Na+ dependent glutamate transporters (EAAT1, EAAT2, and EAAT3) in primary astrocyte cultures: Effect of oxidative stress

Brain Research

Volumn 922, Issue 1, 2001, Pages 21-29

  Miralles, Vicente J ^a   Martínez López, Itziar ^a   Zaragozá, Rosa ^a   Borrás, Elisa ^a   García, Concha ^a   Pallardó, Federico V ^b   Via, Juan R ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

^b UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Astrocyte; Brain; EAATs; Glutamate transporter; Oxidative stress

Indexed keywords

ASCORBIC ACID; BUTHIONINE SULFOXIMINE; DITHIOTHREITOL; EXCITATORY AMINO ACID TRANSPORTER; GLUTAMATE CYSTEINE LIGASE; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; GLUTATHIONE; GLUTATHIONE ETHYL ESTER; LACTATE DEHYDROGENASE; PROTEIN SUBUNIT; TERT BUTYL HYDROPEROXIDE; UNCLASSIFIED DRUG;

AMINO ACID TRANSPORT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL CULTURE; CELL DAMAGE; CELL LEVEL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; INCUBATION TIME; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AMINO ACID TRANSPORT SYSTEM X-AG; ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; BRAIN CHEMISTRY; CARRIER PROTEINS; CELLS, CULTURED; DDT; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EXCITATORY AMINO ACID TRANSPORTER 1; EXCITATORY AMINO ACID TRANSPORTER 2; EXCITATORY AMINO ACID TRANSPORTER 3; GLUTAMATE PLASMA MEMBRANE TRANSPORT PROTEINS; GLUTAMIC ACID; GLUTATHIONE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INSECTICIDES; L-LACTATE DEHYDROGENASE; MICROSCOPY, FLUORESCENCE; OXIDATIVE STRESS; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SODIUM; SYMPORTERS;

EID: 0035856880     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)03124-9     Document Type: Article

References (37)

1. Astrocyte glutamate transport: Review of properties, regulation, and physiological functions
2. Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance
3. Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex
4. Elevated expression of liver γ-cystathionase is required for the maintenance of lactation in rats
5. Identification and quantitation of glutathione in hepatic protein mixed disulfides and its relationships to glutathione disulfides
6. EAAC1, a high-affinity glutamate transporter, is localized to astrocytes and gabaergic neurons besides pyramidal cells in the rat cerebral cortex
7. The glutamate transporter EAAT4 in rat cerebellar Purkinje cells: A glutamate-gated chloride channel concentrated near the synapse in parts of the dendritic membrane facing astroglia
8. Glutathione metabolism in primary astrocyte cultures: Flow cytometric evidence of heterogeneous of GSH content
9. Tumor necrosis factor inhibits glutamate uptake by primary human astrocytes
10. Brain glutamate transporter proteins form homomultimers
11. Comparison of the metabolic disturbances caused by end-to-end and site-to-site protocaval shunts
12. Synthesis and trafficking of neuronal protein
13. Nerve injury enhances rat neuronal glutamate transporter expression: Identification by differential display PCR
14. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
15. Differential expression of two glutamate transporters in rat brain: Quantitative and immunocytochemical observations
16. Glutamine synthetase: Glial localization in brain
17. The L-glutamate transporters GLAST (EAAT1) and GLT-1 (EAAT2): Expression and regulation in rat lactating mammary gland
18. Activity and protein localization of multiple glutamate transporters in gestation day 14 vs. day 20 in rat placenta
19. Biosynthesis and maintenance of GSH in primary astrocyte cultures: Role of L-cystine and ascorbate
20. +-dependent glutamate transporters (EAAT1, EAAT2, and EAAT3) of the blood-brain barrier. A mechanism for glutamate removal
21. Glutamate transporter EAAC1-deficient mice develop dicarboxylic aminoaciduria and behavioral abnormalities but no neurodegeneration
22. Cloning and expression of a rat brain L-glutamate transporter
23. Trasient expression of the glial glutamate transporters GLAST and GLT in hippocampal neurons in primary culture
24. Localization of neuronal and glial glutamate transporters
25. Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis
26. Excitatory amino acid transporters: A family in flux
27. Structure, expression and functional analysis of a Na-dependent glutamate/aspartate transporter from rat brain
28. Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1
29. Regional distribution and extracellular levels of amino acids in rat central nervous system
30. Differential modulation of the uptake currents by redox interconversion of cysteine residues in the human neuronal glutamate transporter EAAC1
31. Neuronal and glial glutamate transporters posses an SH-based redox regulatory mechanism
32. Glutamate transporters are oxidant-vulnerable: A molecular link between oxidative and excitotoxic neurodegeneration?
33. Peroxynitrite inhibits glutamate transporter subtypes
34. S26 ribosomal protein RNA: An invariant control for gene regulation experiments in eucaryotic cells and tissues
35. Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes
36. Antioxidant defense of the brain: A role for astrocytes