The D1 dopamine receptor is constitutively phosphorylated by G protein-coupled receptor kinase 4

Molecular Pharmacology

Volumn 69, Issue 3, 2006, Pages 759-769

  Rankin, Michele L ^a   Marinec, Paul S ^a   Cabrera, David M ^a   Wang, Zheng ^b   Jose, Pedro A ^b   Sibley, David R ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; DOPAMINE 1 RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE; G PROTEIN COUPLED RECEPTOR KINASE 4; G PROTEIN-COUPLED RECEPTOR KINASE 4; GREEN FLUORESCENT PROTEIN; ISOENZYME; PROTEIN SERINE THREONINE KINASE;

ARTICLE; CELL SURFACE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR DOWN REGULATION; AMINO ACID SEQUENCE; CELL CULTURE; CELL MEMBRANE; CHEMISTRY; GENETIC TRANSFECTION; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; PHOSPHORYLATION;

AMINO ACID SEQUENCE; CELL MEMBRANE; CELLS, CULTURED; CYCLIC AMP; GREEN FLUORESCENT PROTEINS; HUMANS; ISOENZYMES; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, DOPAMINE D1; TRANSFECTION;

EID: 33644841768     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.105.019901     Document Type: Article

References (35)

1. Ambrose C, James M, Barnes G, Lin C, Bates G, Altherr M, Duyao M, Groot N, Church D, and Wasmuth JJ (1992) A novel G protein-coupled receptor kinase gene cloned from 4p16.3. Hum Mol Genet 1:697-703.
2. 1 receptor C-terminus. Eur J Cell Biol 81:77-85.
3. Charpentier S, Jarvie KR, Severynse DM, Caron MG, and Tiberi M (1996) Silencing of the constitutive activity of the dopamine D1B receptor. J Biol Chem 271:28071-28076.
4. Felder RA, Sanada H, Xu J, Yu P-Y, Wang Z, Watanabe H, Asico LD, Wang W, Zheng S, Yamaguchi I, et al. (2002) G protein-coupled receptor kinase 4 gene variants in human essential hypertension. Proc Natl Acad Sci USA 99:3872-3877.
5. Ferguson SSG, Barak LS, Zhang J, and Caron MG (1996) G-protein-coupled receptor regulation: role of G-protein coupled receptor kinases and arrestins. Can J Physiol Pharmacol 74:1095-1110.
6. 2-adrenergic receptor. J Biol Chem 271:13796-13803.
7. Gainetdinov RR, Premont RT, Bohn LM, Lefkowitz RJ, and Caron MG (2004) Desensitization of G protein-coupled receptors and neuronal functions. Annu Rev Neurosci 27:107-144.
8. 1 dopamine receptor function: evidence for a novel pathway for receptor dephosphorylation. Mol Pharmacol 59:310-321.
9. Guan X-M, Kobilka TS, and Kobilka BK (1992) Enhancement of membrane insertion and function in a type IIIb membrane protein following introduction of a cleavable signal peptide. J Biol Chem 267:21995-21998.
10. Heinzel SS, Krysan PJ, Calos MP, and DuBridge RB (1988) Use of simian virus 40 replication to amplify Epstein-Barr virus shuttle vectors in human cells. J Virol 62:3738-3746.
11. Hisatomi O, Matsuda S, Satoh T, Kotaka S, Imanishi Y, and Tokunaga F (1998) A novel subtype of G-protein-coupled receptor kinase, GRK7, in teleost cone photoreceptors. FEBS Lett 424:159-164.
12. Iwata K, Luo J, Penn RB, and Benovic JL (2005) Bimodal regulation of the human H1 histamine receptor by G protein-coupled receptor kinase 2. J Biol Chem 280:2197-2204.
13. Jackson A, Iwasiow RM, Chaar ZY, Nantel M-F, and Tiberi M (2002) Homologous regulation of the heptahelical D1A receptor responsiveness: specific cytoplasmic tail regions mediate dopamine-induced phosphorylation, desensitization and endocytosis. J Neurochem 82:683-697.
14. 1 dopamine receptors with mutations of protein kinase phosphorylation sites: attenuation of the rate of agonist-induced desensitization. Mol Pharmacol 56:675-683.
15. Kim J, Ahn S, Ren X-R, Whalen EJ, Reiter E, Wei H, and Lefkowitz RJ (2005) Functional antagonism of different G protein-coupled receptor kinases for β-arrestin-mediated angiotensin II receptor signaling. Proc Natl Acad Sci USA 102:1442-1447.
16. 1 dopamine receptor desensitization: evidence for a novel mechanism of arrestin association. J Biol Chem 279:7999-8010.
17. Krupnick JG, Santini F, Gagnon AW, Keen JH, and Benovic JL (1997) Modulation of the arrestin-clathrin interaction in cells. J Biol Chem 272:32507-32512.
18. 1 receptor. J Biol Chem 277:9415-9421.
19. 1 receptor interaction with arrestin3 in neostriatal neurons. J Neurochem 93:128-134.
20. 1 receptor trafficking by protein kinase A-dependent phosphorylation. Mol Pharmacol 61:806-816.
21. Missale C, Nash SR, Robinson SW, Jaber M, and Caron MG (1998) Dopamine receptors: from structure to function. Physiol Rev 78:189-225.
22. 1 dopamine receptor linked to adenylyl cyclase activation. Proc Natl Acad Sci USA 87:6723-6727.
23. Onorato JJ, Palczewski K, Regan JW, Caron MG, Lefkowitz RJ, and Benovic JL (1991) Role of acidic amino acids in peptide substrates of the β-adrenergic receptor kinase and rhodopsin kinase. Biochemistry 30:5118-5125.
24. Palczewski K, Arendt A, McDowell JH, and Hargrave PA (1989) Substrate recognition determinants for rhodopsin kinase: studies with synthetic peptides, polyanions and polycations. Biochemistry 28:8764-8770.
25. 2-adrenergic receptor is constitutively desensitized and phosphorylated. Proc Natl Acad Sci USA 91:2699-2702.
26. Penela P, Ribas C, and Mayor J, Federico (2003) Mechanisms of regulation of the expression and function of G protein-coupled receptor kinases. Cell Signal 15:973-981.
27. Premont RT, Macrae AD, Aparicio SAJR, Kendall HE, Welch JE, and Lefkowitz RJ (1999) The GRK4 subfamily of G protein-coupled receptor kinases: alternative splicing, gene organization and sequence conservation. J Biol Chem 274:29381-29389.
28. Premont RT, Macrae AD, Stoffel RH, Chung N, Pitcher JA, Ambrose C, Inglese J, MacDonald ME, and Lefkowitz R (1996) Characterization of the G protein-coupled receptor kinase GRK4: identification of four splice variants. J Biol Chem 271:6403-6410.
29. Sallese M, Mariggio S, Collodel G, Moretti E, Piomboni P, Baccetti B, and De Blasi A (1997) G protein-coupled receptor kinase GRK4. Molecular analysis of the four isoforms and ultrastructural localization in spermatozoa and germinal cells. J Biol Chem 272:10188-10195.
30. Sibley DR and Monsma FJ Jr (1992) Molecular biology of dopamine receptors. Trends Pharmacol Sci 13:61-69.
31. Somers RL and Klein DC (1984) Rhodopsin kinase activity in the mammalian pineal gland and other tissues. Science (Wash DC) 226:182-184.
32. Tiberi M, Nash SR, Bertrand L, Lefkowitz RJ, and Caron MG (1996) Differential regulation of dopamine D1A receptor responsiveness by various G protein-coupled receptor kinases. J Biol Chem 271:3771-3778.
33. Vickery RG and von Zastrow M (1999) Distinct dynamin-dependent and -independent mechanisms target structurally homologous dopamine receptors to different endocytic membranes. J Cell Biol 144:31-43.
34. Weiss ER, Raman D, Shirakawa S, Ducceschi MH, Bertram PT, Wong F, Kraft TW, and Osawa S (1998) The cloning of GRK7, a candidate cone opsin kinase, form cone-and rod-dominant mammalian retinas. Mol Vision 4:27-34.
35. Zeng C, Sanada H, Watanabe H, Eisner GM, Felder RA, and Jose PA (2004) Functional genomics of the dopaminergic system in hypertension. Physiol Genomics 19:233-246.