메뉴 건너뛰기




Volumn 13, Issue 3, 2006, Pages 739-749

Hypoxia-inducible factor-1 in human breast and prostate cancer

Author keywords

[No Author keywords available]

Indexed keywords

2 METHOXYESTRADIOL; APURINIC ACID; CYCLOOXYGENASE 2 INHIBITOR; ESTROGEN; HETERODIMER; HYPOXIA INDUCIBLE FACTOR 1; PROTEIN P300; REDOX EFFECTOR FACTOR 1; TRANSCRIPTION FACTOR; TYROSINE KINASE RECEPTOR;

EID: 33751074452     PISSN: 13510088     EISSN: None     Source Type: Journal    
DOI: 10.1677/erc.1.00728     Document Type: Review
Times cited : (213)

References (95)
  • 1
    • 2442650576 scopus 로고    scopus 로고
    • Prognostic significance of erythropoietin expression in human endometrial carcinoma
    • Acs G, Xu X, Chu C, Acs P & Verma A 2004 Prognostic significance of erythropoietin expression in human endometrial carcinoma. Cancer 100 2376-2386.
    • (2004) Cancer , vol.100 , pp. 2376-2386
    • Acs, G.1    Xu, X.2    Chu, C.3    Acs, P.4    Verma, A.5
  • 6
    • 19644376976 scopus 로고    scopus 로고
    • Topotecan blocks hypoxia-inducible factor-1alpha and vascular endothelial growth factor expression induced by insulin-like growth factor-I in neuroblastoma cells
    • Beppu K, Nakamura K, Linehan WM, Rapisarda A & Thiele CJ 2005 Topotecan blocks hypoxia-inducible factor-1alpha and vascular endothelial growth factor expression induced by insulin-like growth factor-I in neuroblastoma cells. Cancer Research 65 4775-4781.
    • (2005) Cancer Research , vol.65 , pp. 4775-4781
    • Beppu, K.1    Nakamura, K.2    Linehan, W.M.3    Rapisarda, A.4    Thiele, C.J.5
  • 8
    • 13444283313 scopus 로고    scopus 로고
    • Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell death
    • Blum R, Jacob-Hirsch J, Amariglio N, Rechavi G & Kloog Y 2005 Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell death. Cancer Research 65 999-1006.
    • (2005) Cancer Research , vol.65 , pp. 999-1006
    • Blum, R.1    Jacob-Hirsch, J.2    Amariglio, N.3    Rechavi, G.4    Kloog, Y.5
  • 9
    • 27744489232 scopus 로고    scopus 로고
    • The androgen receptor is significantly associated with vascular endothelial growth factor and hypoxia sensing via hypoxia-inducible factors HIF-1a, HIF-2a, and the prolyl hydroxylases in human prostate cancer
    • Boddy JL, Fox SB, Han C, Campo L, Turley H, Kanga S, Malone PR & Harris AL 2005 The androgen receptor is significantly associated with vascular endothelial growth factor and hypoxia sensing via hypoxia-inducible factors HIF-1a, HIF-2a, and the prolyl hydroxylases in human prostate cancer. Clinical Cancer Research 11 7658-7663.
    • (2005) Clinical Cancer Research , vol.11 , pp. 7658-7663
    • Boddy, J.L.1    Fox, S.B.2    Han, C.3    Campo, L.4    Turley, H.5    Kanga, S.6    Malone, P.R.7    Harris, A.L.8
  • 12
  • 13
    • 13244284943 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1alpha is associated with angiogenesis, and expression of bFGF, PDGF-BB, and EGFR in invasive breast cancer
    • Bos R, van Diest PJ, de Jong JS, van der Groep P, van der Valk P & van der Wall E 2005 Hypoxia-inducible factor-1alpha is associated with angiogenesis, and expression of bFGF, PDGF-BB, and EGFR in invasive breast cancer. Histopathology 46 31-36.
    • (2005) Histopathology , vol.46 , pp. 31-36
    • Bos, R.1    Van Diest, P.J.2    De Jong, J.S.3    Van Der Groep, P.4    Van Der Valk, P.5    Van Der Wall, E.6
  • 15
    • 19644393302 scopus 로고    scopus 로고
    • Identification of novel small molecule inhibitors of hypoxia-inducible factor-1 that differentially block hypoxia-inducible factor-1 activity and hypoxia-inducible factor-1alpha induction in response to hypoxic stress and growth factors
    • Chau NM, Rogers P, Aherne W, Carroll V, Collins I, McDonald E, Workman P & Ashcroft M 2005 Identification of novel small molecule inhibitors of hypoxia-inducible factor-1 that differentially block hypoxia-inducible factor-1 activity and hypoxia-inducible factor-1alpha induction in response to hypoxic stress and growth factors. Cancer Research 65 4918-4928.
    • (2005) Cancer Research , vol.65 , pp. 4918-4928
    • Chau, N.M.1    Rogers, P.2    Aherne, W.3    Carroll, V.4    Collins, I.5    McDonald, E.6    Workman, P.7    Ashcroft, M.8
  • 16
    • 0346059588 scopus 로고    scopus 로고
    • Phorbol ester stimulates the nonhypoxic induction of a novel hypoxia-inducible factor 1alpha isoform: Implications for tumor promotion
    • Chun YS, Lee KH, Choi E, Bae SY, Yeo EJ, Huang LE, Kim MS & Park JW 2003 Phorbol ester stimulates the nonhypoxic induction of a novel hypoxia-inducible factor 1alpha isoform: implications for tumor promotion. Cancer Research 63 8700-8707.
    • (2003) Cancer Research , vol.63 , pp. 8700-8707
    • Chun, Y.S.1    Lee, K.H.2    Choi, E.3    Bae, S.Y.4    Yeo, E.J.5    Huang, L.E.6    Kim, M.S.7    Park, J.W.8
  • 19
    • 0347364771 scopus 로고    scopus 로고
    • The farnesyltransferase inhibitor R115777 reduces hypoxia and matrix metalloproteinase 2 expression in human glioma xenograft
    • Delmas C, End D, Rochaix P, Favre G, Toulas C & Cohen-Jonathan E 2003 The farnesyltransferase inhibitor R115777 reduces hypoxia and matrix metalloproteinase 2 expression in human glioma xenograft. Clinical Cancer Research 9 6062-6068.
    • (2003) Clinical Cancer Research , vol.9 , pp. 6062-6068
    • Delmas, C.1    End, D.2    Rochaix, P.3    Favre, G.4    Toulas, C.5    Cohen-Jonathan, E.6
  • 20
    • 0742271629 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor 1alpha in human normal, benign, and malignant prostate tissue
    • Du Z, Fujiyama C, Chen Y & Masaki Z 2003 Expression of hypoxia-inducible factor 1alpha in human normal, benign, and malignant prostate tissue. Chinese Medical Journal 116 1936-1939.
    • (2003) Chinese Medical Journal , vol.116 , pp. 1936-1939
    • Du, Z.1    Fujiyama, C.2    Chen, Y.3    Masaki, Z.4
  • 21
  • 22
    • 0031985127 scopus 로고    scopus 로고
    • Down-regulation of vascular endothelial growth factor in a human colon carcinoma cell line transfected with an antisense expression vector specific for c-src
    • Ellis LM, Staley CA, Liu W, Fleming RY, Parikh NU, Bucana CD & Gallick GE 1998 Down-regulation of vascular endothelial growth factor in a human colon carcinoma cell line transfected with an antisense expression vector specific for c-src. Journal of Biological Chemistry 273 1052-1057.
    • (1998) Journal of Biological Chemistry , vol.273 , pp. 1052-1057
    • Ellis, L.M.1    Staley, C.A.2    Liu, W.3    Fleming, R.Y.4    Parikh, N.U.5    Bucana, C.D.6    Gallick, G.E.7
  • 24
    • 0001191028 scopus 로고    scopus 로고
    • Regulation of vascular endothelial growth factor expression in human colon carcinoma cells by activity of src kinase
    • Fleming RY, Ellis LM, Parikh NU, Liu W, Staley CA & Gallick GE 1997 Regulation of vascular endothelial growth factor expression in human colon carcinoma cells by activity of src kinase. Surgery 122 501-507.
    • (1997) Surgery , vol.122 , pp. 501-507
    • Fleming, R.Y.1    Ellis, L.M.2    Parikh, N.U.3    Liu, W.4    Staley, C.A.5    Gallick, G.E.6
  • 26
    • 17644397056 scopus 로고    scopus 로고
    • Identification of hypoxia-inducible factor-1alpha (HIF-1alpha) polymorphism as a mutation in prostate cancer that prevents normoxia-induced degradation
    • Fu XS, Choi E, Bubley GJ & Balk SP 2005 Identification of hypoxia-inducible factor-1alpha (HIF-1alpha) polymorphism as a mutation in prostate cancer that prevents normoxia-induced degradation. Prostate 63 215-221.
    • (2005) Prostate , vol.63 , pp. 215-221
    • Fu, X.S.1    Choi, E.2    Bubley, G.J.3    Balk, S.P.4
  • 28
    • 0031016301 scopus 로고    scopus 로고
    • Induction of hypoxia-inducible factor-1, erythropoietin, vascular endothelial growth factor, and glucose transporter-1 by hypoxia: Evidence against a regulatory role for Src kinase
    • Gleadle JM & Ratcliffe PJ 1997 Induction of hypoxia-inducible factor-1, erythropoietin, vascular endothelial growth factor, and glucose transporter-1 by hypoxia: evidence against a regulatory role for Src kinase. Blood 89 503-509.
    • (1997) Blood , vol.89 , pp. 503-509
    • Gleadle, J.M.1    Ratcliffe, P.J.2
  • 30
    • 18844444774 scopus 로고    scopus 로고
    • HIF-lalpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas
    • Gray MJ, Zhang J, Ellis LM, Semenza GL, Evans DB, Watowich SS & Gallick GE 2005 HIF-lalpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas. Oncogene 24 3110-3120.
    • (2005) Oncogene , vol.24 , pp. 3110-3120
    • Gray, M.J.1    Zhang, J.2    Ellis, L.M.3    Semenza, G.L.4    Evans, D.B.5    Watowich, S.S.6    Gallick, G.E.7
  • 32
    • 24744467401 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha and antiangiogenic activity of farnesyltransferase inhibitor SCH66336 in human aerodigestive tract cancer
    • Han JY, Oh SH, Morgillo F, Myers JN, Kim E, Hong WK & Lee HY 2005 Hypoxia-inducible factor 1alpha and antiangiogenic activity of farnesyltransferase inhibitor SCH66336 in human aerodigestive tract cancer. Journal of the National Cancer Institute 97 1272-1286.
    • (2005) Journal of the National Cancer Institute , vol.97 , pp. 1272-1286
    • Han, J.Y.1    Oh, S.H.2    Morgillo, F.3    Myers, J.N.4    Kim, E.5    Hong, W.K.6    Lee, H.Y.7
  • 37
    • 0029944965 scopus 로고    scopus 로고
    • Dimerization DNA, binding, and transactivation properties of hypoxia-inducible factor 1
    • Jiang BH, Rue E, Wang GL, Roe R & Semenza GL 1996 Dimerization DNA, binding, and transactivation properties of hypoxia-inducible factor 1. Journal of Biological Chemistry 271 17771-17778.
    • (1996) Journal of Biological Chemistry , vol.271 , pp. 17771-17778
    • Jiang, B.H.1    Rue, E.2    Wang, G.L.3    Roe, R.4    Semenza, G.L.5
  • 38
    • 0030659531 scopus 로고    scopus 로고
    • V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: Involvement of HIF-1 in tumor progression
    • Jiang BH, Agani F, Passaniti A & Semenza GL 1997 V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression. Cancer Research 57 5328-5335.
    • (1997) Cancer Research , vol.57 , pp. 5328-5335
    • Jiang, B.H.1    Agani, F.2    Passaniti, A.3    Semenza, G.L.4
  • 41
    • 0036481770 scopus 로고    scopus 로고
    • Hippel Lindau tumor suppressor and HIF-1alpha: New targets of NSAIDs inhibition of hypoxia-induced angiogenesis
    • Jones MK, Szabo IL, Kawanaka H, Husain SS & Tarnawski AS 2002 von Hippel Lindau tumor suppressor and HIF-1alpha: new targets of NSAIDs inhibition of hypoxia-induced angiogenesis. FASEB Journal 16 264-266.
    • (2002) FASEB Journal , vol.16 , pp. 264-266
    • Jones, M.K.1    Szabo, I.L.2    Kawanaka, H.3    Husain, S.S.4    Tarnawski, A.S.5
  • 43
    • 24144467846 scopus 로고    scopus 로고
    • ROS: Really involved in oxygen sensing
    • Kaelin WG, Jr 2005 ROS: really involved in oxygen sensing. Cell Metabolism 1 357-358.
    • (2005) Cell Metabolism , vol.1 , pp. 357-358
    • Kaelin Jr., W.G.1
  • 44
    • 23644441755 scopus 로고    scopus 로고
    • Chromatin immunoprecipitation analysis of gene expression in the rat uterus in vivo: Estrogen-induced recruitment of both estrogen receptor alpha and hypoxia-inducible factor 1 to the vascular endothelial growth factor promoter
    • Kazi AA, Jones JM & Koos RD 2005 Chromatin immunoprecipitation analysis of gene expression in the rat uterus in vivo: estrogen-induced recruitment of both estrogen receptor alpha and hypoxia-inducible factor 1 to the vascular endothelial growth factor promoter. Journal of Molecular Endocrinology 19 2006-2019.
    • (2005) Journal of Molecular Endocrinology , vol.19 , pp. 2006-2019
    • Kazi, A.A.1    Jones, J.M.2    Koos, R.D.3
  • 47
    • 0035012605 scopus 로고    scopus 로고
    • HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
    • Laughner E, Taghavi P, Chiles K, Mahon PC & Semenza GL 2001 HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Molecular and Cellular Biology 21 3995-4004.
    • (2001) Molecular and Cellular Biology , vol.21 , pp. 3995-4004
    • Laughner, E.1    Taghavi, P.2    Chiles, K.3    Mahon, P.C.4    Semenza, G.L.5
  • 48
    • 11244341098 scopus 로고    scopus 로고
    • Ras-dependent induction of HIF-1alpha785 via the Raf/MEK/ERK pathway: A novel mechanism of Ras-mediated tumor promotion
    • Lim JH, Lee ES, You HJ, Lee JW, Park JW & Chun YS 2004 Ras-dependent induction of HIF-1alpha785 via the Raf/MEK/ERK pathway: a novel mechanism of Ras-mediated tumor promotion. Oncogene 23 9427-9431.
    • (2004) Oncogene , vol.23 , pp. 9427-9431
    • Lim, J.H.1    Lee, E.S.2    You, H.J.3    Lee, J.W.4    Park, J.W.5    Chun, Y.S.6
  • 49
    • 21744454494 scopus 로고    scopus 로고
    • The antiepidermal growth factor receptor monoclonal antibody cetuximab/C225 reduces hypoxia-inducible factor-1 alpha, leading to transcriptional inhibition of vascular endothelial growth factor expression
    • Luwor RB, Lu Y, Li X, Mendelsohn J & Fan Z 2005 The antiepidermal growth factor receptor monoclonal antibody cetuximab/C225 reduces hypoxia-inducible factor-1 alpha, leading to transcriptional inhibition of vascular endothelial growth factor expression. Oncogene 24 4433-4441.
    • (2005) Oncogene , vol.24 , pp. 4433-4441
    • Luwor, R.B.1    Lu, Y.2    Li, X.3    Mendelsohn, J.4    Fan, Z.5
  • 51
    • 0038004462 scopus 로고    scopus 로고
    • Androgens stimulate hypoxia-inducible factor 1 activation via autocrine loop of tyrosine kinase receptor/phosphatidylinositol 3′-kinase/protein kinase B in prostate cancer cells
    • Mabjeesh NJ, Willard MT, Frederickson CE, Zhong H & Simons JW 2003b Androgens stimulate hypoxia-inducible factor 1 activation via autocrine loop of tyrosine kinase receptor/phosphatidylinositol 3′-kinase/protein kinase B in prostate cancer cells. Clinical Cancer Research 9 2416-2425.
    • (2003) Clinical Cancer Research , vol.9 , pp. 2416-2425
    • Mabjeesh, N.J.1    Willard, M.T.2    Frederickson, C.E.3    Zhong, H.4    Simons, J.W.5
  • 52
    • 21644445092 scopus 로고    scopus 로고
    • Small molecule-mediated anti-cancer therapy via hypoxia-inducible factor-1 blockade
    • Macpherson GR & Figg WD 2004 Small molecule-mediated anti-cancer therapy via hypoxia-inducible factor-1 blockade. Cancer Biology and Therapy 3 503-504.
    • (2004) Cancer Biology and Therapy , vol.3 , pp. 503-504
    • Macpherson, G.R.1    Figg, W.D.2
  • 54
    • 0034793855 scopus 로고    scopus 로고
    • Cyclooxygenase-2 (COX-2) enzyme inhibitors as potential enhancers of tumor radioresponse
    • Milas L 2001 Cyclooxygenase-2 (COX-2) enzyme inhibitors as potential enhancers of tumor radioresponse. Seminars in Radiation Oncology 11 290-299.
    • (2001) Seminars in Radiation Oncology , vol.11 , pp. 290-299
    • Milas, L.1
  • 55
    • 0029068339 scopus 로고
    • Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation
    • Mukhopadhyay D, Tsiokas L, Zhou XM, Foster D, Brugge JS & Sukhatme VP 1995 Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation. Nature 375 577-581.
    • (1995) Nature , vol.375 , pp. 577-581
    • Mukhopadhyay, D.1    Tsiokas, L.2    Zhou, X.M.3    Foster, D.4    Brugge, J.S.5    Sukhatme, V.P.6
  • 59
    • 0041464531 scopus 로고    scopus 로고
    • Ibuprofen-mediated reduction of hypoxia-inducible factors HIF-1alpha and HIF-2alpha in prostate cancer cells
    • Palayoor ST, Tofilon PJ & Coleman CN 2003 Ibuprofen-mediated reduction of hypoxia-inducible factors HIF-1alpha and HIF-2alpha in prostate cancer cells. Clinical Cancer Research 9 3150-3157.
    • (2003) Clinical Cancer Research , vol.9 , pp. 3150-3157
    • Palayoor, S.T.1    Tofilon, P.J.2    Coleman, C.N.3
  • 60
    • 0001223491 scopus 로고    scopus 로고
    • Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: Angiogenic implications for signal transduction therapy of solid tumors
    • Petit AM, Rak J, Hung MC, Rockwell P, Goldstein N, Fendly B & Kerbel RS 1997 Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors. American Journal of Pathology 151 1523-1530.
    • (1997) American Journal of Pathology , vol.151 , pp. 1523-1530
    • Petit, A.M.1    Rak, J.2    Hung, M.C.3    Rockwell, P.4    Goldstein, N.5    Fendly, B.6    Kerbel, R.S.7
  • 61
    • 0026632457 scopus 로고
    • Gadd45 and Gadd153 messenger RNA levels are increased during hypoxia and after exposure of cells to agents which elevate the levels of the glucose-regulated proteins
    • Price BD & Calderwood SK 1992 Gadd45 and Gadd153 messenger RNA levels are increased during hypoxia and after exposure of cells to agents which elevate the levels of the glucose-regulated proteins. Cancer Research 52 3814-3817.
    • (1992) Cancer Research , vol.52 , pp. 3814-3817
    • Price, B.D.1    Calderwood, S.K.2
  • 62
    • 0037326037 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis
    • Pugh CW & Ratcliffe PJ 2003 The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis. Seminars in Cancer Biology 13 83-89.
    • (2003) Seminars in Cancer Biology , vol.13 , pp. 83-89
    • Pugh, C.W.1    Ratcliffe, P.J.2
  • 64
    • 11144239579 scopus 로고    scopus 로고
    • 2-Methoxyestradiol inhibits hypoxia-inducible factor 1alpha, tumor growth, and angiogenesis and augments paclitaxel efficacy in head and neck squamous cell carcinoma
    • Ricker JL, Chen Z, Yang XP, Pribluda VS, Swartz GM & Van Waes C 2004 2-methoxyestradiol inhibits hypoxia-inducible factor 1alpha, tumor growth, and angiogenesis and augments paclitaxel efficacy in head and neck squamous cell carcinoma. Clinical Cancer Research 10 8665-8673.
    • (2004) Clinical Cancer Research , vol.10 , pp. 8665-8673
    • Ricker, J.L.1    Chen, Z.2    Yang, X.P.3    Pribluda, V.S.4    Swartz, G.M.5    Van Waes, C.6
  • 66
    • 0035917876 scopus 로고    scopus 로고
    • Ser727-dependent transcriptional activation by association of p300 with STAT3 upon IL-6 stimulation
    • Schuringa JJ, Schepers H, Vellenga E & Kruijer W 2001 Ser727-dependent transcriptional activation by association of p300 with STAT3 upon IL-6 stimulation. FEBS Letters 495 71-76.
    • (2001) FEBS Letters , vol.495 , pp. 71-76
    • Schuringa, J.J.1    Schepers, H.2    Vellenga, E.3    Kruijer, W.4
  • 67
    • 0035812772 scopus 로고    scopus 로고
    • HIF-1, O(2), and the 3 PHDs: How animal cells signal hypoxia to the nucleus
    • Semenza GL 2001 HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus. Cell 107 1-3.
    • (2001) Cell , vol.107 , pp. 1-3
    • Semenza, G.L.1
  • 68
    • 0036216692 scopus 로고    scopus 로고
    • HIF-1 and tumor progression: Pathophysiology and therapeutics
    • Semenza GL 2002 HIF-1 and tumor progression: pathophysiology and therapeutics. Trends in Molecular Medicine 8 S62-S67.
    • (2002) Trends in Molecular Medicine , vol.8
    • Semenza, G.L.1
  • 69
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza GL 2003 Targeting HIF-1 for cancer therapy. Nature Reviews Cancer 3 721-732.
    • (2003) Nature Reviews Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 70
    • 0030460724 scopus 로고    scopus 로고
    • Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1
    • Semenza GL, Jiang BH, Leung SW, Passantino R, Concordet JP, Maire P & Giallongo A 1996 Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. Journal of Biological Chemistry 271 32529-32537.
    • (1996) Journal of Biological Chemistry , vol.271 , pp. 32529-32537
    • Semenza, G.L.1    Jiang, B.H.2    Leung, S.W.3    Passantino, R.4    Concordet, J.P.5    Maire, P.6    Giallongo, A.7
  • 72
    • 0036721256 scopus 로고    scopus 로고
    • Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma
    • Sivridis E, Giatromanolaki A, Gatter KC, Harris AL & Koukourakis MI 2002 Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma. Cancer 95 1055-1063.
    • (2002) Cancer , vol.95 , pp. 1055-1063
    • Sivridis, E.1    Giatromanolaki, A.2    Gatter, K.C.3    Harris, A.L.4    Koukourakis, M.I.5
  • 73
    • 0030970723 scopus 로고    scopus 로고
    • Decreased tumorigenicity of a human colon adenocarcinoma cell line by an antisense expression vector specific for c-Src
    • Staley CA, Parikh NU & Gallick GE 1997 Decreased tumorigenicity of a human colon adenocarcinoma cell line by an antisense expression vector specific for c-Src. Cell Growth and Differentiation 8 269-274.
    • (1997) Cell Growth and Differentiation , vol.8 , pp. 269-274
    • Staley, C.A.1    Parikh, N.U.2    Gallick, G.E.3
  • 74
    • 0037081837 scopus 로고    scopus 로고
    • Activation of transcription factors by drugs inducing oxidative stress in rat liver
    • Tacchini L, Fusar-Poli D & Bernelli-Zazzera A 2002 Activation of transcription factors by drugs inducing oxidative stress in rat liver. Biochemical Pharmacology 63 139-148.
    • (2002) Biochemical Pharmacology , vol.63 , pp. 139-148
    • Tacchini, L.1    Fusar-Poli, D.2    Bernelli-Zazzera, A.3
  • 76
    • 0242351598 scopus 로고    scopus 로고
    • Inhibition of angiogenesis by NSAIDs: Molecular mechanisms and clinical implications
    • Tarnawski AS & Jones MK 2003 Inhibition of angiogenesis by NSAIDs: molecular mechanisms and clinical implications. Journal of Molecular Medicine 81 627-636.
    • (2003) Journal of Molecular Medicine , vol.81 , pp. 627-636
    • Tarnawski, A.S.1    Jones, M.K.2
  • 77
    • 10644234769 scopus 로고    scopus 로고
    • The role of hypoxia-induced factors in tumor progression
    • Vaupel P 2004 The role of hypoxia-induced factors in tumor progression. Oncologist 9 (Suppl 5) 10-17.
    • (2004) Oncologist , vol.9 , Issue.SUPPL. 5 , pp. 10-17
    • Vaupel, P.1
  • 78
    • 0034743861 scopus 로고    scopus 로고
    • Oxygen status of malignant tumors: Pathogenesis of hypoxia and significance for tumor therapy
    • Vaupel P, Kelleher DK & Hockel M 2001 Oxygen status of malignant tumors: pathogenesis of hypoxia and significance for tumor therapy. Seminars in Oncology 28 29-35.
    • (2001) Seminars in Oncology , vol.28 , pp. 29-35
    • Vaupel, P.1    Kelleher, D.K.2    Hockel, M.3
  • 82
    • 0342433777 scopus 로고    scopus 로고
    • Hypoxia-inducible factor (HIF-1) and its relationship to apoptosis and proliferation in lung cancer
    • Volm M & Koomagi R 2000 Hypoxia-inducible factor (HIF-1) and its relationship to apoptosis and proliferation in lung cancer. Anticancer Research 20 1527-1533.
    • (2000) Anticancer Research , vol.20 , pp. 1527-1533
    • Volm, M.1    Koomagi, R.2
  • 84
    • 0037461934 scopus 로고    scopus 로고
    • Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis
    • Wei D, Le X, Zheng L, Wang L, Frey JA, Gao AC, Peng Z, Huang S, Xiong HQ, Abbruzzese JL & Xie K 2003 Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. Oncogene 22 319-329.
    • (2003) Oncogene , vol.22 , pp. 319-329
    • Wei, D.1    Le, X.2    Zheng, L.3    Wang, L.4    Frey, J.A.5    Gao, A.C.6    Peng, Z.7    Huang, S.8    Xiong, H.Q.9    Abbruzzese, J.L.10    Xie, K.11
  • 85
    • 4444369682 scopus 로고    scopus 로고
    • Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha
    • Welsh S, Williams R, Kirkpatrick L, Paine-Murrieta G & Powis G 2004 Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha. Molecular Cancer Therapeutics 3 233-244.
    • (2004) Molecular Cancer Therapeutics , vol.3 , pp. 233-244
    • Welsh, S.1    Williams, R.2    Kirkpatrick, L.3    Paine-Murrieta, G.4    Powis, G.5
  • 86
    • 18844429786 scopus 로고    scopus 로고
    • Molecularly targeted therapy for gastrointestinal cancer
    • Wiedmann MW & Caca K 2005 Molecularly targeted therapy for gastrointestinal cancer. Current Cancer Drug Targets 5 171-193.
    • (2005) Current Cancer Drug Targets , vol.5 , pp. 171-193
    • Wiedmann, M.W.1    Caca, K.2
  • 88
    • 22244470409 scopus 로고    scopus 로고
    • Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: Von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor
    • Zagzag D, Krishnamachary B, Yee H, Okuyama H, Chiriboga L, Ali MA, Melamed J & Semenza GL 2005 Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor. Cancer Research 65 6178-6188.
    • (2005) Cancer Research , vol.65 , pp. 6178-6188
    • Zagzag, D.1    Krishnamachary, B.2    Yee, H.3    Okuyama, H.4    Chiriboga, L.5    Ali, M.A.6    Melamed, J.7    Semenza, G.L.8
  • 89
    • 0032880215 scopus 로고    scopus 로고
    • Transitional change in interaction between HIF-1 and HNF-4 in response to hypoxia
    • Zhang W, Tsuchiya T & Yasukochi Y 1999 Transitional change in interaction between HIF-1 and HNF-4 in response to hypoxia. Journal of Human Genetics 44 293-299.
    • (1999) Journal of Human Genetics , vol.44 , pp. 293-299
    • Zhang, W.1    Tsuchiya, T.2    Yasukochi, Y.3
  • 91
    • 0034654174 scopus 로고    scopus 로고
    • Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
    • Zhong H, Chiles K, Feldser D, Laughner E, Hanrahan C, Georgescu MM, Simons IW & Semenza GL 2000 Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Research 60 1541-1545.
    • (2000) Cancer Research , vol.60 , pp. 1541-1545
    • Zhong, H.1    Chiles, K.2    Feldser, D.3    Laughner, E.4    Hanrahan, C.5    Georgescu, M.M.6    Simons, I.W.7    Semenza, G.L.8
  • 92
    • 1842426907 scopus 로고    scopus 로고
    • Up-regulation of hypoxia-inducible factor 1alpha is an early event in prostate carcinogenesis
    • Zhong H, Semenza GL, Simons JW & De Marzo AM 2004a Up-regulation of hypoxia-inducible factor 1alpha is an early event in prostate carcinogenesis. Cancer Detection and Prevention 28 88-93.
    • (2004) Cancer Detection and Prevention , vol.28 , pp. 88-93
    • Zhong, H.1    Semenza, G.L.2    Simons, J.W.3    De Marzo, A.M.4
  • 93
    • 7044227910 scopus 로고    scopus 로고
    • NS398 reduces hypoxia-inducible factor (HIF)-1alpha and HIF-1 activity: Multiple-level effects involving cyclooxygenase-2 dependent and independent mechanisms
    • Zhong H, Willard M & Simons I 2004b NS398 reduces hypoxia-inducible factor (HIF)-1alpha and HIF-1 activity: multiple-level effects involving cyclooxygenase-2 dependent and independent mechanisms. International Journal of Cancer 112 585-595.
    • (2004) International Journal of Cancer , vol.112 , pp. 585-595
    • Zhong, H.1    Willard, M.2    Simons, I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.