Vascular smooth muscle overexpression of G protein-coupled receptor kinase 5 elevates blood pressure, which segregates with sex and is dependent on G i-mediated signaling

Circulation

Volumn 112, Issue 8, 2005, Pages 1145-1153

  Keys, Janelle R ^a,c   Zhou, Rui Hai ^b   Harris, David M ^b   Druckman, Charles A ^b   Eckhart, Andrea D ^b,d  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Blood pressure; Hypertension; Receptors; Receptors, adrenergic, beta; Vasculature

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; 5 [2 [[2 HYDROXY 3 [4 (1 METHYL 4 TRIFLUOROMETHYL 2 IMIDAZOLYL)PHENOXY]PROPYL]AMINO]ETHOXY]SALICYLAMIDE; ADENYLATE CYCLASE; ADRENALIN; ANGIOTENSIN; BETA 1 ADRENERGIC RECEPTOR; BETA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR KINASE; G PROTEIN COUPLED RECEPTOR KINASE 5; GENOMIC DNA; ISOPRENALINE; MESSENGER RNA; NORADRENALIN; PERTUSSIS TOXIN; POTASSIUM CHANNEL; POTASSIUM CHLORIDE; UNCLASSIFIED DRUG;

ABDOMINAL AORTA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CATECHOLAMINE BLOOD LEVEL; ENZYME ACTIVITY; GENE EXPRESSION; HYPERTENSION; IMMUNOHISTOCHEMISTRY; NONHUMAN; NUCLEOTIDE SEQUENCE; OVARIECTOMY; PHENOTYPE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; THORACIC AORTA; TRANSGENIC MOUSE; VASCULAR SMOOTH MUSCLE;

ANGIOTENSIN II; ANIMALS; AORTA; BLOOD PRESSURE; CYCLIC AMP; FEMALE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HYPERTENSION; MICE; MICE, TRANSGENIC; MUSCLE, SMOOTH, VASCULAR; OVARIECTOMY; POTASSIUM CHANNELS; POTASSIUM CHLORIDE; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; SEX CHARACTERISTICS; SIGNAL TRANSDUCTION; TRANSGENES; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS; VASODILATION;

EID: 24044537898     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.104.531657     Document Type: Article

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