Understanding Renal Toxicity of Heavy Metals

Toxicologic Pathology

Volumn 26, Issue 1, 1998, Pages 92-103

  Diamond, Gary L ^a   Zalups, Rudolfs K ^b  

^a SYRACUSE RESEARCH CORPORATION   (United States)

^b MERCER UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Albumin; cadmium; cysteine; glutathione; kidney; mercury; metallothionein; nephrotoxicity; organic anion; p aminohippurate; transport; uranium

Indexed keywords

GAMMA GLUTAMYLTRANSFERASE; MERCURIC CHLORIDE; URANIUM;

CELL TYPE; CELL ULTRASTRUCTURE; CELLULAR DISTRIBUTION; CONFERENCE PAPER; HUMAN; MEMBRANE TRANSPORT; METAL BINDING; NEPHROTOXICITY; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

ANIMALS; BIOLOGICAL TRANSPORT; DOGS; GLOMERULAR FILTRATION RATE; GLUTATHIONE; KIDNEY DISEASES; KIDNEY GLOMERULUS; KIDNEY TUBULES, DISTAL; KIDNEY TUBULES, PROXIMAL; METALS, HEAVY; MICE; RABBITS; RATS; SUBSTRATE SPECIFICITY;

EID: 0031936594     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1177/019262339802600111     Document Type: Article

References (125)

1. Addya A, Chakravanti K, Basu A, Santa M, Haldar S, and Chatterjee GC (1984). Effects of mercuric chloride on several scavenging enzymes in rat kidney and influence of vitamin E supplementation. Acta Vitaminol. Enzymol. 6: 103-107.
2. Adler SG, Wang H, Ward HJ, Cohen AH, and Border WA (1983). Electrical charge. Its role in the pathogenesis and prevention of experimental membranous nephropathy in the rabbit. J. Clin. Invest. 71: 487-499.
3. Alco MD, Taum ML, Olson JR, Nickerson PA, and Kostyniak PJ (1987). Cellular uptake and response of primary cultures of rabbit renal proximal tubule cells exposed to mercuric chloride and methylmercury chloride. In: In Vitro Toxicology: Approaches to Validation, AM Goldberg (ed). Mary Ann Liebert, New York, pp. 211–226.
4. Anner BM and Moosmayer M (1992). Mercury inhibits Na–K ATPase primarily at the cytosolic side. Am. J. Physiol. 262: F843–F848.
5. Anner BM, Moosmayer M, and Imesch E (1992). Mercury blocks Na–K-ATPase by a ligand-dependent reversible mechanism. Am. J. Physiol. 262: F830–F836.
6. Avasti PS, Evan AP, and Hay D (1980). Glomerular endothelial cells in uranyl nitrate-induced acute renal failure in rats. J. Clin. Invest. 65: 121-127.
7. Barfuss DW, Ganapathy V, and Leibach FH (1988). Evidence for active dipeptide transport in isolated proximal straight tubules. Am. J. Physiol. 255: F177–F181.
8. Barfuss DW, Robinson MK, and Zalups RK (1990). Inorganic mercury transport in the proximal tubule of the rabbit. J. Am. Soc. Nephrol. 1: 910-917.
9. Bergstrand A, Friberg L, Mendel L, and Odeblad E (1959). The localization of subcutaneously administered radioactive mercury in the rat kidney. J. Ultrastruct. Res. 3: 238-239.
10. Berndt WO, Baggett JMcC, Blacker A, and Houser M (1985). Renal glutathione and mercury uptake by kidney. Fundam. Appl. Toxicol. 5: 832-839.
11. Bigazzi PE (1992). Lessons from animal models: The scope of mercury-induced autoimmunity. Clin. Immunol. Immunopathol. 65: 81-84.
12. Blantz RC (1977). The mechanisms of acute renal failure after uranyl nitrate. J. Clin. Invest. 55: 621-635.
13. Border WA, Ward HJ, Kami ES, and Cohen AH (1982). Induction of membranous nephropathy in rabbits by administration of an exogenous cationic antigen. J. Clin. Invest. 69: 451-461.
14. Brenner BM, Troy JL, and Daugharty TM (1971). The dynamics of glomerular filtration in the rat. J. Clin. Invest. 50: 1776-1789.
15. Brown JR and Shockley P (1982). Serum albumin: Structure and characterization of its ligand binding sites. In: Lipid-Protein Interactions, Vol. 1, PC Jost and OH Griffith (eds). Wiley, New York, pp. 25–68.
16. Cain K and Holt DE (1983). Studies of cadmium-thionein induced nephropathy: Time course of cadmium-thionein uptake and degradation. Chem.-Biol. Interact. 43: 223-237.
17. Cember H, Gallagher P, and Faulkner A (1968). Distribution of mercury among blood fractions and serum proteins. Am. Ind. Hyg. Assoc. J. 29: 233-237.
18. Chan HM, Satoh M, Zalups RK, and Cherian MG (1992). Exogenous metallothionein and renal toxicity of cadmium and mercury in rats. Toxicology 76: 15-26.
19. Chavez E and Holguin JA (1988). Mitochondrial calcium release induced by Hg2+. J. Biol. Chem. 283: 3581-3587.
20. Chavez E, Zazueta C, Osornio A, Holguin JA, and Miranda ME (1991). Protective behavior of captopril on Hg++-induced toxicity on kidney mitochondria. In vivo and in vitro experiments. J. Pharmacol. Exp. Ther. 256: 385-390.
21. Cherian MG, Goyer RA, and DeLaquerriere-Rechardson L (1976). Cadmium–metallothionein induced nephropathy. Toxicol. Appl. Pharmacol 38: 399-408.
22. Chung A-S, Maines MD, and Reynolds WA (1982). Inhibition of the enzymes of glutathione metabolism by mercuric chloride in the rat kidney: Reversal by selenium. Biochem. Pharmacol. 31: 3093-3100.
23. Cohen JJ and Kamm DE (1981). Renal metabolism: Relation to renal function. In: The Kidney, BM Brenner and FC Rector (eds). WB Saunders, Philadelphia, pp. 144–248.
24. Dass PD, Misra RP, and Welbourne TC (1981). Presence of γ-glutamyltransferase in the renal microvascular compartment. Can. J. Biochem. 59: 383-386.
25. de Ceaurriz J, Pyan JP, Morel G, and Brondeau MT (1994). Role of extracellular glutathione and γ-glutamyltranspeptidase in the disposition and kidney toxicity of mercury. J. Appl. Toxicol. 14: 201-206.
26. Diamond GL (1989). Biological consequences of exposure to soluble forms of natural uranium. Radial. Protect. Dosim. 26: 23-33.
27. Diamond GL, Morrow PE, Panner BJ, Gelein RM, and Baggs RB (1989). Reversible uranyl fluoride nephrotoxicity in the Long Evans rat. Fund. Appl. Toxicol. 13: 65-78.
28. Dobyan DC, Levi J, Jacobs C, Kosek J, and Weiner MW (1980). Mechanism of cis-platinum nephrotoxicity. II. Morphologic observations. J. Pharmacol. Exp. Ther. 213: 551-562.
29. Druet P, Druet E, Potdevin F, and Sapin C (1978). Immune type glomerulonephritis induced by HgCl2 in the Brown-Norway rat. Ann. Immunol. (Inst. Pasteur) 129C: 777-792.
30. Enestrom S and Hultman P (1984). Immune-mediated glomerularnephritis induced by mercuric chloride in mice. Experientia 40: 1234-1240.
31. Enestrom S and Hultman P (1992). Dose-response studies in murine mercury-induced autoimmunity and immune-complex disease. Toxicol. Appl. Pharmacol. 113: 199-208.
32. Felley-Bosco E and Diezi J (1987). Fate of cadmium in rat renal tubules: A microinjection study. Toxicol. Appl. Pharmacol. 91: 204-211.
33. Flamenbaum W (1973). Pathophysiology of acute renal failure. Arch. Intern. Med. 131: 911-928.
34. Flamenbaum W, Huddleston ML, McNeil JS, and Hamburger RJ (1974). Uranyl nitrite-induced acute renal failure in the rat: Micropuncture and hemodynamic studies. Kidney Int. 6: 408-418.
35. Flamenbaum W, McNeil JS, Kotchen TA, and Saladino AJ (1972). Experimental acute renal failure induced by uranyl nitrate in the dog. Circ. Res. 31: 682-697.
36. Foulkes EC (1971). Glomerular filtration and renal plasma flow in uranium poisoned rabbits. Toxicol. Appl. Pharmacol. 20: 380-385.
37. Foulkes EC (1978). Renal tubular transport of Cd–metallothionein. Toxicol. Appl. Pharmacol. 45: 505-512.
38. Fuhr BJ and Rabenstein DL (1973). Nuclear magnetic-resonance studies of solution chemistry of metal-complexes. 9. Binding of cadmium, zinc, lead and mercury by glutathione. J. Am. Chem. Soc. 95: 6944-6950.
39. Fukino H, Hirai M, Hsueh YM, Moriyasu S, and Yamane Y (1986). Mechanism of protection by zinc against mercuric chloride toxicity in rats: Effects of zinc and mercury on glutathione metabolism. J. Toxicol. Environ. Health 19: 75-89.
40. Fukino H, Hirai M, Hsueh YM, and Yamane Y (1984). Effect of zinc pretreatment on mercuric chloride-induced lipid peroxidation in the rat kidney. Toxicol. Appl. Pharmacol. 73: 395-401.
41. Girardi C and Elias MM (1991). Effectiveness of N-acctylcysteine in protecting against mercuric chloride-induced nephrotoxicity. Toxicology 67: 155-164.
42. Gstraunthaler C, Pfaller W, and Kotankp P (1983). Glutathione depletion and in vitro lipid peroxidation in mercury or maleate-induced acute renal failure. Biochem. Pharmacol. 32: 2969-2972.
43. Haley DP (1982). Morphologic changes in uranyl nitrate-induced acute renal failure in saline-and water-drinking rats. Lab. Invest. 46: 196-208.
44. Haley DP, Bulger RE, and Dobyan DC (1982). The long-term effect of uranyl nitrate on the structure and function of the rat kidney. Virchows Arch. (Cell Pathol.) 4: 181-192.
45. Heinle H and Wendel A (1977). The activities of the key enzymes of the γ-glutamyl cycle in microdissected segments of the rat nephron. FEBS Lett. 73: 220-224.
46. Hodge HC (1973). A history of uranium poisoning. In: Uranium, Plutonium, Transplutonic Elements, HC Hodge, JN Stannard, and JB Hursh (eds). Springer-Verlag, New York, pp. 5–68.
47. Hultman P and Enestrom S (1986). Localization of mercury in the kidney during experimental acute renal tubular necrosis studied by the cytochemical silver amplification method. Br. J. Exp. Pathol. 67: 493-503.
48. Hultman P and Enestrom S (1992). Dose–response studies in murine mercury-induced autoimmunity and immune-complex disease. Toxicol. Appl. Pharmacol. 113: 199-208.
49. Hultman P, Enestrom S, and von Schenck H (1985). Renal handling of inorganic mercury in mice. The early excretion phase following a single intravenous injection of mercuric chloride studies by the silver amplification method. Virchows Arch. (Cell Pathol.) 49: 209-224.
50. Imesch E, Moosmayer M, and Anner BM (1992). Mercury weakens membrane anchoring of Na–K ATPase. Am. J. Physiol. 262: F837–F842.
51. Jocelyn PC (1972). Biochemistry of the SH Group. Academic Press, London.
52. Jung KY, Uchida S, and Edou H (1989). Nephrotoxicity assessment by measuring cellular ATP content. I. Substrate specificities in the maintenance of ATP content in isolated rat nephron segments. Toxicol. Appl. Pharmacol. 100: 369-382.
53. Kagi JHR and Nordberg GF (1979). Metallothionein. Beerkhauser Verlag, Basel.
54. Kagi JHR and Vallee BL (1961). Metallothionein: A cadmium and zinc-containing protein from equine cortex. II. Physiochemical properties. J. Biol. Chem. 236: 2435-2442.
55. Kajikawa K, Nakanishi I, and Kudoa K (1981). Morphological changes in the kidney and bone of rats in chronic cadmium poisoning. Exp. Mol. Pathol. 34: 9-24
56. Kobayashi S, Nagase M, Honda N, and Hishida A (1984). Glomerular alterations in uranyl acetate-induced acute renal failure in rabbits. Kidney Int. 26: 808-815
57. Lash LH and Anders MW (1989). Uptake of nephrotoxic S-conjugates by isolated proximal tubule cells. J. Pharmacol. Exp. Ther. 248: 531-537.
58. Lash LH and Jones DP (1983). Transport of glutathione by renal glutathione by renal basal-lateral membrane vesicles. Biochem. Biophys. Commun. 112: 55-60.
59. Lash LH and Jones DP (1984). Renal glutathione transport: Characteristics of the sodium-dependent system in the basal-lateral membrane. J. Biol. Chem. 259: 14508-14514.
60. Lash LH and Jones DP (1985). Distribution of oxidized and reduced forms of glutathione and cysteine in rat plasma. Arch. Biochem. Biophys. 240: 583-592.
61. Lash LH and Zalups RK (1992). Mercuric chloride-induced cytotoxicity and compensatory hypertrophy in rat kidney proximal tubular cells. J. Pharmacol. Exp. Ther. 261: 819-829.
62. Lash LH and Zalups RK (1996). Alterations in renal cellular glutathione metabolism after in vivo administration of a subtoxic dose of mercuric chloride. J. Biochem. Toxicol. 11: 1-9.
63. Leach U, Gelein RM, Panner BJ, Yuile CL, Cox CC, Balys MM, and Rolchigo PM (1984). The acute toxicity of the hydrolysis products of uranium hexafluoride when inhaled by the rat and guinea pig. Department of Energy Report K/SUB/81-9039/3.
64. Leach U, Yuile CL, Hodge HC, Sylvester GE, and Wilson HB (1973). A five-year inhalation study with natural uranium dioxide (UO2) dust. II. Postexposure retention and biologic effects in the monkey, dog and rat. Health Phys. 25: 239-258.
65. Lund B-O, Miller DM, and Woods JS (1991). Mercury-induced H2O2 production and lipid peroxidation in vitro in rat kidney mitochondria. Biochem. Pharmacol. 42(suppl.): S181–S187.
66. Lund, B.-O., Miller DM, and Woods JS (1993). Studies in Hg(II)-induced H2O2 formation and oxidative stress in vivo and in vitro in rat kidney mitochondria. Biochem. Pharmacol. 45: 2017-2024.
67. Maack T (1992). Renal handling of proteins and polypeptides. In: Handbook of Physiology, Section 8, Renal Physiology, Vol. 2, EE Windhager (ed). Oxford University Press, New York, pp. 2039–2082.
68. Madsen KM (1980). Mercury accumulation in kidney lysosomes of proteinuric rats. Kidney Int. 18: 445-453.
69. Madsen KM and Christensen EL (1978). Effects of mercury on lysosomal protein digestion in the kidney proximal tubule. Lab. Invest. 38: 165-174.
70. Madsen KM and Hansen JC (1980). Subcellular distribution of mercury in the rat kidney cortex after exposure to mercuric chloride. Toxicol. Appl. Pharmacol. 54: 443-453.
71. Malvin RL and Wilde MS (1973). Stop-flow technique. In: Handbook of Physiology, Section 8, Renal Physiology, Vol. 1, J Orloff and RW Berliner (eds). American Physiology Society, Washington, DC, pp. 119–128.
72. Mason J, Olbricht C, Takabatake T, and Thurau K (1977). The early phase of experimental acute renal failure. I. Intratubule pressure and obstruction. Pflugers Arch. 370: 155-163.
73. McDowell EM, Nagle RB, Zalme RC, McNeil JS, Flamenbaum W, and Trump BF (1976). Studies of the pathophysiology of acute renal failure. I. Correlation of ultrastructure and function in the proximal tubule of the rat following administration of mercuric chloride. Virchows Arch. (Cell Pathol.) 22: 173-196.
74. Morrow PE, Leach L, Smith FA, Gelein RM, Scott JM, Beiter HD, Amato FJ, Picano JJ, Yule CL, and Consler TG (1981). Metabolic fate and evaluation of injury in rats and dogs following exposure to the hydrolysis products of uranium hexafluoride. U.S. Nuclear Regulatory Commission Report NUREG/CR-2268.
75. Murakami M and Webb M (1981). A morphological and biochemical study of the effects of l-cysteine on the renal uptake and nephrotoxicity of cadmium. Br. J. Exp. Pathol. 62: 115-130.
76. Nizet A (1981). Influence of uranyl nitrate upon tubular reabsorption and glomerular filtration in blood perfused isolated dog kidneys. Pflugers Arch. 391: 296-300.
77. Nomiyama K and Foulkes EC (1968). Some effects of uranyl acetate on proximal tubular function in rabbit kidney. Toxicol. Appl. Pharmacol. 13: 89-98.
78. Nordberg GF, Goyer R, and Nordberg M (1975). Comparative toxicity of cadmium–metallothionein and cadmium chloride on mouse kidney. Arch. Pathol. 99: 192-197.
79. Oken DE, Cotes SC, and Mende CW (1972). Micropuncture study of tubular transport of albumin in rats with aminonucleoside nephrosis. Kidney Int. 1: 3-11.
80. Pesce AJ and First MR (1979). Proteinuria: An Integrated Review. Marcel Dekker, New York, pp. 5–31.
81. Rabenstein DL (1989). Metal complexes of glutathione and their biological significance. In: Glutathione: Chemical, Biochemical and Medical Aspects. Coenzymes and Cofactors, Vol 3, D Dolphin, O Auramovbic, and R Poulson (eds). Wiley, New York, pp. 147–186.
82. Rodier PM, Kates B, and Simons R (1988). Mercury localization in mouse kidney over time: Audoradiography versus silver staining. Toxicol. Appl. Pharmacol. 257: 235-245.
83. Roman-Franco AA, Turiello M, Albini B, Ossi E, Milgrom F, and Andres GA (1978). Anti-basement membrane antibodies and antigen–antibody complexes in rabbits injected with mercuric chloride. Clin. Immunol. Immunopathol. 9: 464-481.
84. Rothstein A (1970). Sulfhydryl groups in membrane structure and function. Curr. Top. Membr. Transp. 1: 135-176.
85. Ruegg CE, Gandolfi AJ, Nagle RB, and Brendel K (1987). Differential patterns of injury to the proximal tubule of renal cortical slices following in vitro exposure to mercuric chloride, potassium dichromate, or hypoxic conditions. Toxicol. Appl. Pharmacol. 90: 261-271.
86. Sapin C, Druet E, and Druet P (1977). Induction of anti-glomerular basement membrane antibodies in the Brown-Norway rat by mercuric chloride. Clin. Exp. Immunol. 28: 173-179.
87. Smith MW, Ambudkar IS, Phelps PC, Regec AL, and Trump BF (1987). HgCl2-induced changes in cytosolic Ca2+ of cultured rabbit renal tubular cells. Biochim. Biophys. Acta 931: 130-142.
88. Spater HW, Poruchynsky MS, Quintana N, Inoue M, and Novikoff AB (1982). Immunocytochemical localization of γ-glutamyltransferase in rat kidney with protein A-horseradish peroxidase. Proc. Natl. Acad. Sci. USA 79: 3547-3550.
89. Squibb KS, Riddlington JW, Carmichael NG, and Folwer BA (1979). Early cellular effects of circulating cadmium–thionein on proximal tubules. Environ. Health Perspect. 28: 287-296.
90. Stein JH, Gottschall J, Osgood W, and Ferris TF (1975). Pathophysiology of a nephrotoxic model of acute renal failure. Kidney Int. 6: 27-41.
91. Sudo M, Honda N, Hishida A, and Nagase M (1977). Renal hemodynamics in uranyl acetate-induced actute renal failure in of rabbits. Kidney Int. 11: 35-43.
92. Tanaka T, Naganuma A, and Imura N (1990). Role of γ-glutamyltranspeptidase in renal uptake and toxicity of inorganic mercury in mice. Toxicology 60: 187-198.
93. Tanaka-Kagawa T, Naganuma A, and Imura N (1993). Tubular secretion and reabsorption of mercury compounds in mouse kidney. J. Pharmacol. Exp. Ther. 264: 776-782.
94. Taugner R, Winkel K, and Iravani J (1966). Zur lokalization der sublimatanreicherung in der ratenniere. Virchows Arch. Pathol. Anat. Physiol. 340: 369-383.
95. Webb M and Etienne T (1977). Studies on the toxicity and metabolism of Cd–thionein. Biochem. Pharmacol. 26: 25-30.
96. Weening JJ, Hoedemaefer PJ, and Bakker WW (1981). Imuno-regulation and anti-nuclear antibodies in mercury-induced glomerulopathy in the rat. Clin. Exp. Immunol. 45: 64-71.
97. Weinberg JM, Harding PG, and Humes HD (1982). Mitochondrial bioenergetics during the initiation of mercuric chloride-induced renal injury. I. Direct effects of in vitro mercuric chloride on renal cortical mitochondrial function. J. Biol. Chem. 257: 60-67.
98. Weinberg JM, Harding PG, and Humes HD (1982). Mitochondrial bioenergetics during the initiation of mercuric chloride-induced renal injury. II. Functional alterations of renal cortical mitochondria isolated after mercuric chloride treatment. J. Biol. Chem. 257: 68-74.
99. Wilson CD and Dixon FJ (1986). The renal response to immunological injury. In: The Kidney, BM Brenner and FC Rector (eds). WB Saunders, Philadelphia, pp. 800–889.
100. Woods JS, Calas CA, and Aicher LD (1990). Stimulation of porphyrinogen oxidation by mercuric ion. II. Promotion of oxidation from the interaction of mercuric ion by glutathione, and mitochondrial-generated hydrogen peroxide. Mol. Pharmacol. 38: 261-266.
101. Woods JS, Calas CA, Aicher LD, Robinson BH, and Mailer C (1990). Stimulation of porphyrinogen oxidation by mercuric ion. I. Evidence of free radical formation in the presence of thiols and hydrogen peroxide. Mol. Pharmacol. 38: 253-260.
102. Zalme RC, McDowell EM, Nagle RB, McNeil JS, Flamenbaum W, and Trump BF (1976). Studies of the pathophysiology of acute renal failure. II. A histochemical study of the proximal tubule of the rat following administration of mercuric chloride. Virchows Arch. (Cell Pathol.) 22: 197-216.
103. Zalups RK (1991). Autometallographic localization of inorganic mercury in the kidneys of rats: Effect of unilateral nephrectomy and compensatory renal growth. Exp. Mol. Pathol. 54: 10-21.
104. Zalups RK (1993). Early aspects of the intrarenal distribution of mercury after the intravenous administration of mercuric chloride. Toxicology 79: 215-228.
105. Zalups RK (1995). Organic anion transport and action of γ-glutamyl transpeptidase in kidney linked mechanistically to renal tubular uptake of inorganic mercury. Toxicol. Appl. Pharmacol. 132: 289-298.
106. Zalups RK (1997). Enhanced renal outer medullary uptake of mercury associated with unilateral nephrectomy: Implication of a luminal mechanism. J. Toxicol. Environ. Health 50: 173-194.
107. Zalups RK and Barfuss D (1990). Accumulation of inorganic mercury along the renal proximal tubule of the rabbit. Toxicol. Appl. Pharmacol. 106: 245-253.
108. Zalups RK and Barfuss D (1995). Accumulation and handling of inorganic mercury in the kidney after coadministration with glutathione. J. Toxicol. Environ. Health 44: 385-399.
109. Zalups RK and Barfuss D (1995). Renal disposition of mercury in rats after intravenous injection of inorganic mercury and cysteine. J. Toxicol. Environ. Health 44: 401-413.
110. Zalups RK and Barfuss D (1996). Nephrotoxicity of inorganic mercury co-administered with L-cysteine. Toxicology 109: 15-29.
111. Zalups RK and Cherian MG (1992). Renal metallothionein metabolism after a reduction of renal mass. I. Effect of unilateral nephrectomy and compensatory renal growth on basal and metal-induced renal metallothionein metabolism. Toxicology 73: 81-102.
112. Zalups RK and Cherian MG (1992). Renal metallothionein metabolism after a reduction of renal mass. II. Effect of zinc pre-treatment on the renal toxicity and intrarenal accumulation of inorganic mercury. Toxicology 71: 103-117.
113. Zalups RK, Cherian MG, and Barfuss DW (1995). Mercury-metallothionein and the renal accumulation and handling of mercury. Toxciology 83: 61-78.
114. Zalups RK, Cherian MG, and Barfuss DW (1995). Lack of luminal or basolateral uptake and transepithelial transport of mercury in isolated perfused proximal tubules exposed to mercury-metallothionein. J. Toxicol. Environ. Health 44: 101-113.
115. Zalups RK, Cox C, and Diamond GL (1988). Histological and urinalysis assessment of nephrotoxicity induced by mercuric chloride in normal and uninephrectomized rats. In: Biological Monitoring of Toxic Metals, TW Clarkson, L Friberg, GF Nordberg, and PR Sager (eds). Plenum, New York, pp. 531–545.
116. Zalups RK and Diamond GL (1987). Mercuric chloride-induced nephrotoxicity in the rat following unilateral nephrectomy and compensatory renal growth. Virchows Arch. B 53: 336-346.
117. Zalups RK, Knutson KL, and Schnellman RC (1993). In vitro analysis of the accumulation and toxicity of inorganic mercury in segments of the proximal tubule isolated from the rabbit kidney. Toxicol. Appl. Pharmacol. 116: 221-227.
118. Zalups RK and Lash LH (1990). Effects of uninephrectomy and mercuric chloride on renal glutathione homeostasis. J. Pharmacol. Exp. Ther. 254: 962-970.
119. Zalups RK and Lash LH (1994). Advances in understanding the renal transport and toxicity of mercury. J. Toxicol. Ind. Health 42: 1-44.
120. Zalups RK and Lash LH (1996). Interactions between glutathione and mercury in the kidney, liver and blood. In: Toxicology of Metals, LW Chang (ed). CRC Lewis Publishers, New York, pp. 145–163.
121. Zalups RF and Lash LH (1997). Depletion of glutathione in the kidney and the renal disposition of administered inorganic mercury. Drug. Metab. Disp 25: 516-523.
122. Zalups RK and Lash LH (1997). Binding of mercury in renal brush-border and basolateral membrane-vesicles. Implication of a cysteine conjugate of mercury involved in the luminal uptake of inorganic mercury in the kidney. Biochem. Pharmacol. 53: 1889-1900.
123. Zalups RK and Minor KH (1995). Luminal and basolateral mechanisms involved in the renal tubular uptake of inorganic mercury. J. Toxicol. Environ. Health 46: 73-100.
124. Zalups RK, Robinson MK, and Barfuss DW (1991). Factors affecting inorganic mercury transport and toxicity in the isolated perfused tubule. J. Am. Soc. Nephrol. 2: 866-878.
125. Zalups RK and Veltman JC (1988). Renal glutathione homeostasis in compensatory renal growth. Life Sci 42: 2171-2176.