1. Yoshida, T. and Kikuchi, G., Purification and properties of heme oxygenase from pig spleen microsomes, J. Biol. Chem., 253, 4224, 1978.
2. Abraham, N.G. et al., Biological significance and physiological role of heme oxygenase, Cell Physiol. Biochem., 6, 129, 1996.
3. McCoubrey, W.K., Jr., Huang, T.J., and Maines, M.D., Isolation and characterization of a cDNA from the rat brain that encodes hemoprotein heme oxygenase-3, Eur. J. Biochem., 247, 725, 1997.
4. Maines, M.D., The heme oxygenase system; a regulator of second messenger gases, Annu. Rev. Pharmacol. Toxicol., 37, 517, 1997.
5. Zakhary, R. et al., Heme oxygenase 2: endothelial and neuronal localization and role in endothelium-dependent relaxation, Proc. Natl. Acad. Sci. U.S.A., 93, 795, 1996.
6. Choi, A.M.K. and Alam, J., Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury, Am. J. Respir. Cell. Mol. Biol., 15, 9, 1996.
7. Lutton, J.D. et al., Differential induction of heme oxygenase in the hepatocarcinoma cell line (Hep3b) by environmental agents, J. Cell. Biochem., 49, 259, 1992.
8. Neil, T.K. et al., Modulation of corneal heme oxygenase expression by oxidative stress agents, J. Ocul. Pharmacol. Ther., 11, 455, 1995.
9. Dennery, P.A. et al., Heme oxygenase-mediated resistance to oxygen toxicity in hamster fibroblasts, J. Biol. Chem., 272, 14937, 1997.
10. Lu, T.H. et al., Molecular cloning, characterization, and expression of the chicken heme oxygenase-1 gene in transfected primary cultures of chick embryo liver cells, Gene, 207, 177, 1998.
11. Mitani, K. et al., Heme oxygenase is a positive acute phase reactant in human Hep3B hepatoma cells, Blood, 79, 1255, 1992.
12. Verma, A. et al., Carbon monoxide: a putative neural messenger, Science, 259, 381, 1993.
13. McCoubrey, W.K., Jr., Ewing, J.F., and Maines, M.D., Human heme oxygenase-2:characterization and expression of a full-length cDNA and evidence suggesting that the two HO-2 transcripts may differ by choice of polyadenylation signal, Arch. Biochem. Biophys., 295, 13, 1992.
14. Zhang, F. et al., Carbon monoxide produced by isolated arterioles attenuates pressureinduced vasoconstriction, Am. J. Physiol., 14, 625, 2001.
15. Johnson, R.A. et al., Role of endogenous carbon monoxide in central regulation of arterial pressure, Hypertension, 30, 962, 1997.
16. Abraham, N.G., Jiang, S., Yang, L., Zand, B.A., Marji, J., Drummond, G.S., and Kappas, A., Adenoviral vector-mediated transfer of human heme oxygenase in rats virtually decreases renal heme-dependent arachidonic acid epoxygenase activity, J. Exp. Pharm. Ther., 293, 494, 2000.
17. Sabaawy, H.E. et al., Transfer of the human heme oxygenase-1 gene decreases blood pressure and promotes growth in spontaneously hypertensive rats, 54th Annual Conference of the Council for High Blood Presure, Fall 2000, p. 52.
18. Gadano, A.C. et al., Endothelial calcium-calmodulin dependent nitric oxide synthase in the in vitro vascular hyporeactivity of portal hypertensive rats, J. Hepatol., 26, 678, 1997.
19. Yang, L., Quan, S., and Abraham, N.G., Retrovirus-mediated HO gene transfer into endothelial cells protects against oxidant-induced injury, Am. J. Physiol., 277, L127, 1999.
20. Martasek, P. et al., Hemin and L-arginine regulation of blood pressure in spontaneous hypertensive rats, J. Am. Soc. Nephrol., 2, 1078, 1991.
21. Levere, R.D. et al., Effect of heme arginate administration on blood pressure in spontaneously hypertensive rats, J. Clin. Invest., 86, 213, 1990.
22. da-Silva, J.L. et al., Tin-mediated heme oxygenase gene activation and cytochrome P450 arachidonate hydroxylase inhibition in spontaneously hypertensive rats [published erratum appears in Am. J. Med. Sci., 308, 138. 1994], Am. J. Med. Sci., 307, 173, 1994.
23. Kappas, A. and Drummond, G., Control of heme metabolism with synthetic metalloporphyrins, J. Clin. Invest., 77, 335, 1986.
24. Kappas, A., Simionatto, C.S., Drummond, G.S., Sassa, S., and Anderson, K.E., The liver excretes large amounts of heme into bile when heme oxygenase is inhibited competitively by Sn-protoporphyrin, Proc. Natl. Acad. Sci. U.S.A., 82, 896, 1985.
25. Kappas, A., Drummond, G.S., Manola, T., Petmezaki, S., and Valaes, T., Sn-protoporphyrin use in the management of hyperbilirubinemia in term newborns with direct Coombs-positive ABO incompatibility, Pediatrics, 81, 485, 1988.
26. Kappas, A. et al., Direct comparison of Sn-mesoporphyrin, an inhibitor of bilirubin production, and phototherapy in controlling hyperbilirubinemia in term and near-term newborns, Pediatrics, 95, 468, 1995.
27. Kappas, A., Drummond, G.S., and Vallaes, J., A single dose of Sn-mesoporphyrin prevents development of significant hyperbilirubinemia in glucose-6 phosphate dehydrogenase deficient newborns, Pediatrics, 108, 25, 2001.
28. Lutton, J.D. et al., Zinc porphyrins: potent inhibitors of hematopoiesis in animal and human bone marrow, Proc. Natl. Acad. Sci. U.S.A., 94,1432, 1997.
29. Kappas, A. and Maines, M.D., Tin: a potent inducer of heme oxygenase in kidney, Science, 192, 60, 1976.
30. Abraham, N.G., Quantitation of heme oxygenase (HO-1) copies in human tissues by competitive RT/PCR, Methods Mol. Biol., 108,199, 1998.
31. Sacerdoti, D. et al., Treatment with tin prevents the development of hypertension in spontaneously hypertensive rats, Science, 243, 388, 1989.
32. Omata, K. et al., Age-related changes in renal cytochrome P-450 arachidonic acid metabolism in spontaneously hypertensive rats, Am. J. Physiol., 262, F8, 1992.
33. Imig, J.D. et al., Elevated renovascular tone in young spontaneously hypertensive rats. Role of cytochrome P-450, Hypertension, 22, 357, 1993.
34. Sabaawy, H.E. et al., Human heme oxygenase-1 gene transfer lowers blood pressure and promotes growth in spontaneously hypertensive rats, Hypertension, 2001, in press.
35. Yachie, A. et al., Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency, J. Clin. Invest., 103, 129, 1999.
36. Poss, K.D. and Tonegawa, S., Reduced stress defense in heme oxygenase-1 deficient cells, Proc. Natl. Acad. Sci. U.S.A., 94, 10925, 1997.
37. Deramaudt, B.M. et al., Gene transfer of human heme oxygenase into coronary endothelial cells potentially promotes angiogenesis, J. Cell. Biochem., 68, 121, 1998.
38. Deramaudt, B.J.M., Remy, P., and Abraham, N.G., Upregulation of human heme oxygenase gene expression by Ets-family proteins, J. Cell. Biochem., 72, 311, 1999.
39. Lee, P.J. et al., Overexpression of heme oxygenase-1 in human pulmonary epithelial cells results in cell growth arrest and increased resistance to hyperoxia, Proc. Natl. Acad. Sci. U.S.A., 93, 10393, 1996.
40. Lavrovsky, Y. et al., Activation of nuclear factor kappa B and oncogene expression by 12(R)-hydroxyeicosatrienoic acid, an angiogenic factor in microvessel endothelial cells, J. Biol. Chem., 269, 24321, 1994.
41. Cheriathundam, E., Doi, S.Q., Knapp, J.R., Jasser, M.Z., Kopchick, J.J., and Alvares, A.P., Consequences of overexpression of growth hormone in transgenic mice on liver cytochrome P450 enzymes, Biochem. Pharmacol., 55, 1481, 1998.