Epidermal growth factor receptor agonists increase expression of glutamate transporter GLT-1 in astrocytes through pathways dependent on phosphatidylinositol 3-kinase and transcription factor NF-κB

Molecular Pharmacology

Volumn 57, Issue 4, 2000, Pages 667-678

  Zelenaia, Olga ^a   Schlag, Brian D ^a   Gochenauer, Gordon E ^a   Ganel, Raquelli ^b   Song, Wei ^a   Beesley, Jacqueline S ^a   Grinspan, Judith B ^a   Rothstein, Jeffrey D ^b   Robinson, Michael B ^a,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c 502N Abramson Pediat Res Building ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; GLUTAMATE TRANSPORTER; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN INJURY; CELL CULTURE; CELL DIFFERENTIATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOSE RESPONSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; TIME; VELOCITY;

EID: 0034038270     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.57.4.667     Document Type: Article

References (40)

1. Baichwal VR and Baeuerle PA (1997) Apoptosis: Activate NF-κB or die? Curr Biol 7:R94-R96.
2. Béraud C, Henzel WJ and Baeuerle PA (1999) Involvement of regulatory and catalytic suninits of phosphoinositide 3-kinase in NF-κB activation. Proc Natl Acad Sci USA 96:429-434.
3. Bridges AJ, Zhou H, Cody DR, Rewcastle GW, McMichael A, Showalter HD, Fry DW, Kraker AJ and Denny WA (1996) Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-[3-bromoanilino]-6,7-dimethoxyquinazoline (PD153035), a potent inhibitor of the epidermal growth factor receptor. J Med Chem 39:267-276.
4. Brown EJ, Beal PA, Keith CT, Chen J, Shin TB and Schreiber SL (1995) Control of p70 s6 kinase by kinase activity of FRAP in vivo. Nature (Lond) 377:441-446.
5. Burgering BM, deVries-Smith AM, Medema RH, vanWeeren PC, Tertoolen LG and Bos JL (1993) Epidermal growth factor induces phosphorylation of extracellular signal-regulated kinase 2 via multiple pathways. Mol Cell Biol 13:7248-7256.
6. Burrows RC, Wancio D, Levitt P and Lillien L (1997) Response diversity and timing of progenitor cell maturation are regulated by developmental changes in the EGFR expression in the cortex. Neuron 19:251-267.
7. Chew CS, Nakamura K and Petropoulos AC (1994) Multiple actions of epidermal growth factor and TGFα on rabbit gastric parietal cell function. Am J Physiol 267:G818-G826.
8. Dudley DT, Pang L, Decker SJ, Bridges AJ and Saltiel AR (1995) A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc Natl Acad Sci USA 92:7686-7689.
9. Duronio V, Scheid MP and Ettinger S (1998) Downstream signalling events regulated by phosphatidylinositol 3-kinase activity. Cell Signal 10:233-239.
10. Egan SE and Weinberg RA (1993) The pathway to signal achievement. Nature (Lond) 365:781-783.
11. Ferrer I, Alcantara S, Ballabriga J, Olive M, Blanco R, Rivera R, Carmona M, Berruezo M, Pitarch S and Planas AM (1996) Transforming growth factor alpha (TGF-alpha) and epidermal growth factor-receptor (EGF-R) immunoreactivity in normal and pathologic brain. Prog Neurobiol 49:99-123.
12. Gegelashvili G, Danbolt NC and Schousboe A (1997) Neuronal soluble factors differentially regulate the expression of the GLT1 and GLAST glutamate transporters in cultured astroglia. J Neurochem 69:2612-2615.
13. Graus-Porta D, Beerli RR, Daly JM and Hynes NE (1994) ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling. EMBO J 16:1647-1655.
14. Grinspan JB, Reeves MF, Coulaloglou MJ, Nathanson D and Pleasure D (1996) Re-entry into the cell cycle is required for bFGF-induced oligodendroglial dedifferentiation and survival. J Neurosci Res 46:456-464.
15. Honegger P and Guentert-Lauber B (1983) Epidermal growth factor (EGF) stimulation of cultured brain cells. I. Enhancement of the developmental increase in glial enzymatic activity. Brain Res 313:245-251.
16. Hu Q, Klippel A, Muslin AJ, Fantl WJ and Williams LT (1995) Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase. Science (Wash DC) 268:100-102.
17. Johe KK, Hazel TG, Muller T, Dugich-Djorjievic MM and McKay RDG (1996) Single factors direct the differentiation of stem cells from the fetal and adult central nervous system. Genes Dev 10:3129-3140.
18. Kahn MA and Vellis JD (1995) Growth factors in the CNS and their effects on oligodendroglia. Prog Brain Res 105:145-169.
19. Kimura K, Hattori S, Kabuyama Y, Shizawa Y, Takayanagi J, Nakamura S, Toki S, Matsuda Y, Onodera K and Fukui Y (1994) Neurite outgrowth of PC 12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase. J Biol Chem 269:18961-18967.
20. Kornblum HI, Hussain RJ, Bronstein JM, Gall CM, Lee DC and Seroogy KB (1997) Prenatal ontogeny of the epidermal growth factor receptor and its ligand, transforming growth factor alpha, in the rat brain. J Comp Neurol 380:243-261.
21. Lee DC, Fenton FE, Berkowitz EA and Hissong MA (1995) Transforming growth factor α: Expression, regulation, and biological activities. Pharmacol Rev 47:51-85.
22. Miller S, Romano C and Cotman CW (1995) Growth factor upregulation of a phosphoinositide-coupled metabotropic glutamate receptor in cortical astrocytes. J Neurosci 15:6103-6109.
23. Montminy M (1997) Transcriptional regulation by cyclic AMP. Annu Rev Biochem 66:807-822.
24. Robinson MB (1999) The family of sodium-dependent glutamate transporters: A focus on the GLT-1/EAAT2 subtype. Neurochem Int 33:479-491.
25. Robinson MB and Dowd LA (1997) Heterogeneity and functional properties of subtypes of sodium-dependent glutamate transporters in the mammalian central nervous system. Adv Pharmacol 37:69-115.
26. Rodrigues-Viciana P, Marte BM, Warne PH and Downward J (1996) Phosphatidylinositol 3′ kinase: One of the effectors of Ras. Philos Trans R Soc London B 351:225-232.
27. Rothstein JD, Jin L, Dykes-Hoberg M and Kuncl RW (1993) Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity. Proc Natl Acad Sci USA 90:6591-6595.
28. Scherck R, Meier B, Mannel DN, Droge W and Baeuerle PA (1992) Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells. J Exp Med 175:1181-1194.
29. +-dependent glutamate transporters by cyclic AMP analogs and neurons. Mol Pharmacol 53:355-369.
30. Sibilia M, Steinbach JP, Stingl L, Aguzzi A and Wagner EF (1998) A strain-independent neurodegeneration in mice lacking the EGF receptor. EMBO J 17: 719-731.
31. Siebenlist U, Franzoso G and Brown K (1994) Structure, regulation and function of NF-κB. Annu Rev Cell Biol 10:405-455.
32. Sims KD and Robinson MB (1999) Expression patterns and regulation of glutamate transporters in the developing and adult nervous system. Crit Rev Neurobiol 13:169-197.
33. Sun L and Carpenter G (1998) Epidermal growth factor activation of NF-κB is mediated through IκBα degradation and intracellular free calcium. Oncogene 16:2095-2102.
34. Sutherland M (1998) The role of glutamate transport in seizure-induced excitotoxic cell death: A new transgenic model. Epilepsia 39:62.
35. Swanson RA, Liu J, Miller JW, Rothstein JD, Farrell K, Stein BA and Longuemare MC (1997) Neuronal regulation of glutamate transporter subtype expression in astrocytes. J Neurosci 17:932-940.
36. Vartanian T, Goodearl A, Viehover A and Fischbach G (1997) Axonal neuregulin signals cells of the oligodendrocyte lineage through activation of HER4 and Schwann cells through HER2 and HER3. J Cell Biol 137:211-220.
37. Vossler MR, Yao H, York RD, Pan M-G, Rim CS and Stork PJS (1997) cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rapl-dependent pathway. Cell 89:73-82.
38. Wang Z, Gluck S, Zhang L and Moran MF (1998) Requirement for phospholipase C-gamma 1 enzymatic activity in growth factor induced mitogenesis. Mol Cell Biol 18:590-597.
39. Yamada M, Ikeuchi T and Hatanaka H (1997) The neurotrophic action and signalling of the epidermal growth factor. Prog Neurobiol 51:19-37.
40. Yao R and Cooper GM (1995) Requirement for phosphatidylinositol-3 kinase in prevention of apoptosis by nerve growth factor. Science (Wash DC) 267:2003-2006.