Gene transfer of immunomodulatory peptides correlates with heme oxygenase-1 induction and enhanced allograft survival

Transplantation

Volumn 69, Issue 1, 2000, Pages 120-128

  Debruyne, Lisa A ^a   Magee, John C ^a   Buelow, Roland ^b   Bromberg, Jonathan S ^a,c  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b GENZYME CORPORATION   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEME OXYGENASE; HLA ANTIGEN CLASS 1; PEPTIDE; PLASMID DNA; PROTOPORPHYRIN;

ALLOGRAFT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; FEMALE; GENE TRANSFER; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNOMODULATION; IMMUNOREGULATION; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL;

EID: 0034650234     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-200001150-00021     Document Type: Article

References (53)

1. Krensky AM, Lyu S-C, Pouletty P, Benjamin R, Parham P, Clayberger C. Peptides corresponding to the CD8 binding region of HLA class I block the differentiation of cytotoxic T lymphocyte precursors. Transplant Proc 1993; 25: 483.
2. Clayberger C, Lyu S-C, Pouletty P, Krensky AM. Peptides corresponding to T-cell receptor-HLA contact regions inhibit class I-restricted immune responses. Transplant Proc 1993; 25: 477.
3. Woo J, Gao L, Cornejo M-C, Buelow R. A synthetic dimeric HLA class I peptide inhibits T cell activity in vitro and prolongs allogeneic heart graft survival in a mouse model. Transplantation 1995; 60: 1156.
4. Buelow R, Veyron P, Clayberger C, Pouletty P, Touraine J-L. Prolongation of skin allograft survival in mice following administration of Allotrap. Transplantation 1995; 59: 455.
5. Nisco S, Vriens P, Hoyt G, et al. Induction of allograft tolerance in rats by an HLA class-I derived peptide and cyclosporine A. J Immunol 1994; 152: 3786.
6. Cuturi M-C, Josien R, Douillard P, et al. Prolongation of allogeneic heart graft survival in rats by administration of a peptide (a.a 75-84) from the α1 helix of the first domain of HLA-B7 01. Transplantation 1995; 59: 661.
7. Hanaway MJ, Geissler EK, Wang J, Fechner JH, Buelow R, Knechtle SJ. Immunosuppressive effects of an HLA class I-derived peptide in a rat cardiac allograft model. Transplantation 1996; 61: 1222.
8. Murphy B, Kim KS, Buelow R, Sayegh MH, Hancock WW. Synthetic MHC class I peptide prolongs cardiac survival and attenuates transplant arteriosclerosis in the Lewis→Fischer 344 model of chronic allograft rejection. Transplantation 1997; 64: 14.
9. Nobner E, Goldberg JE, Naftzger C, Lyu S-C, Clayberger C, Krensky AM. HLA-derived peptides which inhibit T cell function bind to members of the heat-shock protein 70 family. J Exp Med 1996; 183: 339.
10. Woo J, Iyer S, Cornejo M-C, et al. Immunosuppression by D-isomers of HLA class I heavy chain (amino acid 75-84)-derived peptides is independent of binding to HSC70. Transplantation 1997; 64: 1460.
11. Iyer S, Woo J, Cornejo M-C, et al. Characterization and biological significance of immunosuppressive peptide D2702.75-84(E→V) binding protein. J Biol Chem 1998; 273: 2692.
12. Fulmer R, Cramer A, Liebelt A. Transplantation of cardiac tissue into the mouse ear. Am J Anat 1963; 113: 273.
13. Judd KP, Trentin JJ. Cardiac transplantation in mice: I. Factors influencing the take and survival of heterotopic grafts. Transplantation 1971; 11: 298.
14. Moore KW, Vieira P, Fiorentino DF, Trounstine ML, Khan TA, Mosmann TR. Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr Virus Gene BCRFI. Science 1990; 248: 1230.
15. Philip R, Brunette E, Kilinski L, et al. Efficient and sustained gene expression in primary T lymphocytes and primary and cultured tumor cells mediated by adeno-associated virus plasmid DNA complexed to cationic liposomes. Mol Cell Biol 1994; 14: 2411.
16. Subramaniam A, Gulick J, Neumann J, Knotts S, Robbins J Transgenic analysis of the thyroid-responsive elements in the α-cardiac myosin heavy chain gene promoter. J Biol Chem 1993; 268: 4331.
17. Kozak M. Analysis of vertebrate mRNA sequences: intimations of translational control. J Cell Biol 1991; 155: 887.
18. Bromberg JS, Chavin KD, Altevogt P, et al. Anti-CD2 monoclonal antibodies alter cell-mediated immunity in vivo. Transplantation 1991; 51: 219.
19. Grassy G, Calas B, Yasri A, et al. Computer-assisted rational design of immunosuppressive compounds. Nature Biotechnol 1998; 16: 748.
20. Grassy G, Calas B, Yasri A, et al. "In silico screening" applied to the rational design of immunosuppressive compounds. Nat Biotechnol 1998; 16: 748.
21. Qin L, Ding Y, Pahud DR, Chang E, Imperiale MJ, Bromberg JS. Promoter attenuation in gene therapy: interferon-γ and tumor necrosis factor-α inhibit transgene expression. Hum Gene Ther 1997; 8: 2019.
22. Qin L, Chavin KD, Ding Y, et al. Retrovirus-mediated transfer of viral IL-10 gene prolongs murine cardiac allograft survival. J Immunol 1996; 156: 2316.
23. Qin L, Chavin KD, Ding Y, et al. Multiple vectors effectively achieve gene transfer in a murine cardiac transplantation model. Transplantation 1995; 59: 809.
24. Woo J, Iyer S, Cornejo M-C, et al. Stress protein induced immunosuppression: inhibition of cellular immune effector functions following overexpression of hemeoxygenase (HSP 32). Transplant Immunol 1998; 6: 84.
25. Bromberg JS, DeBruyne LA, Qin L. Interactions between the immune system and gene therapy vectors: bidirectional regulation of response and expression. Adv Immunol 1998; 69: 353.
26. Knechtle SJ, Zhai Y, Fechner J. Gene therapy in transplantation. Transplant Immunol 1996; 4: 257.
27. Gao L, Woo J, Buelow R. Both L-and D-isomers of HLA class I heavy chain derived peptides prolong heart allograft survival in mice. Heart Lung Transplantation 1996; 15: 78.
28. Ewing J, Maines MD. Rapid induction of heme oxygenase 1 mRNA and protein by hyperthermia in rat brain: heme oxygenase 2 is not a heat shock protein. Proc Natl Acad Sci USA 1991; 88: 5364.
29. Maines MD, Sinclair P. Cobalt regulation of heme synthesis and degradation in avian embryo liver cell culture. J Biol Chem 1977; 252: 219.
30. Maines MD. The heme oxygenase system: A regulator of second messenger gases. Annu Rev Pharmacol Toxicol 1997; 37: 517.
31. Duquesnoy RJ, Liu K, Moliterno RA, Attfield D. Do heat shock proteins play a role in transplant immunity? Transplantation Rev 1996; 10: 175.
32. Willis D, Moore AR, Frederick R, Willoughby DA. Heme oxygenase: a novel target for the modulation of the inflammatory response. Nat Med 1996; 2: 87.
33. Agarwal A, Kim Y, Matas A, Alam J, Nath KA. Gas-generating systems in acute renal allograft rejection in the rat. Transplantation 1996; 61: 93.
34. Tenhunen R, Marver HS, Schmid R. The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. Proc Natl Acad Sci USA 1968; 61: 748.
35. Tenhunen R, Marver HS, Schmid R. Microsomal heme oxygenase: characterization of the enzyme. J Biol Chem 1969; 244: 6388.
36. Lee PJ, Alam J, Wiegand GW, Choi AMK. Overexpression of heme oxygenase-1 in human pulmonary epithelial cells results in cell growth arrest and increased resistance to hyperoxia. Proc Natl Acad Sci USA 1996; 93: 10393.
37. Briine B, Ulrich V. Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase. Mol Pharmacol 1987; 32: 497.
38. Verma A, Hirsch DJ, Glatt CE, Ronnett GV, Synder SH. Carbon monoxide: a putative neural messenger. Science 1993; 259: 381.
39. Diaz JA, Vara E, Garcia C, Villa N, Balibrea JL. Evidence for a cyclic guanosine monophosphate-dependent, carbon monoxide-mediated, signaling system in the regulation of TNF-α production by human pulmonary macrophages. Arch Surg 1995; 130: 1287.
40. Vaadrager AB, de Jonge HR. Signalling by cGMP-dependent protein kinases. Mol Cell Biochem 1996; 157: 23.
41. Lincoln TM, Komalavilas P, Boerth NJ, MacMillan-Crow LA, Cornwell TL. cGMP signalling through cAMP-and cGMP-dependent protein kinases. Adv Pharmacol 1995; 34: 305.
42. Finn JT, Grunwald ME, Yau KW. Cyclic nucleotide-gated ion channels: an extended family with diverse functions. Annu Rev Physiol 1996; 58: 395.
43. Degerman E, Belfrage P, Manganiello VC. cGMP-inhibited phosphodiesterases (PDE gene family). Biochem Soc Trans 1996; 24: 1010.
44. Palacios JM, Beleta J, Segarra V. Second messenger systems as targets for new therapeutic agents: focus on selective phosphodiesterase inhibitors. Farmaco 1995; 50: 819.
45. Nakagami T, Toyomura K, Kinoshita T, Morisawa S. A beneficial role of bile pigments as an endogenous tissue protector: anti-complement effects of biliverdin and conjugated bilirubin. Biochim Biophys Acta 1993; 1158: 189.
46. Stocker R, Yamamoto Y, McDonagh AF, Glazer AN, Ames BN. Bilirubin is an antioxidant of possible physiological importance. Science 1987; 235: 1043.
47. Neuzil J, Stocker R. Free and albumin-bound bilirubin are efficient anti-oxidants for α-tocopherol, inhibiting plasma and low density lipoprotein peroxidation. J Biol Chem 1994; 261: 411.
48. Sano K, Nakamura H, Matsuo T. Mode of inhibitory action of bilirubin on proteinase kinase C. Pediatr Res 1985; 19: 587.
49. Kwak JY, Takeshiege K, Cheung BS, Minakami S. Bilirubin inhibits the activation of superoxide-producing NADPH oxidase in a neutrophil cell-free system. Biochim Biophys Acta 1991; 1076: 369.
50. Haga Y, Tempero MA, Kay D, Zetterman RK. Intracellular accumulation of unconjugated bilirubin inhibits phytohemagglutin-induced proliferation and interleukin-2 production of human lymphocytes. Dig Dis Sci 1996; 41: 1468.
51. Haga Y, Tempero MA, Zetterman RK. Unconjugated bilirubin inhibits in vitro major histocompatibility complex-unrestricted cytotoxicity of human lymphocytes. Biochim Biophys Acta 1996; 1316: 29.
52. Soares MP, Lin Y, Anrather J, et al. Expression of heme oxygenase-1 can determine cardiac xenograft survival. Nat Med 1998; 4: 1073.
53. Hancock WW, Buelow R, Sayegh MH, Turka LA. Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes. Nat Med 1998; 4: 1392.