Structure-activity relationships of novel piperazines as antagonists for the melanocortin-4 receptor

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 5, 2007, Pages 1989-2005

  Nozawa, Dai ^a   Okubo, Taketoshi ^a   Ishii, Takaaki ^a   Kakinuma, Hiroyuki ^a   Chaki, Shigeyuki ^a   Okuyama, Shigeru ^a   Nakazato, Atsuro ^a  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Antagonist; Anxiety and depression; Bis piperazine synthesis; Melanocortin 4 receptor

Indexed keywords

1 [2 (4 FLUOROPHENYL) 2 (4 ISOPROPYLPIPERAZIN 1 YL)ETHYL] 4 [4 (2 METHOXY 1 NAPHTHYL)BUTYL]PIPERAZIN 3 MALEATE; MELANOCORTIN 4 RECEPTOR; NAPHTHYL GROUP; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG CONFORMATION; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; IC 50; QUANTUM YIELD; REACTION ANALYSIS; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; MAGNETIC RESONANCE SPECTROSCOPY; PIPERAZINES; RATS; RECEPTOR, MELANOCORTIN, TYPE 4; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33846642613     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.12.039     Document Type: Article

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