Molecular cloning of rat G-protein-coupled receptor kinase 6 (GRK6) from brain tissue, and its mRNA expression in different brain regions and peripheral tissues

Molecular Brain Research

Volumn 49, Issue 1-2, 1997, Pages 278-282

  Fehr, Christoph ^a   Fickova, Martina ^a   Hiemke, Christoph ^a   Reuss, Stefan ^a   Dahmen, Norbert ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

G protein coupled receptor kinase 6 (GRK6); Gene expression; RACE PCR; Rat brain

Indexed keywords

COMPLEMENTARY DNA; GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN KINASE;

AMINO ACID SEQUENCE; ANIMAL TISSUE; AORTA; ARTICLE; BRAIN TISSUE; HEART; KIDNEY; LIVER; LUNG; MOLECULAR CLONING; NONHUMAN; OPEN READING FRAME; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; SKELETAL MUSCLE; SMALL INTESTINE; STOMACH; THYMUS; TISSUE DISTRIBUTION; UTERUS;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BRAIN; CLONING, MOLECULAR; DNA, COMPLEMENTARY; FEMALE; GTP-BINDING PROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; OPEN READING FRAMES; ORGAN SPECIFICITY; POLYMERASE CHAIN REACTION; PROTEIN-SERINE-THREONINE KINASES; RATS; RECEPTOR PROTEIN-TYROSINE KINASES; RNA, MESSENGER; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION, GENETIC;

ANIMALIA;

EID: 0030657022     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(97)00186-1     Document Type: Article

References (25)

1. Arriza J.L., Dawson T.M., Simerly R.B., Martin L.J., Caron M.G., Snyder S.H., Lefkowitz R.J. The G protein-receptor kinases β-ARK1 and β-ARK2 are widely distributed at synapses in rat brain. J. Neurosci. 12:1992;4045-4055.
2. Benovic J.L., De Blasi A., Stone W.C., Caron M.G., Lefkowitz R.J. β-Adrenergic receptor kinase: primary structure delineates a multigene family. Science. 246:1989;235-240.
3. Benovic J.L., Gomez J. Molecular cloning and expression of GRK6. J. Biol. Chem. 268:1993;19527-19532.
4. Birnstiel M.L., Busslinger M., Strub K. Transcription termination and 3′ processing: the end is in site! Cell. 41:1985;349-359.
5. Chomcznyski P., Sacchi N. Single step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:1987;156-159.
6. Chuang T.T., Iacovelli L., Sallese M., De Blasi A. G protein coupled receptors: heterologous regulation of homologous desensitization and its implications. Trends Pharmacol. Sci. 17:1996;416-421.
7. D. Firsov, B. Virlon, A.C. Bellanger and J.M. Elalouf, Molecular diversity of type IV G protein-coupled receptor kinase, GenBank Accession Number, X97568.
8. Freedman N.J., Lefkowitz R.J. Desensitization of G protein-coupled receptors. Recent Prog. Horm. Res. 51:1996;319-351.
9. 1-adrenergic receptor. J. Biol. Chem. 270:1995;17953-17961.
10. Frohman M.A., Dush M.K., Martin G.R. Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. Proc. Natl. Acad. Sci. USA. 85:1988;8998-9002.
11. Hanks S.K., Quinn A.M., Hunter T. The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science. 241:1988;42-52.
12. Hanks S.K., Quinn A.M. Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members. Methods Enzymol. 200:1991;38-62.
13. Haribabu B., Synderman R. Identification of additional members of human G-protein-coupled receptor kinase multigene family. Proc. Natl. Acad. Sci. USA. 90:1993;9398-9402.
14. Inglese J., Freedman N.J., Koch W.J., Lefkowitz R.J. Structure and mechanism of the G protein-coupled receptor kinases. J. Biol. Chem. 268:1993;23735-23738.
15. Kim C.M., Dion S.B., Benovic J.L. Mechanism of β-adrenergic receptor kinase activation by G proteins. J. Biol. Chem. 268:1993;15412-15418.
16. Lefkowitz R.J. G protein coupled receptor kinases. Cell. 74:1993;409-412.
17. Lefkowitz R.J., Caron M.G. Regulation of adrenergic receptor function by phosphorylation. Curr. Top. Cell Regul. 28:1986;209-231.
18. Lohse M.J., Krasel C., Winstel R., Mayor F. Jr. G-protein-coupled receptor kinases. Kidney Int. 49:1996;1047-1052.
19. Loudon R.P., Benovic J.L. Expression, purification, and characterization of the G protein-coupled receptor kinase GRK6. J. Biol. Chem. 269:1996;22691-22697.
20. Nagayama Y., Tanaka K., Hara T., Namba H., Yamashita S., Taniyama K., Niwa M. Involvement of G-protein-coupled receptor kinase 5 in homologeous desensitization of the thyrotropin receptor. J. Biol. Chem. 271:1996;10143-10148.
21. Palczewski K., Benovic J.L. G-protein-coupled receptor kinases. Trends Biochem. Sci. 16:1991;190-387.
22. Pitcher J.A., Inglese J., Higgins J.B., Arriza J.L., Casey P.J., Kim C., Benovic J.L., Kwatra M.M., Caron M.G., Lefkowitz R.J. Role of the βγ subunits of G proteins in targeting the β-adrenergic receptor kinase to membrane-bound receptors. Science. 257:1992;1264-1267.
23. Stoffel R.H., Randall R.R., Premont R.T., Lefkowitz R.J., Inglese J. Palmitoylation of G protein-coupled receptor kinase, GRK6. J. Biol. Chem. 269:1994;27791-27794.
24. 1-induced translocation of the β-adrenergic receptor kinase: evidence that the kinase may act on multiple adenylate cyclase-coupled receptors. Proc. Natl. Acad. Sci. USA. 83:1986;6362-6366.
25. X. Zhao, F. Haeseleer, R.N. Fariss, J. Huang, W. Baehr, A.H. Milam and K. Palczewski, Molecular cloning and localization of rhodopsin kinase in mammalian, Vis. Neurosci. (1997, in press).