Heme oxygenase-1-dependent and -independent regulation of angiogenic genes expression: Effect of cobalt protoporphyrin and cobalt chloride on VEGF and IL-8 synthesis in human microvascular endothelial cells

Cellular and Molecular Biology

Volumn 51, Issue 4, 2005, Pages 347-355

  Loboda, A ^a   Jazwa, A ^a   Wegiel, B ^a   Jozkowicz, A ^a   Dulak, J ^a  

^a JAGIELLONIAN UNIVERSITY   (Poland)

Author keywords

Angiogenesis; Heme oxygenase; HIF 1; Hypoxia; IL 8; Reactive oxygen species; VEGF

Indexed keywords

COBALT CHLORIDE; HEME OXYGENASE 1; HYPOXIA INDUCIBLE FACTOR 1; INTERLEUKIN 8; PORPHYRIN COBALT; PROTOPORPHYRIN; PROTOPORPHYRIN TIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; CYTOKINE PRODUCTION; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MEDIATOR; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS;

CELLS, CULTURED; COBALT; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; HEME OXYGENASE-1; HUMANS; INTERLEUKIN-8; NEOVASCULARIZATION, PHYSIOLOGIC; PROTOPORPHYRINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 27744556130     PISSN: 01455680     EISSN: 1165158X     Source Type: Journal    
DOI: 10.1170/T637     Document Type: Article

References (36)

1. Abid, M.R., Guo, S., Minami, T., Spokes, K.C., Ueki, K., Skurk, C., Walsh, K. and Aird, W.C., Vascular endothelial growth factor activates PI3K/Akt/forkhead signaling in endothelial cells. Arterioscler. Thromb. Vasc. Biol. 2004, 24: 294-300.
2. Amersi, F., Buelow, R., Kato, H., Ke, B., Coito, A.J., Shen, X.D., Zhao, D., Zaky, J., Melinek, J., Lassman, C.R., Kolls, J.K., Alam, J., Ritter, T., Volk, H.D., Farmer, D.G., Ghobrial, R.M., Busuttil, R.W. and Kupiec-Weglinski, J.W., Upregulation of heme oxygenase-1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury. J. Clin. Invest. 1999, 104: 1631-1639.
3. Azenshtein, E., Meshel, T., Shina, S., Barak, N., Keydar, I. and Ben-Baruch, A., The angiogenic factors CXCL8 and VEGF in breast cancer: regulation by an array of pro-malignancy factors. Cancer Lett. 2005, 217: 73-86.
4. BelAiba, R.S., Djordjevic, T., Bonello, S., Flugel, D., Hess, J., Kietzmann, T. and Gorlach, A., Redox-sensitive regulation of the HIF pathway under non-hypoxic conditions in pulmonary artery smooth muscle cells. J. Biol. Chem. 2004, 385: 249-257.
5. Bussolati, B., Ahmed, A., Pemberton, H., Landis, R.C., Di Carlo, F., Haskard, D.O. and Mason, J.C., Bifunctional role for VEGF-induced heme oxygenase-1 in vivo: induction of angiogenesis and inhibition of leukocytic infiltration. Blood 2004, 103: 761-766.
6. Christova, T.Y., Gorneva, G.A., Taxirov, S.I., Duridanova, D.B. and Setchenska, M.S., Effect of cisplatin and cobalt chloride on antioxidant enzymes in the livers of Lewis lung carcinoma-bearing mice: protective role of heme oxygenase. Toxicol. Lett. 2003, 138: 235-242.
7. Dulak, J. and Jozkowicz, A., Regulation of vascular endothelial growth factor synthesis by nitric oxide: facts and controversies. Antioxid. Redox. Signal. 2003, 5: 123-132.
8. Dulak, J., Jozkowicz, A., Foresti, R., Kasza, A., Frick, M., Huk, I., Green, C.J., Pachinger, O., Weidinger, F. and Motterlini, R., Heme oxygenase activity modulates vascular endothelial growth factor synthesis in vascular smooth muscle cells. Antioxid. Redox. Signal. 2002, 4: 229-240.
9. Duyndam, M.C., Hulscher, T.M., Fontijn, D., Pinedo, H.M. and Boven, E., Induction of vascular endothelial growth factor expression and hypoxia-inducible factor 1alpha protein by the oxidative stressor arsenite. J. Biol. Chem. 2001, 276: 48066-48076.
10. Ferrara, N., Vascular endothelial growth factor: basic science and clinical progress. Endocrin. Rev. 2004, 25: 581-611.
11. Foresti, R. and Motterlini, R., The heme oxygenase pathway and its interaction with nitric oxide in the control of cellular homeostasis. Free Radic. Res. 1999, 31: 459-475.
12. Fujishima, S., Hoffman, A.R., Vu, T., Kim, K.J., Zheng, H., Daniel, D., Kim, Y., Wallace, E.F., Larrick, J.W. and Raffin, T.A., Regulation of neutrophil interleukin 8 gene expression and protein secretion by LPS, TNF-alpha, and IL-1 beta. J. Cell. Physiol. 1993, 154: 478-485.
13. Gerbitz, A., Ewing, P., Wilke, A., Schubert, T., Eissner, G., Dietl, B., Andreesen, R., Cooke, K.R. and Holler, E., Induction of heme oxygenase-1 before conditioning results in improved survival and reduced graft-versus-host disease after experimental allogeneic bone marrow transplantation. Biol. Blood Marrow Transplant. 2004, 10: 461-472.
14. Grzenkowicz-Wydra, J., Cisowski, J., Nakonieczna, J., Zarebski, A., Udilova, N., Nohl, H., Jozkowicz, A., Podhajska, A. and Dulak, J., Gene transfer of CuZn superoxide dismutase enhances the synthesis of vascular endothelial growth factor. Mol. Cell. Biochem. 2004, 264: 169-181.
15. Jozkowicz, A. and Dulak, J., Effects ofprotoporphyrins on production of nitric oxide and expression of vascular endothelial growth factor in vascular smooth muscle cells and macrophages. Acta Biochim. Pol. 2003, 50: 69-79.
16. Jozkowicz, A., Huk, I., Nigisch, A., Weigel, G., Weidinger, F. and Dulak, J., Effect of prostaglandin-J(2) on VEGF synthesis depends on the induction of heme oxygenase-1. Antioxid. Redox. Signal. 2002, 4: 577-585.
17. Kaliman, P.A., Nikitchenko, I.V., Sokol, O.A. and Strel'chenko, E.V., Regulation of heme oxygenase activity in rat liver during oxidative stress induced by cobalt chloride and mercury chloride. Biochemistry 2001, 66: 77-82.
18. Kim, H.H., Lee, S.E., Chung, W.J., Choi, Y., Kwack, K., Kim, S.W., Kim, M.S., Park, H. and Lee, Z.H., Stabilization of hypoxia-inducible factor-1alpha is involved in the hypoxic stimuli-induced expression of vascular endothelial growth factor in osteoblastic cells. Cytokine 2002, 17: 14-27.
19. Kimura, H., Weisz, A., Ogura, T., Hitomi, Y., Kurashima, Y., Hashimoto, K., D'Acquisto, F., Makuuchi, M. and Esumi, H., Identification of hypoxia-inducible factor 1 ancillary sequence and its function in vascular endothelial growth factor gene induction by hypoxia and nitric oxide. J. Biol. Chem. 2001, 276: 2292-2298.
20. Kofler, S., Nickel, T. and Weis, M., Role of cytokines in cardiovascular diseases: a focus on endothelial responses to inflammation. Clin. Sci. 2005, 108: 205-213.
21. Kreiser, D., Nguyen, X., Wong, R., Seidman, D., Stevenson, D., Quan, S., Abraham, N. and Dennery P.A., Heme oxygenase-1 modulates fetal growth in the rat. Lab. Invest. 2002, 82: 687-692.
22. Lee, T.H., Avraham, H., Lee, S.H. and Avraham, S., Vascular endothelial growth factor modulates neutrophil transendothelial migration via up-regulation of interleukin-8 in human brain microvascular endothelial cells. J. Biol. Chem. 2002, 277: 10445-10451.
23. Li, A., Dubey, S., Varney, M.L., Dave, B.J. and Singh, R.K., IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis. J. Immunol. 2003, 170: 3369-3376.
24. Maines, M.D., The heme oxygenase system: a regulator of second messenger gases. Annu. Rev. Pharmacol. Toxicol. 1997, 37: 517-554.
25. Otterbein, L.E., Soares, M.P., Yamashita, K. and Bach, F.H., Heme oxygenase-1: unleashing the protective properties of heme. Trends Immunol. 2003 24: 449-455.
26. Pae, H.O., Oh, G.S., Choi, B.M., Kim, Y.M. and Chung, H.T., A molecular cascade showing nitric oxide-heme oxygenase-1-vascular endothelial growth factor-interleukin-8 sequence in human endothelial cells. Endocrinology 2005, 146: 2229-2238.
27. Reinders, M.E., Sho, M., Izawa, A., Wang, P., Mukhopadhyay, D., Koss, K.E., Geehan, C.S., Luster, A.D., Sayegh, M.H. and Briscoe, D.M., Proinflammatory functions of vascular endothelial growth factor in alloimmunity. J. Clin. Invest. 2003, 112: 1655-1665.
28. Richard, D.E., Berra, E. and Pouyssegur, J., Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells. J. Biol. Chem. 2000, 275: 26765-26771.
29. Suzuki, M., Iso-o, N., Takeshita, S., Tsukamoto, K., Mori, I., Sato, T., Ohno, M., Nagai, R., Ishizaka, N., Facilitated angiogenesis induced by heme oxygenase-1 gene transfer in a rat model of hindlimb ischemia. Biochem. Biophys. Res. Commun. 2003, 302: 138-143.
30. Taketani, S., Kohno, H., Yoshinaga, T. and Tokunaga, R., Induction of heme oxygenase in rat hepatoma cells by exposure to heavy metals and hyperthermia. Biochem. Int. 1988, 17: 665-672.
31. Villarete, L.H. and Remick, D.G., Nitric oxide regulation of IL-8 expression in human endothelial cells. Biochem. Biophys. Res. Commun. 1995, 211: 671-676.
32. Wagner, M., Cadetg, P., Ruf, R., Mazzucchelli, L., Ferrari, P. and Redaelli, C.A., Heme oxygenase-1 attenuates ischemia/reperfusion-induced apoptosis and improves survival in rat renal allografts. Kidney Int. 2003, 63: 1564-1573.
33. Wang, G.L. and Semenza, G.L., Purification and characterization of hypoxia-inducible factor 1. J. Biol. Chem. 1995, 270: 1230-1237.
34. Yeh, M., Leitinger, N., de Martin, R., Onai, N., Matsushima, K., Vora, D.K., Berliner, J.A. and Reddy, S.T., Increased transcription of IL-8 in endothelial cells is differentially regulated by TNF-alpha and oxidized phospholipids. Arterioscler. Thromb. Vasc. Biol. 2001, 21: 1585-1591.
35. Yilmaz, A., Kliche, S., Mayr-Beyrle, U., Fellbrich, G. and Waltenberger, J., p38 MAPK inhibition is critically involved in VEGFR-2-mediated endothelial cell survival. Biochem. Biophys. Res. Commun. 2003, 306: 730-736.
36. Zagorska, A. and Dulak, J., HIF-1: the knowns and unknowns of hypoxia sensing. Acta Biochim. Pol. 2004, 51: 563-585.