Gentamicin traffics rapidly and directly to the Golgi complex in LLC-PK1 cells

American Journal of Physiology - Renal Physiology

Volumn 279, Issue 5 48-5, 2000, Pages

  Sandoval, Ruben M ^a   Dunn, Kenneth W ^a   Molitoris, Bruce A ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aminoglycosides; Lysosomal fluorescence quenching; Nephrotoxicity

Indexed keywords

AGGLUTININ; GENTAMICIN; LECTIN; SPHINGOSINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CELL STRAIN; CLINICAL PATHWAY; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG TRANSPORT; FLUORESCENCE; GOLGI COMPLEX; KIDNEY EPITHELIUM; KINETICS; LYSOSOME; NEPHROTOXICITY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN SYNTHESIS;

EID: 0033725157     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.2000.279.5.f884     Document Type: Article

References (24)

1. Subcellular distribution of gentamicin in proximal tubular cells, determined by imunogold labeling
2. Microsomal protein synthesis inhibition: An early manifestation of gentamicin nephrotoxicity
3. Gentamicin administered in vivo reduces protein synthesis in microsomes subsequently isolated from rat kidney but not from rat brain
4. Aminoglycoside nephorotoxicity in cirrhosis
5. Iterative fractionation of recycling receptors from lysosomally destined ligands in an early sorting endosome
6. 1 lysosomes and alter cell function
7. Multivesicular endosomes containing internalized EGF-EGF receptor complexes mature and then fuse directly with lysosomes
8. Toxin entry: Retrograde transport through the secretory pathway
9. Evidence that epithelial Glycoprotein 330/Megalin mediates uptake of polybasic drugs
10. Intracellular distribution of gentamicin within the rat kidney cortex: A cell fractionation study
11. Apical and basolateral endosomes of MDCK cells are interconnected and contain a polarized sorting mechanism
12. A fluorescent derivative of ceramide: Physical properties and use in studying the Golgi apparatus of animal cells
13. Affinity cytochemical differentiation of glycoconjugates of small intestine absorptive cells using Pisum sativum and Lens culinaris lectins
14. Photoconversion of some fluorescent markers to a diaminobenzidine product
15. 1 cells
16. Retrograde transport from the Golgi complex to the ER of both Shiga toxin and the nontoxic Shiga b-fragment is regulated by butyric acid and cAMP
17. Importance of glycolipid synthesis for butyric acid-induced sensitization to Shiga toxin and intracellular sorting of toxin in A 431 cells
18. Identification of aminoglycoside binding site in rat renal brush border membranes
19. Comparative nephrotoxicity of gentamicin and tobramycin: Pharmacokinetic and clinical studies in 201 patients
20. Computer reconstruction in three-dimensional fluorescence microscopy
21. Autoradiography of gentamicin uptake by the rat proximal tubule cell
22. Mild ischemia predisposes the S3 segment of the proximal tubule to acute gentamicin toxicity
23. Transport of gentamicin in rat proximal tubule
24. Distribution of gentamicin among subcellular fractions from rat renal cortex