Corrigendum to "Astrocyte elevated gene-1: Recent insights into a novel gene involved in tumor progression, metastasis and neurodegeneration" [Pharmacol. Ther., 114 (2007) 155-170] (DOI:10.1016/j.pharmthera.2007.01.010);Astrocyte elevated gene-1: Recent insights into a novel gene involved in tumor progression, metastasis and neurodegeneration

Pharmacology and Therapeutics

Volumn 114, Issue 2, 2007, Pages 155-170

  Emdad, Luni ^a   Sarkar, Devanand ^a   Su, Zao Zhong ^a   Lee, Seok Geun ^a   Kang, Dong Chul ^b   Bruce, Jeffrey N ^a   Volsky, David J ^a,c   Fisher, Paul B ^a  

^a NewYork Presbyterian Hospital   (United States)

^b Hallym University   (South Korea)

^c ST LUKE S ROOSEVELT HOSPITAL CENTER   (United States)

Author keywords

AEG 1; AEG 1 promoter; Glutamate excitotoxicity; Ha ras oncogene; Metastasis; Progression

Indexed keywords

EXCITATORY AMINO ACID TRANSPORTER 2; GENE PRODUCT; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA;

ASTROCYTE; ASTROCYTE ELEVATED GENE 1; BREAST CANCER; CARCINOGENESIS; CELL IMMORTALIZATION; DOWN REGULATION; GENE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE OVEREXPRESSION; GENE STRUCTURE; GENE TARGETING; GLIOBLASTOMA; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HYBRIDIZATION; LUNG METASTASIS; MELANOMA CELL; METASTASIS; MOLECULAR CLONING; NERVE CELL LESION; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE H RAS; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SYSTEMATIC REVIEW; TUMOR GROWTH;

EID: 34147165551     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2007.05.001     Document Type: Erratum

References (151)

1. Anderson C.M., and Swanson R.A. Astrocyte glutamate transport: review of properties, regulation, and physiological functions. Glia 32 (2000) 1-14
2. Arriza J.L., Fairman W.A., Wadiche J.I., Murdoch G.H., Kavanaugh M.P., and Amara S.G. Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. J Neurosci 14 (1994) 5559-5569
3. Bader A.G., Kang S., Zhao L., and Vogt P.K. Oncogenic PI3K deregulates transcription and translation. Nat Rev Cancer 5 (2005) 921-929
4. Baldwin Jr. A.S. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 14 (1996) 649-683
5. Baldwin Jr. A.S. Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. J Clin Invest 107 (2001) 241-246
6. Baldwin Jr. A.S. Series introduction: the transcription factor NF-kappaB and human disease. J Clin Invest 107 (2001) 3-6
7. Bargou R.C., Emmerich F., Krappmann D., Bommert K., Mapara M.Y., Arnold W., et al. Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells. J Clin Invest 100 (1997) 2961-2969
8. Bar-Sagi D., and Feramisco J.R. Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation. Cell 42 (1985) 841-848
9. Beattie E.C., Stellwagen D., Morishita W., Bresnahan J.C., Ha B.K., Von Zastrow M., et al. Control of synaptic strength by glial TNFalpha. Science 295 (2002) 2282-2285
10. Benito M., Porras A., Nebreda A.R., and Santos E. Differentiation of 3T3-L1 fibroblasts to adipocytes induced by transfection of ras oncogenes. Science 253 (1991) 565-568
11. Benos D.J., Hahn B.H., Bubien J.K., Ghosh S.K., Mashburn N.A., Chaikin M.A., et al. Envelope glycoprotein gp120 of human immunodeficiency virus type 1 alters ion transport in astrocytes: implications for AIDS dementia complex. Proc Natl Acad Sci U S A 91 (1994) 494-498
12. Benos D.J., Hahn B.H., Shaw G.M., Bubien J.K., and Benveniste E.N. gp120-mediated alterations in astrocyte ion transport. Adv Neuroimmunol 4 (1994) 175-179
13. Bezzi P., Domercq M., Brambilla L., Galli R., Schols D., De Clercq E., et al. CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity. Nat Neurosci 4 (2001) 702-710
14. Blumenthal D.T., Raizer J.J., Rosenblum M.K., Bilsky M.H., Hariharan S., and Abrey L.E. Primary intracranial neoplasms in patients with HIV. Neurology 52 (1999) 1648-1651
15. Born T.L., Frost J.A., Schonthal A., Prendergast G.C., and Feramisco J.R. c-Myc cooperates with activated Ras to induce the cdc2 promoter. Mol Cell Biol 14 (1994) 5710-5718
16. Bos J.L. ras oncogenes in human cancer: a review. Cancer Res 49 (1989) 4682-4689
17. Boukerche H., Su Z.-Z., Kang D.-C., and Fisher P.B. Identification and cloning of genes displaying elevated expression as a consequence of metastatic progression in human melanoma cells by rapid subtraction hybridization. Gene 343 (2004) 191-201
18. Boukerche, H., Su, Z. -Z., & Fisher, P. B. (in press). Cloning differentially expressed genes using rapid subtraction hybridization (RaSH). In: P.B. Fisher (Ed.), Methods in Molecular Biology. New Jersey: Humana Press.
19. Bours V., Dejardin E., Goujon-Letawe F., Merville M.P., and Castronovo V. The NF-kappa B transcription factor and cancer: high expression of NF-kappa B- and I kappa B-related proteins in tumor cell lines. Biochem Pharmacol 47 (1994) 145-149
20. Brack-Werner R. Astrocytes: HIV cellular reservoirs and important participants in neuropathogenesis. Aids 13 (1999) 1-22
21. Brown D.M., and Ruoslahti E. Metadherin, a cell surface protein in breast tumors that mediates lung metastasis. Cancer Cell 5 (2004) 365-374
22. Budka H. Neuropathology of human immunodeficiency virus infection. Brain Pathol 1 (1991) 163-175
23. Carrasco D., Rizzo C.A., Dorfman K., and Bravo R. The v-rel oncogene promotes malignant T-cell leukemia/lymphoma in transgenic mice. EMBO J 15 (1996) 3640-3650
24. Carystinos G.D., Kandouz M., Alaoui-Jamali M.A., and Batist G. Unexpected induction of the human connexin 43 promoter by the ras signaling pathway is mediated by a novel putative promoter sequence. Mol Pharmacol 63 (2003) 821-831
25. Chambers A.F., and Tuck A.B. Ras-responsive genes and tumor metastasis. Crit Rev Oncog 4 (1993) 95-114
26. Chang F., Steelman L.S., Lee J.T., Shelton J.G., Navolanic P.M., Blalock W.L., et al. Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention. Leukemia 17 (2003) 1263-1293
27. Chaudhry F.A., Lehre K.P., van Lookeren Campagne M., Ottersen O.P., Danbolt N.C., and Storm-Mathisen J. Glutamate transporters in glial plasma membranes: highly differentiated localizations revealed by quantitative ultrastructural immunocytochemistry. Neuron 15 (1995) 711-720
28. Choi D.W. Glutamate neurotoxicity and diseases of the nervous system. Neuron 1 (1988) 623-634
29. Chong H., Vikis H.G., and Guan K.L. Mechanisms of regulating the Raf kinase family. Cell Signal 15 (2003) 463-469
30. Collier D.A. Abnormal EAAT2 splicing in amyotrophic lateral sclerosis. Mol Psychiatry 3 (1998) 298
31. Conant K., McArthur J.C., Griffin D.E., Sjulson L., Wahl L.M., and Irani D.N. Cerebrospinal fluid levels of MMP-2, 7, and 9 are elevated in association with human immunodeficiency virus dementia. Ann Neurol 46 (1999) 391-398
32. Coso O.A., Chiariello M., Yu J.C., Teramoto H., Crespo P., Xu N., et al. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81 (1995) 1137-1146
33. de Haij S., Bakker A.C., van der Geest R.N., Haegeman G., Vanden Berghe W., Aarbiou J., et al. NF-kappaB mediated IL-6 production by renal epithelial cells is regulated by c-jun NH2-terminal kinase. J Am Soc Nephrol 16 (2005) 1603-1611
34. Denhardt D.T., Mistretta D., Chambers A.F., Krishna S., Porter J.F., Raghuram S., et al. Transcriptional regulation of osteopontin and the metastatic phenotype: evidence for a Ras-activated enhancer in the human OPN promoter. Clin Exp Metastasis 20 (2003) 77-84
35. Devalaraja M.N., Wang D.Z., Ballard D.W., and Richmond A. Elevated constitutive IkappaB kinase activity and IkappaB-alpha phosphorylation in Hs294T melanoma cells lead to increased basal MGSA/GRO-alpha transcription. Cancer Res 59 (1999) 1372-1377
36. Doble A. The role of excitotoxicity in neurodegenerative disease: implications for therapy. Pharmacol Ther 81 (1999) 163-221
37. Emdad L., Sarkar D., Su Z.-Z., Randolph A., Boukerche H., Valerie K., et al. Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis. Cancer Res 66 (2006) 1509-1516
38. Etienne-Manneville S., and Hall A. Rho GTPases in cell biology. Nature 420 (2002) 629-635
39. Everall I.P., Luthert P.J., and Lantos P.L. Neuronal loss in the frontal cortex in HIV infection. Lancet 337 (1991) 1119-1121
40. Fairman W.A., Vandenberg R.J., Arriza J.L., Kavanaugh M.P., and Amara S.G. An excitatory amino-acid transporter with properties of a ligand-gated chloride channel. Nature 375 (1995) 599-603
41. Feig L.A., and Buchsbaum R.J. Cell signaling: life or death decisions of ras proteins. Curr Biol 12 (2002) R259-R261
42. Fidler I.J. The biology of cancer metastasis or, 'you cannot fix it if you do not know how it works'. Bioessays 13 (1991) 551-554
43. Fidler I.J., and Ellis L.M. The implications of angiogenesis for the biology and therapy of cancer metastasis. Cell 79 (1994) 185-188
44. Fine S.M., Angel R.A., Perry S.W., Epstein L.G., Rothstein J.D., Dewhurst S., et al. Tumor necrosis factor alpha inhibits glutamate uptake by primary human astrocytes. Implications for pathogenesis of HIV-1 dementia. J Biol Chem 271 (1996) 15303-15306
45. Fisher P.B. Is mda-7/IL-24 a "magic bullet" for cancer?. Cancer Res 65 (2005) 10128-10138
46. Flotho C., Valcamonica S., Mach-Pascual S., Schmahl G., Corral L., Ritterbach J., et al. RAS mutations and clonality analysis in children with juvenile myelomonocytic leukemia (JMML). Leukemia 13 (1999) 32-37
47. Fonnum F. Glutamate: a neurotransmitter in mammalian brain. J Neurochem 42 (1984) 1-11
48. Furuta A., Rothstein J.D., and Martin L.J. Glutamate transporter protein subtypes are expressed differentially during rat CNS development. J Neurosci 17 (1997) 8363-8375
49. Gegelashvili G., Danbolt N.C., and Schousboe A. Neuronal soluble factors differentially regulate the expression of the GLT1 and GLAST glutamate transporters in cultured astroglia. J Neurochem 69 (1997) 2612-2615
50. Ghosh D., Sachdev S., Hannink M., and Roberts R.M. Coordinate regulation of basal and cyclic 5′-adenosine monophosphate (cAMP)-activated expression of human chorionic gonadotropin-alpha by Ets-2 and cAMP-responsive element binding protein. Mol Endocrinol 19 (2005) 1049-1066
51. Gilmore T.D., Koedood M., Piffat K.A., and White D.W. Rel/NF-kappaB/IkappaB proteins and cancer. Oncogene 13 (1996) 1367-1378
52. Gordon S., Akopyan G., Garban H., and Bonavida B. Transcription factor YY1: structure, function, and therapeutic implications in cancer biology. Oncogene 25 (2006) 1125-1142
53. Grimes C.A., and Jope R.S. The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling. Prog Neurobiol 65 (2001) 391-426
54. Gupta P., Su Z.Z., Lebedeva I.V., Sarkar D., Sauane M., Emdad L., et al. mda-7/IL-24: Multifunctional cancer-specific apoptosis-inducing cytokine. Pharmacol Ther 111 (2006) 596-628
55. Guttridge D.C., Albanese C., Reuther J.Y., Pestell R.G., and Baldwin Jr. A.S. NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol Cell Biol 19 (1999) 5785-5799
56. Hahn W.C., and Weinberg R.A. Modelling the molecular circuitry of cancer. Nat Rev Cancer 2 (2002) 331-341
57. Hanahan D., and Weinberg R.A. The hallmarks of cancer. Cell 100 (2000) 57-70
58. Headley P.M., and Grillner S. Excitatory amino acids and synaptic transmission: the evidence for a physiological function. Trends Pharmacol Sci 11 (1990) 205-211
59. Henriksson M., Bakardjiev A., Klein G., and Luscher B. Phosphorylation sites mapping in the N-terminal domain of c-myc modulate its transforming potential. Oncogene 8 (1993) 3199-3209
60. Himelstein B.P., Lee E.J., Sato H., Seiki M., and Muschel R.J. Transcriptional activation of the matrix metalloproteinase-9 gene in an H-ras and v-myc transformed rat embryo cell line. Oncogene 14 (1997) 1995-1998
61. 1-to-S-phase transition. Mol Cell Biol 19 (1999) 2690-2698
62. Hirakawa T., and Ruley H.E. Rescue of cells from ras oncogene-induced growth arrest by a second, complementing, oncogene. Proc Natl Acad Sci U S A 85 (1988) 1519-1523
63. Janssen-Heininger Y.M., Macara I., and Mossman B.T. Cooperativity between oxidants and tumor necrosis factor in the activation of nuclear factor (NF)-kappaB: requirement of Ras/mitogen-activated protein kinases in the activation of NF-kappaB by oxidants. Am J Respir Cell Mol Biol 20 (1999) 942-952
64. Jiang H., Kang D.C., Alexandre D., and Fisher P.B. RaSH, a rapid subtraction hybridization approach for identifying and cloning differentially expressed genes. Proc Natl Acad Sci U S A 97 (2000) 12684-12689
65. Johnson J.L., van Eys G.J., Angelini G.D., and George S.J. Injury induces dedifferentiation of smooth muscle cells and increased matrix-degrading metalloproteinase activity in human saphenous vein. Arterioscler Thromb Vasc Biol 21 (2001) 1146-1151
66. Kabrun N., and Enrietto P.J. The Rel family of proteins in oncogenesis and differentiation. Semin Cancer Biol 5 (1994) 103-112
67. Kanai Y., and Hediger M.A. Primary structure and functional characterization of a high-affinity glutamate transporter. Nature 360 (1992) 467-471
68. Kang D.-C., and Fisher P.B. Complete open reading frame (C-ORF) technology: simple and efficient technique for cloning full-length protein-coding sequences. Gene 353 (2005) 1-7
69. Kang, D. -C., & Fisher, P.B. (in press). Complete open reading frame (C-ORF) technique: a rapid and efficient method for obtaining complete protein coding sequences. In: P.B. Fisher (Ed.), Methods in Molecular Biology. New Jersey: Humana Press.
70. Kang D.-C., Jiang H., Wu Q., Pestka S., and Fisher P.B. Cloning and characterization of human ubiquitin-processing protease-43 from terminally differentiated human melanoma cells using a rapid subtraction hybridization protocol RaSH. Gene 267 (2001) 233-242
71. Kang D.-C., Su Z.-Z., Sarkar D., Emdad L., Volsky D.J., and Fisher P.B. Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1. Gene 353 (2005) 8-15
72. Kaul M., Garden G.A., and Lipton S.A. Pathways to neuronal injury and apoptosis in HIV-associated dementia. Nature 410 (2001) 988-994
73. Kim S.Y., Choi S.Y., Chao W., and Volsky D.J. Transcriptional regulation of human excitatory amino acid transporter 1 (EAAT1): cloning of the EAAT1 promoter and characterization of its basal and inducible activity in human astrocytes. J Neurochem 87 (2003) 1485-1498
74. Knobbe C.B., Merlo A., and Reifenberger G. Pten signaling in gliomas. Neurooncology 4 (2002) 196-211
75. Koenig S., Gendelman H.E., Orenstein J.M., Dal Canto M.C., Pezeshkpour G.H., Yungbluth M., et al. Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science 233 (1986) 1089-1093
76. Kurschat P., and Mauch C. Mechanisms of metastasis. Clin Exp Dermatol 25 (2000) 482-489
77. Lebedeva I.V., Su Z.Z., Sarkar D., and Fisher P.B. Restoring apoptosis as a strategy for cancer gene therapy: focus on p53 and mda-7. Semin Cancer Biol 13 (2003) 169-178
78. Lee S.G., Su Z.Z., Emdad L., Sarkar D., and Fisher P.B. Astrocyte Elevated Gene-1 is a target gene of oncogenic Harvey-ras requiring phosphatidylinositol 3-kinase and c-Myc. Proc Natl Acad Sci U S A 103 (2006) 17390-17395
79. Lehre K.P., and Danbolt N.C. The number of glutamate transporter subtype molecules at glutamatergic synapses: chemical and stereological quantification in young adult rat brain. J Neurosci 18 (1998) 8751-8757
80. Leone G., DeGregori J., Sears R., Jakoi L., and Nevins J.R. Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F. Nature 387 (1997) 422-426
81. Liotta L.A., and Kohn E.C. The microenvironment of the tumour-host interface. Nature 411 (2001) 375-379
82. Lipton S.A., and Gendelman H.E. Seminars in medicine of the Beth Israel Hospital, Boston. Dementia associated with the acquired immunodeficiency syndrome. N Engl J Med 332 (1995) 934-940
83. Macaluso M., Russo G., Cinti C., Bazan V., Gebbia N., and Russo A. Ras family genes: an interesting link between cell cycle and cancer. J Cell Physiol 192 (2002) 125-130
84. Malumbres M., and Barbacid M. To cycle or not to cycle: a critical decision in cancer. Nat Rev Cancer 1 (2001) 222-231
85. Malumbres M., Perez De Castro I., Hernandez M.I., Jimenez M., Corral T., and Pellicer A. Cellular response to oncogenic ras involves induction of the Cdk4 and Cdk6 inhibitor p15(INK4b). Mol Cell Biol 20 (2000) 2915-2925
86. Masliah E., Alford M., DeTeresa R., Mallory M., and Hansen L. Deficient glutamate transport is associated with neurodegeneration in Alzheimer's disease. Ann Neurol 40 (1996) 759-766
87. Mayo M.W., Wang C.Y., Cogswell P.C., Rogers-Graham K.S., Lowe S.W., Der C.J., et al. Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras. Science 278 (1997) 1812-1815
88. Mettouchi A., Cabon F., Montreau N., Dejong V., Vernier P., Gherzi R., et al. The c-Jun-induced transformation process involves complex regulation of tenascin-C expression. Mol Cell Biol 17 (1997) 3202-3209
89. Minden A., Lin A., Claret F.X., Abo A., and Karin M. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 81 (1995) 1147-1157
90. + dependent glutamate transporters (EAAT1, EAAT2, and EAAT3) in primary astrocyte cultures: effect of oxidative stress. Brain Res 922 (2001) 21-29
91. Mitrovic A.D., Amara S.G., Johnston G.A., and Vandenberg R.J. Identification of functional domains of the human glutamate transporters EAAT1 and EAAT2. J Biol Chem 273 (1998) 14698-14706
92. Mori N., Fujii M., Ikeda S., Yamada Y., Tomonaga M., Ballard D.W., et al. Constitutive activation of NF-kappaB in primary adult T-cell leukemia cells. Blood 93 (1999) 2360-2368
93. Mukhopadhyay A., Bueso-Ramos C., Chatterjee D., Pantazis P., and Aggarwal B.B. Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines. Oncogene 20 (2001) 7597-7609
94. Munch C., Schwalenstocker B., Hermann C., Cirovic S., Stamm S., Ludolph A., et al. Differential RNA cleavage and polyadenylation of the glutamate transporter EAAT2 in the human brain. Brain Res Mol Brain Res 80 (2000) 244-251
95. Navia B.A., and Price R.W. The acquired immunodeficiency syndrome dementia complex as the presenting or sole manifestation of human immunodeficiency virus infection. Arch Neurol 44 (1987) 65-69
96. O'Leary K.A., and Kasper C.B. Molecular basis for cell-specific regulation of the NADPH-cytochrome P450 oxidoreductase gene. Arch Biochem Biophys 379 (2000) 97-108
97. Oliet S.H., Piet R., and Poulain D.A. Control of glutamate clearance and synaptic efficacy by glial coverage of neurons. Science 292 (2001) 923-926
98. Palmada M., Kinne-Saffran E., Centelles J.J., and Kinne R.K. Benzodiazepines differently modulate EAAT1/GLAST and EAAT2/GLT1 glutamate transporters expressed in CHO cells. Neurochem Int 40 (2002) 321-326
99. Peeper D.S., Upton T.M., Ladha M.H., Neuman E., Zalvide J., Bernards R., et al. Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein. Nature 386 (1997) 177-181
100. Perego C., Vanoni C., Bossi M., Massari S., Basudev H., Longhi R., et al. The GLT-1 and GLAST glutamate transporters are expressed on morphologically distinct astrocytes and regulated by neuronal activity in primary hippocampal cocultures. J Neurochem 75 (2000) 1076-1084
101. Pines G., Danbolt N.C., Bjoras M., Zhang Y., Bendahan A., Eide L., et al. Cloning and expression of a rat brain L-glutamate transporter. Nature 360 (1992) 464-467
102. Pitt D., Werner P., and Raine C.S. Glutamate excitotoxicity in a model of multiple sclerosis. Nat Med 6 (2000) 67-70
103. Pulverer B.J., Fisher C., Vousden K., Littlewood T., Evan G., and Woodgett J.R. Site-specific modulation of c-Myc cotransformation by residues phosphorylated in vivo. Oncogene 9 (1994) 59-70
104. Rich J.N., Guo C., McLendon R.E., Bigner D.D., Wang X.F., and Counter C.M. A genetically tractable model of human glioma formation. Cancer Res 61 (2001) 3556-3560
105. Ridley A.J. Rho family proteins: coordinating cell responses. Trends Cell Biol 11 (2001) 471-477
106. Robinson M.B. The family of sodium-dependent glutamate transporters: a focus on the GLT-1/EAAT2 subtype. Neurochem Int 33 (1998) 479-491
107. Rodriguez-Viciana P., Warne P.H., Dhand R., Vanhaesebroeck B., Gout I., Fry M.J., et al. Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 370 (1994) 527-532
108. Rodriguez-Viciana P., Warne P.H., Khwaja A., Marte B.M., Pappin D., Das P., et al. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell 89 (1997) 457-467
109. Rothstein J.D., Dykes-Hoberg M., Pardo C.A., Bristol L.A., Jin L., Kuncl R.W., et al. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron 16 (1996) 675-686
110. Sacktor N., Lyles R.H., Skolasky R., Kleeberger C., Selnes O.A., Miller E.N., et al. HIV-associated neurologic disease incidence changes: Multicenter AIDS Cohort Study, 1990-1998. Neurology 56 (2001) 257-260
111. Sahai E., Olson M.F., and Marshall C.J. Cross-talk between Ras and Rho signalling pathways in transformation favors proliferation and increased motility. EMBO J 20 (2001) 755-766
112. Saito Y., Sharer L.R., Epstein L.G., Michaels J., Mintz M., Louder M., et al. Overexpression of nef as a marker for restricted HIV-1 infection of astrocytes in postmortem pediatric central nervous tissues. Neurology 44 (1994) 474-481
113. Saksela K., Makela T.P., Hughes K., Woodgett J.R., and Alitalo K. Activation of protein kinase C increases phosphorylation of the L-myc trans-activator domain at a GSK-3 target site. Oncogene 7 (1992) 347-353
114. +-dependent glutamate transporters by cyclic AMP analogs and neurons. Mol Pharmacol 53 (1998) 355-369
115. Schule R., Rangarajan P., Yang N., Kliewer S., Ransone L.J., Bolado J., et al. Retinoic acid is a negative regulator of AP-1-responsive genes. Proc Natl Acad Sci U S A 88 (1991) 6092-6096
116. Seth A., Gonzalez F.A., Gupta S., Raden D.L., and Davis R.J. Signal transduction within the nucleus by mitogen-activated protein kinase. J Biol Chem 267 (1992) 24796-24804
117. Shahabuddin M., Volsky B., Kim H., Sakai K., and Volsky D.J. Regulated expression of human immunodeficiency virus type 1 in human glial cells: induction of dormant virus. Pathobiology 60 (1992) 195-205
118. Sharer L.R., Epstein L.G., Cho E.S., Joshi V.V., Meyenhofer M.F., Rankin L.F., et al. Pathologic features of AIDS encephalopathy in children: evidence for LAV/HTLV-III infection of brain. Hum Pathol 17 (1986) 271-284
119. Sharma G., and Vijayaraghavan S. Nicotinic cholinergic signaling in hippocampal astrocytes involves calcium-induced calcium release from intracellular stores. Proc Natl Acad Sci U S A 98 (2001) 4148-4153
120. Shields J.M., Pruitt K., McFall A., Shaub A., and Der C.J. Understanding Ras: 'it ain't over 'til it's over'. Trends Cell Biol 10 (2000) 147-154
121. Shin S.M., Cho I.J., and Kim S.G. CCAAT/enhancer binding protein activation by PD98059 contributes to the inhibition of AhR-mediated 3-methylcholanthrene induction of CYP1A1. Xenobiotica 35 (2005) 975-987
122. Simm M., Su Z.-Z., Huang E.Y., Chen Y., Jiang H., Volsky D.J., et al. Cloning of differentially expressed genes in an HIV-1 resistant T cell clone by rapid subtraction hybridization, RaSH. Gene 269 (2001) 93-101
123. Sitcheran R., Gupta P., Fisher P.B., and Baldwin A.S. Positive and negative regulation of EAAT2 by NF-kappaB: a role for N-myc in TNFalpha-controlled repression. EMBO J 24 (2005) 510-520
124. Sontheimer H. Malignant gliomas: perverting glutamate and ion homeostasis for selective advantage. Trends Neurosci 26 (2003) 543-549
125. Sporer B., Paul R., Koedel U., Grimm R., Wick M., Goebel F.D., et al. Presence of matrix metalloproteinase-9 activity in the cerebrospinal fluid of human immunodeficiency virus-infected patients. J Infect Dis 178 (1998) 854-857
126. Stirewalt D.L., Kopecky K.J., Meshinchi S., Appelbaum F.R., Slovak M.L., Willman C.L., et al. FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia. Blood 97 (2001) 3589-3595
127. Storck T., Schulte S., Hofmann K., and Stoffel W. Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain. Proc Natl Acad Sci U S A 89 (1992) 10955-10959
128. Su Z.-Z., Kang D.-C., Chen Y., Pekarskaya O., Chao W., Volsky D.J., et al. Identification and cloning of human astrocyte genes displaying elevated expression after infection with HIV-1 or exposure to HIV-1 envelope glycoprotein by rapid subtraction hybridization, RaSH. Oncogene 21 (2002) 3592-3602
129. Su Z.-Z., Chen Y., Kang D.C., Chao W., Simm M., Volsky D.J., et al. Customized rapid subtraction hybridization (RaSH) gene microarrays identify overlapping expression changes in human fetal astrocytes resulting from human immunodeficiency virus-1 infection or tumor necrosis factor-alpha treatment. Gene 306 (2003) 67-78
130. Su Z.-Z., Kang D.-C., Chen Y., Pekarskaya O., Chao W., Volsky D.J., et al. Identification of gene products suppressed by human immunodeficiency virus type 1 infection or gp120 exposure of primary human astrocytes by rapid subtraction hybridization. J Neurovirol 9 (2003) 372-389
131. Su Z.-Z., Leszczyniecka M., Kang D.C., Sarkar D., Chao W., Volsky D.J., et al. Insights into glutamate transport regulation in human astrocytes: cloning of the promoter for excitatory amino acid transporter 2 (EAAT2). Proc Natl Acad Sci U S A 100 (2003) 1955-1960
132. Sucharov C.C., Helmke S.M., Langer S.J., Perryman M.B., Bristow M., and Leinwand L. The Ku protein complex interacts with YY1, is up-regulated in human heart failure, and represses alpha myosin heavy-chain gene expression. Mol Cell Biol 24 (2004) 8705-8715
133. Sulis M.L., and Parsons R. PTEN: from pathology to biology. Trends Cell Biol 13 (2003) 478-483
134. Sutherland H.G., Lam Y.W., Briers S., Lamond A.I., and Bickmore W.A. 3D3/lyric: a novel transmembrane protein of the endoplasmic reticulum and nuclear envelope, which is also present in the nucleolus. Exp Cell Res 294 (2004) 94-105
135. Szymocha R., Akaoka H., Dutuit M., Malcus C., Didier-Bazes M., Belin M.F., et al. Human T-cell lymphotropic virus type 1-infected T lymphocytes impair catabolism and uptake of glutamate by astrocytes via Tax-1 and tumor necrosis factor alpha. J Virol 74 (2000) 6433-6441
136. Tanaka K., Watase K., Manabe T., Yamada K., Watanabe M., Takahashi K., et al. Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science 276 (1997) 1699-1702
137. Tornatore C., Nath A., Amemiya K., and Major E.O. Persistent human immunodeficiency virus type 1 infection in human fetal glial cells reactivated by T-cell factor(s) or by the cytokines tumor necrosis factor alpha and interleukin-1 beta. J Virol 65 (1991) 6094-6100
138. Ullian E.M., Sapperstein S.K., Christopherson K.S., and Barres B.A. Control of synapse number by glia. Science 291 (2001) 657-661
139. Vandenberg R.J., Mitrovic A.D., Chebib M., Balcar V.J., and Johnston G.A. Contrasting modes of action of methylglutamate derivatives on the excitatory amino acid transporters, EAAT1 and EAAT2. Mol Pharmacol 51 (1997) 809-815
140. Visconti R., Cerutti J., Battista S., Fedele M., Trapasso F., Zeki K., et al. Expression of the neoplastic phenotype by human thyroid carcinoma cell lines requires NFkappaB p65 protein expression. Oncogene 15 (1997) 1987-1994
141. Wang W., Abbruzzese J.L., Evans D.B., Larry L., Cleary K.R., and Chiao P.J. The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Clin Cancer Res 5 (1999) 119-127
142. Wang Z., Pekarskaya O., Bencheikh M., Chao W., Gelbard H.A., Ghorpade A., et al. Reduced expression of glutamate transporter EAAT2 and impaired glutamate transport in human primary astrocytes exposed to HIV-1 or gp120. Virology 312 (2003) 60-73
143. White M.A., Nicolette C., Minden A., Polverino A., Van Aelst L., Karin M., et al. Multiple Ras functions can contribute to mammalian cell transformation. Cell 80 (1995) 533-541
144. Wiley C.A., Schrier R.D., Nelson J.A., Lampert P.W., and Oldstone M.B. Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients. Proc Natl Acad Sci U S A 83 (1986) 7089-7093
145. Wu R.C., Qin J., Hashimoto Y., Wong J., Xu J., Tsai S.Y., et al. Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) coactivator activity by I kappa B kinase. Mol Cell Biol 22 (2002) 3549-3561
146. Xia Z., Dickens M., Raingeaud J., Davis R.J., and Greenberg M.E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270 (1995) 1326-1331
147. Ye K., Dinarello C.A., and Clark B.D. Identification of the promoter region of human interleukin 1 type I receptor gene: multiple initiation sites, high G+C content, and constitutive expression. Proc Natl Acad Sci U S A 90 (1993) 2295-2299
148. Ye Z.C., Rothstein J.D., and Sontheimer H. Compromised glutamate transport in human glioma cells: reduction-mislocalization of sodium-dependent glutamate transporters and enhanced activity of cystine-glutamate exchange. J Neurosci 19 (1999) 10767-10777
149. Yordy J.S., and Muise-Helmericks R.C. Signal transduction and the Ets family of transcription factors. Oncogene 19 (2000) 6503-6513
150. Yu N., Billaud J.N., and Phillips T.R. Effects of feline immunodeficiency virus on astrocyte glutamate uptake: implications for lentivirus-induced central nervous system diseases. Proc Natl Acad Sci U S A 95 (1998) 2624-2629
151. Zelenaia O., Schlag B.D., Gochenauer G.E., Ganel R., Song W., Beesley J.S., et al. Epidermal growth factor receptor agonists increase expression of glutamate transporter GLT-1 in astrocytes through pathways dependent on phosphatidylinositol 3-kinase and transcription factor NF-kappaB. Mol Pharmacol 57 (2000) 667-678