G protein-coupled receptor kinase mediates desensitization of norepinephrine-induced Ca2+ channel inhibition

Neuron

Volumn 16, Issue 3, 1996, Pages 579-585

  Diversé Pierluissi, María ^a   Inglese, James ^b   Stoffel, Robert H ^c   Lefkowitz, Robert J ^c   Dunlap, Kathleen ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PHARMACOPEIA INC   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; CALCIUM CHANNEL; CALCIUM ION; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN COUPLED RECEPTOR KINASE; NORADRENALIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHICK EMBRYO; CONCENTRATION RESPONSE; CONTROLLED STUDY; DESENSITIZATION; EMBRYO; ENZYME REGULATION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR SENSITIVITY; SENSORY NERVE CELL; SPINAL GANGLION; SYNAPTIC TRANSMISSION;

ANIMALS; CALCIUM CHANNELS; CELLS, CULTURED; CHICK EMBRYO; DOSE-RESPONSE RELATIONSHIP, DRUG; GTP-BINDING PROTEINS; NOREPINEPHRINE; PATCH-CLAMP TECHNIQUES; PHOSPHORYLATION; PROTEIN KINASES; SYNAPTIC TRANSMISSION;

EID: 0029943769     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(00)80077-X     Document Type: Article

References (40)

1. Arriza, J.L., Dawson, T.M., Simerly, R.B., Marin, L.J., Caron, M.G., Snyder, S.H., and Lefkowitz, R.J. (1992). The G protein-coupled receptor kinases βARK1 and βARK2 are widely distributed at synapses in rat brain. J. Neurosci. 12, 4045-4055.
2. 2-adrenergic receptor by the β-adrenergic receptor kinase. J. Biol. Chem. 262, 17251-17253.
3. Benovic, J.L., Onorato, J.J., Arriza, J.L., Stone, W.C., Lohse, M., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., Caron, M.G., and Lefkowitz, R.J. (1991). Cloning, expression, and chromosomal localization of β-adrenergic receptor kinase 2: a new member of the receptor kinase family. J. Biol. Chem. 266, 14939-14946.
4. Boekhoff, I., and Breer, H. (1992). Termination of second messenger signaling in olfaction. Proc. Natl. Acad. Sci. USA 9, 471-474.
5. Canfield, D.R., and Dunlap, K. (1984). Pharmacological characterization of amine receptors on embryonic chick sensory neurones. Br. J. Pharmacol. 82, 557-563.
6. Clements, J.D., Lester, R., Tong, G., Jahr, C.E., and Westbrook, G. (1992). The time course of glutamate in the synaptic cleft. Science 258, 12498-12501.
7. Cox, D.H., and Dunlap, K. (1992). Pharmacological discrimination of N-type from L-type calcium current and its selective modulation by transmitters. J. Neurosci. 12, 906-914.
8. Diversé-Pierluissi, M., and Dunlap, K. (1993). Distinct, convergent second messenger pathways modulate neuronal calcium currents. Neuron 10, 753-760.
9. Diversé-Pierluissi, M., and Dunlap, K. (1995). Interaction of convergent pathways that inhibit N-type calcium currents in sensory neurons. Neuroscience 65, 477-483.
10. Diversé-Pierluissi, M., Goldsmith, P.K., and Dunlap, K. (1995).Transmitter-mediated inhibition of N-type calcium channels in sensory neurons involves multiple GTP-binding proteins and subunits. Neuron 14, 191-200.
11. 2-C2. J. Biol. Chem. 267, 25473-25479.
12. Elmslie, K.S., Werz, M.A., Overholt, J.L., and Jones, S.W. (1993). Intracellular ATP and GTP are both required to preserve modulation of N-type calcium current by norepinephrine. Pflügers Arch. 423, 472-479.
13. Freedman, N.J., Liggett, S.B., Drachman, D.E., Pei, G., Caron, M.G., and Lefkowitz, R.J. (1995). Phosphorylation and desensitization of the human β1-adrenergic receptor: involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase. J. Biol. Chem. 270, 17953-17961.
14. Haga, T., Haga, K., and Kameyana, K. (1994). G protein-coupled receptor kinases. J. Neurochem. 63, 400-411.
15. Hamill, O.P., Marty, A., Neher, E., Sakmann, B., and Sigworth, F.J. (1981). Improved patch-clamptechniques for high resolution current recording from cells and cell-free membrane patches. Pflügers Arch. 381, 85-100
16. Hausdorf, W.P., Caron, M.G., and Lefkowitz, R.J. (1990). Turning off the signal: desensitization of the β-adrenergic receptor. FASEB J. 4, 2881-2889.
17. Headley, P.M., Duggan, A.W., and Griersmith, B.T. (1978). Selective reduction by norepinephrine and 5-hydroxytryptamine of nociceptive responses of cat dorsal horn neurons. Brain Res. 145, 185-189.
18. Homcy, C.J., Vatner, S.F., and Vatner, D.E. (1991). β-adrenergic receptor regulation in the heart in pathophysiologic states: abnormal adrenergic responsiveness. Annu. Rev. Physiol. 53, 137-160.
19. Huganir, R.L., and Greengard, P. (1990). Regulation of neurotransmitter receptor desensitization by protein phosphorylation. Neuron 5, 555-567.
20. Inglese, J., Freedman, N.J., Koch, W.J., and Lefkowitz, R.J. (1993). Structure and mechanism of the G protein-coupled receptor kinases. J. Biol. Chem. 268, 23735-23738.
21. Ishii, K., Chem, J., Ishii, M., Koch, W.J., Freedman, N.J., Lefkowitz, R.J., and Coughlin, S.R. (1994). Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. J. Biol. Chem. 269, 1125-1130.
22. Jones, S.W., and Marks, T.N. (1989). Calcium currents in bullfrog sympathetic neurons. J. Gen. Physiol. 94, 169-182.
23. Klein, W.L., Sullivan, J., Skorupa, A., and Aguilar J.S. (1989). Plasticity of neuronal receptors. FASEB J. 3, 2132-2140.
24. Koch, W.J., Inglese, J., Stone, W.C., and Lefkowitz, R.J. (1993). The binding site for the βγ subunits of heterotrimeric G proteins on the β-adrenergic receptor kinase. J. Biol. Chem. 268, 8256-8260.
25. Koch, W.J., Hawes, B.E., Inglese, J., Luttrell, L.M., and Lefkowitz, R. J. (1994). Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuate Gβγ-mediated signaling. J. Biol. Chem. 269, 6193-6197.
26. Koch, W.J., Rockman, H.A., Samama, P., Hamilton, R., Bond, R.A., Milano, C. A., and Lefkowitz, R.J. (1995). Cardiac function in mice overexpressing the β-adrenergic receptor kinase or a βARK inhibitor. Science 268, 1350-1353.
27. 2-adrenergic receptor subtypes. J. Biol. Chem. 269, 10093-10099.
28. q/11, is a substrate of β-adrenergic receptor kinase 1 and 2. J. Biol. Chem. 265, 9161-9164.
29. Lefkowitz, R.J. (1993). G protein-coupled receptor kinases. Cell 74, 409-412.
30. Luebke, J.I., and Dunlap, K. (1994). Sensory neuron N-type calcium currents are inhibited by both voltage-dependent and -independent mechanisms. Pflügers Arch. 428, 499-507.
31. Muller, S., Hekman, M., and Lohse, M.J. (1993) Specific enhancement of β-adrenergic receptor kinase activity by defined G-protein β and γ subunits. Proc. Natl. Acad. Sci. USA 90, 10439-10443.
32. Pitcher, J., Inglese, J., Higgins, J.B., Arriza, J.L., Casey, P.J., Kim, C., Benovic, J.L., Kwatra, M.M., Caron, M.G., and Lefkowitz, R.J. (1992). Role of β-γ subunits of G proteins in targeting the β-adrenergic receptor kinase to membrane-bound receptors. Science 257, 1264-1267.
33. Pitcher, J., Touhara, K., Payne, E.S., and Lefkowitz, R.J. (1995). Pleckstrin homology domain-mediated membrane association and activation requires coordinate interaction with Gβ-γ and lipid. J. Biol. Chem. 270, 11707-11710.
34. Premont, R.T., Koch, W.J., Inglese, J., and Lefkowitz, R.J. (1994). Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases. J. Biol. Chem. 269, 6832-6841.
35. Premont, R.T., Inglese, J., and Lefkowitz, R.J. (1995). Protein kinases that phosphorylate activated G protein-coupled receptors. FASEB J. 9, 175-182.
36. Rane, S.G., Walsh, M.P., MacDonald, J.R., and Dunlap, K. (1989). Specific inhibitors of protein kinase C block transmitter-induced modulation of sensory neuron calcium current. Neuron 3, 239-245.
37. Schleicher, S., Boekhoff, I., Arriza, J., Lefkowitz, R.J., and Breer, H. (1993). A β-adrenergic receptor kinase-like enzyme is involved in olfactory signal termination. Proc. Natl. Acad. Sci. USA 90, 1420-1424.
38. Touhara, K., Koch, W.J., Hawes, B.E., and Lefkowitz, R.J. (1995). Mutational analysis of the pleckstrin homology domain of the β-adrenergic receptor kinase: differential effects on Gβγ and phosphatidylinositol 4,5-biphosphate binding. J. Biol. Chem. 270, 17000-17005.
39. Trussell, L.O., Zhang, S., and Raman, I.M. (1993). Desensitization of AMPA receptors upon multiquantal neurotransmitter release. Neuron 10, 1185-1196.
40. Ungerer, M., Parruti, G., Bohm, M., Puzicha, M., DeBlasi, A., Erdmann, E., and Lohse, M. (1994). Expression of β-arrestins and β-adrenergic receptor kinases in the failing human heart. Circ. Res. 74, 206-213