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Volumn 26, Issue 1, 2006, Pages 55-64

Hypoxia and metastasis in breast cancer

Author keywords

Breast carcinoma; Gene expression; Hypoxia; Metastasis; Transient changes; Tumor microenvironment

Indexed keywords

CARBONATE DEHYDRATASE IX; CHEMOKINE RECEPTOR CXCR4; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1BETA; HYPOXIA INDUCIBLE FACTOR 2; OSTEOPONTIN; STROMAL CELL DERIVED FACTOR 1; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; UROKINASE; UROKINASE RECEPTOR;

EID: 34247528557     PISSN: 08886008     EISSN: None     Source Type: Journal    
DOI: 10.3233/bd-2007-26105     Document Type: Article
Times cited : (64)

References (124)
  • 1
    • 33747109086 scopus 로고    scopus 로고
    • Stromal cell-derived factor-1 and CXCR4 receptor interaction in tumor growth and metastasis of breast cancer
    • M.Z. Dewan, S. Ahmed, Y. Iwasaki, K. Ohba, M. Toi and N. Yamamoto, Stromal cell-derived factor-1 and CXCR4 receptor interaction in tumor growth and metastasis of breast cancer, Biomed Pharmacother 60 (2006), 273-276.
    • (2006) Biomed Pharmacother , vol.60 , pp. 273-276
    • Dewan, M.Z.1    Ahmed, S.2    Iwasaki, Y.3    Ohba, K.4    Toi, M.5    Yamamoto, N.6
  • 2
    • 0024708518 scopus 로고
    • The distribution of sedondary growths in cancer of the breast. 1889
    • S. Paget, The distribution of sedondary growths in cancer of the breast. 1889, Cancer Metastasis Rev 8 (1989), 98-101.
    • (1989) Cancer Metastasis Rev , vol.8 , pp. 98-101
    • Paget, S.1
  • 3
    • 0038481970 scopus 로고    scopus 로고
    • The pathogenesis of cancer metastasis: The 'seed and soil' hypothesis revisited
    • I.J. Fidler, The pathogenesis of cancer metastasis: The 'seed and soil' hypothesis revisited, Nat Rev Cancer 3 (2003), 453-458.
    • (2003) Nat Rev Cancer , vol.3 , pp. 453-458
    • Fidler, I.J.1
  • 4
    • 2942590732 scopus 로고    scopus 로고
    • Exploiting tum our hypoxia in cancer treatment
    • J.M. Brown and W.R. Wilson, Exploiting tum our hypoxia in cancer treatment, Nat Rev Cancer 4 (2004), 437-447.
    • (2004) Nat Rev Cancer , vol.4 , pp. 437-447
    • Brown, J.M.1    Wilson, W.R.2
  • 6
    • 33751074452 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 in human breast and prostate cancer
    • K.S. Kimbro and J.W. Simons, Hypoxia-inducible factor-1 in human breast and prostate cancer, Endocr Relat Cancer 13 (2006), 739-749.
    • (2006) Endocr Relat Cancer , vol.13 , pp. 739-749
    • Kimbro, K.S.1    Simons, J.W.2
  • 7
    • 33748150486 scopus 로고    scopus 로고
    • Long-term performance of interstial fluid pressure and hypoxia as prognostic factors in cervix cancer
    • A. Fyles, M. Milosevic, M. Pintilie, A. Syed, W. Levin, L. Manchul and R.P. Hill, Long-term performance of interstial fluid pressure and hypoxia as prognostic factors in cervix cancer, Radiother Oncol 80 (2066), 132-137.
    • Radiother Oncol , vol.80 , Issue.2066 , pp. 132-137
    • Fyles, A.1    Milosevic, M.2    Pintilie, M.3    Syed, A.4    Levin, W.5    Manchul, L.6    Hill, R.P.7
  • 8
    • 10644234769 scopus 로고    scopus 로고
    • The role of hypoxia-induced factors in tumor progression
    • P. Vaupel, The role of hypoxia-induced factors in tumor progression, Oncologist 9(Suppl 5) (2004), 10-17.
    • (2004) Oncologist , vol.9 , Issue.SUPPL. 5 , pp. 10-17
    • Vaupel, P.1
  • 9
    • 0037279517 scopus 로고    scopus 로고
    • The hypoxic tumour microenvironment and metastatic progression
    • P. Subarsky and R.P. Hill, The hypoxic tumour microenvironment and metastatic progression, Clin, Exp Metastasis 20 (2003), 237-250.
    • (2003) Clin, Exp Metastasis , vol.20 , pp. 237-250
    • Subarsky, P.1    Hill, R.P.2
  • 10
    • 34247526202 scopus 로고    scopus 로고
    • Mircroenvironmental Effects on Tumour Progression and Metastasis
    • G.G. Meadows, ed
    • K. Maseide, T. Kalliomaki and R.P. Hill, Mircroenvironmental Effects on Tumour Progression and Metastasis, in: Integration/Interaction of Oncologic Growth, (Vol. 15), G.G. Meadows, ed., 2005, p. 1.
    • (2005) Integration/Interaction of Oncologic Growth , vol.15 , pp. 1
    • Maseide, K.1    Kalliomaki, T.2    Hill, R.P.3
  • 11
    • 0034006016 scopus 로고    scopus 로고
    • HIF-1: Mediator of physiological and patho-physiologal responses to hypoxia
    • G.L. Semenza, HIF-1: Mediator of physiological and patho-physiologal responses to hypoxia, J Appl Physiol 88 (2000), 1474-1480.
    • (2000) J Appl Physiol , vol.88 , pp. 1474-1480
    • Semenza, G.L.1
  • 15
    • 0036674501 scopus 로고    scopus 로고
    • Dissemination and growth of cancer cells in metastatic sites
    • A.F. Chambers, A.C. Groom and I.C. MacDonald, Dissemination and growth of cancer cells in metastatic sites, Nat Rev Cancer 2 (2002), 563-572.
    • (2002) Nat Rev Cancer , vol.2 , pp. 563-572
    • Chambers, A.F.1    Groom, A.C.2    MacDonald, I.C.3
  • 17
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia - a key regulatory factor in tumour growth
    • A.L. Harris, Hypoxia - a key regulatory factor in tumour growth, Nat Rev Cancer 2 (2002), 38-47.
    • (2002) Nat Rev Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 21
    • 0035501217 scopus 로고    scopus 로고
    • Tumor size and oxygenation are independent predictors of nodal diseases in patients with cervix cancer
    • G. Pitson, A. Fyles, M. Milosevic, J. Wylie, M. Pintilie and R. Hill, Tumor size and oxygenation are independent predictors of nodal diseases in patients with cervix cancer, Int J Radiat Oncol Biol Phys 51 (2001), 699-703.
    • (2001) Int J Radiat Oncol Biol Phys , vol.51 , pp. 699-703
    • Pitson, G.1    Fyles, A.2    Milosevic, M.3    Wylie, J.4    Pintilie, M.5    Hill, R.6
  • 23
    • 0035255024 scopus 로고    scopus 로고
    • Cancer cells surviving hypoxia obtain hypoxia resistance and maintain anti-apoptotic potential under reoxygenation
    • M. Kinoshita, D.L. Johnson, C.H. Shatney, Y.L. Lee and H. Mochizuki, Cancer cells surviving hypoxia obtain hypoxia resistance and maintain anti-apoptotic potential under reoxygenation, Int J Cancer 91 (2001), 322-326.
    • (2001) Int J Cancer , vol.91 , pp. 322-326
    • Kinoshita, M.1    Johnson, D.L.2    Shatney, C.H.3    Lee, Y.L.4    Mochizuki, H.5
  • 24
    • 0038293080 scopus 로고    scopus 로고
    • Prognostic significance of tumor oxygenation in humans
    • S.M. Evans and C.J. Koch, Prognostic significance of tumor oxygenation in humans, Cancer Lett 195 (2003), 1-16.
    • (2003) Cancer Lett , vol.195 , pp. 1-16
    • Evans, S.M.1    Koch, C.J.2
  • 26
    • 0035925098 scopus 로고    scopus 로고
    • Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects
    • M. Hockel and P. Vaupel, Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects, J Natl Cancer Inst 93 (2001), 266-276.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 266-276
    • Hockel, M.1    Vaupel, P.2
  • 27
    • 0345491970 scopus 로고    scopus 로고
    • Carbonic anhydrase IX expression, hypoxia, and prognosis in patients with uterine cervical carcinomas
    • D. Hedley, M. Pintilie, J. Woo, A. Morrison, D. Birle, A. Fyles, M. Milosevic and R. Hill, Carbonic anhydrase IX expression, hypoxia, and prognosis in patients with uterine cervical carcinomas, Clin Cancer Res 9 (2003), 5666-5674.
    • (2003) Clin Cancer Res , vol.9 , pp. 5666-5674
    • Hedley, D.1    Pintilie, M.2    Woo, J.3    Morrison, A.4    Birle, D.5    Fyles, A.6    Milosevic, M.7    Hill, R.8
  • 28
    • 33646887011 scopus 로고    scopus 로고
    • Hypoxia in breast cancer: Role of blood flow, oxygen diffusion distances, and anemia in the development of oxygen depletion
    • P. Vaupel, A. Mayer, S. Briest and M. Hockel, Hypoxia in breast cancer: role of blood flow, oxygen diffusion distances, and anemia in the development of oxygen depletion, Adv Exp Med Biol 566 (2005), 333-342.
    • (2005) Adv Exp Med Biol , vol.566 , pp. 333-342
    • Vaupel, P.1    Mayer, A.2    Briest, S.3    Hockel, M.4
  • 30
    • 0345707572 scopus 로고    scopus 로고
    • Oxygenation gain factor: A novel parameter characterizing the association between hemoglobin level and the oxygenation status of breast cancers
    • P. Vaupel, A. Mayer, S. Briest and M. Hockel, Oxygenation gain factor: A novel parameter characterizing the association between hemoglobin level and the oxygenation status of breast cancers, Cancer Res 63 (2003), 7634-7637.
    • (2003) Cancer Res , vol.63 , pp. 7634-7637
    • Vaupel, P.1    Mayer, A.2    Briest, S.3    Hockel, M.4
  • 31
    • 0025807618 scopus 로고
    • Oxygenation of human tumors: Evaluation of tissue oxygen distribution in breast cancer by computerized O2 tention measurements
    • P. Vaupel, K. Schlenger, C. Knoope and M. Hockel, Oxygenation of human tumors: Evaluation of tissue oxygen distribution in breast cancer by computerized O2 tention measurements, Cancer Res 51 (1991), 3316-3322.
    • (1991) Cancer Res , vol.51 , pp. 3316-3322
    • Vaupel, P.1    Schlenger, K.2    Knoope, C.3    Hockel, M.4
  • 32
    • 0031970946 scopus 로고    scopus 로고
    • Tumor oxygenation correlates with molecular growth determinants in breast cancer
    • P. Hohenberger, C. Felgner, W. Haensch and P.M. Schlag, Tumor oxygenation correlates with molecular growth determinants in breast cancer Breast Cancer Res Treat 48 (1998), 97-106.
    • (1998) Breast Cancer Res Treat , vol.48 , pp. 97-106
    • Hohenberger, P.1    Felgner, C.2    Haensch, W.3    Schlag, P.M.4
  • 33
    • 0034021690 scopus 로고    scopus 로고
    • Hypoxia, clonal selection, and the role of HIF-1 in tumor progression
    • G.L. Semenza, Hypoxia, clonal selection, and the role of HIF-1 in tumor progression, Crit Rev Biochem Mol Biol 35 (2000), 71-103.
    • (2000) Crit Rev Biochem Mol Biol , vol.35 , pp. 71-103
    • Semenza, G.L.1
  • 34
    • 33745788652 scopus 로고    scopus 로고
    • Regulation of HIF: Prolyl hydroxylases
    • discussion 25-36
    • I.P. Stolze, D.R. Mole and P.J. Ratcliffe, Regulation of HIF: Prolyl hydroxylases, Novartis Found Symp 272 (2006), 15-25; discussion 25-36.
    • (2006) Novartis Found Symp , vol.272 , pp. 15-25
    • Stolze, I.P.1    Mole, D.R.2    Ratcliffe, P.J.3
  • 36
  • 40
    • 13244284943 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1alpha is associated with angiogenesis, and expression of bFGF, PDGF-BB, and EGFR in invasive breast cancer
    • R. Bos, P.J. van Diest, J.S. de Jong, P. van der Groep, P. van der Valk and E. van der Wall, Hypoxia-inducible factor-1alpha is associated with angiogenesis, and expression of bFGF, PDGF-BB, and EGFR in invasive breast cancer, Histopathology 46 (2005), 31-36.
    • (2005) Histopathology , vol.46 , pp. 31-36
    • Bos, R.1    van Diest, P.J.2    de Jong, J.S.3    van der Groep, P.4    van der Valk, P.5    van der Wall, E.6
  • 42
    • 14844288340 scopus 로고    scopus 로고
    • Characterization of carbonic anhydrase IX (CA IX) as an endogenous marker of chronic hypoxia in live human tumor cells
    • D. Vordermark, A. Kaffer, S. Riedl, A. Katzer and M. Flentje, Characterization of carbonic anhydrase IX (CA IX) as an endogenous marker of chronic hypoxia in live human tumor cells, Int J Radiat Oncol Biol Phys 61 (2005), 1197-1207.
    • (2005) Int J Radiat Oncol Biol Phys , vol.61 , pp. 1197-1207
    • Vordermark, D.1    Kaffer, A.2    Riedl, S.3    Katzer, A.4    Flentje, M.5
  • 43
    • 33646872450 scopus 로고    scopus 로고
    • Exogenous and endogenous markers of tumour oxygenation status: Definitive markers of tumour hypoxia?
    • K.J. Williams, C.A. Parker and I.J. Stratford, Exogenous and endogenous markers of tumour oxygenation status: Definitive markers of tumour hypoxia? Adv Exp Med Biol 566 (2005), 285-294.
    • (2005) Adv Exp Med Biol , vol.566 , pp. 285-294
    • Williams, K.J.1    Parker, C.A.2    Stratford, I.J.3
  • 44
    • 2542601328 scopus 로고    scopus 로고
    • Hypoxia inducible cabonic anhydrase IX, marker of tumour hypoxia, survival pathway and therapy target
    • C. Potter and A.L. Harris, Hypoxia inducible cabonic anhydrase IX, marker of tumour hypoxia, survival pathway and therapy target, Cell Cycle 3 (2004), 164-167.
    • (2004) Cell Cycle , vol.3 , pp. 164-167
    • Potter, C.1    Harris, A.L.2
  • 48
    • 0043123069 scopus 로고    scopus 로고
    • Carbonic anhydrase-9 expression levels and prognosis in human breast cancer: Association with treatment outcome
    • P.N. Span, J. Bussink, P. Manders, L.V. Beex and C.G. Sweep, Carbonic anhydrase-9 expression levels and prognosis in human breast cancer: association with treatment outcome, Br J Cancer 89 (2003), 271-276.
    • (2003) Br J Cancer , vol.89 , pp. 271-276
    • Span, P.N.1    Bussink, J.2    Manders, P.3    Beex, L.V.4    Sweep, C.G.5
  • 50
    • 10044277941 scopus 로고    scopus 로고
    • Cyclic exposure to hypoxia and reoxygenation selects for tumor cells with defects in mitochondrial apoptotic pathways
    • M. Weinmann, V. Jendrossek, D. Guner, B. Goecke and C. Belka, Cyclic exposure to hypoxia and reoxygenation selects for tumor cells with defects in mitochondrial apoptotic pathways, Faseb J 18 (2004), 1906-1908.
    • (2004) Faseb J , vol.18 , pp. 1906-1908
    • Weinmann, M.1    Jendrossek, V.2    Guner, D.3    Goecke, B.4    Belka, C.5
  • 51
    • 0029088440 scopus 로고
    • Patterns and variability of tumor oxygenation in human soft tissue sarcomas, cervical carcinomas, and lymphnode metastases
    • D.M. Brizel, G.L. Rosner, L.R. Prosnitz and M.W. Dewhirst, Patterns and variability of tumor oxygenation in human soft tissue sarcomas, cervical carcinomas, and lymphnode metastases, Int J Radiant Oncol Biol Phys 32 (1995), 1121-1125.
    • (1995) Int J Radiant Oncol Biol Phys , vol.32 , pp. 1121-1125
    • Brizel, D.M.1    Rosner, G.L.2    Prosnitz, L.R.3    Dewhirst, M.W.4
  • 52
    • 0034652620 scopus 로고    scopus 로고
    • High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers
    • S. Walenta, M. Wetterling, M. Lehrke, G. Schwickert, K. Sundfor, E.K. Rofstad and W. Mueller-Klieser, High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers, Cancer Res 60 (2000), 916-921.
    • (2000) Cancer Res , vol.60 , pp. 916-921
    • Walenta, S.1    Wetterling, M.2    Lehrke, M.3    Schwickert, G.4    Sundfor, K.5    Rofstad, E.K.6    Mueller-Klieser, W.7
  • 53
    • 0029775242 scopus 로고    scopus 로고
    • Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
    • M. Hockel, K. Schlenger, B. Aral, M. Mitze, U. Schaffer and P. Vaupel, Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix, Cancer Res 56 (1996), 4509-4515.
    • (1996) Cancer Res , vol.56 , pp. 4509-4515
    • Hockel, M.1    Schlenger, K.2    Aral, B.3    Mitze, M.4    Schaffer, U.5    Vaupel, P.6
  • 54
    • 0034900493 scopus 로고    scopus 로고
    • Glucose transporter glut-1 expression correlates with tumor hypoxia and predicts metastasis-free survival in advanced carcinoma of the cervix
    • R. Airley, J. Loncaster, S. Davidson, M. Bromley, S. Roberts, A. Patterson, R. Hunter, I. Stratford and C. West, Glucose transporter glut-1 expression correlates with tumor hypoxia and predicts metastasis-free survival in advanced carcinoma of the cervix, Clin Cancer Res 7 (2001), 928-934.
    • (2001) Clin Cancer Res , vol.7 , pp. 928-934
    • Airley, R.1    Loncaster, J.2    Davidson, S.3    Bromley, M.4    Roberts, S.5    Patterson, A.6    Hunter, R.7    Stratford, I.8    West, C.9
  • 55
  • 57
    • 0033867776 scopus 로고    scopus 로고
    • Hypoxia modulated gene expression: Angiogenesis, metastasis and therapeutic exploitation
    • G.U. Dachs and G.M. Tozer, Hypoxia modulated gene expression: angiogenesis, metastasis and therapeutic exploitation, Eur J Cancer 36 (2000), 1649-1660.
    • (2000) Eur J Cancer , vol.36 , pp. 1649-1660
    • Dachs, G.U.1    Tozer, G.M.2
  • 58
    • 0010170555 scopus 로고
    • Hypoxia induces DNA overreplication and enhanced metastasis potential of murine tumor cells
    • S.D. Young, R.S. Marshall and R.P. Hill, Hypoxia induces DNA overreplication and enhanced metastasis potential of murine tumor cells, Proc Natl Acad Sci USA 85 (1988), 9533-9537.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 9533-9537
    • Young, S.D.1    Marshall, R.S.2    Hill, R.P.3
  • 60
    • 0025150111 scopus 로고
    • Effects of reoxygenation on cells from hypoxic regions of solid tumors: Analysis of transplanted murine tumors for evidence of DNA overreplication
    • S.D. Young and R.P. Hill, Effects of reoxygenation on cells from hypoxic regions of solid tumors: Analysis of transplanted murine tumors for evidence of DNA overreplication, Cancer Res 50 (1990), 5031-5038.
    • (1990) Cancer Res , vol.50 , pp. 5031-5038
    • Young, S.D.1    Hill, R.P.2
  • 61
    • 16844371587 scopus 로고    scopus 로고
    • The tumor bed effect: Increased metastatic dissemination from hypoxia-induced up-regulation of metastasis-promoting gene products
    • E.K. Rofstad, B. Mathiesen, K. Henriksen, K. Kindem and K. Galappathi, The tumor bed effect: Increased metastatic dissemination from hypoxia-induced up-regulation of metastasis-promoting gene products, Cancer Res 65 (2005), 2387-2396.
    • (2005) Cancer Res , vol.65 , pp. 2387-2396
    • Rofstad, E.K.1    Mathiesen, B.2    Henriksen, K.3    Kindem, K.4    Galappathi, K.5
  • 62
    • 0035805046 scopus 로고    scopus 로고
    • Relationship of hypoxia to metastatic ability in rodent tumours
    • K. De Jaeger, M.C. Kavanagh and R.P. Hill, Relationship of hypoxia to metastatic ability in rodent tumours, Br J Cancer 84 (2001), 1280-1285.
    • (2001) Br J Cancer , vol.84 , pp. 1280-1285
    • De Jaeger, K.1    Kavanagh, M.C.2    Hill, R.P.3
  • 63
    • 34247523971 scopus 로고    scopus 로고
    • Expression of metastatic genes in hypoxic cells in cervix cancer xenografts and their lymph node metastases: Effects of acute and chronic hypoxia
    • manuscript in preparation
    • N. Chaudary, A. Yuen and R.P. Hill, Expression of metastatic genes in hypoxic cells in cervix cancer xenografts and their lymph node metastases: Effects of acute and chronic hypoxia, Cancer Research, manuscript in preparation.
    • Cancer Research
    • Chaudary, N.1    Yuen, A.2    Hill, R.P.3
  • 64
    • 1542405875 scopus 로고    scopus 로고
    • Acute hypoxia enhances spontaneous lymph node metastasis in an orthotopic murine model of human cervical carcinoma
    • R.A. Cairns and R.P. Hill, Acute hypoxia enhances spontaneous lymph node metastasis in an orthotopic murine model of human cervical carcinoma, Cancer Res 64 (2004), 2054-2061.
    • (2004) Cancer Res , vol.64 , pp. 2054-2061
    • Cairns, R.A.1    Hill, R.P.2
  • 65
    • 0035893396 scopus 로고    scopus 로고
    • Acute (cyclic) hypoxia enhances spontaneous metastasis of KHT murine tumors
    • R.A. Cairns, T. Kalliomaki and R.P. Hill, Acute (cyclic) hypoxia enhances spontaneous metastasis of KHT murine tumors, Cancer Res 61 (2001), 8903-8908.
    • (2001) Cancer Res , vol.61 , pp. 8903-8908
    • Cairns, R.A.1    Kalliomaki, T.2    Hill, R.P.3
  • 66
    • 0025025779 scopus 로고
    • Tumor progression: Potential role of unstable genomic changes
    • R.P. Hill, Tumor progression: Potential role of unstable genomic changes, Cancer Metastasis Rev 9 (1990), 137-147.
    • (1990) Cancer Metastasis Rev , vol.9 , pp. 137-147
    • Hill, R.P.1
  • 67
    • 3042616216 scopus 로고    scopus 로고
    • Hypoxia enhances metastatic efficiency by up-regulating Mdm2 in KHT cells and increasing resistance to apoptosis
    • L. Zhang and R.P. Hill, Hypoxia enhances metastatic efficiency by up-regulating Mdm2 in KHT cells and increasing resistance to apoptosis, Cancer Res 64 (2004), 4180-4189.
    • (2004) Cancer Res , vol.64 , pp. 4180-4189
    • Zhang, L.1    Hill, R.P.2
  • 69
    • 0031149430 scopus 로고    scopus 로고
    • Hypoxia-induced apoptosis in human cells with normal p53 status and function, without any alteration in the nuclear protein level
    • O. Amellem, T. Stokke, J.A. Sandvik, L. Smedshammer and E.O. Pettersen, Hypoxia-induced apoptosis in human cells with normal p53 status and function, without any alteration in the nuclear protein level, Exp Cell Res 232 (1997), 361-370.
    • (1997) Exp Cell Res , vol.232 , pp. 361-370
    • Amellem, O.1    Stokke, T.2    Sandvik, J.A.3    Smedshammer, L.4    Pettersen, E.O.5
  • 70
    • 0037137519 scopus 로고    scopus 로고
    • M.J. van de Vijver, Y.D. He, L.J. van't Veer, H. Dai, A.A. Hart, D.W. Voskuil, G.J. Schreiber, J.L. Peterse, C. Roberts, M.J. Marton, M. Parrish, D. Atsma, A. Witteveen, A. Glas, L. Delahaye, T. van der Velde, H. Bartelink, S. Rodenhuis, E.T. Rutgers, S.H. Friend and R. Bernards, A gene-expression signature as a predictor of survival in breast cancer, N Engl J Med 347 (2002), 1999-2009.
    • M.J. van de Vijver, Y.D. He, L.J. van't Veer, H. Dai, A.A. Hart, D.W. Voskuil, G.J. Schreiber, J.L. Peterse, C. Roberts, M.J. Marton, M. Parrish, D. Atsma, A. Witteveen, A. Glas, L. Delahaye, T. van der Velde, H. Bartelink, S. Rodenhuis, E.T. Rutgers, S.H. Friend and R. Bernards, A gene-expression signature as a predictor of survival in breast cancer, N Engl J Med 347 (2002), 1999-2009.
  • 73
    • 27144488136 scopus 로고    scopus 로고
    • Molecular portraits and 70-gene prognosis signature are preserved throughout the metastatic process of breast cancer
    • B. Weigelt, Z. Hu, X. He, C. Livasy, L.A. Carey, M.G. Ewend, A.M. Glas, C.M. Perou and L.J. Van't Veer, Molecular portraits and 70-gene prognosis signature are preserved throughout the metastatic process of breast cancer, Cancer Res 65 (2005), 9155-9158.
    • (2005) Cancer Res , vol.65 , pp. 9155-9158
    • Weigelt, B.1    Hu, Z.2    He, X.3    Livasy, C.4    Carey, L.A.5    Ewend, M.G.6    Glas, A.M.7    Perou, C.M.8    Van't Veer, L.J.9
  • 75
    • 0037226593 scopus 로고    scopus 로고
    • A molecular signature of metastasis in primary solid tumors
    • S. Ramaswamy, K.N. Ross, E.S. Lander and T.R. Golub, A molecular signature of metastasis in primary solid tumors, Nat Genet 33 (2003), 49-54.
    • (2003) Nat Genet , vol.33 , pp. 49-54
    • Ramaswamy, S.1    Ross, K.N.2    Lander, E.S.3    Golub, T.R.4
  • 78
    • 0141927332 scopus 로고    scopus 로고
    • Genes commonly upregulated by hypoxia in human breast cancer cells MCF-7 and MDA-MB-231
    • H. Bando, M. Toi, K. Kitada and M. Koike, Genes commonly upregulated by hypoxia in human breast cancer cells MCF-7 and MDA-MB-231, Biomed Pharmacother 57 (2003), 333-340.
    • (2003) Biomed Pharmacother , vol.57 , pp. 333-340
    • Bando, H.1    Toi, M.2    Kitada, K.3    Koike, M.4
  • 79
    • 0037980379 scopus 로고    scopus 로고
    • Metastasis suppressor pathways - an evolving paradigm
    • L.A. Shevde and D.R. Welch, Metastasis suppressor pathways - an evolving paradigm, Cancer Lett 198 (2003), 1-20.
    • (2003) Cancer Lett , vol.198 , pp. 1-20
    • Shevde, L.A.1    Welch, D.R.2
  • 80
    • 0033604516 scopus 로고    scopus 로고
    • The role of the epidermal growth factor receptor family in mammary tumorigenesis and metastasis
    • H. Kim and W.J. Muller, The role of the epidermal growth factor receptor family in mammary tumorigenesis and metastasis, Exp Cell Res 253 (1999), 78-87.
    • (1999) Exp Cell Res , vol.253 , pp. 78-87
    • Kim, H.1    Muller, W.J.2
  • 82
    • 10844288136 scopus 로고    scopus 로고
    • CXCR4 knockdown by small interfering RNA abrogates breast tumor growth in vivo
    • N. Lapteva, A.G. Yang, D.E. Sanders, R.W. Strube and S.Y. Chen, CXCR4 knockdown by small interfering RNA abrogates breast tumor growth in vivo, Cancer Gene Ther 12 (2005), 84-89.
    • (2005) Cancer Gene Ther , vol.12 , pp. 84-89
    • Lapteva, N.1    Yang, A.G.2    Sanders, D.E.3    Strube, R.W.4    Chen, S.Y.5
  • 83
    • 0141685979 scopus 로고    scopus 로고
    • Expression pattern of CXC chemokine receptor-4 is correlated with lymph node metastasis in human invasive ductal carcinoma
    • M. Kato, J. Kitayama, S. Kazama and H. Nagawa, Expression pattern of CXC chemokine receptor-4 is correlated with lymph node metastasis in human invasive ductal carcinoma, Breast Cancer Res 5 (2003), R144-R150.
    • (2003) Breast Cancer Res , vol.5
    • Kato, M.1    Kitayama, J.2    Kazama, S.3    Nagawa, H.4
  • 85
    • 1842534500 scopus 로고    scopus 로고
    • CXCR4 is expressed in ductal carcinoma in situ of the breast and in atypical ductal hyperplasia
    • B.C. Schmid, M. Rudas, G.A. Rezniczek, S. Leodolter and R. Zeillinger, CXCR4 is expressed in ductal carcinoma in situ of the breast and in atypical ductal hyperplasia, Breast Cancer Res Threat 84 (2004), 247-250.
    • (2004) Breast Cancer Res Threat , vol.84 , pp. 247-250
    • Schmid, B.C.1    Rudas, M.2    Rezniczek, G.A.3    Leodolter, S.4    Zeillinger, R.5
  • 86
    • 33744994778 scopus 로고    scopus 로고
    • Lower expression of CXCR4 in lymphnode metastases than in primary breast cancers: Potential regulation by ligand-dependent degradation and HIF-1alpha
    • H. Shim, S.K. Lau, S. Devi, Y. Yoon, H. T. Cho and Z. Liang, Lower expression of CXCR4 in lymphnode metastases than in primary breast cancers: Potential regulation by ligand-dependent degradation and HIF-1alpha, Biochem Biophys Res Commun 346 (2006), 252-258.
    • (2006) Biochem Biophys Res Commun , vol.346 , pp. 252-258
    • Shim, H.1    Lau, S.K.2    Devi, S.3    Yoon, Y.4    Cho, H.T.5    Liang, Z.6
  • 89
    • 33646261865 scopus 로고    scopus 로고
    • Differential functional activation of chemokine receptor CXCR4 is mediated by G proteins in breast cancer cells
    • J.D. Holland, M. Kochetkova, C. Akekawatchai, M. Dottore, A. Lopez and S.R. McColl, Differential functional activation of chemokine receptor CXCR4 is mediated by G proteins in breast cancer cells, Cancer Res 66 (2006), 4117-4124.
    • (2006) Cancer Res , vol.66 , pp. 4117-4124
    • Holland, J.D.1    Kochetkova, M.2    Akekawatchai, C.3    Dottore, M.4    Lopez, A.5    McColl, S.R.6
  • 90
    • 0035524455 scopus 로고    scopus 로고
    • The functional and clinical roles of osteopontin in cancer and metastasis
    • K.A. Furger, R.K. Menon, A.B. Tuck, V.H. Bramwell and A.F. Chambers, The functional and clinical roles of osteopontin in cancer and metastasis, Curr Mol Med 1 (2001), 621-632.
    • (2001) Curr Mol Med , vol.1 , pp. 621-632
    • Furger, K.A.1    Menon, R.K.2    Tuck, A.B.3    Bramwell, V.H.4    Chambers, A.F.5
  • 92
    • 0030926461 scopus 로고    scopus 로고
    • Osteopontin and p53 expression are associated with tumor progression in a case of synchronous, bilateral, invasive mammary carcinomas
    • A.B. Tuck, F.P. O'Malley, H. Singhal, K.S. Tonkin, J.F. Harris, D. Bautista and A.F. Chambers, Osteopontin and p53 expression are associated with tumor progression in a case of synchronous, bilateral, invasive mammary carcinomas, Arch Pathol Lab Med 121 (1997), 578-584.
    • (1997) Arch Pathol Lab Med , vol.121 , pp. 578-584
    • Tuck, A.B.1    O'Malley, F.P.2    Singhal, H.3    Tonkin, K.S.4    Harris, J.F.5    Bautista, D.6    Chambers, A.F.7
  • 93
    • 3843068715 scopus 로고    scopus 로고
    • A transcriptional repressor of osteopontin expression in the 4T1 murine breast cancer cell line
    • C. Gao, Z. Mi, H. Guo, J. Wei, P.Y. Wai and P.C. Kuo, A transcriptional repressor of osteopontin expression in the 4T1 murine breast cancer cell line, Biochem Biophys Res Commun 321 (2004), 1010-1016.
    • (2004) Biochem Biophys Res Commun , vol.321 , pp. 1010-1016
    • Gao, C.1    Mi, Z.2    Guo, H.3    Wei, J.4    Wai, P.Y.5    Kuo, P.C.6
  • 99
    • 24644441893 scopus 로고    scopus 로고
    • Urokinase-type plaminogen activator system and breast cancer (Review)
    • B. Han, M. Nakamura, I. Mori, Y. Nakamura and K. Kakudo, Urokinase-type plaminogen activator system and breast cancer (Review), Oncol Rep 14 (2005), 105-112.
    • (2005) Oncol Rep , vol.14 , pp. 105-112
    • Han, B.1    Nakamura, M.2    Mori, I.3    Nakamura, Y.4    Kakudo, K.5
  • 100
    • 33744725239 scopus 로고    scopus 로고
    • siRNA-mediated simultaneous downregulation of uPA and its receptor inhibits angiogenesis and invasiveness triggering apoptosis in breast cancer cells
    • R. Subramanian, C.S. Gondi, S. S. Lakka, A Jutla and J.S. Rao, siRNA-mediated simultaneous downregulation of uPA and its receptor inhibits angiogenesis and invasiveness triggering apoptosis in breast cancer cells, Int J Oncol 28 (2006), 831-839.
    • (2006) Int J Oncol , vol.28 , pp. 831-839
    • Subramanian, R.1    Gondi, C.S.2    Lakka, S.S.3    Jutla, A.4    Rao, J.S.5
  • 102
    • 0141828145 scopus 로고    scopus 로고
    • Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL
    • P. Staller, J. Sulitkova, J. Lisztwan, H. Moch, E.J. Oakeley and W. Krek, Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL, Nature 425 (2003), 307-311.
    • (2003) Nature , vol.425 , pp. 307-311
    • Staller, P.1    Sulitkova, J.2    Lisztwan, J.3    Moch, H.4    Oakeley, E.J.5    Krek, W.6
  • 103
    • 33751071832 scopus 로고    scopus 로고
    • Regulation of the Chemokine Receptor CXCR4 and Metastasis by Hypoxia-inducible Factor in Non Small Cell Lung Cancer Cell Lines
    • Y.L. Liu, J.M. Yu, X.R. Song, X.W. Wang, L.G. Xing and B.B. Gao, Regulation of the Chemokine Receptor CXCR4 and Metastasis by Hypoxia-inducible Factor in Non Small Cell Lung Cancer Cell Lines, Cancer Biol Ther 5 (2006).
    • (2006) Cancer Biol Ther , vol.5
    • Liu, Y.L.1    Yu, J.M.2    Song, X.R.3    Wang, X.W.4    Xing, L.G.5    Gao, B.B.6
  • 104
    • 0034653379 scopus 로고    scopus 로고
    • Both increased stability and transcription contribute to the induction of the urokinase plasminogen activator receptor (uPAR) message by by hypoxia
    • A. Maity and D. Solomon, Both increased stability and transcription contribute to the induction of the urokinase plasminogen activator receptor (uPAR) message by by hypoxia, Exp Cell Res 255 (2000), 250-257.
    • (2000) Exp Cell Res , vol.255 , pp. 250-257
    • Maity, A.1    Solomon, D.2
  • 108
    • 0037331996 scopus 로고    scopus 로고
    • Overexpression of the c-Met/HGF receptor and its prognostic significance in uterine cervix car carcinomas
    • C. Baykal, A. Ayhan, A. Al, K. Yuce and A. Ayhan, Overexpression of the c-Met/HGF receptor and its prognostic significance in uterine cervix car carcinomas, Gynecol Oncol 88 (2003), 123-129.
    • (2003) Gynecol Oncol , vol.88 , pp. 123-129
    • Baykal, C.1    Ayhan, A.2    Al, A.3    Yuce, K.4    Ayhan, A.5
  • 109
    • 0038724909 scopus 로고    scopus 로고
    • c-Met: Structure, functions and potential for therapeutic inhibition
    • P.C. Ma, G. Maulik, J. Christensen and R. Salgia, c-Met: Structure, functions and potential for therapeutic inhibition, Cancer Metastasis Rev 22 (2003), 309-325.
    • (2003) Cancer Metastasis Rev , vol.22 , pp. 309-325
    • Ma, P.C.1    Maulik, G.2    Christensen, J.3    Salgia, R.4
  • 110
    • 22544464690 scopus 로고    scopus 로고
    • Expression of the c-Met in advanced epithelial ovarian cancer and its prognostic significance
    • A. Ayhan, D. Ertunc, E.C. Tok and A. Ayhan, Expression of the c-Met in advanced epithelial ovarian cancer and its prognostic significance, Int J Gynecol Cancer 15 (2005), 618-623.
    • (2005) Int J Gynecol Cancer , vol.15 , pp. 618-623
    • Ayhan, A.1    Ertunc, D.2    Tok, E.C.3    Ayhan, A.4
  • 111
    • 24644488689 scopus 로고    scopus 로고
    • Regulation of phosphoglucose isomerase/autocrine motility factor expression by hypoxia
    • T. Funasaka, T. Yanagawa, V. Hogan and A. Raz, Regulation of phosphoglucose isomerase/autocrine motility factor expression by hypoxia, Faseb J 19 (2005), 1422-1430.
    • (2005) Faseb J , vol.19 , pp. 1422-1430
    • Funasaka, T.1    Yanagawa, T.2    Hogan, V.3    Raz, A.4
  • 112
    • 9344260855 scopus 로고    scopus 로고
    • Autocrine motility factor signaling enhances pancreatic cancer metastasis
    • S. Tsutsumi, T. Yanagawa, T. Shimura, H. Kuwano and A. Raz, Autocrine motility factor signaling enhances pancreatic cancer metastasis, Clin Cancer Res 10 (2004), 7775-7784.
    • (2004) Clin Cancer Res , vol.10 , pp. 7775-7784
    • Tsutsumi, S.1    Yanagawa, T.2    Shimura, T.3    Kuwano, H.4    Raz, A.5
  • 114
    • 33749344471 scopus 로고    scopus 로고
    • W.Y. Kim, M. Safran, M.R. Buckley, B.L. Ebert, J. Glickman, M. Bosenberg, M. Regan and W.G. Kaelin, Jr., Failure to prolyl hydroxylate hypoxia-inducible factor alpha pheno-copies VHL inactivation in vivo, Embo J (2006).
    • W.Y. Kim, M. Safran, M.R. Buckley, B.L. Ebert, J. Glickman, M. Bosenberg, M. Regan and W.G. Kaelin, Jr., Failure to prolyl hydroxylate hypoxia-inducible factor alpha pheno-copies VHL inactivation in vivo, Embo J (2006).
  • 116
    • 22944466403 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor (HIF-1alpha), VEGF-C and VEGF-D in non-invasive and invasive breast ductal carcinomas
    • K. Okada, M. Osaki, K. Araki, K. Ishiguro, H. Ito and S. Ohgi, Expression of hypoxia-inducible factor (HIF-1alpha), VEGF-C and VEGF-D in non-invasive and invasive breast ductal carcinomas, Anticancer Res 25 (2005), 3003-3009.
    • (2005) Anticancer Res , vol.25 , pp. 3003-3009
    • Okada, K.1    Osaki, M.2    Araki, K.3    Ishiguro, K.4    Ito, H.5    Ohgi, S.6
  • 117
    • 4143145525 scopus 로고    scopus 로고
    • Clinical implication of expression of vascular endothelial growth factor-C in metastatic lymph nodes of uterine cervical cancers
    • J. Fujimoto, H. Toyoki, E. Sato, H. Sakaguchi and T. Tamaya, Clinical implication of expression of vascular endothelial growth factor-C in metastatic lymph nodes of uterine cervical cancers, Br J Cancer 91 (2004), 466-469.
    • (2004) Br J Cancer , vol.91 , pp. 466-469
    • Fujimoto, J.1    Toyoki, H.2    Sato, E.3    Sakaguchi, H.4    Tamaya, T.5
  • 118
    • 0032923081 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-C expression in human prostatic carcinoma and its relationship to lymph node metastasis
    • T. Tsurusaki, S. Kanda, H. Sakai, H. Kanetake, Y. Saito, K. Alitalo and T. Koji, Vascular endothelial growth factor-C expression in human prostatic carcinoma and its relationship to lymph node metastasis, Br J Cancer 80 (1999), 309-313.
    • (1999) Br J Cancer , vol.80 , pp. 309-313
    • Tsurusaki, T.1    Kanda, S.2    Sakai, H.3    Kanetake, H.4    Saito, Y.5    Alitalo, K.6    Koji, T.7
  • 119
    • 2942557118 scopus 로고    scopus 로고
    • Expression of the pro-angiogenic factor vascular endothelial growth factor and interleukin-8/CXCL8 by human breast carcinomas is responsive to nutrient deprivation and endo-plasmic reticulum stress
    • P.L. Marjon, E.V. Bobrovnikova-Marjon and S.F. Abcouwer, Expression of the pro-angiogenic factor vascular endothelial growth factor and interleukin-8/CXCL8 by human breast carcinomas is responsive to nutrient deprivation and endo-plasmic reticulum stress, Mol Cancer 3 (2004), 4.
    • (2004) Mol Cancer , vol.3 , pp. 4
    • Marjon, P.L.1    Bobrovnikova-Marjon, E.V.2    Abcouwer, S.F.3
  • 120
    • 3142708680 scopus 로고    scopus 로고
    • Expression of angiogenic factors vascular endothelial growth factor and interleukin-8/CXCL8 is highly responsive to ambient glutamine availability: Role of nuclear factor-kappaB and activating protein-1
    • E.V. Bobrovnikova-Marjon, P.L. Marjon, O. Barbash, D.L. Vander Jagt and S.F. Abcouwer, Expression of angiogenic factors vascular endothelial growth factor and interleukin-8/CXCL8 is highly responsive to ambient glutamine availability: Role of nuclear factor-kappaB and activating protein-1, Cancer Res 64 (2004), 4858-4869.
    • (2004) Cancer Res , vol.64 , pp. 4858-4869
    • Bobrovnikova-Marjon, E.V.1    Marjon, P.L.2    Barbash, O.3    Vander Jagt, D.L.4    Abcouwer, S.F.5
  • 121
    • 1842850792 scopus 로고    scopus 로고
    • Vascular endothelial growth factor interleukin-8 are associated with poor prognosis in epithelial ovarian cancer patients
    • S.K. Kassim, E. M. El-Salahy, S.T. Fayed, S.A. Helal, T. Helal, D. Azzam Eel and A. Khalifa, Vascular endothelial growth factor interleukin-8 are associated with poor prognosis in epithelial ovarian cancer patients, Clin Biochem 37 (2004), 363-369.
    • (2004) Clin Biochem , vol.37 , pp. 363-369
    • Kassim, S.K.1    El-Salahy, E.M.2    Fayed, S.T.3    Helal, S.A.4    Helal, T.5    Azzam Eel, D.6    Khalifa, A.7
  • 122
    • 33644845897 scopus 로고    scopus 로고
    • S. Lukacova, A.A. Khalil, J. Overgaard, J. Alsner and M.R. Horsman, Relationship between radiobiological hypoxia in a C3H mouse mammary carcinoma and osteopontin levels in mouse serum, Int J Radiat Biol 81 (2005), 937-944.
    • S. Lukacova, A.A. Khalil, J. Overgaard, J. Alsner and M.R. Horsman, Relationship between radiobiological hypoxia in a C3H mouse mammary carcinoma and osteopontin levels in mouse serum, Int J Radiat Biol 81 (2005), 937-944.
  • 123
    • 28444471148 scopus 로고    scopus 로고
    • Response of the plasma hypoxia marker osteopontin to in vitro hypoxia in human tumor cells
    • H.M. Said, A. Katzer, M. Flentje and D. Vordermark, Response of the plasma hypoxia marker osteopontin to in vitro hypoxia in human tumor cells, Radiother Oncol 76 (2005), 200-205.
    • (2005) Radiother Oncol , vol.76 , pp. 200-205
    • Said, H.M.1    Katzer, A.2    Flentje, M.3    Vordermark, D.4


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