The tumor bed effect: Increased metastatic dissemination from hypoxia-induced up-regulation of metastasis-promoting gene products

Cancer Research

Volumn 65, Issue 6, 2005, Pages 2387-2396

  Rofstad, Einar K ^a   Mathiesen, Berit ^a   Henriksen, Kristin ^a   Kindem, Kristil ^a   Galappathi, Kanthi ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 8; INTERLEUKIN 8 ANTIBODY; MONOCLONAL ANTIBODY; PIMONIDAZOLE; UROKINASE RECEPTOR;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER RADIOTHERAPY; CELL HYPOXIA; CONTROLLED STUDY; CORRELATION ANALYSIS; DOSE RESPONSE; FEMALE; IMMUNOHISTOCHEMISTRY; IRRADIATION; METASTASIS INHIBITION; METASTASIS POTENTIAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION EXPOSURE; TUMOR VASCULARIZATION;

ANIMALS; CELL GROWTH PROCESSES; CELL HYPOXIA; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERLEUKIN-8; LUNG NEOPLASMS; LYMPHATIC METASTASIS; MELANOMA; MICE; MICE, INBRED BALB C; NEOPLASM TRANSPLANTATION; RECEPTORS, CELL SURFACE; TRANSPLANTATION, HETEROLOGOUS; UP-REGULATION;

EID: 16844371587     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-3039     Document Type: Article

References (50)

1. Suit HD, Westgate SJ. Impact of improved local control on survival. Int J Radiat Oncol Biol Phys 1986;12:453-8.
2. Suit HD. Local control and patient survival. Int J Radiat Oncol Biol Phys 1992;23:653-60.
3. Höckel M, Schlenger K, Höckel S, Aral B, Schäffer U, Vaupel P. Tumor hypoxia in pelvic recurrences of cervical cancer. Int J Cancer 1998;79:365-9.
4. Ginos MA, Page GP, Michalowicz BS, et al. Identification of a gene expression signature associated with recurrent disease in squamous cell carcinoma of the head and neck. Cancer Res 2004;64:55-63.
5. Leitao MM Jr, Chi DS. Recurrent cervical cancer. Curr Treat Options Oncol 2002;3:105-11.
6. Stewart FA. Re-treatment after full-course radiotherapy: is it a viable option? Acta Oncol 1999;38:855-62.
7. Kao J, Garofalo MC, Milano MT, Chmura SJ, Citron JR, Haraf DJ. Reirradiation of recurrent and second primary head and neck malignancies: a comprehensive review. Cancer Treat Rev 2003;29:21-30.
8. Milas L, Milas M. Tumor bed phenomenon: effect on tumor progression and therapy. In: Rubin DB, editor. The radiation biology of the vascular endothelium. Boca Raton: CRC Press LLC; 1998. p. 209-29.
9. Camplejohn RS, Penhaligon M. The tumour bed effect: a cell kinetic and histological investigation of tumours growing in irradiated mouse skin. Br J Radiol 1985;58:443-51.
10. Milas M, Ito H, Hunter N, Jones S, Peters LJ. Retardation of tumor growth in mice caused by radiation-induced injury of tumor bed stroma: dependency on tumor type. Cancer Res 1986;46:723-7.
11. Petersen C, Eicheler W, Baisch H, Zips D, Baumann M. Impact of preirradiation of the tumour bed on cell production rate and cell loss of human FaDu squamous cell carcinoma growing in nude mice. Int J Radiat Biol 1999;75:1293-7.
12. Frankl O, Kimball CP. Über die Beeinflussung von Mäusetumoren durch Röntgenstrahlen. Wien Klin Wochenschr 1914;27:1448-50.
13. Senström KW, Vermund H, Mosser GG, Marvin JF. Effects of Roentgen irradiation on the tumor bed. I. The inhibiting action of local pretransplantation Roentgen irradiation (1500 r) on the growth of mouse mammary carcinoma. Radiat Res 1955;2:180-91.
14. Saeki Y, Shimazaki S, Urano M. Radiation effect on the vascularization of a C3H mouse mammary carcinoma. Microangiographic studies of the tumor in preirradiated tissue and of the recurrent tumor. Radiology 1971;101:175-80.
15. Clifton KH, Jirtle R. Mammary carcinoma cell population growth in preirradiated and unirradiated transplant sites. Viable tumor growth, vascularity, and the tumor-bed effect. Radiology 1975;117: 459-65.
16. 2H nuclear magnetic resonance studies. Cancer Res 1991;51:3289-95.
17. Kim IH, Lemmon MJ, Brown JM. The influence of irradiation of the tumor bed on tumor hypoxia: measurements by radiation response, oxygen electrodes, and nitroimidazole binding. Radiat Res 1993;135:411-7.
18. Penhaligon M, Courtenay VD, Camplejohn RS. Tumour bed effect: hypoxic fraction of tumours growing in preirradiated beds. Int J Radiat Biol 1987;52:635-41.
19. Leith JT. Increase in hypoxic fraction of human colon tumor xenografts by preirradiation of tumor bed. J Natl Cancer Inst Monogr 1988;6:107-9.
20. Milas L, Hunter N, Peters LJ. Tumor bed effect-induced reduction of tumor radiocurability through the increase in hypoxic cell fraction. Int J Radiat Oncol Biol Phys 1989;16:139-42.
21. Leith JT, Padfield G, Quaranto L, Michelson S. Effect of preirradiation of transplantation site on growth characteristics and hypoxic fractions in human colon tumor xenografts. Cancer Res 1992;52:2162-6.
22. Zips D, Eicheler W, Brüchner K, et al. Impact of the tumour bed effect on microenvironment, radiobiological hypoxia and the outcome of fractionated radiotherapy of human FaDu squamous-cell carcinoma growing in the nude mouse. Int J Radiat Biol 2001;77:1185-93.
23. Ito H, Barkley T, Peters LJ, Milas L. Modification of tumor responses to cyclophosphamide and irradiation by preirradiation of the tumor bed: prolonged growth delay but reduced curability. Int J Radiat Oncol Biol Phys 1985;11:547-53.
24. van den Brenk HAS, Crowe MC, Stone MG. Reactions of the tumor bed to lethally irradiated tumor cells and the Revesz effect. Br J Cancer 1977;36:94-104.
25. Rappaport DS, Brown JM. Influence of localized preinoculation irradiation of the foot on lymphatic metastasis from a primary tumor growing in the foot. Radiat Res 1979;78:108-21.
26. Milas L, Hunter N, Peters LJ. The tumor bed effect: dependence of tumor take, growth rate, and metastasis on the time interval between irradiation and tumor cell transplantation. Int J Radiat Oncol Biol Phys 1987;13:379-83.
27. Ohizumi Y, Maezawa H, Mori T. Relationship between primary tumor volume and lung metastasis in Lewis lung carcinoma. (II). Tumor bed effect. Tokai J Exp Clin Med 1987;12:237-42.
28. Milas L, Hirata H, Hunter N, Peters LJ. Effect of radiation-induced injury of tumor bed stroma on metastatic spread of murine sarcomas and carcinomas. Cancer Res 1988;48:2116-20.
29. Baker DG, Morgan EP, Persing JA. Squamous cell carcinoma growth in irradiated tissue: a murine model for quantitative assessment of treatment. Ann Plast Surg 1995;35:171-7.
30. Weiss L. Principles of metastasis. New York: Academic Press; 1985.
31. Rofstad EK. Microenvironment-induced cancer metastasis. Int J Radiat Biol 2000;76:589-605.
32. Subarsky P, Hill RP. The hypoxic tumour microenvironment and metastatic progression. Clin Exp Metastasis 2003;20:237-50.
33. Höckel M, Schlenger K, Aral B, Mitze M, Schäffer U, Vaupel P. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 1996;56:4509-15.
34. Sundfer K, Lyng H, Rofstad EK. Tumour hypoxia and vascular density as predictors of metastasis in squamous cell carcinoma of the uterine cervix. Br J Cancer 1998;78:822-7.
35. Brizel DM, Dodge RK, Clough RW, Dewhirst MW. Oxygenation of head and neck cancer: changes during radiotherapy and impact on treatment outcome. Radiother Oncol 1999;53:113-7.
36. Brizel DM, Scully SP, Harrelson JM, et al. Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res 1996;56:941-3.
37. Cairns RA, Kalliomaki T, Hill RP. Acute (cyclic) hypoxia enhances spontaneous metastasis of KHT murine tumors. Cancer Res 2001;61:8903-8.
38. Cairns RA, Hill RP. Acute hypoxia enhances spontaneous lymph node metastasis in an orthotopic murine model of human cervical carcinoma. Cancer Res 2004;64:2054-61.
39. Rofstad EK, Halsør EF. Hypoxia-associated spontaneous pulmonary metastasis in human melanoma xenografts: involvement of microvascular hot spots induced in hypoxic foci by interleukin 8. Br J Cancer 2002;86:301-8.
40. Rofstad EK, Rasmussen H, Galappathi K, Mathiesen B, Nilsen K, Graff BA. Hypoxia promotes lymph node metastasis in human melanoma xenografts by up-regulating the urokinase-type plasminogen activator receptor. Cancer Res 2002;62:1847-53.
41. Rofstad EK, Mathiesen B, Galappathi K. Increased metastatic dissemination in human melanoma xenografts after subcurative radiation treatment: radiation-induced increase in fraction of hypoxic cells and hypoxia-induced up-regulation of urokinase-type plasminogen activator receptor. Cancer Res 2004;64:13-8.
42. Rofstad EK. Orthotopic human melanoma xenograft model systems for studies of tumour angiogenesis, pathophysiology, treatment sensitivity and metastatic pattern. Br J Cancer 1994;70:804-12.
43. Rofstad EK, Halsor EF. Vascular endothelial growth factor, interleukin 8, platelet-derived endothelial cell growth factor, and basic fibroblast growth factor promote angiogenesis and metastasis in human melanoma xenografts. Cancer Res 2000; 60:4932-8.
44. Rofstad EK, Mȧseide K. Radiobiological and immunohistochemical assessment of hypoxia in human melanoma xenografts: acute and chronic hypoxia in individual tumours. Int J Radiat Biol 1999;75:1377-93.
45. Harris AL. Hypoxiāa key regulatory factor in tumour growth. Nature Rev Cancer 2002;2:38-47.
46. DeVries TJ, van Muijen GNP, Ruiter DJ. The plasminogen activation system in tumor invasion and metastasis. Pathol Res Pract 1996;192:718-33.
47. Duffy MJ. The role of proteolytic enzymes in cancer invasion and metastasis. Clin Exp Metastasis 1992; 10:145-55.
48. Niizeki H, Kobayashi M, Horiuchi I, et al. Hypoxia enhances the expression of autocrine motility factor and the motility of human pancreatic cancer cell. Br J Cancer 2002;86:1914-9.
49. Pennacchietti S, Michieli P, Galluzzo M, Mazzone M, Giordano S, Comoglio PM. Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell 2003;3:347-61.
50. Skobe M, Hawighorst T, Jackson DG, et al. Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis. Nat Med 2001; 7:192-8.