메뉴 건너뛰기




Volumn 46, Issue 1, 2005, Pages 31-36

Hypoxia-inducible factor-1α is associated with angiogenesis, and expression of bFGF, PDGF-BB, and EGFR in invasive breast cancer

Author keywords

Angiogenesis; Breast cancer; Growth factors; HIF 1; Hypoxia

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GROWTH FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PLATELET DERIVED GROWTH FACTOR BB; TRANSCRIPTION FACTOR;

EID: 13244284943     PISSN: 03090167     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2005.02045.x     Document Type: Article
Times cited : (175)

References (52)
  • 1
    • 0015008620 scopus 로고
    • Isolation of a tumor factor responsible or angiogenesis
    • Folkman J, Mener E, Abernathy C et al. Isolation of a tumor factor responsible or angiogenesis. J. Exp. Med. 1971; 133; 275-288.
    • (1971) J. Exp. Med. , vol.133 , pp. 275-288
    • Folkman, J.1    Mener, E.2    Abernathy, C.3
  • 2
    • 0024549349 scopus 로고
    • Induction of angiogenesis during the transition from hyperplasia to neoplasia
    • Folkman J, Watson K, Ingber D et al. Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature 1989; 339; 58-61.
    • (1989) Nature , vol.339 , pp. 58-61
    • Folkman, J.1    Watson, K.2    Ingber, D.3
  • 3
    • 0031884413 scopus 로고    scopus 로고
    • Expression of growth factors, growth-inhibiting factors, and their receptors in invasive breast cancer. II. Correlations with proliferation and angiogenesis
    • de Jong JS, van Diest PJ, van der Valk P, Baak JP. Expression of growth factors, growth-inhibiting factors, and their receptors in invasive breast cancer. II. Correlations with proliferation and angiogenesis. J. Pathol. 1998; 184; 53-57.
    • (1998) J. Pathol. , vol.184 , pp. 53-57
    • De Jong, J.S.1    Van Diest, P.J.2    Van Der Valk, P.3    Baak, J.P.4
  • 4
    • 0032889971 scopus 로고    scopus 로고
    • Role of vascular endothelial growth factor and vascular endothelial growth factor receptors in vascular development
    • Carmeliet P, Collen D. Role of vascular endothelial growth factor and vascular endothelial growth factor receptors in vascular development. Curr. Top. Microbiol. Immunol 1999; 237; 133-158.
    • (1999) Curr. Top. Microbiol. Immunol. , vol.237 , pp. 133-158
    • Carmeliet, P.1    Collen, D.2
  • 5
    • 0032890361 scopus 로고    scopus 로고
    • Structure, expression and receptor-binding properties of novel vascular endothelial growth factors
    • Eriksson U, Alitalo K. Structure, expression and receptor-binding properties of novel vascular endothelial growth factors. Curr. Top. Microbiol. Immunol. 1999; 237; 41-57.
    • (1999) Curr. Top. Microbiol. Immunol. , vol.237 , pp. 41-57
    • Eriksson, U.1    Alitalo, K.2
  • 6
    • 0030968939 scopus 로고    scopus 로고
    • Targeting gene expression to hypoxic tumor cells
    • Dachs GU, Patterson AV, Firth JD et al. Targeting gene expression to hypoxic tumor cells. Nat. Med. 1997; 3; 515-520.
    • (1997) Nat. Med. , vol.3 , pp. 515-520
    • Dachs, G.U.1    Patterson, A.V.2    Firth, J.D.3
  • 7
    • 0031032073 scopus 로고    scopus 로고
    • Prognostic significance of vascular endothelial growth factor protein in node-negative breast carcinoma
    • Gasparini G, Toi M, Gion M et al. Prognostic significance of vascular endothelial growth factor protein in node-negative breast carcinoma. J. Natl Cancer Inst. 1997; 89; 139-147.
    • (1997) J. Natl Cancer Inst. , vol.89 , pp. 139-147
    • Gasparini, G.1    Toi, M.2    Gion, M.3
  • 8
    • 0032907687 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) and its receptors
    • Neufeld G, Cohen T, Gengrinovitch S et al. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J. 1999; 13; 9-22.
    • (1999) FASEB J. , vol.13 , pp. 9-22
    • Neufeld, G.1    Cohen, T.2    Gengrinovitch, S.3
  • 9
    • 0036139515 scopus 로고    scopus 로고
    • The neuropilins; multifunctional semaphorin and VEGF receptors that modulate axon guidance and angiogenesis
    • Neufeld G, Cohen T, Shraga N et al. The neuropilins; multifunctional semaphorin and VEGF receptors that modulate axon guidance and angiogenesis. Trends Cardiovasc. Med. 2002; 12; 13-19.
    • (2002) Trends Cardiovasc. Med. , vol.12 , pp. 13-19
    • Neufeld, G.1    Cohen, T.2    Shraga, N.3
  • 10
    • 0032549799 scopus 로고    scopus 로고
    • Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor
    • Soker S, Takashima S, Miao HQ et al. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 1998; 92; 735-745.
    • (1998) Cell , vol.92 , pp. 735-745
    • Soker, S.1    Takashima, S.2    Miao, H.Q.3
  • 11
    • 0024917883 scopus 로고
    • Structural and functional aspects of the receptors for platelet-derived growth factor
    • Westermark B. Claesson-Welsh L, Heldin CH. Structural and functional aspects of the receptors for platelet-derived growth factor. Prog. Growth Factor Res. 1989; 1; 253-266.
    • (1989) Prog. Growth Factor Res. , vol.1 , pp. 253-266
    • Westermark, B.1    Claesson-Welsh, L.2    Heldin, C.H.3
  • 12
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature 2000; 407; 249-257.
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 13
    • 0024504371 scopus 로고
    • In vitro angiogenesis on the human amniotic membrane: Requirement for basic fibroblast growth factor-induced proteinases
    • Mignatti P, Tsuboi R, Robbins E et al. In vitro angiogenesis on the human amniotic membrane: requirement for basic fibroblast growth factor-induced proteinases. J. Cell Biol. 1989; 108; 671-682.
    • (1989) J. Cell Biol. , vol.108 , pp. 671-682
    • Mignatti, P.1    Tsuboi, R.2    Robbins, E.3
  • 14
    • 0023746649 scopus 로고
    • Membrane and matrix localization of proteinases: A common theme in tumor cell invasion and angiogenesis
    • Moscatelli D, Rifkin DB. Membrane and matrix localization of proteinases: a common theme in tumor cell invasion and angiogenesis. Biochim. Biophys. Acta 1988; 948; 67-85.
    • (1988) Biochim. Biophys. Acta , vol.948 , pp. 67-85
    • Moscatelli, D.1    Rifkin, D.B.2
  • 15
    • 0342312351 scopus 로고
    • Purification of a factor from human placenta that stimulates capillary endothelial cell protease production. DNA synthesis, and migration
    • Moscatelli D, Presta M, Rifkin DB. Purification of a factor from human placenta that stimulates capillary endothelial cell protease production. DNA synthesis, and migration. Proc. Natl. Acad. Sci. USA 1986; 83; 2091-2095.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 2091-2095
    • Moscatelli, D.1    Presta, M.2    Rifkin, D.B.3
  • 16
    • 0034696398 scopus 로고    scopus 로고
    • Transforming growth factor alpha and mouse models of human breast cancer
    • Humphreys RC, Hennighausen L. Transforming growth factor alpha and mouse models of human breast cancer. Oncogens 2000; 19; 1085-1091.
    • (2000) Oncogens , vol.19 , pp. 1085-1091
    • Humphreys, R.C.1    Hennighausen, L.2
  • 17
    • 0037037832 scopus 로고    scopus 로고
    • Clinical impact of novel treatment strategies
    • Giaccone G. Clinical impact of novel treatment strategies. Oncogene 2002; 21; 6970-6981.
    • (2002) Oncogene , vol.21 , pp. 6970-6981
    • Giaccone, G.1
  • 18
    • 0026468180 scopus 로고
    • A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    • Semenza GL, Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol. Cell Biol 1992; 12; 5447-5454.
    • (1992) Mol. Cell Biol. , vol.12 , pp. 5447-5454
    • Semenza, G.L.1    Wang, G.L.2
  • 20
    • 0034663989 scopus 로고    scopus 로고
    • HIF-1 and human disease: One highly involved factor
    • Semenza GL. HIF-1 and human disease: one highly involved factor. Genes Dev. 2000; 14; 1983-1991.
    • (2000) Genes Dev. , vol.14 , pp. 1983-1991
    • Semenza, G.L.1
  • 23
    • 0034021690 scopus 로고    scopus 로고
    • Hypoxia, clonal selection, and the role of HIF-1 in tumor progression
    • Semenza GL. Hypoxia, clonal selection, and the role of HIF-1 in tumor progression. Crit. Rev. Biochem. Mol. Biol. 2000; 35; 71-103.
    • (2000) Crit. Rev. Biochem. Mol. Biol. , vol.35 , pp. 71-103
    • Semenza, G.L.1
  • 24
    • 0029761644 scopus 로고    scopus 로고
    • Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
    • Forsythe JA, Jiang BH, Iyer NV et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell Biol. 1996; 16; 4604-4613.
    • (1996) Mol. Cell Biol. , vol.16 , pp. 4604-4613
    • Forsythe, J.A.1    Jiang, B.H.2    Iyer, N.V.3
  • 25
    • 0034100836 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3)
    • Caniggia I, Mostachfi H, Winter J et al. Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3). J. Clin. Invest. 2000; 105; 577-587.
    • (2000) J. Clin. Invest. , vol.105 , pp. 577-587
    • Caniggia, I.1    Mostachfi, H.2    Winter, J.3
  • 26
    • 0033566693 scopus 로고    scopus 로고
    • Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2
    • Feldser D, Agani F, Iyer NV et al. Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2. Cancer Res. 1999; 59; 3915-3918.
    • (1999) Cancer Res. , vol.59 , pp. 3915-3918
    • Feldser, D.1    Agani, F.2    Iyer, N.V.3
  • 27
    • 0030751493 scopus 로고    scopus 로고
    • Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia
    • Gerber HP, Condorelli F, Park J et al. Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia. J. Biol. Chem. 1997; 272; 23659-23667.
    • (1997) J. Biol. Chem. , vol.272 , pp. 23659-23667
    • Gerber, H.P.1    Condorelli, F.2    Park, J.3
  • 28
    • 0035925072 scopus 로고    scopus 로고
    • Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis
    • Bos R, Zhong H, Hanrahan CF et al. Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis. J. Natl Cancer Inst. 2001; 93; 309-314.
    • (2001) J. Natl Cancer Inst. , vol.93 , pp. 309-314
    • Bos, R.1    Zhong, H.2    Hanrahan, C.F.3
  • 29
    • 0037443587 scopus 로고    scopus 로고
    • Levels of hypoxia-inducible factor-1 alpha independently predict prognosis in patients with lymph node negative breast carcinoma
    • Bos R, van der Groep P, Greijer AE et al. Levels of hypoxia-inducible factor-1 alpha independently predict prognosis in patients with lymph node negative breast carcinoma. Cancer 2003; 97; 1573-1581.
    • (2003) Cancer , vol.97 , pp. 1573-1581
    • Bos, R.1    Van Der Groep, P.2    Greijer, A.E.3
  • 30
    • 0026072872 scopus 로고
    • Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: Experience from a large study with long-term follow-up
    • Elston CW, Ellis 10. Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 1991; 19; 403-410.
    • (1991) Histopathology , vol.19 , pp. 403-410
    • Elston, C.W.1    Ellis, I.O.2
  • 31
    • 0037151917 scopus 로고    scopus 로고
    • No consent should be needed for using leftover body material for scientific purposes
    • van Diest PJ. No consent should be needed for using leftover body material for scientific purposes. BMJ 2002; 325; 648-651.
    • (2002) BMJ , vol.325 , pp. 648-651
    • Van Diest, P.J.1
  • 32
    • 0031910169 scopus 로고    scopus 로고
    • Expression of growth factors, growth inhibiting factors, and their receptors in invasive breast cancer. I. An inventory in search of autocrine and paracrine loops
    • de Jong JS, van Diest PJ, van der Valk P et al. Expression of growth factors, growth inhibiting factors, and their receptors in invasive breast cancer. I. An inventory in search of autocrine and paracrine loops. J. Pathol. 1998; 184; 44-52.
    • (1998) J. Pathol. , vol.184 , pp. 44-52
    • De Jong, J.S.1    Van Diest, P.J.2    Van Der Valk, P.3
  • 33
    • 0033571682 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
    • Zhong H, De Marzo AM, Laughner E et al. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res. 1999; 59; 5830-5835.
    • (1999) Cancer Res. , vol.59 , pp. 5830-5835
    • Zhong, H.1    De Marzo, A.M.2    Laughner, E.3
  • 34
    • 0029589670 scopus 로고
    • Heterogeneity and reproducibility of microvessel counts in breast cancer
    • de Jong JS, van Diest PJ, Baak JP. Heterogeneity and reproducibility of microvessel counts in breast cancer. Lab. Invest. 1995; 73; 922-926.
    • (1995) Lab. Invest. , vol.73 , pp. 922-926
    • De Jong, J.S.1    Van Diest, P.J.2    Baak, J.P.3
  • 35
    • 0026083903 scopus 로고
    • Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma
    • Weidner N, Semple JP, Welch WR et al. Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma. N. Engl J. Med. 1991; 324; 1-8.
    • (1991) N. Engl J. Med. , vol.324 , pp. 1-8
    • Weidner, N.1    Semple, J.P.2    Welch, W.R.3
  • 36
    • 0027043136 scopus 로고
    • Tumor angiogenesis: A new significant and independent prognostic indicator in early-stage breast carcinoma
    • Weidner N, Folkman J, Pozza F et al. Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma. J. Natl Cancer Inst. 1992; 84; 1875-1887.
    • (1992) J. Natl Cancer Inst. , vol.84 , pp. 1875-1887
    • Weidner, N.1    Folkman, J.2    Pozza, F.3
  • 37
    • 0035395098 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor-1 alpha in oligodendrogliomas: Its impact on prognosis and on neoangiogenesis
    • Birner P, Gatterbauer B, Oberhuber G et al. Expression of hypoxia-inducible factor-1 alpha in oligodendrogliomas: its impact on prognosis and on neoangiogenesis. Cancer 2001; 92; 165-171.
    • (2001) Cancer , vol.92 , pp. 165-171
    • Birner, P.1    Gatterbauer, B.2    Oberhuber, G.3
  • 38
    • 0036721256 scopus 로고    scopus 로고
    • Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma
    • Stvridis E, Giatromanolaki A, Gatter KC et al. Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma. Cancer 2002; 95; 1055-1063.
    • (2002) Cancer , vol.95 , pp. 1055-1063
    • Stvridis, E.1    Giatromanolaki, A.2    Gatter, K.C.3
  • 39
    • 0142175222 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 alpha expression and angiogenesis in gastrointestinal stromal tumor of the stomach
    • Takahashi R., Tanaka S, Hiyama T et al. Hypoxia-inducible factor-1 alpha expression and angiogenesis in gastrointestinal stromal tumor of the stomach. Oncol. Report 2003; 10; 797-802.
    • (2003) Oncol. Report , vol.10 , pp. 797-802
    • Takahashi, R.1    Tanaka, S.2    Hiyama, T.3
  • 40
    • 0037431557 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor-1alpha is associated with tumor vascularization in human colorectal carcinoma
    • Kuwai T, Kitadai Y, Tanaka S et al. Expression of hypoxia-inducible factor-1alpha is associated with tumor vascularization in human colorectal carcinoma. Int. J. Cancer 2003; 105; 176-181.
    • (2003) Int. J. Cancer , vol.105 , pp. 176-181
    • Kuwai, T.1    Kitadai, Y.2    Tanaka, S.3
  • 41
    • 0034076192 scopus 로고    scopus 로고
    • Hot spot microvessel density and the mitotic activity index are strong additional prognostic indicators in invasive breast cancer
    • de Jong JS, van Diest PJ, Baak JP. Hot spot microvessel density and the mitotic activity index are strong additional prognostic indicators in invasive breast cancer. Histopathology 2000; 36; 306-312.
    • (2000) Histopathology , vol.36 , pp. 306-312
    • De Jong, J.S.1    Van Diest, P.J.2    Baak, J.P.3
  • 42
    • 10744231706 scopus 로고    scopus 로고
    • 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF
    • Mabjeesh NJ, Escuin D, LaVallee TM et al. 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell 2003; 3; 363-375.
    • (2003) Cancer Cell , vol.3 , pp. 363-375
    • Mabjeesh, N.J.1    Escuin, D.2    LaVallee, T.M.3
  • 43
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza GL. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 2003: 3; 721-732.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 44
    • 0035413326 scopus 로고    scopus 로고
    • HIF-1alpha-mediated up-regulation of vascular endothelial growth factor, independent of basic Sbroblast growth factor, is important in the switch to the angiogenic phenotype during early tumorigenesis
    • Fang J, Yan L, Shing Y et al. HIF-1alpha-mediated up-regulation of vascular endothelial growth factor, independent of basic Sbroblast growth factor, is important in the switch to the angiogenic phenotype during early tumorigenesis. Cancer Res. 2001; 61; 5731-5735.
    • (2001) Cancer Res. , vol.61 , pp. 5731-5735
    • Fang, J.1    Yan, L.2    Shing, Y.3
  • 45
    • 0035012605 scopus 로고    scopus 로고
    • Her2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (hif-1alpha) synthesis: Novel mechanism for hif-1-mediated vascular endothelial growth factor expression
    • Laughner E, Taghavi P, Chiles K et al. Her2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (hif-1alpha) synthesis: novel mechanism for hif-1-mediated vascular endothelial growth factor expression. Mol. Cell Biol. 2001; 21; 3995-4004.
    • (2001) Mol. Cell Biol. , vol.21 , pp. 3995-4004
    • Laughner, E.1    Taghavi, P.2    Chiles, K.3
  • 46
    • 0034654174 scopus 로고    scopus 로고
    • Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
    • Zhong H, Chiles K, Feldser D et al. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res. 2000; 60; 1541-1545.
    • (2000) Cancer Res. , vol.60 , pp. 1541-1545
    • Zhong, H.1    Chiles, K.2    Feldser, D.3
  • 47
    • 0242581718 scopus 로고    scopus 로고
    • Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL(-/-) renal cell carcinoma cells
    • Gunaratnam L, Morley M, Franovic A et al. Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL(-/-) renal cell carcinoma cells. J. Biol. Chem. 2003; 278; 44966-44974.
    • (2003) J. Biol. Chem. , vol.278 , pp. 44966-44974
    • Gunaratnam, L.1    Morley, M.2    Franovic, A.3
  • 48
    • 0025050735 scopus 로고
    • Oxygen tension regulates the expression of the platelet-derived growth factor-B chain gene in human endothelial cells
    • Kourembanas S, Hannan RL, Faller DV. Oxygen tension regulates the expression of the platelet-derived growth factor-B chain gene in human endothelial cells. J. Clin. Invest. 1990; 86; 670-674.
    • (1990) J. Clin. Invest. , vol.86 , pp. 670-674
    • Kourembanas, S.1    Hannan, R.L.2    Faller, D.V.3
  • 49
    • 0035692847 scopus 로고    scopus 로고
    • The sequential activation and repression of the human PDGF-B gene during chronic hypoxia reveals antagonistic roles for the depletion of oxygen and glucose
    • Ulleras E, Wilcock A, Miller SJ et al. The sequential activation and repression of the human PDGF-B gene during chronic hypoxia reveals antagonistic roles for the depletion of oxygen and glucose. Growth Factors 2001; 19; 233-245.
    • (2001) Growth Factors , vol.19 , pp. 233-245
    • Ulleras, E.1    Wilcock, A.2    Miller, S.J.3
  • 50
    • 0141818115 scopus 로고    scopus 로고
    • Hypoxia induces an autocrine-paracrine survival pathway via platelet-derived growth factor (PDGF)-B/PDGF-beta receptor/phosphatidylinositol 3-kinase/Akt signaling in RN46A neuronal cells
    • Zhang SX, Gozal D, Sachleben LR Jr et al. Hypoxia induces an autocrine-paracrine survival pathway via platelet-derived growth factor (PDGF)-B/PDGF-beta receptor/phosphatidylinositol 3-kinase/Akt signaling in RN46A neuronal cells. FASEB J. 2003; 17; 1709-1711.
    • (2003) FASEB J. , vol.17 , pp. 1709-1711
    • Zhang, S.X.1    Gozal, D.2    Sachleben Jr., L.R.3
  • 51
    • 0035860147 scopus 로고    scopus 로고
    • Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival
    • Giatromanolaki A, Koukourakis MI, Sivridis E et al. Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival. Br. J. Cancer 2001; 85; 881-890.
    • (2001) Br. J. Cancer , vol.85 , pp. 881-890
    • Giatromanolaki, A.1    Koukourakis, M.I.2    Sivridis, E.3
  • 52
    • 0036558290 scopus 로고    scopus 로고
    • Increased responsiveness of hypoxic endothelial cells to FGF2 is mediated by HIF-1alpha-dependent regulation of enzymes involved in synthesis of heparan sulfate FGF2-binding sites
    • Li J, Shworak NW, Simons M. Increased responsiveness of hypoxic endothelial cells to FGF2 is mediated by HIF-1alpha-dependent regulation of enzymes involved in synthesis of heparan sulfate FGF2-binding sites. J. Cell Sci. 2002; 115; 1951-1959.
    • (2002) J. Cell Sci. , vol.115 , pp. 1951-1959
    • Li, J.1    Shworak, N.W.2    Simons, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.