메뉴 건너뛰기




Volumn 312, Issue 19, 2006, Pages 3711-3727

Requirements for proximal tubule epithelial cell detachment in response to ischemia: Role of oxidative stress

Author keywords

Actin cytoskeleton; Adherens junctions; Cell adhesion; Focal adhesion complexes; Hypoxia reoxygenation; RhoGTPases; ROS

Indexed keywords

ACETYLCYSTEINE; ACTIN; ANTIOXIDANT; BETA CATENIN; COLLAGEN TYPE 4; FOCAL ADHESION KINASE 1; HYDROGEN PEROXIDE; MANGANESE SUPEROXIDE DISMUTASE; PAXILLIN; PROTEIN ZO1; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UVOMORULIN;

EID: 33750395930     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2006.05.024     Document Type: Article
Times cited : (39)

References (55)
  • 1
    • 3242811296 scopus 로고    scopus 로고
    • Acute renal failure: definitions, diagnosis, pathogenesis, and therapy
    • Schrier R.W., Wang W., Poole B., and Mitra A. Acute renal failure: definitions, diagnosis, pathogenesis, and therapy. J. Clin. Invest. 114 (2004) 5-14
    • (2004) J. Clin. Invest. , vol.114 , pp. 5-14
    • Schrier, R.W.1    Wang, W.2    Poole, B.3    Mitra, A.4
  • 2
    • 0031691367 scopus 로고    scopus 로고
    • Mechanisms of cellular injury in ischemic acute renal failure
    • Sutton T.A., and Molitoris B.A. Mechanisms of cellular injury in ischemic acute renal failure. Semin. Nephrol. 18 5 (1998) 490-497
    • (1998) Semin. Nephrol. , vol.18 , Issue.5 , pp. 490-497
    • Sutton, T.A.1    Molitoris, B.A.2
  • 3
    • 0033679661 scopus 로고    scopus 로고
    • Modeling ischemia in vitro: selective depletion of adenine and guanine nucleotide pools
    • Dagher P.C. Modeling ischemia in vitro: selective depletion of adenine and guanine nucleotide pools. Am. J. Physiol.: Cell Physiol. 279 (2000) C1270
    • (2000) Am. J. Physiol.: Cell Physiol. , vol.279
    • Dagher, P.C.1
  • 4
    • 3242808973 scopus 로고    scopus 로고
    • Actin cytoskeleton in ischemic acute renal failure
    • Molitoris B.A. Actin cytoskeleton in ischemic acute renal failure. Kidney Int. 66 (2004) 871-883
    • (2004) Kidney Int. , vol.66 , pp. 871-883
    • Molitoris, B.A.1
  • 5
    • 0037069690 scopus 로고    scopus 로고
    • Rho GTPases in cell biology
    • Etienne-Manneville S., and Hall A. Rho GTPases in cell biology. Nature 420 (2002) 629-635
    • (2002) Nature , vol.420 , pp. 629-635
    • Etienne-Manneville, S.1    Hall, A.2
  • 6
    • 0033039738 scopus 로고    scopus 로고
    • Rho controls actin cytoskeletal assembly in renal epithelial cells during ATP depletion and recovery
    • Raman N., and Atkinson S.J. Rho controls actin cytoskeletal assembly in renal epithelial cells during ATP depletion and recovery. Am. J. Physiol.: Cell Physiol. 276 (1999) C1312-C1324
    • (1999) Am. J. Physiol.: Cell Physiol. , vol.276
    • Raman, N.1    Atkinson, S.J.2
  • 7
    • 0038679291 scopus 로고    scopus 로고
    • Rho GTPases show differential sensitivity to nucleotide triphosphate depletion in a model of ischemic cell injury
    • Hallett M.A., Dagher P.C., and Atkinson S.J. Rho GTPases show differential sensitivity to nucleotide triphosphate depletion in a model of ischemic cell injury. Am. J. Physiol.: Cell Physiol. 285 (2003) C129-C138
    • (2003) Am. J. Physiol.: Cell Physiol. , vol.285
    • Hallett, M.A.1    Dagher, P.C.2    Atkinson, S.J.3
  • 8
    • 5344242464 scopus 로고    scopus 로고
    • Kidney ischemia-reperfusion regulates expression and distribution of tubulin subunits, beta-actin and rho GTPases in proximal tubules
    • Caron A., Desrosiers R., and Beliveau R. Kidney ischemia-reperfusion regulates expression and distribution of tubulin subunits, beta-actin and rho GTPases in proximal tubules. Arch. Biochem. Biophys. 134 (2004) 31-46
    • (2004) Arch. Biochem. Biophys. , vol.134 , pp. 31-46
    • Caron, A.1    Desrosiers, R.2    Beliveau, R.3
  • 9
    • 0035516140 scopus 로고    scopus 로고
    • Transmembrane crosstalk between the extracellular matrix-cytoskeleton crosstalk
    • Geiger B., Bershadsky A., Pankov R., and Yamada K.M. Transmembrane crosstalk between the extracellular matrix-cytoskeleton crosstalk. Nat. Rev., Mol. Cell Biol. 2 (2001) 793-805
    • (2001) Nat. Rev., Mol. Cell Biol. , vol.2 , pp. 793-805
    • Geiger, B.1    Bershadsky, A.2    Pankov, R.3    Yamada, K.M.4
  • 11
    • 0034970924 scopus 로고    scopus 로고
    • Energetic determinants of tyrosine phosphorylation of focal adhesion proteins during hypoxia/reoxygenation of kidney proximal tubules
    • Weinberg J.M., Venkatachalam M.A., Roeser N.F., Senter R.A., and Nissim I. Energetic determinants of tyrosine phosphorylation of focal adhesion proteins during hypoxia/reoxygenation of kidney proximal tubules. Am. J. Pathol. 158 (2001) 2153-2164
    • (2001) Am. J. Pathol. , vol.158 , pp. 2153-2164
    • Weinberg, J.M.1    Venkatachalam, M.A.2    Roeser, N.F.3    Senter, R.A.4    Nissim, I.5
  • 13
    • 0034116268 scopus 로고    scopus 로고
    • Selective degradation of E-cadherin and dissolution of E-cadherin-catenin complexes in epithelial ischemia
    • Bush K.T., Tsukamoto T., and Nigam S.K. Selective degradation of E-cadherin and dissolution of E-cadherin-catenin complexes in epithelial ischemia. Am. J. Physiol.: Renal Physiol. 278 (2000) F847-F852
    • (2000) Am. J. Physiol.: Renal Physiol. , vol.278
    • Bush, K.T.1    Tsukamoto, T.2    Nigam, S.K.3
  • 14
  • 16
    • 0030946064 scopus 로고    scopus 로고
    • Tight junctions proteins form large complexes associate with the cytoskeleton in an ATP depletion model for reversible junction assembly
    • Tsukamoto T., and Nigam S.J. Tight junctions proteins form large complexes associate with the cytoskeleton in an ATP depletion model for reversible junction assembly. J. Biol. Chem. 272 (1997) 16133-16139
    • (1997) J. Biol. Chem. , vol.272 , pp. 16133-16139
    • Tsukamoto, T.1    Nigam, S.J.2
  • 17
    • 2342647446 scopus 로고    scopus 로고
    • Radical scavenger edaravone developed for clinical use ameliorates ischemia/reperfusion injury in rat kidney
    • Doi K., Suzuki Y., Nakao A., Fujita T., and Noiri E. Radical scavenger edaravone developed for clinical use ameliorates ischemia/reperfusion injury in rat kidney. Kidney Int. 65 (2004) 1714-1723
    • (2004) Kidney Int. , vol.65 , pp. 1714-1723
    • Doi, K.1    Suzuki, Y.2    Nakao, A.3    Fujita, T.4    Noiri, E.5
  • 19
    • 0036901407 scopus 로고    scopus 로고
    • Tyrosine phosphorylation and dissociation of occludin-ZO-1 and E-cadherin-b-catenin complexes from the cytoskeleton by oxidative stress
    • Rao R.K., Basuroy S., Rao V.U., Karnaki Jr. K.J., and Gupta A. Tyrosine phosphorylation and dissociation of occludin-ZO-1 and E-cadherin-b-catenin complexes from the cytoskeleton by oxidative stress. Biochem. J. 368 Pt2 (2002) 471-481
    • (2002) Biochem. J. , vol.368 , Issue.Pt2 , pp. 471-481
    • Rao, R.K.1    Basuroy, S.2    Rao, V.U.3    Karnaki Jr., K.J.4    Gupta, A.5
  • 21
    • 0141890293 scopus 로고    scopus 로고
    • The role of HIF-1 alpha in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia
    • Leonard M.O., Cottell D.C., Godson C., Brady H.R., and Taylor C.T. The role of HIF-1 alpha in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia. J. Biol. Chem. 278 41 (2003) 40296-40304
    • (2003) J. Biol. Chem. , vol.278 , Issue.41 , pp. 40296-40304
    • Leonard, M.O.1    Cottell, D.C.2    Godson, C.3    Brady, H.R.4    Taylor, C.T.5
  • 22
    • 0028609124 scopus 로고
    • ATP depletion: a novel method to study junctional properties in epithelial tissues: I. Rearrangement of the actin cytoskeleton
    • Bacallao R., Garfinkel A., Monke S., Zampighi G., and Mandel L.J. ATP depletion: a novel method to study junctional properties in epithelial tissues: I. Rearrangement of the actin cytoskeleton. J. Cell Sci. 107 (1994) 3301-3313
    • (1994) J. Cell Sci. , vol.107 , pp. 3301-3313
    • Bacallao, R.1    Garfinkel, A.2    Monke, S.3    Zampighi, G.4    Mandel, L.J.5
  • 23
    • 1242294492 scopus 로고    scopus 로고
    • Mechanism of actin polymerization in cellular ATP depletion
    • Atkinson S.J., Hosford M.A., and Molitoris B.A. Mechanism of actin polymerization in cellular ATP depletion. J. Biol. Chem. 279 (2004) 5194-5199
    • (2004) J. Biol. Chem. , vol.279 , pp. 5194-5199
    • Atkinson, S.J.1    Hosford, M.A.2    Molitoris, B.A.3
  • 25
    • 0032514134 scopus 로고    scopus 로고
    • Structural and functional regulation of tight junctions by RhoA and Rac1 small GTPases
    • Jou T.-S., Schneeberger E.E., and James Nelson W. Structural and functional regulation of tight junctions by RhoA and Rac1 small GTPases. J. Cell Biol. 142 (1998) 101-115
    • (1998) J. Cell Biol. , vol.142 , pp. 101-115
    • Jou, T.-S.1    Schneeberger, E.E.2    James Nelson, W.3
  • 26
    • 1842426730 scopus 로고    scopus 로고
    • Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment
    • McBeath R., Pirone D.M., Nelson C.M., Bhadriraju K., and Chen C.S. Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev. Cell 6 4 (2004) 483-495
    • (2004) Dev. Cell , vol.6 , Issue.4 , pp. 483-495
    • McBeath, R.1    Pirone, D.M.2    Nelson, C.M.3    Bhadriraju, K.4    Chen, C.S.5
  • 27
    • 0029995797 scopus 로고    scopus 로고
    • Rho-stimulated contractility drives the formation of stress fibers and focal adhesions
    • Chrzanowska-Wodnicka M., and Burridge K. Rho-stimulated contractility drives the formation of stress fibers and focal adhesions. J. Cell Biol. 133 6 (1996) 1403-1415
    • (1996) J. Cell Biol. , vol.133 , Issue.6 , pp. 1403-1415
    • Chrzanowska-Wodnicka, M.1    Burridge, K.2
  • 28
    • 15544387084 scopus 로고    scopus 로고
    • Rac and Rho play opposing roles in the regulation of hypoxia/reoxygenation-induced permeability changes in pulmonary artery endothelial cells
    • Wojciak-Stothard B., Tsang L.Y.F., and Haworth S.G. Rac and Rho play opposing roles in the regulation of hypoxia/reoxygenation-induced permeability changes in pulmonary artery endothelial cells. Am. J. Physiol.: Lung Cell. Mol. Physiol. 288 (2005) L749-L760
    • (2005) Am. J. Physiol.: Lung Cell. Mol. Physiol. , vol.288
    • Wojciak-Stothard, B.1    Tsang, L.Y.F.2    Haworth, S.G.3
  • 29
    • 0028581961 scopus 로고
    • ATP depletion: a novel method to study junctional properties in epithelial tissues. II. Internalization of Na+,K(+)-ATPase and E-cadherin
    • Mandel L.J., Doctor R.B., and Bacallao R. ATP depletion: a novel method to study junctional properties in epithelial tissues. II. Internalization of Na+,K(+)-ATPase and E-cadherin. J. Cell Sci. 107 (1994) 3315-3324
    • (1994) J. Cell Sci. , vol.107 , pp. 3315-3324
    • Mandel, L.J.1    Doctor, R.B.2    Bacallao, R.3
  • 30
    • 0036232486 scopus 로고    scopus 로고
    • ATP depletion of tubular cells causes dissociation of the zonula adherens and nuclear translocation of {beta}-catenin and LEF-1
    • Price V.R., Reed C.A., Lieberthal W., and Schwartz J.H. ATP depletion of tubular cells causes dissociation of the zonula adherens and nuclear translocation of {beta}-catenin and LEF-1. J. Am. Soc. Nephrol. 13 (2002) 1152-1161
    • (2002) J. Am. Soc. Nephrol. , vol.13 , pp. 1152-1161
    • Price, V.R.1    Reed, C.A.2    Lieberthal, W.3    Schwartz, J.H.4
  • 31
    • 0033813810 scopus 로고    scopus 로고
    • Genesis and reversal of the ischemic phenotype in epithelial cells
    • Bush K.T., Keller S.H., and Nigam S.K. Genesis and reversal of the ischemic phenotype in epithelial cells. J. Clin. Invest. 106 5 (2000) 621-626
    • (2000) J. Clin. Invest. , vol.106 , Issue.5 , pp. 621-626
    • Bush, K.T.1    Keller, S.H.2    Nigam, S.K.3
  • 34
    • 0036088604 scopus 로고    scopus 로고
    • Rac1, but not RhoA, signaling protects epithelial adherens junction assembly during ATP depletion
    • Gopalakrishnan S., Dunn K.W., and Marrs J.A. Rac1, but not RhoA, signaling protects epithelial adherens junction assembly during ATP depletion. Am. J. Physiol.: Cell Physiol. 283 (2002) C261-C272
    • (2002) Am. J. Physiol.: Cell Physiol. , vol.283
    • Gopalakrishnan, S.1    Dunn, K.W.2    Marrs, J.A.3
  • 35
    • 3242705077 scopus 로고    scopus 로고
    • RhoA, Rac1 and Cdc42 exerts distinct effects on epithelial barrier via selective structural and biochemical modulation of junctional proteins and F-actin
    • Bruewer M., Hopkins A.M., Hobert M.E., Nusrat A., and Madara J.L. RhoA, Rac1 and Cdc42 exerts distinct effects on epithelial barrier via selective structural and biochemical modulation of junctional proteins and F-actin. Am. J. Physiol.: Cell Physiol. 287 (2004) C-327-C-335
    • (2004) Am. J. Physiol.: Cell Physiol. , vol.287
    • Bruewer, M.1    Hopkins, A.M.2    Hobert, M.E.3    Nusrat, A.4    Madara, J.L.5
  • 36
    • 0037509990 scopus 로고    scopus 로고
    • Focal adhesion kinase: the first ten years
    • Parsons J.T. Focal adhesion kinase: the first ten years. J. Cell Sci. 116 (2003) 1409-1416
    • (2003) J. Cell Sci. , vol.116 , pp. 1409-1416
    • Parsons, J.T.1
  • 37
    • 0033584438 scopus 로고    scopus 로고
    • Hypoxia induces activation and subcellular translocation of focal adhesion kinase (p125(FAK)) in cultured rat cardiac myocytes
    • Seko Y., T.N., Sabe H., Tobe K., Kadowaki T., and Nagai R. Hypoxia induces activation and subcellular translocation of focal adhesion kinase (p125(FAK)) in cultured rat cardiac myocytes. Biochem. Biophys. Res. Commun. 262 (1999) 290-296
    • (1999) Biochem. Biophys. Res. Commun. , vol.262 , pp. 290-296
    • Seko, Y.T.N.1    Sabe, H.2    Tobe, K.3    Kadowaki, T.4    Nagai, R.5
  • 38
    • 28044462434 scopus 로고    scopus 로고
    • Hypoxia inducible factor 1alpha modulates adhesion, migration and FAK phosphorylation in vascular smooth muscle cells
    • Corley K.M., Taylor C.J., and Lilly B. Hypoxia inducible factor 1alpha modulates adhesion, migration and FAK phosphorylation in vascular smooth muscle cells. J. Cell. Biochem. 96 5 (2005) 971-985
    • (2005) J. Cell. Biochem. , vol.96 , Issue.5 , pp. 971-985
    • Corley, K.M.1    Taylor, C.J.2    Lilly, B.3
  • 39
    • 2442427558 scopus 로고    scopus 로고
    • Hsp72 Interacts with paxillin and facilitates the reassembly of focal adhesions during recovery from ATP depletion
    • Mao H., Wang Y., Li Z., Ruchalski K.L., Yu X., Schwartz J.H., and Borkan S.C. Hsp72 Interacts with paxillin and facilitates the reassembly of focal adhesions during recovery from ATP depletion. J. Biol. Chem. 279 (2004) 15472-15480
    • (2004) J. Biol. Chem. , vol.279 , pp. 15472-15480
    • Mao, H.1    Wang, Y.2    Li, Z.3    Ruchalski, K.L.4    Yu, X.5    Schwartz, J.H.6    Borkan, S.C.7
  • 41
    • 0037380667 scopus 로고    scopus 로고
    • Hypoxia-induced endocytosis of Na,K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC-{zeta}
    • Dada L.A., Chandel N.S., Ridge K.M., Pedemonte C., Bertorello A.M., and Sznajder J.I. Hypoxia-induced endocytosis of Na,K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC-{zeta}. J. Clin. Invest. 111 (2003) 1057-1064
    • (2003) J. Clin. Invest. , vol.111 , pp. 1057-1064
    • Dada, L.A.1    Chandel, N.S.2    Ridge, K.M.3    Pedemonte, C.4    Bertorello, A.M.5    Sznajder, J.I.6
  • 42
    • 4644317883 scopus 로고    scopus 로고
    • Hypoxic reduction in cellular glutathione levels requires mitochondrial reactive oxygen species
    • Mansfield K.D., Simon M.C., and Keith B. Hypoxic reduction in cellular glutathione levels requires mitochondrial reactive oxygen species. J. Appl. Physiol. 97 4 (2004) 1358-1366
    • (2004) J. Appl. Physiol. , vol.97 , Issue.4 , pp. 1358-1366
    • Mansfield, K.D.1    Simon, M.C.2    Keith, B.3
  • 43
    • 0036052648 scopus 로고    scopus 로고
    • Differential role of reactive oxygen species in chemical hypoxia-induced cell injury in opossum kidney cells and rabbit renal cortical slices
    • Kim Y.K., Lee S.K., Ha M.S., Woo J.S., and Jung J.S. Differential role of reactive oxygen species in chemical hypoxia-induced cell injury in opossum kidney cells and rabbit renal cortical slices. Exp. Nephrol. 2002 10 (2005) 275-284
    • (2005) Exp. Nephrol. , vol.2002 , Issue.10 , pp. 275-284
    • Kim, Y.K.1    Lee, S.K.2    Ha, M.S.3    Woo, J.S.4    Jung, J.S.5
  • 44
    • 0348226836 scopus 로고    scopus 로고
    • Role of apoptosis in hypoxic/ischemic damage in the kidney
    • Saikumar P., and Venkatachalam M. Role of apoptosis in hypoxic/ischemic damage in the kidney. Semin. Nephrol. 23 (2003) 511-521
    • (2003) Semin. Nephrol. , vol.23 , pp. 511-521
    • Saikumar, P.1    Venkatachalam, M.2
  • 45
    • 0034082278 scopus 로고    scopus 로고
    • Cellular oxygen sensing by mitochondria: old questions, new insight
    • Chandel N.S., and Schumacker P.T. Cellular oxygen sensing by mitochondria: old questions, new insight. J. Appl. Physiol. 88 (2000) 1880-1889
    • (2000) J. Appl. Physiol. , vol.88 , pp. 1880-1889
    • Chandel, N.S.1    Schumacker, P.T.2
  • 48
    • 0037780966 scopus 로고    scopus 로고
    • Reactive oxygen species as essential mediators of cell adhesion: the oxidative inhibition of a FAK tyrosine phosphatase is required for cell adhesion
    • Chiarugi P., Pani G., Giannoni E., Taddei L., Colavitti R., Raugei G., Symons M., Borrello S., Galeotti T., and Ramponi G. Reactive oxygen species as essential mediators of cell adhesion: the oxidative inhibition of a FAK tyrosine phosphatase is required for cell adhesion. J. Cell Biol. 161 5 (2003) 933-944
    • (2003) J. Cell Biol. , vol.161 , Issue.5 , pp. 933-944
    • Chiarugi, P.1    Pani, G.2    Giannoni, E.3    Taddei, L.4    Colavitti, R.5    Raugei, G.6    Symons, M.7    Borrello, S.8    Galeotti, T.9    Ramponi, G.10
  • 49
    • 24344434553 scopus 로고    scopus 로고
    • Cell adhesion strengthening: contributions of adhesive area, integrin binding, and focal adhesion assembly
    • Gallant N.D., Michael K.E., and Garcia A.J. Cell adhesion strengthening: contributions of adhesive area, integrin binding, and focal adhesion assembly. Mol. Biol. Cell 16 9 (2005) 4329-4340
    • (2005) Mol. Biol. Cell , vol.16 , Issue.9 , pp. 4329-4340
    • Gallant, N.D.1    Michael, K.E.2    Garcia, A.J.3
  • 50
    • 33646201289 scopus 로고    scopus 로고
    • Remodelling epithelial tubes trough cell rearrangements: from cells to molecules
    • Neumann M., and Affolter M. Remodelling epithelial tubes trough cell rearrangements: from cells to molecules. EMBO Rep. 7 1 (2006) 36-40
    • (2006) EMBO Rep. , vol.7 , Issue.1 , pp. 36-40
    • Neumann, M.1    Affolter, M.2
  • 51
    • 2442664118 scopus 로고    scopus 로고
    • Rational design and characterization of a Rac GTPase-specific small molecule inhibitor
    • Gao Y., Dickerson J.B., Guo F., Zheng J., and Zheng Y. Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc. Natl. Acad. Sci. U. S. A. 101 20 (2004) 7618-7623
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , Issue.20 , pp. 7618-7623
    • Gao, Y.1    Dickerson, J.B.2    Guo, F.3    Zheng, J.4    Zheng, Y.5
  • 52
    • 20344391148 scopus 로고    scopus 로고
    • Outgrowth of neurites from NIE-115 neuroblastoma cells is prevented on repulsive substrates trough the action of PAK
    • Marler K.J.M., Kozma R., Ahmed S., Dong J.M., Hall C., and Lim L. Outgrowth of neurites from NIE-115 neuroblastoma cells is prevented on repulsive substrates trough the action of PAK. Mol. Cell. Biol. 25 12 (2005) 5226-5241
    • (2005) Mol. Cell. Biol. , vol.25 , Issue.12 , pp. 5226-5241
    • Marler, K.J.M.1    Kozma, R.2    Ahmed, S.3    Dong, J.M.4    Hall, C.5    Lim, L.6
  • 53
    • 33745833345 scopus 로고    scopus 로고
    • Genetic deletion of Rac1 GTPase reveals its critical role in actin stress fiber formation and focal adhesion complex assembly
    • Guo F., Debidda M., Yang L., Williams D.A., and Zheng Y. Genetic deletion of Rac1 GTPase reveals its critical role in actin stress fiber formation and focal adhesion complex assembly. J. Biol. Chem. 281 27 (2006) 18652-18659
    • (2006) J. Biol. Chem. , vol.281 , Issue.27 , pp. 18652-18659
    • Guo, F.1    Debidda, M.2    Yang, L.3    Williams, D.A.4    Zheng, Y.5
  • 54
    • 85029462480 scopus 로고    scopus 로고
    • M.M. Escribese, D. Sáenz-Morales, M. Garcia-Martos, D. Amrán, E. Conde, L. Alegre, F. Liaño, M.L. Garcia-Bermejo, Moderate renal ischemia/reperfusion tubular damage is reproduced by an in vitro model (in preparation).
  • 55
    • 85029463665 scopus 로고    scopus 로고
    • L. Alegre, M. Garcia-Martos, D. Sáenz-Morales, E. Conde, M.M. Escribese, M. López-Cabrera, J.A. Sanchez-Tomero, R. Selgas, M.L. Garcia-Bermejo, HIF-1alpha is required for human proximal tubule epithelial cells survival after moderate ischemia (in preparation).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.