Cell adhesion molecules in chemically-induced renal injury

Pharmacology and Therapeutics

Volumn 114, Issue 1, 2007, Pages 74-93

  Prozialeck, Walter C ^a   Edwards, Joshua R ^a  

^a MIDWESTERN UNIVERSITY   (United States)

Author keywords

Cadherins; Cadmium; Cell adhesion molecules; Kidney; Nephrotoxicity; Renal injury

Indexed keywords

1,2 DICHLOROVINYLCYSTEINE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); AMINOGLYCOSIDE ANTIBIOTIC AGENT; BETA CATENIN; BISMUTH; CADHERIN; CADMIUM; CATENIN; CELL ADHESION MOLECULE; CELL MEMBRANE PROTEIN; CISPLATIN; CLAUDIN; CLAUDIN 2; CYANIDE; CYSTEINE DERIVATIVE; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; MERCURY; METAL; NERVE CELL ADHESION MOLECULE; OCCLUDIN; PLAKOGLOBIN; PROTEIN; SELECTIN; TOXIC SUBSTANCE; UNCLASSIFIED DRUG; UNINDEXED DRUG; UVOMORULIN; VENOM; YESSOTOXIN; ZONULA OCCLUDENS PROTEIN 1;

CELL ADHESION; CHEMICAL INJURY; DRUG EFFECT; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; KIDNEY INJURY; LEUKOCYTE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; TOXIN ANALYSIS;

ANIMALS; CARCINOGENS; CELL ADHESION MOLECULES; GAP JUNCTIONS; HUMANS; KIDNEY DISEASES; KIDNEY GLOMERULUS; KIDNEY TUBULES; XENOBIOTICS;

EID: 33947673334     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2007.01.001     Document Type: Review

References (303)

1. Abe T., Kobayashi E., Okubo Y., Suwazono Y., Kido T., Shaikh Z.A., et al. Application of path analysis to urinary findings of cadmium-induced renal dysfunction. J Environ Sci Health A Tox Hazard Subst Environ Eng 36 (2001) 75-87
2. Adams C.L., and Nelson W.J. Cytomechanics of cadherin-mediated cell-cell adhesion. Curr Opin Cell Biol 10 (1998) 572-577
3. Adams C.L., Chen Y.T., Smith S.J., and Nelson W.J. Mechanisms of epithelial cell-cell adhesion and cell compaction revealed by high-resolution tracking of E-cadherin-green fluorescent protein. J Cell Biol 142 (1998) 1105-1119
4. Adler S., and Brady H.R. Cell adhesion molecules and the glomerulopathies. Am J Med 107 (1999) 371-386
5. Aird W.C. Endothelium as an organ system. Crit Care Med 32 (2004) S271-S279
6. Alema S., and Salvatore A.M. p120 catenin and phosphorylation: mechanisms and traits of an unresolved issue. Biochim Biophys Acta 1773 (2007) 47-58
7. Amin R.P., Vickers A.E., Sistare F., Thompson K.L., Roman R.J., Lawton M., et al. Identification of putative gene based markers of renal toxicity. Environ Health Perspect 112 (2004) 465-479
8. Andreeva A.Y., Krause E., Muller E.C., Blasig I.E., and Utepbergenov D.I. Protein kinase C regulates the phosphorylation and cellular localization of occludin. J Biol Chem 276 (2001) 38480-38486
9. Bacallao R., Garfinkel A., Monke S., Zampighi G., and Mandel L.J. ATP depletion: a novel method to study junctional properties in epithelial tissues: I. Rearrangement of the actin cytoskeleton. J Cell Sci 107 Pt 12 (1994) 3301-3313
10. Bagchi D., Bagchi M., Tang L., and Stohs S.J. Comparative in vitro and in vivo protein kinase C activation by selected pesticides and transition metal salts. Toxicol Lett 91 (1997) 31-37
11. Bailly V., Zhang Z., Meier W., Cate R., Sanicola M., and Bonventre J.V. Shedding of kidney injury molecule-1, a putative adhesion protein involved in renal regeneration. J Biol Chem 277 (2002) 39739-39748
12. Bains R., Furness P.N., and Critchley D.R. A quantitative immunofluorescence study of glomerular cell adhesion proteins in proteinuric states. J Pathol 183 (1997) 272-280
13. Balzac F., Avolio M., Degani S., Kaverina I., Torti M., Silengo L., et al. E-cadherin endocytosis regulates the activity of Rap1: a traffic light GTPase at the crossroads between cadherin and integrin function. J Cell Sci 118 (2005) 4765-4783
14. Barisoni L., Trudel M., Chretien N., Ward L., van Adelsberg J., and D'Agati V. Analysis of the role of membrane polarity in polycystic kidney disease of transgenic SBM mice. Am J Pathol 147 (1995) 1728-1735
15. Bartosiewicz M.J., Jenkins D., Penn S., Emery J., and Buckpitt A. Unique gene expression patterns in liver and kidney associated with exposure to chemical toxicants. J Pharmacol Exp Ther 297 (2001) 895-905
16. Basuroy S., Seth A., Elias B., Naren A.P., and Rao R. MAPK interacts with occludin and mediates EGF-induced prevention of tight junction disruption by hydrogen peroxide. Biochem J 393 (2006) 69-77
17. Beavon I.R. The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation. Eur J Cancer 36 (2000) 1607-1620
18. Behrens J. Cadherins and catenins: role in signal transduction and tumor progression. Cancer Metastasis Rev 18 (1999) 15-30
19. Behrens J., Birchmeier W., Goodman S.L., and Imhof B.A. Dissociation of Madin-Darby canine kidney epithelial cells by the monoclonal antibody anti-arc-1: mechanistic aspects and identification of the antigen as a component related to uvomorulin. J Cell Biol 101 (1985) 1307-1315
20. Ben Ze'ev A., Shtutman M., and Zhurinsky J. The integration of cell adhesion with gene expression: the role of beta-catenin. Exp Cell Res 261 (2000) 75-82
21. Bernard A., Lauwerys R., Gengoux P., Mahieu P., Foidart J.M., Druet P., et al. Anti-laminin antibodies in Sprague-Dawley and brown Norway rats chronically exposed to cadmium. Toxicology 31 (1984) 307-313
22. Bertolotti R., Rutishauser U., and Edelman G.M. A cell surface molecule involved in aggregation of embryonic liver cells. Proc Natl Acad Sci U S A 77 (1980) 4831-4835
23. Beyersmann D., Block C., and Malviya A.N. Effects of cadmium on nuclear protein kinase C. Environ Health Perspect 102 Suppl 3 (1994) 177-180
24. Birukova A.A., Birukov K.G., Gorshkov B., Liu F., Garcia J.G., and Verin A.D. MAP kinases in lung endothelial permeability induced by microtubule disassembly. Am J Physiol Lung Cell Mol Physiol 289 (2005) L75-L84
25. Boehm C., Gibert M., Geny B., Popoff M.R., and Rodriguez P. Modification of epithelial cell barrier permeability and intercellular junctions by Clostridium sordellii lethal toxins. Cell Microbiol 8 (2006) 1070-1085
26. Bogatcheva N.V., Dudek S.M., Garcia J.G., and Verin A.D. Mitogen-activated protein kinases in endothelial pathophysiology. J Investig Med 51 (2003) 341-352
27. Bonventre J.V. Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure. J Am Soc Nephrol 14 Suppl 1 (2003) S55-S61
28. Bonventre J.V., and Colvin R.B. Adhesion molecules in renal disease. Curr Opin Nephrol Hypertens 5 (1996) 254-261
29. Bonventre J.V., and Kelly K.J. Adhesion molecules and acute renal failure. Adv Nephrol Necker Hosp 25 (1996) 159-176
30. Borbiev T., Birukova A., Liu F., Nurmukhambetova S., Gerthoffer W.T., Garcia J.G., et al. p38 MAP kinase-dependent regulation of endothelial cell permeability. Am J Physiol Lung Cell Mol Physiol 287 (2004) L911-L918
31. Boyer B., and Thiery J.P. Epithelial cell adhesion mechanisms. J Membr Biol 112 (1989) 97-108
32. Brancolini C., Lazarevic D., Rodriguez J., and Schneider C. Dismantling cell-cell contacts during apoptosis is coupled to a caspase-dependent proteolytic cleavage of beta-catenin. J Cell Biol 139 (1997) 759-771
33. Brancolini C., Sgorbissa A., and Schneider C. Proteolytic processing of the adherens junctions components beta-catenin and gamma-catenin/plakoglobin during apoptosis. Cell Death Differ 5 (1998) 1042-1050
34. Brown D., and Stow J.L. Protein trafficking and polarity in kidney epithelium: from cell biology to physiology. Physiol Rev 76 (1996) 245-297
35. Burne-Taney M.J., and Rabb H. The role of adhesion molecules and T cells in ischemic renal injury. Curr Opin Nephrol Hypertens 12 (2003) 85-90
36. Bush K.T., Tsukamoto T., and Nigam S.K. Selective degradation of E-cadherin and dissolution of E-cadherin-catenin complexes in epithelial ischemia. Am J Physiol Renal Physiol 278 (2000) F847-F852
37. Cadigan K.M., and Nusse R. Wnt signaling: a common theme in animal development. Genes Dev 11 (1997) 3286-3305
38. Canfield P.E., Geerdes A.M., and Molitoris B.A. Effect of reversible ATP depletion on tight-junction integrity in LLC-PK1 cells. Am J Physiol 261 (1991) F1038-F1045
39. Cereijido M., Robbins E.S., Dolan W.J., Rotunno C.A., and Sabatini D.D. Polarized monolayers formed by epithelial cells on a permeable and translucent support. J Cell Biol 77 (1978) 853-880
40. Cereijido M., Gonzalez-Mariscal L., Avila G., and Contreras R.G. Tight junctions. Crit Rev Anat Sci 1 (1988) 171-191
41. Cereijido M., Shoshani L., and Contreras R.G. Molecular physiology and pathophysiology of tight junctions: I. Biogenesis of tight junctions and epithelial polarity. Am J Physiol Gastrointest Liver Physiol 279 (2000) G477-G482
42. Chamoun F., Burne M., O'Donnell M., and Rabb H. Pathophysiologic role of selectins and their ligands in ischemia reperfusion injury. Front Biosci 5 (2000) E103-E109
43. Chipman J.K., Mally A., and Edwards G.O. Disruption of gap junctions in toxicity and carcinogenicity. Toxicol Sci 71 (2003) 146-153
44. Cho E.A., Patterson L.T., Brookhiser W.T., Mah S., Kintner C., and Dressler G.R. Differential expression and function of cadherin-6 during renal epithelium development. Development 125 (1998) 803-812
45. Clarke H., Soler A.P., and Mullin J.M. Protein kinase C activation leads to dephosphorylation of occludin and tight junction permeability increase in LLC-PK1 epithelial cell sheets. J Cell Sci 113 Pt 18 (2000) 3187-3196
46. Colegio O.R., Van Itallie C.M., McCrea H.J., Rahner C., and Anderson J.M. Claudins create charge-selective channels in the paracellular pathway between epithelial cells. Am J Physiol Cell Physiol 283 (2002) C142-C147
47. Contreras R.G., Miller J.H., Zamora M., Gonzalez-Mariscal L., and Cereijido M. Interaction of calcium with plasma membrane of epithelial (MDCK) cells during junction formation. Am J Physiol 263 (1992) C313-C318
48. Covington M.D., Bayless K.J., Burghardt R.C., Davis G.E., and Parrish A.R. Ischemia-induced cleavage of cadherins in NRK cells: evidence for a role of metalloproteinases. Am J Physiol Renal Physiol 289 (2005) F280-F288
49. Covington M.D., Burghardt R.C., and Parrish A.R. Ischemia-induced cleavage of cadherins in NRK cells requires MT1-MMP (MMP-14). Am J Physiol Renal Physiol 290 (2006) F43-F51
50. Crean J.K., Furlong F., Finlay D., Mitchell D., Murphy M., Conway B., et al. Connective tissue growth factor [CTGF]/CCN2 stimulates mesangial cell migration through integrated dissolution of focal adhesion complexes and activation of cell polarization. FASEB J 18 (2004) 1541-1543
51. Crompton M. The mitochondrial permeability transition pore and its role in cell death. Biochem J 341 Pt 2 (1999) 233-249
52. Dahl U., Sjodin A., Larue L., Radice G.L., Cajander S., Takeichi M., et al. Genetic dissection of cadherin function during nephrogenesis. Mol Cell Biol 22 (2002) 1474-1487
53. 2-induced ARF. Kidney Int 63 (2003) 1697-1707
54. Deen W.M., Lazzara M.J., and Myers B.D. Structural determinants of glomerular permeability. Am J Physiol Renal Physiol 281 (2001) F579-F596
55. Defouw L.M., and Defouw D.O. Protein kinase C activity contributes to endothelial hyperpermeability during early angiogenesis in the chick chorioallantoic membrane. Tissue Cell 33 (2001) 135-140
56. Denker B.M., and Nigam S.K. Molecular structure and assembly of the tight junction. Am J Physiol 274 (1998) F1-F9
57. Devarajan P. Cellular and molecular derangements in acute tubular necrosis. Curr Opin Pediatr 17 (2005) 193-199
58. Diamond G.L., and Zalups R.K. Understanding renal toxicity of heavy metals. Toxicol Pathol 26 (1998) 92-103
59. Ding W., and Templeton D.M. Stress-activated protein kinase-dependent induction of c-fos by Cd(2+) is mediated by MKK7. Biochem Biophys Res Commun 273 (2000) 718-722
60. Donnahoo K.K., Shames B.D., Harken A.H., and Meldrum D.R. Review article: the role of tumor necrosis factor in renal ischemia-reperfusion injury. J Urol 162 (1999) 196-203
61. Drees F., Pokutta S., Yamada S., Nelson W.J., and Weis W.I. Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly. Cell 123 (2005) 903-915
62. Edelstein C.L., Ling H., and Schrier R.W. The nature of renal cell injury. Kidney Int 51 (1997) 1341-1351
63. Edwards J.R., Lamar P.C., Diamantakos E., Peuler J.D., Liu J., Waalkes M., et al. Cadmium-induced disruption of proximal tubule cell adhesion is associated with redistribution of cell adhesion molecules and loss of epithelial polarity. Toxicol Sci 90 (2006) S414
64. Enck A.H., Berger U.V., and Yu A.S. Claudin-2 is selectively expressed in proximal nephron in mouse kidney. Am J Physiol Renal Physiol 281 (2001) F966-F974
65. Escudero E., Martin A., Nieto M., Nieto E., Navarro E., Luque A., et al. Functional relevance of activated beta1 integrins in mercury-induced nephritis. J Am Soc Nephrol 11 (2000) 1075-1084
66. Evans W.H., De Vuyst E., and Leybaert L. The gap junction cellular internet: connexin hemichannels enter the signalling limelight. Biochem J 397 (2006) 1-14
67. Fanning A.S., Mitic L.L., and Anderson J.M. Transmembrane proteins in the tight junction barrier. J Am Soc Nephrol 10 (1999) 1337-1345
68. Fanning A.S., Ma T.Y., and Anderson J.M. Isolation and functional characterization of the actin binding region in the tight junction protein ZO-1. FASEB J 16 (2002) 1835-1837
69. Ferri K.F., and Kroemer G. Organelle-specific initiation of cell death pathways. Nat Cell Biol 3 (2001) E255-E263
70. Fish E.M., and Molitoris B.A. Alterations in epithelial polarity and the pathogenesis of disease states. N Engl J Med 330 (1994) 1580-1588
71. Frishberg Y., Meyers C.M., and Kelly C.J. Cyclosporine A regulates T cell-epithelial cell adhesion by altering LFA-1 and ICAM-1 expression. Kidney Int 50 (1996) 45-53
72. Fukumoto M., Kujiraoka T., Hara M., Shibasaki T., Hosoya T., and Yoshida M. Effect of cadmium on gap junctional intercellular communication in primary cultures of rat renal proximal tubular cells. Life Sci 69 (2001) 247-254
73. Furuse M., Sasaki H., and Tsukita S. Manner of interaction of heterogeneous claudin species within and between tight junction strands. J Cell Biol 147 (1999) 891-903
74. Furuse M., Furuse K., Sasaki H., and Tsukita S. Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cells. J Cell Biol 153 (2001) 263-272
75. Gagliano N., Torri C., Donetti E., Grizzi F., Costa F., Bertelli A.A., et al. Ochratoxin A-induced renal cortex fibrosis and epithelial-to-mesenchymal transition: molecular mechanisms of ochratoxin A-injury and potential effects of red wine. Mol Med 11 (2005) 30-38
76. Gailit J., Colflesh D., Rabiner I., Simone J., and Goligorsky M.S. Redistribution and dysfunction of integrins in cultured renal epithelial cells exposed to oxidative stress. Am J Physiol 264 (1993) F149-F157
77. Gallin W.J. Evolution of the "classical" cadherin family of cell adhesion molecules in vertebrates. Mol Biol Evol 15 (1998) 1099-1107
78. Gallin W.J., Edelman G.M., and Cunningham B.A. Characterization of L-CAM, a major cell adhesion molecule from embryonic liver cells. Proc Natl Acad Sci U S A 80 (1983) 1038-1042
79. Gauer S., Yao J., Schoecklmann H.O., and Sterzel R.B. Adhesion molecules in the glomerular mesangium. Kidney Int 51 (1997) 1447-1453
80. 2) injury. Kidney Int 58 (2000) 1121-1134
81. Gobe G.C., and Endre Z.H. Cell death in toxic nephropathies. Semin Nephrol 23 (2003) 416-424
82. Goering, P. L., Vaidya, V. S., Brown, R. P., Vikili, Z., Rosenzweig, B. A., Johnson, A. M. et al. (2006). Kidney injury molecule-1 (KIM-1) expression in kidney and urine following acute exposure to gentamicin and mercury. The Toxicologist CD - An Official Journal of the Society of Toxicology 90, Number S-1.
83. Goligorsky M.S., Lieberthal W., Racusen L., and Simon E.E. Integrin receptors in renal tubular epithelium: new insights into pathophysiology of acute renal failure. Am J Physiol 264 (1993) F1-F8
84. Gonzalez-Mariscal L., Betanzos A., Nava P., and Jaramillo B.E. Tight junction proteins. Prog Biophys Mol Biol 81 (2003) 1-44
85. Goodwin M., and Yap A.S. Classical cadherin adhesion molecules: coordinating cell adhesion, signaling and the cytoskeleton. J Mol Histol 35 (2004) 839-844
86. Goto S., Yaoita E., Matsunami H., Kondo D., Yamamoto T., Kawasaki K., et al. Involvement of R-cadherin in the early stage of glomerulogenesis. J Am Soc Nephrol 9 (1998) 1234-1241
87. Grunwald G.B. The conceptual and experimental foundations of vertebrate embryonic cell adhesion research. Dev Biol (N Y 1985) 7 (1991) 129-158
88. Grunwald G.B., Geller R.L., and Lilien J. Enzymatic dissection of embryonic cell adhesive mechanisms. J Cell Biol 85 (1980) 766-776
89. Han W.K., and Bonventre J.V. Biologic markers for the early detection of acute kidney injury. Curr Opin Crit Care 10 (2004) 476-482
90. Harhaj N.S., and Antonetti D.A. Regulation of tight junctions and loss of barrier function in pathophysiology. Int J Biochem Cell Biol 36 (2004) 1206-1237
91. Harriman J.F., and Schnellmann R.G. Mechanisms of Renal Cell Death. In: Tarloff J.B., and Lash L.H. (Eds). Toxicology of the Kidney. (Third ed.). (2005), CRC Press, Boca Raton 245-297
92. Harrington E.O., Brunelle J.L., Shannon C.J., Kim E.S., Mennella K., and Rounds S. Role of protein kinase C isoforms in rat epididymal microvascular endothelial barrier function. Am J Respir Cell Mol Biol 28 (2003) 626-636
93. Hazen-Martin D.J., Todd J.H., Sens M.A., Khan W., Bylander J.E., Smyth B.J., et al. Electrical and freeze-fracture analysis of the effects of ionic cadmium on cell membranes of human proximal tubule cells. Environ Health Perspect 101 (1993) 510-516
94. Hehlgans S., Haase M., and Cordes N. Signalling via integrins: implications for cell survival and anticancer strategies. Biochim Biophys Acta 1775 (2007) 163-180
95. Heicappell R. Cadherins in renal cell carcinoma. Anticancer Res 19 (1999) 1501-1504
96. Heinzelmann M., Mercer-Jones M.A., and Passmore J.C. Neutrophils and renal failure. Am J Kidney Dis 34 (1999) 384-399
97. Hengartner M.O. The biochemistry of apoptosis. Nature 407 (2000) 770-776
98. Hillis G.S., Duthie L.A., Mlynski R., McKay N.G., Mistry S., MacLeod A.M., et al. The expression of connexin 43 in human kidney and cultured renal cells. Nephron 75 (1997) 458-463
99. Hirano S., Sun X., DeGuzman C.A., Ransom R.F., McLeish K.R., Smoyer W.E., et al. p38 MAPK/HSP25 signaling mediates cadmium-induced contraction of mesangial cells and renal glomeruli. Am J Physiol Renal Physiol 288 (2005) F1133-F1143
100. Hirsch M., and Noske W. The tight junction: structure and function. Micron 24 (1993) 325-352
101. Holzman L.B., St John P.L., Kovari I.A., Verma R., Holthofer H., and Abrahamson D.R. Nephrin localizes to the slit pore of the glomerular epithelial cell. Kidney Int 56 (1999) 1481-1491
102. Homsy J.G., Jasper H., Peralta X.G., Wu H., Kiehart D.P., and Bohmann D. JNK signaling coordinates integrin and actin functions during Drosophila embryogenesis. Dev Dyn 235 (2006) 427-434
103. Hong M.E., Hong J.C., Stepkowski S., and Kahan B.D. Correlation between cyclosporine-induced nephrotoxicity in reduced nephron mass and expression of kidney injury molecule-1 and aquaporin-2 gene. Transplant Proc 37 (2005) 4254-4258
104. Horvath A., Upham B.L., Ganev V., and Trosko J.E. Determination of the epigenetic effects of ochratoxin in a human kidney and a rat liver epithelial cell line. Toxicon 40 (2002) 273-282
105. Hou J., Gomes A.S., Paul D.L., and Goodenough D.A. Study of claudin function by RNA interference. J Biol Chem 281 (2006) 36117-36123
106. Howarth A.G., and Stevenson B.R. Molecular environment of ZO-1 in epithelial and non-epithelial cells. Cell Motil Cytoskeleton 31 (1995) 323-332
107. Howarth A.G., Singer K.L., and Stevenson B.R. Analysis of the distribution and phosphorylation state of ZO-1 in MDCK and nonepithelial cells. J Membr Biol 137 (1994) 261-270
108. Hu W., Jones P.D., Upham B.L., Trosko J.E., Lau C., and Giesy J.P. Inhibition of gap junctional intercellular communication by perfluorinated compounds in rat liver and dolphin kidney epithelial cell lines in vitro and Sprague-Dawley rats in vivo. Toxicol Sci 68 (2002) 429-436
109. Huang Q., Dunn R.T., Jayadev S., DiSorbo O., Pack F.D., Farr S.B., et al. Assessment of cisplatin-induced nephrotoxicity by microarray technology. Toxicol Sci 63 (2001) 196-207
110. Huber A.H., Stewart D.B., Laurents D.V., Nelson W.J., and Weis W.I. The cadherin cytoplasmic domain is unstructured in the absence of beta-catenin. A possible mechanism for regulating cadherin turnover. J Biol Chem 276 (2001) 12301-12309
111. Hynes R.O. Integrins: bidirectional, allosteric signaling machines. Cell 110 (2002) 673-687
112. Ichimura T., Hung C.C., Yang S.A., Stevens J.L., and Bonventre J.V. Kidney injury molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury. Am J Physiol Renal Physiol 286 (2004) F552-F563
113. Igarashi P., Shashikant C.S., Thomson R.B., Whyte D.A., Liu-Chen S., Ruddle F.H., et al. Ksp-cadherin gene promoter: II. Kidney-specific activity in transgenic mice. Am J Physiol 277 (1999) F599-F610
114. Ihm C.G., Hong S.P., Park J.K., Ahn J.H., Lee T.W., and Kim M.J. Effects of cyclosporine on expression of adhesion molecules on mesangial and endothelial cells. Transplant Proc 28 (1996) 1228
115. Imamdi R., de Graauw M., and van de Water B. Protein kinase C mediates cisplatin-induced loss of adherens junctions followed by apoptosis of renal proximal tubular epithelial cells. J Pharmacol Exp Ther 311 (2004) 892-903
116. Inoue T., Yaoita E., Kurihara H., Shimizu F., Sakai T., Kobayashi T., et al. FAT is a component of glomerular slit diaphragms. Kidney Int 59 (2001) 1003-1012
117. Jacquillet G., Barbier O., Cougnon M., Tauc M., Namorado M.C., Martin D., et al. Zinc protects renal function during cadmium intoxication in the rat. Am J Physiol Renal Physiol 290 (2006) F127-F137
118. 2: distinct responses of Caco-2 and Madin-Darby canine kidney (MDCK) strains. Cell Mol Biol (Noisy-le-grand) 49 (2003) 101-112
119. Jiang J., McCool B.A., and Parrish A.R. Cadmium- and mercury-induced intercellular adhesion molecule-1 expression in immortalized proximal tubule cells: evidence for a role of decreased transforming growth factor-beta1. Toxicol Appl Pharmacol 179 (2002) 13-20
120. 2-induced nephrotoxicity. Toxicol Sci 80 (2004) 170-182
121. Jou T.S., Stewart D.B., Stappert J., Nelson W.J., and Marrs J.A. Genetic and biochemical dissection of protein linkages in the cadherin-catenin complex. Proc Natl Acad Sci U S A 92 (1995) 5067-5071
122. Juliano R.L. Signal transduction by cell adhesion receptors and the cytoskeleton: functions of integrins, cadherins, selectins, and immunoglobulin-superfamily members. Annu Rev Pharmacol Toxicol 42 (2002) 283-323
123. Jung K.Y., Dean D., Jiang J., Gaylor S., Griffith W.H., Burghardt R.C., et al. Loss of N-cadherin and alpha-catenin in the proximal tubules of aging male Fischer 344 rats. Mech Ageing Dev 125 (2004) 445-453
124. Kagami S., and Kondo S. Beta1-integrins and glomerular injury. J Med Invest 51 (2004) 1-13
125. Kaushal G.P., Basnakian A.G., and Shah S.V. Apoptotic pathways in ischemic acute renal failure. Kidney Int 66 (2004) 500-506
126. Kawachi H., Miyauchi N., Suzuki K., Han G.D., Orikasa M., and Shimizu F. Role of podocyte slit diaphragm as a filtration barrier. Nephrology (Carlton) 11 (2006) 274-281
127. Keller S.H., and Nigam S.K. Biochemical processing of E-cadherin under cellular stress. Biochem Biophys Res Commun 307 (2003) 215-223
128. Kelley V.R., and Singer G.G. The antigen presentation function of renal tubular epithelial cells. Exp Nephrol 1 (1993) 102-111
129. Kelly K.J., Williams Jr. W.W., Colvin R.B., and Bonventre J.V. Antibody to intercellular adhesion molecule 1 protects the kidney against ischemic injury. Proc Natl Acad Sci U S A 91 (1994) 812-816
130. Kelly K.J., Meehan S.M., Colvin R.B., Williams W.W., and Bonventre J.V. Protection from toxicant-mediated renal injury in the rat with anti-CD54 antibody. Kidney Int 56 (1999) 922-931
131. Kestila M., Lenkkeri U., Mannikko M., Lamerdin J., McCready P., Putaala H., et al. Positionally cloned gene for a novel glomerular protein-nephrin-is mutated in congenital nephrotic syndrome. Mol Cell 1 (1998) 575-582
132. Khoshnoodi J., Sigmundsson K., Ofverstedt L.G., Skoglund U., Obrink B., Wartiovaara J., et al. Nephrin promotes cell-cell adhesion through homophilic interactions. Am J Pathol 163 (2003) 2337-2346
133. Kiuchi-Saishin Y., Gotoh S., Furuse M., Takasuga A., Tano Y., and Tsukita S. Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments. J Am Soc Nephrol 13 (2002) 875-886
134. Koch A.W., Manzur K.L., and Shan W. Structure-based models of cadherin-mediated cell adhesion: the evolution continues. Cell Mol Life Sci 61 (2004) 1884-1895
135. Korhonen M., Ylanne J., Laitinen L., and Virtanen I. The alpha 1-alpha 6 subunits of integrins are characteristically expressed in distinct segments of developing and adult human nephron. J Cell Biol 111 (1990) 1245-1254
136. Korhonen M., Laitinen L., Ylanne J., Gould V.E., and Virtanen I. Integrins in developing, normal and malignant human kidney. Kidney Int 41 (1992) 641-644
137. Kowalczyk A.P., and Reynolds A.B. Protecting your tail: regulation of cadherin degradation by p120-catenin. Curr Opin Cell Biol 16 (2004) 522-527
138. Kriz W., and Kaissling B. Structural organization of the mammalian kidney. In: Seldin D.W., and Giebisch G. (Eds). The Kidney: Physiology and Pathophysiology (2000), Lippincott, Williams and Wilkins, Philadelphia 587-654
139. Kroemer G., and Reed J.C. Mitochondrial control of cell death. Nat Med 6 (2000) 513-519
140. Kuroda N., Guo L., Toi M., Naruse K., Miyazaki E., Hayashi Y., et al. Paxillin: application of immunohistochemistry to the diagnosis of chromophobe renal cell carcinoma and oncocytoma. Appl Immunohistochem Mol Morphol 9 (2001) 315-318
141. Kwon O., Nelson W.J., Sibley R., Huie P., Scandling J.D., Dafoe D., et al. Backleak, tight junctions, and cell-cell adhesion in postischemic injury to the renal allograft. J Clin Invest 101 (1998) 2054-2064
142. Lag M., Refsnes M., Lilleaas E.M., Holme J.A., Becher R., and Schwarze P.E. Role of mitogen activated protein kinases and protein kinase C in cadmium-induced apoptosis of primary epithelial lung cells. Toxicology 211 (2005) 253-264
143. Le T.L., Joseph S.R., Yap A.S., and Stow J.L. Protein kinase C regulates endocytosis and recycling of E-cadherin. Am J Physiol Cell Physiol 283 (2002) C489-C499
144. Leussink B.T., Litvinov S.V., de Heer E., Slikkerveer A., van der Voet G.B., Bruijn J.A., et al. Loss of homotypic epithelial cell adhesion by selective N-cadherin displacement in bismuth nephrotoxicity. Toxicol Appl Pharmacol 175 (2001) 54-59
145. Lieberthal W., Koh J.S., and Levine J.S. Necrosis and apoptosis in acute renal failure. Semin Nephrol 18 (1998) 505-518
146. Linas S.L., Whittenburg D., Parsons P.E., and Repine J.E. Ischemia increases neutrophil retention and worsens acute renal failure: role of oxygen metabolites and ICAM 1. Kidney Int 48 (1995) 1584-1591
147. Liu J., and Waalkes M. Focal adhesion kinase as a potential target in arsenic toxicity. Toxicol Sci 84 (2005) 212-213
148. Long G.J. The effect of cadmium on cytosolic free calcium, protein kinase C, and collagen synthesis in rat osteosarcoma (ROS 17/2 8) cells. Toxicol Appl Pharmacol 143 (1997) 189-195
149. Lui W.Y., Wong C.H., Mruk D.D., and Cheng C.Y. TGF-beta3 regulates the blood-testis barrier dynamics via the p38 mitogen activated protein (MAP) kinase pathway: an in vivo study. Endocrinology 144 (2003) 1139-1142
150. Lutz K.L., and Siahaan T.J. Molecular structure of the apical junction complex and its contribution to the paracellular barrier. J Pharm Sci 86 (1997) 977-984
151. Mally A., and Chipman J.K. Non-genotoxic carcinogens: early effects on gap junctions, cell proliferation and apoptosis in the rat. Toxicology 180 (2002) 233-248
152. Mally A., Decker M., Bekteshi M., and Dekant W. Ochratoxin A alters cell adhesion and gap junction intercellular communication in MDCK cells. Toxicology 223 (2006) 15-25
153. Mampaso F., Marcen R., Molina A., Pascual J., Martin A., and Bricio T. Expression of adhesion molecules in allograft renal dysfunction: a distinct diagnostic pattern in rejection and cyclosporine nephrotoxicity. Transplant Proc 26 (1994) 2859-2860
154. Mandel L.J., Doctor R.B., and Bacallao R. ATP depletion: a novel method to study junctional properties in epithelial tissues: II. Internalization of Na+, K(+)-ATPase and E-cadherin. J Cell Sci 107 Pt 12 (1994) 3315-3324
155. Marin-Kuan M., Nestler S., Verguet C., Bezencon C., Piguet D., Mansourian R., et al. A toxicogenomics approach to identify new plausible epigenetic mechanisms of ochratoxin a carcinogenicity in rat. Toxicol Sci 89 (2006) 120-134
156. Martinez-Palomo A., Meza I., Beaty G., and Cereijido M. Experimental modulation of occluding junctions in a cultured transporting epithelium. J Cell Biol 87 (1980) 736-745
157. Matlin K.S., and Caplan M.J. Epithelial cell structure and polarity. In: Seldin D.W., and Giebisch G. (Eds). The Kidney: Physiology and Pathophysiology (2000), Lippincott, Williams and Wilkins, Philadelphia 533-567
158. Matsuoka M., and Call K.M. Cadmium-induced expression of immediate early genes in LLC-PK1 cells. Kidney Int 48 (1995) 383-389
159. Maunsbach A.B. Functional ultrastructure of the proximal tubule. In: Windhagen E.E. (Ed). Handbook of Physiology (1992), Oxford University Press, New York 41-108
160. Mays R.W., Nelson W.J., and Marrs J.A. Generation of epithelial cell polarity: roles for protein trafficking, membrane-cytoskeleton, and E-cadherin-mediated cell adhesion. Cold Spring Harb Symp Quant Biol 60 (1995) 763-773
161. McCulloch F., Chambrey R., Eladari D., and Peti-Peterdi J. Localization of connexin 30 in the luminal membrane of cells in the distal nephron. Am J Physiol Renal Physiol 289 (2005) F1304-F1312
162. McMorrow T., Gaffney M.M., Slattery C., Campbell E., and Ryan M.P. Cyclosporine A induced epithelial-mesenchymal transition in human renal proximal tubular epithelial cells. Nephrol Dial Transplant 20 (2005) 2215-2225
163. Meyer T.N., Schwesinger C., Ye J., Denker B.M., and Nigam S.K. Reassembly of the tight junction after oxidative stress depends on tyrosine kinase activity. J Biol Chem 276 (2001) 22048-22055
164. Meza I., Ibarra G., Sabanero M., Martinez-Palomo A., and Cereijido M. Occluding junctions and cytoskeletal components in a cultured transporting epithelium. J Cell Biol 87 (1980) 746-754
165. Molina A., Sanchez-Madrid F., Bricio T., Martin A., Barat A., Alvarez V., et al. Prevention of mercuric chloride-induced nephritis in the brown Norway rat by treatment with antibodies against the alpha 4 integrin. J Immunol 153 (1994) 2313-2320
166. Molitoris B.A. Ischemia-induced loss of epithelial polarity: potential role of the actin cytoskeleton. Am J Physiol 260 (1991) F769-F778
167. Molitoris B.A. Putting the actin cytoskeleton into perspective: pathophysiology of ischemic alterations. Am J Physiol 272 (1997) F430-F433
168. Molitoris B.A., and Marrs J. The role of cell adhesion molecules in ischemic acute renal failure. Am J Med 106 (1999) 583-592
169. Molitoris B.A., and Wagner M.C. Surface membrane polarity of proximal tubular cells: alterations as a basis for malfunction. Kidney Int 49 (1996) 1592-1597
170. Molitoris B.A., Wilson P.D., Schrier R.W., and Simon F.R. Ischemia induces partial loss of surface membrane polarity and accumulation of putative calcium ionophores. J Clin Invest 76 (1985) 2097-2105
171. Molitoris B.A., Falk S.A., and Dahl R.H. Ischemia-induced loss of epithelial polarity. Role of the tight junction. J Clin Invest 84 (1989) 1334-1339
172. Molitoris B.A., Sandoval R., and Sutton T.A. Endothelial injury and dysfunction in ischemic acute renal failure. Crit Care Med 30 (2002) S235-S240
173. Morgan G., Pearson J.D., and Sepulveda F.V. Absence of gap junctional complexes in two established renal epithelial cell lines (LLC-PK1 and MDCK). Cell Biol Int Rep 8 (1984) 917-922
174. Muller U., and Brandli A.W. Cell adhesion molecules and extracellular-matrix constituents in kidney development and disease. J Cell Sci 112 Pt 22 (1999) 3855-3867
175. Muller U., Wang D., Denda S., Meneses J.J., Pedersen R.A., and Reichardt L.F. Integrin alpha8beta1 is critically important for epithelial-mesenchymal interactions during kidney morphogenesis. Cell 88 (1997) 603-613
176. Myers B.D., Chui F., Hilberman M., and Michaels A.S. Transtubular leakage of glomerular filtrate in human acute renal failure. Am J Physiol 237 (1979) F319-F325
177. Nakopoulou L., Lazaris A.C., Boletis I.N., Michail S., Giannopoulou I., Zeis P.M., et al. Evaluation of E-cadherin/catenin complex in primary and secondary glomerulonephritis. Am J Kidney Dis 39 (2002) 469-474
178. Nelson W.J., and Nusse R. Convergence of Wnt, beta-catenin, and cadherin pathways. Science 303 (2004) 1483-1487
179. Niessen C.M., and Yap A.S. Another job for the talented p120-catenin. Cell 127 (2006) 875-877
180. Nieto E., Escudero E., Navarro E., Yanez-Mo M., Martin A., Perez de Lema G., et al. Effects of mycophenolate mofetil in mercury-induced autoimmune nephritis. J Am Soc Nephrol 13 (2002) 937-945
181. Niewenhuis R.J., Dimitriu C., and Prozialeck W.C. Ultrastructural characterization of the early changes in intercellular junctions in response to cadmium (Cd2+) exposure in LLC-PK1 cells. Toxicol Appl Pharmacol 142 (1997) 1-12
182. Nikolic-Paterson D.J., and Atkins R.C. The role of macrophages in glomerulonephritis. Nephrol Dial Transplant 16 Suppl 5 (2001) 3-7
183. Noguchi M., Nomata K., Watanabe J., Kanetake H., and Saito Y. Changes in the gap junctional intercellular communication in renal tubular epithelial cells in vitro treated with renal carcinogens. Cancer Lett 122 (1998) 77-84
184. Nolan C.V., and Shaikh Z.A. The vascular endothelium as a target tissue in acute cadmium toxicity. Life Sci 39 (1986) 1403-1409
185. Nollet F., Kools P., and van Roy F. Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. J Mol Biol 299 (2000) 551-572
186. Nony P.A., and Schnellmann R.G. Interactions between collagen IV and collagen-binding integrins in renal cell repair after sublethal injury. Mol Pharmacol 60 (2001) 1226-1234
187. Nony P.A., and Schnellmann R.G. Mechanisms of renal cell repair and regeneration after acute renal failure. J Pharmacol Exp Ther 304 (2003) 905-912
188. Nouwen E.J., Dauwe S., van der Biest I., and de Broe M.E. Stage- and segment-specific expression of cell-adhesion molecules N-CAM, A-CAM, and L-CAM in the kidney. Kidney Int 44 (1993) 147-158
189. Novak A., Hsu S.C., Leung-Hagesteijn C., Radeva G., Papkoff J., Montesano R., et al. Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways. Proc Natl Acad Sci U S A 95 (1998) 4374-4379
190. Nurko S., Sogabe K., Davis J.A., Roeser N.F., Defrain M., Chien A., et al. Contribution of actin cytoskeletal alterations to ATP depletion and calcium-induced proximal tubule cell injury. Am J Physiol 270 (1996) F39-F52
191. Oliver J., MacDowell M., and Tracy A. The pathogenesis of acute renal failure associated with traumatic and toxic injury; renal ischemia, nephrotoxic damage and the ischemic episode. J Clin Invest 30 (1951) 1307-1439
192. Ozawa M., and Kemler R. Molecular organization of the uvomorulin-catenin complex. J Cell Biol 116 (1992) 989-996
193. Padanilam B.J. Cell death induced by acute renal injury: a perspective on the contributions of apoptosis and necrosis. Am J Physiol Renal Physiol 284 (2003) F608-F627
194. Parrish A.R. Adhesion molecules in renal physiology and pathology. In: Tarloff J.B., and Lash L.H. (Eds). Toxicology of the Kidney (2005), CRC Press, Boca Raton, FL 475-498
195. Pavenstadt H., Kriz W., and Kretzler M. Cell biology of the glomerular podocyte. Physiol Rev 83 (2003) 253-307
196. Pearson C.A., and Prozialeck W.C. E-cadherin, beta-catenin and cadmium carcinogenesis. Med Hypotheses 56 (2001) 573-581
197. Perantoni A.O. Cell adhesion molecules in the kidney: from embryo to adult. Exp Nephrol 7 (1999) 80-102
198. Perez-Rojas J., Blanco J.A., Cruz C., Trujillo J., Vaidya V.S., Uribe N., et al. Mineralocorticoid receptor blockade confers renoprotection in preexisting chronic cyclosporine nephrotoxicity. Am J Physiol Renal Physiol 292 (2007) F131-F139
199. Petruzzelli L., Takami M., and Humes H.D. Structure and function of cell adhesion molecules. Am J Med 106 (1999) 467-476
200. Peyrieras N., Hyafil F., Louvard D., Ploegh H.L., and Jacob F. Uvomorulin: a nonintegral membrane protein of early mouse embryo. Proc Natl Acad Sci U S A 80 (1983) 6274-6277
201. Pfaller W., and Gstraunthaler G. Nephrotoxicity testing in vitro-what we know and what we need to know. Environ Health Perspect 106 Suppl 2 (1998) 559-569
202. Piepenhagen P.A., and Nelson W.J. Differential expression of cell-cell and cell-substratum adhesion proteins along the kidney nephron. Am J Physiol 269 (1995) C1433-C1449
203. Piepenhagen P.A., and Nelson W.J. Biogenesis of polarized epithelial cells during kidney development in situ: roles of E-cadherin-mediated cell-cell adhesion and membrane cytoskeleton organization. Mol Biol Cell 9 (1998) 3161-3177
204. Piepenhagen P.A., Peters L.L., Lux S.E., and Nelson W.J. Differential expression of Na(+)-K(+)-ATPase, ankyrin, fodrin, and E-cadherin along the kidney nephron. Am J Physiol 269 (1995) C1417-C1432
205. Price V.R., Reed C.A., Lieberthal W., and Schwartz J.H. ATP depletion of tubular cells causes dissociation of the zonula adherens and nuclear translocation of beta-catenin and LEF-1. J Am Soc Nephrol 13 (2002) 1152-1161
206. Prozialeck W.C. Evidence that E-cadherin may be a target for cadmium toxicity in epithelial cells. Toxicol Appl Pharmacol 164 (2000) 231-249
207. Prozialeck W.C., and Lamar P.C. Cadmium (Cd2+) disrupts E-cadherin-dependent cell-cell junctions in MDCK cells. In Vitro Cell Dev Biol Anim 33 (1997) 516-526
208. Prozialeck W.C., and Lamar P.C. Interaction of cadmium (Cd(2+)) with a 13-residue polypeptide analog of a putative calcium-binding motif of E-cadherin. Biochim Biophys Acta 1451 (1999) 93-100
209. Prozialeck W.C., and Lamar P.C. Cadmium nephrotoxicity is associated with a loss of N-cadherin-mediated adhesion and alterations in epithelial polarity in the proximal tubule. Toxicol Sci 84 (2005) S327
210. Prozialeck W.C., and Niewenhuis R.J. Cadmium (Cd2+) disrupts Ca(2+)-dependent cell-cell junctions and alters the pattern of E-cadherin immunofluorescence in LLC-PK1 cells. Biochem Biophys Res Commun 181 (1991) 1118-1124
211. Prozialeck W.C., and Niewenhuis R.J. Cadmium (Cd2+) disrupts intercellular junctions and actin filaments in LLC-PK1 cells. Toxicol Appl Pharmacol 107 (1991) 81-97
212. Prozialeck W.C., Lamar P.C., and Ikura M. Binding of cadmium (Cd2+) to E-CAD1, a calcium-binding polypeptide analog of E-cadherin. Life Sci 58 (1996) L325-L330
213. Prozialeck W.C., Lamar P.C., and Lynch S.M. Cadmium alters the localization of N-cadherin, E-cadherin, and beta-catenin in the proximal tubule epithelium. Toxicol Appl Pharmacol 189 (2003) 180-195
214. Prozialeck W.C., Lamar P.C., and Appelt D.M. Differential expression of E-cadherin, N-cadherin and beta-catenin in proximal and distal segments of the rat nephron. BMC Physiol 4 (2004) 10
215. Prozialeck W.C., Edwards J.R., Lamar P.C., and Smith C.S. Epithelial barrier characteristics and expression of cell adhesion molecules in proximal tubule-derived cell lines commonly used for in vitro toxicity studies. Toxicol In Vitro 20 (2006) 942-953
216. Prozialeck W.C., Edwards J.R., and Woods J.M. The vascular endothelium as a target of cadmium toxicity. Life Sci 79 (2006) 1493-1506
217. Prozialeck W.C., Vaidya V.S., Johnson A.M., Liu J., Waalkes M.P., Edwards J.R., et al. Kidney injury molecule-1 (Kim-1) as an early biomarker of cadmium (Cd) nephrotoxicity. Toxicol Sci 90 (2006) S340
218. Rabb H., Mendiola C.C., Saba S.R., Dietz J.R., Smith C.W., Bonventre J.V., et al. Antibodies to ICAM-1 protect kidneys in severe ischemic reperfusion injury. Biochem Biophys Res Commun 211 (1995) 67-73
219. Rabb H., O'Meara Y.M., Maderna P., Coleman P., and Brady H.R. Leukocytes, cell adhesion molecules and ischemic acute renal failure. Kidney Int 51 (1997) 1463-1468
220. Rabito C.A. Occluding junctions in a renal cell line (LLC-PK1) with characteristics of proximal tubular cells. Am J Physiol 250 (1986) F734-F743
221. Rabito C.A., Tchao R., Valentich J., and Leighton J. Distribution and characteristics of the occluding junctions in a monolayer of a cell line (MDCK) derived from canine kidney. J Membr Biol 43 (1978) 351-365
222. Racusen L.C. Alterations in human proximal tubule cell attachment in response to hypoxia: role of microfilaments. J Lab Clin Med 123 (1994) 357-364
223. Racusen L.C. The histopathology of acute renal failure. New Horiz 3 (1995) 662-668
224. Racusen L.C., Fivush B.A., Li Y.L., Slatnik I., and Solez K. Dissociation of tubular cell detachment and tubular cell death in clinical and experimental "acute tubular necrosis". Lab Invest 64 (1991) 546-556
225. Radice G.L., Ferreira-Cornwell M.C., Robinson S.D., Rayburn H., Chodosh L.A., Takeichi M., et al. Precocious mammary gland development in P-cadherin-deficient mice. J Cell Biol 139 (1997) 1025-1032
226. Rao R.K., Basuroy S., Rao V.U., Karnaky Jr. K.J., and Gupta A. Tyrosine phosphorylation and dissociation of occludin-ZO-1 and E-cadherin-beta-catenin complexes from the cytoskeleton by oxidative stress. Biochem J 368 (2002) 471-481
227. Raschperger E., Thyberg J., Pettersson S., Philipson L., Fuxe J., and Pettersson R.F. The coxsackie- and adenovirus receptor (CAR) is an in vivo marker for epithelial tight junctions, with a potential role in regulating permeability and tissue homeostasis. Exp Cell Res 312 (2006) 1566-1580
228. Reiser J., Kriz W., Kretzler M., and Mundel P. The glomerular slit diaphragm is a modified adherens junction. J Am Soc Nephrol 11 (2000) 1-8
229. Reyes J.L., Lamas M., Martin D., del Carmen N.M., Islas S., Luna J., et al. The renal segmental distribution of claudins changes with development. Kidney Int 62 (2002) 476-487
230. Rhyu D.Y., Yang Y., Ha H., Lee G.T., Song J.S., Uh S.T., et al. Role of reactive oxygen species in TGF-beta1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells. J Am Soc Nephrol 16 (2005) 667-675
231. Rincon J., Parra G., Quiroz Y., Benatuil L., and Rodriguez-Iturbe B. Cyclosporin A reduces expression of adhesion molecules in the kidney of rats with chronic serum sickness. Clin Exp Immunol 121 (2000) 391-398
232. Rocco M.V., Neilson E.G., Hoyer J.R., and Ziyadeh F.N. Attenuated expression of epithelial cell adhesion molecules in murine polycystic kidney disease. Am J Physiol 262 (1992) F679-F686
233. Romare A., and Lundholm C.E. Cadmium-induced calcium release and prostaglandin E2 production in neonatal mouse calvaria are dependent on cox-2 induction and protein kinase C activation. Arch Toxicol 73 (1999) 223-228
234. Ronzitti G., Callegari F., Malaguti C., and Rossini G.P. Selective disruption of the E-cadherin-catenin system by an algal toxin. Br J Cancer 90 (2004) 1100-1107
235. Rosson D., O'Brien T.G., Kampherstein J.A., Szallasi Z., Bogi K., Blumberg P.M., et al. Protein kinase C-alpha activity modulates transepithelial permeability and cell junctions in the LLC-PK1 epithelial cell line. J Biol Chem 272 (1997) 14950-14953
236. Roy-Chaudhury P., Hillis G., McDonald S., Simpson J.G., and Power D.A. Importance of the tubulointerstitium in human glomerulonephritis. II. Distribution of integrin chains beta 1, alpha 1 to 6 and alpha V. Kidney Int 52 (1997) 103-110
237. Sabolic I. Common mechanisms in nephropathy induced by toxic metals. Nephron Physiol 104 (2006) 107-114
238. Sabolic I., Herak-Kramberger C.M., and Brown D. Subchronic cadmium treatment affects the abundance and arrangement of cytoskeletal proteins in rat renal proximal tubule cells. Toxicology 165 (2001) 205-216
239. Saenz-Morales D., Escribese M.M., Stamatakis K., Garcia-Martos M., Alegre L., Conde E., et al. Requirements for proximal tubule epithelial cell detachment in response to ischemia: role of oxidative stress. Exp Cell Res 312 (2007) 3717-3727
240. Sandoval R.M., Dunn K.W., and Molitoris B.A. Gentamicin traffics rapidly and directly to the Golgi complex in LLC-PK(1) cells. Am J Physiol Renal Physiol 279 (2000) F884-F890
241. Sandoval R.M., Bacallao R.L., Dunn K.W., Leiser J.D., and Molitoris B.A. Nucleotide depletion increases trafficking of gentamicin to the Golgi complex in LLC-PK1 cells. Am J Physiol Renal Physiol 283 (2002) F1422-F1429
242. Schick C.S., and Haller C. Comparative cytotoxicity of ionic and non-ionic radiocontrast agents on MDCK cell monolayers in vitro. Nephrol Dial Transplant 14 (1999) 342-347
243. Schick C.S., Bangert R., Kubler W., and Haller C. Ionic radiocontrast media disrupt intercellular contacts via an extracellular calcium-independent mechanism. Exp Nephrol 10 (2002) 209-215
244. Schmelz M., Schmid V.J., and Parrish A.R. Selective disruption of cadherin/catenin complexes by oxidative stress in precision-cut mouse liver slices. Toxicol Sci 61 (2001) 389-394
245. Schneeberger E.E., and Lynch R.D. The tight junction: a multifunctional complex. Am J Physiol Cell Physiol 286 (2004) C1213-C1228
246. Schwartz M.A., and Ginsberg M.H. Networks and crosstalk: integrin signalling spreads. Nat Cell Biol 4 (2002) E65-E68
247. Scott R., Aughey E., and Sinclair J. Histological and ultrastructural changes in rat kidney following cadmium injection. Urol Res 5 (1977) 15-20
248. Sepulveda J.L., and Wu C. The parvins. Cell Mol Life Sci 63 (2006) 25-35
249. Shankland S.J. The podocyte's response to injury: role in proteinuria and glomerulosclerosis. Kidney Int 69 (2006) 2131-2147
250. Shelden E.A., Weinberg J.M., Sorenson D.R., Edwards C.A., and Pollock F.M. Site-specific alteration of actin assembly visualized in living renal epithelial cells during ATP depletion. J Am Soc Nephrol 13 (2002) 2667-2680
251. Shimazui T., Oosterwijk-Wakka J., Akaza H., Bringuier P.P., Ruijter E., Debruyne F.M., et al. Alterations in expression of cadherin-6 and E-cadherin during kidney development and in renal cell carcinoma. Eur Urol 38 (2000) 331-338
252. Singbartl K., and Ley K. Leukocyte recruitment and acute renal failure. J Mol Med 82 (2004) 91-101
253. Sinha D., Wang Z., Price V.R., Schwartz J.H., and Lieberthal W. Chemical anoxia of tubular cells induces activation of c-Src and its translocation to the zonula adherens. Am J Physiol Renal Physiol 284 (2003) F488-F497
254. Steinhusen U., Weiske J., Badock V., Tauber R., Bommert K., and Huber O. Cleavage and shedding of E-cadherin after induction of apoptosis. J Biol Chem 276 (2001) 4972-4980
255. Sundin D.P., Sandoval R., and Molitoris B.A. Gentamicin inhibits renal protein and phospholipid metabolism in rats: implications involving intracellular trafficking. J Am Soc Nephrol 12 (2001) 114-123
256. Taal M.W., Omer S.A., Nadim M.K., and Mackenzie H.S. Cellular and molecular mediators in common pathway mechanisms of chronic renal disease progression. Curr Opin Nephrol Hypertens 9 (2000) 323-331
257. Takada M., Nadeau K.C., Shaw G.D., Marquette K.A., and Tilney N.L. The cytokine-adhesion molecule cascade in ischemia/reperfusion injury of the rat kidney inhibition by a soluble P-selectin ligand. J Clin Invest 99 (1997) 2682-2690
258. Takeichi M. Cadherins: a molecular family important in selective cell-cell adhesion. Annu Rev Biochem 59 (1990) 237-252
259. Tam F.W. Role of selectins in glomerulonephritis. Clin Exp Immunol 129 (2002) 1-3
260. Tamagiku Y., Sonoda Y., Kunisawa M., Ichikawa D., Murakami Y., Aizu-Yokota E., et al. Down-regulation of procaspase-8 expression by focal adhesion kinase protects HL-60 cells from TRAIL-induced apoptosis. Biochem Biophys Res Commun 323 (2004) 445-452
261. Tani T., Laitinen L., Kangas L., Lehto V.P., and Virtanen I. Expression of E- and N-cadherin in renal cell carcinomas, in renal cell carcinoma cell lines in vitro and in their xenografts. Int J Cancer 64 (1995) 407-414
262. Thomson R.B., and Aronson P.S. Immunolocalization of Ksp-cadherin in the adult and developing rabbit kidney. Am J Physiol 277 (1999) F146-F156
263. Thomson R.B., Igarashi P., Biemesderfer D., Kim R., Abu-Alfa A., Soleimani M., et al. Isolation and cDNA cloning of Ksp-cadherin, a novel kidney-specific member of the cadherin multigene family. J Biol Chem 270 (1995) 17594-17601
264. Thukral S.K., Nordone P.J., Hu R., Sullivan L., Galambos E., Fitzpatrick V.D., et al. Prediction of nephrotoxicant action and identification of candidate toxicity-related biomarkers. Toxicol Pathol 33 (2005) 343-355
265. Timoshanko J.R., and Tipping P.G. Resident kidney cells and their involvement in glomerulonephritis. Curr Drug Targets Inflamm Allergy 4 (2005) 353-362
266. Tipping P.G., and Timoshanko J. Contributions of intrinsic renal cells to crescentic glomerulonephritis. Nephron Exp Nephrol 101 (2005) e173-e178
267. Trosko J.E., Madhukar B.V., and Chang C.C. Endogenous and exogenous modulation of gap junctional intercellular communication: toxicological and pharmacological implications. Life Sci 53 (1993) 1-19
268. Troussard A.A., Tan C., Yoganathan T.N., and Dedhar S. Cell-extracellular matrix interactions stimulate the AP-1 transcription factor in an integrin-linked kinase- and glycogen synthase kinase 3-dependent manner. Mol Cell Biol 19 (1999) 7420-7427
269. Turksen K., and Troy T.C. Barriers built on claudins. J Cell Sci 117 (2004) 2435-2447
270. Uchio-Yamada K., Manabe N., Yamaguchi M., Akashi N., Goto Y., Yamamoto Y., et al. Localization of extracellular matrix receptors in ICGN mice, a strain of mice with hereditary nephrotic syndrome. J Vet Med Sci 63 (2001) 1171-1178
271. Umeda K., Ikenouchi J., Katahira-Tayama S., Furuse K., Sasaki H., Nakayama M., et al. ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation. Cell 126 (2006) 741-754
272. Vaaraniemi J., Huotari V., Lehto V.P., and Eskelinen S. The effects of PMA and TFP and alterations in intracellular pH and calcium concentration on the membrane associations of phospholipid-binding proteins fodrin, protein kinase C and annexin II in cultured MDCK cells. Biochim Biophys Acta 1189 (1994) 21-30
273. Vaidya V.S., Ramirez V., Ichimura T., Bobadilla N.A., and Bonventre J.V. Urinary kidney injury molecule-1: a sensitive quantitative biomarker for early detection of kidney tubular injury. Am J Physiol Renal Physiol 290 (2006) F517-F529
274. van de Water B., de Graauw M., Le Devedec S., and Alderliesten M. Cellular stress responses and molecular mechanisms of nephrotoxicity. Toxicol Lett 162 (2006) 83-93
275. Versteilen A.M., Di Maggio F., Leemreis J.R., Groeneveld A.B., Musters R.J., and Sipkema P. Molecular mechanisms of acute renal failure following ischemia/reperfusion. Int J Artif Organs 27 (2004) 1019-1029
276. Verstrepen W.A., Nouwen E.J., Yue X.S., and de Broe M.E. Altered growth factor expression during toxic proximal tubular necrosis and regeneration. Kidney Int 43 (1993) 1267-1279
277. Verstrepen W.A., Nouwen E.J., Zhu M.Q., Ghielli M., and de Broe M.E. Time course of growth factor expression in mercuric chloride acute renal failure. Nephrol Dial Transplant 10 (1995) 1361-1371
278. Vestweber D., Kemler R., and Ekblom P. Cell-adhesion molecule uvomorulin during kidney development. Dev Biol 112 (1985) 213-221
279. Vickers A.E., Rose K., Fisher R., Saulnier M., Sahota P., and Bentley P. Kidney slices of human and rat to characterize cisplatin-induced injury on cellular pathways and morphology. Toxicol Pathol 32 (2004) 577-590
280. Wagner M.C., and Molitoris B.A. Renal epithelial polarity in health and disease. Pediatr Nephrol 13 (1999) 163-170
281. Weaver V.M., Lelievre S., Lakins J.N., Chrenek M.A., Jones J.C., Giancotti F., et al. beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell 2 (2002) 205-216
282. Weidner W.J., Waddell D.S., and Sillman A.J. Low levels of cadmium chloride alter the immunoprecipitation of corneal cadherin-complex proteins. Arch Toxicol 74 (2000) 578-581
283. Weis W.I., and Nelson W.J. Re-solving the cadherin-catenin-actin conundrum. J Biol Chem 281 (2006) 35593-35597
284. White L., Blanchette J., Ren L., Awn A., Trpkov K., and Muruve D. The characterization of {alpha}5-integrin expression on tubular epithelium during renal injury. Am J Physiol Renal Physiol 292 (2007) F567-F576
285. Whyte D.A., Li C., Thomson R.B., Nix S.L., Zanjani R., Karp S.L., et al. Ksp-cadherin gene promoter: I. Characterization and renal epithelial cell-specific activity. Am J Physiol 277 (1999) F587-F598
286. Wijesekera D.S., Zarama M.J., and Paller M.S. Effects of integrins on proliferation and apoptosis of renal epithelial cells after acute injury. Kidney Int 52 (1997) 1511-1520
287. Wong V. Phosphorylation of occludin correlates with occludin localization and function at the tight junction. Am J Physiol 273 (1997) C1859-C1867
288. Wu Z., Nybom P., and Magnusson K.E. Distinct effects of Vibrio cholerae haemagglutinin/protease on the structure and localization of the tight junction-associated proteins occludin and ZO-1. Cell Microbiol 2 (2000) 11-17
289. Xiao K., Oas R.G., Chiasson C.M., and Kowalczyk A.P. Role of p120-catenin in cadherin trafficking. Biochim Biophys Acta 1773 (2007) 8-16
290. Yagil Y., Myers B.D., and Jamison R.L. Course and pathogenesis of postischemic acute renal failure in the rat. Am J Physiol 255 (1988) F257-F264
291. Yamada S., Pokutta S., Drees F., Weis W.I., and Nelson W.J. Deconstructing the cadherin-catenin-actin complex. Cell 123 (2005) 889-901
292. Yancy S.L., Shelden E.A., Gilmont R.R., and Welsh M.J. Sodium arsenite exposure alters cell migration, focal adhesion localization and decreases tyrosine phosphorylation of focal adhesion kinase in H9C2 myoblasts. Toxicol Sci 84 (2005) 278-286
293. Yaoita E., Sato N., Yoshida Y., Nameta M., and Yamamoto T. Cadherin and catenin staining in podocytes in development and puromycin aminonucleoside nephrosis. Nephrol Dial Transplant 17 Suppl 9 (2002) 16-19
294. Yaoita E., Kurihara H., Yoshida Y., Inoue T., Matsuki A., Sakai T., et al. Role of Fat1 in cell-cell contact formation of podocytes in puromycin aminonucleoside nephrosis and neonatal kidney. Kidney Int 68 (2005) 542-551
295. Yap A.S., Brieher W.M., and Gumbiner B.M. Molecular and functional analysis of cadherin-based adherens junctions. Annu Rev Cell Dev Biol 13 (1997) 119-146
296. Ysebaert D.K., De Greef K.E., Vercauteren S.R., Ghielli M., Verpooten G.A., Eyskens E.J., et al. Identification and kinetics of leukocytes after severe ischaemia/reperfusion renal injury. Nephrol Dial Transplant 15 (2000) 1562-1574
297. Yuan S.Y. Protein kinase signaling in the modulation of microvascular permeability. Vascul Pharmacol 39 (2002) 213-223
298. Yuen P.S., Jo S.K., Holly M.K., Hu X., and Star R.A. Ischemic and nephrotoxic acute renal failure are distinguished by their broad transcriptomic responses. Physiol Genomics 25 (2006) 375-386
299. Zalups R.K., and Ahmad S. Molecular handling of cadmium in transporting epithelia. Toxicol Appl Pharmacol 186 (2003) 163-188
300. Zhang L., Bewick M., and Lafrenie R.M. Role of Raf-1 and FAK in cell density-dependent regulation of integrin-dependent activation of MAP kinase. Carcinogenesis 23 (2002) 1251-1258
301. Zhang F., Tom C.C., Kugler M.C., Ching T.T., Kreidberg J.A., Wei Y., et al. Distinct ligand binding sites in integrin alpha3beta1 regulate matrix adhesion and cell-cell contact. J Cell Biol 163 (2003) 177-188
302. Zimmerhackl L.B., Mesa H., Kramer F., Kolmel C., Wiegele G., and Brandis M. Tubular toxicity of cyclosporine A and the influence of endothelin-1 in renal cell culture models (LLC-PK1 and MDCK). Pediatr Nephrol 11 (1997) 778-783
303. Zimmerhackl L.B., Momm F., Wiegele G., and Brandis M. Cadmium is more toxic to LLC-PK1 cells than to MDCK cells acting on the cadherin-catenin complex. Am J Physiol 275 (1998) F143-F153