Neuropathic pain activates the endogenous κ opioid system in mouse spinal cord and induces opioid receptor tolerance

Journal of Neuroscience

Volumn 24, Issue 19, 2004, Pages 4576-4584

  Xu, Mei ^a   Petraschka, Michael ^a   McLaughlin, Jay P ^a   Westenbroek, Ruth E ^a   Caron, Marc G ^b   Lefkowitz, Robert J ^b   Czyzyk, Traci A ^c   Pintar, John E ^c   Terman, Gregory W ^a   Chavkin, Charles ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

opioid receptor; Allodynia; Desensitization; Dynorphin; Hyperalgesia; Opiate; Receptor phosphorylation

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; 4 AMINOBUTYRIC ACID RECEPTOR; DYNORPHIN; G PROTEIN COUPLED RECEPTOR KINASE; G PROTEIN COUPLED RECEPTOR KINASE 3; GLIAL FIBRILLARY ACIDIC PROTEIN; KAPPA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR AGONIST; KAPPA OPIATE RECEPTOR ANTAGONIST; NORBINALTORPHIMINE; PRODYNORPHIN; SERINE; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; ASTROCYTE; CONTROLLED STUDY; GENE LOCATION; HYPERALGESIA; IMMUNOREACTIVITY; KNOCKOUT MOUSE; MOUSE; NERVE LIGATION; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SCIATIC NERVE; SPINAL CORD; SPINAL CORD DORSAL HORN; WILD TYPE;

ANIMALS; ASTROCYTES; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; DRUG TOLERANCE; DYNORPHINS; ENKEPHALINS; HYPERALGESIA; LUMBOSACRAL REGION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NARCOTIC ANTAGONISTS; NARCOTICS; NEURALGIA; NEURONS; PROTEIN PRECURSORS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, OPIOID; RECEPTORS, OPIOID, KAPPA; SCIATIC NEUROPATHY; SPINAL CORD;

EID: 2442659170     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5552-03.2004     Document Type: Article

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