Endothelin-1 Activates Endothelial Cell Nitric-oxide Synthase via Heterotrimeric G-protein βγ Subunit Signaling to Protein Kinase B/Akt

Journal of Biological Chemistry

Volumn 278, Issue 50, 2003, Pages 49929-49935

  Liu, Songling ^a   Premont, Richard T ^a   Kontos, Christopher D ^a   Huang, Jianhua ^a   Rockey, Don C ^a,b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; MUSCLE; NITROGEN OXIDES; SYNTHESIS (CHEMICAL);

VASOACTIVE EFFECTS;

CELLS;

ENDOTHELIN 1; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; NITRIC OXIDE SYNTHASE; PERTUSSIS TOXIN; PROTEIN KINASE B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL REACTIVITY; CELL SURVIVAL; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME SUBUNIT; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN PROCESSING; RAT; RECEPTOR GENE; SMOOTH MUSCLE FIBER; SMOOTH MUSCLE RELAXATION; VASCULAR SMOOTH MUSCLE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CULTURE MEDIA, SERUM-FREE; ENDOTHELIAL CELLS; ENDOTHELIN-1; ENZYME ACTIVATION; GTP-BINDING PROTEIN BETA SUBUNITS; GTP-BINDING PROTEIN GAMMA SUBUNITS; MALE; MODELS, BIOLOGICAL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ENDOTHELIN; SIGNAL TRANSDUCTION; TIME FACTORS; TYROSINE;

ANIMALIA;

EID: 0347379916     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M306930200     Document Type: Article

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