The GLT-1 and GLAST glutamate transporters are expressed on morphologically distinct astrocytes and regulated by neuronal activity in primary hippocampal cocultures

Journal of Neurochemistry

Volumn 75, Issue 3, 2000, Pages 1076-1084

  Perego, C ^a,b,c,d   Vanoni, C ^a,b,c,d   Bossi, M ^a,b,c,d   Massari, S ^a,b,c,d   Basudev, H ^a,b,c,d   Longhi, R ^a,b,c,d   Pietrini, G ^a,b,c,d  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF MILANO BICOCCA   (Italy)

^c Schering Plough Research Institute   (Italy)

^d CNR   (Italy)

Author keywords

Amyotrophic lateral sclerosis; Cerebral ischemia; Excitotoxicity; Glutamate transporters; Neuron astrocyte cocultures

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; SYNAPTOPHYSIN;

AMINO ACID TRANSPORT; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN ISCHEMIA; COCULTURE; DEGENERATIVE DISEASE; EPILEPSY; GENE EXPRESSION; HIPPOCAMPUS; NERVE CELL; NERVE CELL DIFFERENTIATION; NERVE CELL NECROSIS; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT;

AMINO ACID TRANSPORT SYSTEM X-AG; ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; ATP-BINDING CASSETTE TRANSPORTERS; CELL DIFFERENTIATION; CELLS, CULTURED; COCULTURE TECHNIQUES; CULTURE MEDIA, CONDITIONED; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMIC ACID; HIPPOCAMPUS; MICROSCOPY, IMMUNOELECTRON; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; SYNAPTIC VESICLES; SYNAPTOPHYSIN;

EID: 0033840578     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0751076.x     Document Type: Article

References (41)

1. Establishment, characterization, and evolution of cultures enriched in type-2 astrocytes
2. Calcium elevation in astrocytes causes an NMDA receptor-dependent increase in the frequency of miniature synaptic currents in cultured hippocampal neurons
3. Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex
4. Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance
5. A synaptic model of memory: Long-term potentiation in the hippocampus
6. 5 reductase, studied with a quantitative radioimmunoblotting assay
7. Sorting out genes that regulate epithelial and neuronal polarity
8. The glutamate transporter, GLT-1, is expressed in cultured hippocampal neurons
9. Colocalization of synaptophysin with transferrin receptors: Implications for synaptic vesicle biogenesis
10. Glutamate transporters in glial plasma membranes: Highly differentiated localizations revealed by quantitative ultrastructural immunocyto chemistry
11. Selective clustering of glutamate and gamma-aminobutyric acid receptors opposite terminals releasing the corresponding neurotransmitters
12. An excitatory amino-acid transporter with properties of ligand-gated chloride channel
13. The distribution of synapsin I in hippocampal neurons developing in culture
14. Glutamate transporter protein subtypes are expressed differentially during rat central nervous system development
15. Glutamate receptor agonists up-regulate the glutamate transporter GLAST in astrocytes
16. Neuronal soluble factors differentially regulate the expression of the GLT1 and GLAST glutamate transporters in cultured astroglia
17. Regional deafferentiation down-regulates subtypes of glutamate transporter proteins
18. Excitatory amino acids and Alzheimer's disease
19. Brain glutamate transporter proteins form homomultimers
20. Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation
21. Primary structure and functional characterization of a high-affinity glutamate transporter
22. The number of glutamate transporter subtype molecules at glutamatergic synapses: Chemical and stereological quantification in young adult rat brain
23. Differential expression of two glial glutamate transporters in the rat brain: Quantitative and immunocyto-chemical observations
24. Down-regulation of glial glutamate transporters after glutamatergic denervation in the rat brain
25. C-terminal interactions modulate the affinity of GLAST glutamate transporters in salamander retinal glial cells
26. Neuronal expression of the glutamate transporter GLT-1 in hippocampal microcultures
27. Astrocytes from human hippocampal epileptogenic foci exhibit action potential-like responses
28. PDZ-mediated interactions retain the epithelial GABA transporter on the basolateral surface of polarized epithelial cells
29. What excitotoxin kills striatal neurons in Huntington's disease? Clues from neurochemical studies
30. Cloning and expression of a rat brain L-glutamate transporter
31. Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis
32. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate
33. +-dependent glutamate transporters by cyclic AMP analogs and neurons
34. Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain
35. Glutamate transporter mRNA expression in proliferative zones of the developing and adult murine CNS
36. Neuronal regulation of glutamate transporter subtype expression in astrocytes
37. Regulation of the glial glutamate transporter GLT-1 by glutamate and delta-opioid receptor stimulation
38. Differential developmental expression of the two rat brain glutamate transporter proteins GLAST and GLT
39. Spatial changes in calcium signaling during the establishment of neuronal polarity and synaptogenesis
40. ++ homeostasis